Correlation between Infrared Colors and Intensity Ratios of SiO Maser Lines

We present the results of SiO millimeter-line observations of a sample of known SiO maser sources covering a wide dust-temperature range. A cold part of the sample was selected from the SiO maser sources found in our recent SiO maser survey of cold dusty objects. The aim of the present research is to investigate the causes of the correlation between infrared colors and SiO maser intensity ratios among different transition lines. In particular, the correlation between infrared colors and SiO maser intensity ratio among the J=1-0 v=1, 2, and 3 lines are mainly concerned in this paper. We observed in total 75 SiO maser sources with the Nobeyama 45m telescope quasi-simultaneously in the SiO J=1-0 v=0, 1, 2, 3, 4 and J=2-1 v=1, 2 lines. We also observed the sample in the 29SiO J=1-0 v=0 and J=2-1 v=0, and 30SiO J=1-0 v=0 lines, and the H2O 6(1,6)-5(2,3) line. As reported in previous papers, we confirmed that the intensity ratios of the SiO J=1-0 v=2 to v=1 lines clearly correlate with infrared colors. In addition, we found possible correlation between infrared colors and the intensity ratios of the SiO J=1-0 v=3 to v=1&2 lines. Two overlap lines of H2O (i.e., 11(6,6) nu_2=1 -> 12(7,5) nu_2=0 and 5(0,5) nu_2=2 -> 6(3,4) nu_2=1) might explain these correlation if these overlap lines become stronger with increase of infrared colors, although the phenomena also might be explained by more fundamental ways if we take into account the variation of opacity from object to object.Comment: 49 pages, 7 figures, 3 tables, accepted for publication in ApJ. Full resolution version available at http://www.asiaa.sinica.edu.tw/~junichi/paper

VERA Observation of the W49N H2O Maser Outburst in 2003 October

We report on a strong outburst of the W49N H2O maser observed with VERA. Single-dish monitoring with VERA 20 m telescopes detected a strong outburst of the maser feature at V_LSR = -30.7 km/s in 2003 October. The outburst had a duration of ~100 days and a peak intensity of 7.9 x 10^4 Jy, being one of the strongest outbursts in W49N observed so far. VLBI observations with the VERA array were also carried out near to the maximum phase of the outburst, and the outburst spot was identified in the VLBI map. While the map was in good agreement with previous studies, showing three major concentrations of maser spots, we found a newly formed arc-like structure in the central maser concentration, which may be a shock front powered by a forming star or a star cluster. The outburst spot was found to be located on the arc-like structure, indicating a possible connection of the present outburst to a shock phenomenon.Comment: 4 pages, 2 figures included, to appear in PASJ letter (Vol.56, #3, 2004 June

The inflammatory microenvironment in colorectal neoplasia

Peer reviewedPublisher PD

Effect of substrate-target distance and sputtering pressure in the synthesis of AlN thin films

In this work, we analyze the influence of the processing pressure and the substrate–target distance on the synthesis by reactive sputtering of c-axis oriented polycrystalline aluminum nitride thin films deposited on Si(100) wafers. The crystalline quality of AlN has been characterized by high-resolution X-ray diffraction (HR-XRD). The films exhibited a very high degree of c-axis orientation especially when a low process pressure was used. After growth, residual stress measurements obtained indirectly from radius of curvature measurements of the wafer prior and after deposition are also provided. Two different techniques are used to determine the curvature—an optically levered laser beam and a method based on X-ray diffraction. