3,559 research outputs found
Structure of BSCCO supermodulation from ab initio calculations
We present results of density functional theory (DFT) calculation of the
structural supermodulation in BSCCO-2212 structure, and show that the
supermodulation is indeed a spontaneous symmetry breaking of the nominal
crystal symmetry, rather than a phenomenon driven by interstitial O dopants.
The structure obtained is in excellent quantitative agreement with recent x-ray
studies, and reproduces several qualitative aspects of scanning tunnelling
microscopy (STM) experiments as well. The primary structural modulation
affecting the CuO_2 plane is found to be a buckling wave of tilted CuO_5
half-octahedra, with maximum tilt angle near the phase of the supermodulation
where recent STM experiments have discovered an enhancement of the
superconducting gap. We argue that the tilting of the half-octahedra and
concommitant planar buckling are directly modulating the superconducting pair
interaction.Comment: 4 pages, 3 figure
Apoptosis induced by Staphylococcus aureus in human monocytic U937 cells involves Akt and mitogen-activated protein (MAPK) phosphorylation
Staphylococcus aureus (S. aureus) is a leading etiologic agent of nosocomial and community-acquired infectious diseases. Numerous studies have shown that, S. aureus could promote apoptosis in host cells. Unfortunately, the cellular and molecular mechanisms responsible for this phenomenon are still poorly understood. The present study aims to elucidate the signaling mechanisms involved in S. aureus-induced U937 cells apoptosis by investigating the role of phosphatidylinositol 3-kinase/Akt (PI3K/Akt), mitogen-activated protein (MAPK) and caspases. Our results showed that, i decreased the expression of phosphorylation-Akt. In contrast, S. aureus increased phosphorylation-JNK1/2, phosphorylation-ERK1/2 and phosphorylation-p38 MAPK. Treatment of U937 cells with S. aureus resulted in the activation of caspase-3 and -9. Furthermore, caspases inhibitors, SP600125 (JNK inhibitor), SB203580 (p38MAPK inhibitor) and PD98059 (ERK inhibitor) decreased apoptosis in U937 cells. However, LY294002 (Akt inhibitor) increased U937 cells apoptosis. Taken together, our study for the first time suggest that S. aureus is able to enhance apoptosis of U937 cells through inhibition of PI3K/Akt and activation of MAPK signaling pathways.Key words: Staphylococcus aureus, mitogen-activated protein (MAPK), apoptosis, U937
Effects of electrostatic screening on the conformation of single DNA molecules confined in a nanochannel
Single T4-DNA molecules were confined in rectangular-shaped channels with a
depth of 300 nm and a width in the range 150-300 nm casted in a
poly(dimethylsiloxane) nanofluidic chip. The extensions of the DNA molecules
were measured with fluorescence microscopy as a function of the ionic strength
and composition of the buffer as well as the DNA intercalation level by the
YOYO-1 dye. The data were interpreted with scaling theory for a wormlike
polymer in good solvent, including the effects of confinement, charge, and
self-avoidance. It was found that the elongation of the DNA molecules with
decreasing ionic strength can be interpreted in terms of an increase of the
persistence length. Self-avoidance effects on the extension are moderate, due
to the small correlation length imposed by the channel cross-sectional
diameter. Intercalation of the dye results in an increase of the DNA contour
length and a partial neutralization of the DNA charge, but besides effects of
electrostatic origin it has no significant effect on the bare bending rigidity.
In the presence of divalent cations, the DNA molecules were observed to
contract, but they do not collapse into a condensed structure. It is proposed
that this contraction results from a divalent counterion mediated attractive
force between the segments of the DNA molecule.Comment: 38 pages, 10 figures, accepted for publication in The Journal of
Chemical Physic
Appearance of Flat Bands and Edge States in Boron-Carbon-Nitride Nanoribbons
Presence of flat bands and edge states at the Fermi level in graphene
nanoribbons with zigzag edges is one of the most interesting and attracting
properties of nanocarbon materials but it is believed that they are quite
fragile states and disappear when B and N atoms are doped at around the edges.
In this paper, we theoretically investigate electronic and magnetic properties
of boron-carbon-nitride (BCN) nanoribbons with zigzag edges where the outermost
C atoms on the edges are alternately replaced with B and N atoms using the
first principles calculations. We show that BCN nanoribbons have the flat bands
and edge states at the Fermi level in both H_2 rich and poor environments. The
flat bands are similar to those at graphene nanoribbons with zigzag edges, but
the distributions of charge and spin densities are different between them. A
tight binding model and the Hubbard model analysis show that the difference in
the distribution of charge and spin densities is caused by the different site
energies of B and N atoms compared with C atoms.Comment: 5 pages; 3 figure
The effects of matter density uncertainties on neutrino oscillations in the Earth
We compare three different methods to evaluate uncertainties in the Earth's
matter density profile, which are relevant to long baseline experiments, such
as neutrino factories.Comment: 3 pages, 1 figure. Talk given at the NuFact'02 Workshop, London, 1-6
July, 200
Microlensing optical depth towards the Galactic bulge from MOA observations during 2000 with Difference Image Analysis
We analyze the data of the gravitational microlensing survey carried out by
by the MOA group during 2000 towards the Galactic Bulge (GB). Our observations
are designed to detect efficiently high magnification events with faint source
stars and short timescale events, by increasing the the sampling rate up to 6
times per night and using Difference Image Analysis (DIA). We detect 28
microlensing candidates in 12 GB fields corresponding to 16 deg^2. We use Monte
Carlo simulations to estimate our microlensing event detection efficiency,
where we construct the I-band extinction map of our GB fields in order to find
dereddened magnitudes. We find a systematic bias and large uncertainty in the
measured value of the timescale in our simulations. They are
associated with blending and unresolved sources, and are allowed for in our
measurements. We compute an optical depth tau = 2.59_{-0.64}^{+0.84} \times
10^{-6} towards the GB for events with timescales 0.3<t_E<200 days. We consider
disk-disk lensing, and obtain an optical depth tau_{bulge} =
3.36_{-0.81}^{+1.11} \times 10^{-6}[0.77/(1-f_{disk})] for the bulge component
assuming a 23% stellar contribution from disk stars. These observed optical
depths are consistent with previous measurements by the MACHO and OGLE groups,
and still higher than those predicted by existing Galactic models. We present
the timescale distribution of the observed events, and find there are no
significant short events of a few days, in spite of our high detection
efficiency for short timescale events down to t_E = 0.3 days. We find that half
of all our detected events have high magnification (>10). These events are
useful for studies of extra-solar planets.Comment: 65 pages and 30 figures, accepted for publication in ApJ. A
systematic bias and uncertainty in the optical depth measurement has been
quantified by simulation
Coexistence of antiferromagnetic order and unconventional superconductivity in heavy fermion compounds CeRh_{1-x}Ir_xIn_5: nuclear quadrupole resonance studies
We present a systematic ^{115}In NQR study on the heavy fermion compounds
CeRh_{1-x}Ir_xIn_5 (x=0.25, 0.35, 0.45, 0.5, 0.55 and 0.75). The results
provide strong evidence for the microscopic coexistence of antiferromagnetic
(AF) order and superconductivity (SC) in the range of 0.35 \leq x \leq 0.55.
Specifically, for x=0.5, T_N is observed at 3 K with a subsequent onset of
superconductivity at T_c=0.9 K. T_c reaches a maximum (0.94 K) at x=0.45 where
T_N is found to be the highest (4.0 K). Detailed analysis of the measured
spectra indicate that the same electrons participate in both SC and AF order.
The nuclear spin-lattice relaxation rate 1/T_1 shows a broad peak at T_N and
follows a T^3 variation below T_c, the latter property indicating
unconventional SC as in CeIrIn_5 (T_c=0.4 K). We further find that, in the
coexistence region, the T^3 dependence of 1/T_1 is replaced by a T-linear
variation below T\sim 0.4 K, with the value \frac{(T_1)_{T_c}}{(T_1)_{low-T}}
increasing with decreasing x, likely due to low-lying magnetic excitations
associated with the coexisting magnetism.Comment: 20 pages, 14 figure
STRENGTH AND CONDITIONING PROGRAMMES FOR IMPROVING BACK MUSCLE FATIGABILITY IN FIREFIGHTERS
Back pain and back-related injuries are common in firefighters. The purpose of this study was to compare the effectiveness of two different types of strength and conditioning programmes in improving back muscle fatigability in firefighters. A total of 12 male firefighters completed 16 weeks on supervised exercise intervention programme. The Functional Group was prescribed unilateral movements that mimicked the asymmetrical nature of firefighting tasks. The Conventional Group performed more bilaterally loaded, symmetrical exercise training. The lumbar extensor muscles’ resistance to fatigue was assessed using the Modified Sorensen test with electromyography (EMG). The EMG median frequency slope was less steep (p = 0.023, η²p =0.420) after training, indicating improvement in fatigability. There was no difference between the groups (p = .605, η²p = 0.028) and no interaction effect (p = 0.245, η²p =0.132). In conclusion, a well-rounded strength and conditioning programme is promising in improving back muscle fatigability in firefighters
Electronic and Magnetic Properties of Partially-Open Carbon Nanotubes
On the basis of the spin-polarized density functional theory calculations, we
demonstrate that partially-open carbon nanotubes (CNTs) observed in recent
experiments have rich electronic and magnetic properties which depend on the
degree of the opening. A partially-open armchair CNT is converted from a metal
to a semiconductor, and then to a spin-polarized semiconductor by increasing
the length of the opening on the wall. Spin-polarized states become
increasingly more stable than nonmagnetic states as the length of the opening
is further increased. In addition, external electric fields or chemical
modifications are usable to control the electronic and magnetic properties of
the system. We show that half-metallicity may be achieved and the spin current
may be controlled by external electric fields or by asymmetric
functionalization of the edges of the opening. Our findings suggest that
partially-open CNTs may offer unique opportunities for the future development
of nanoscale electronics and spintronics.Comment: 6 figures, to appear in J. Am. Chem. So
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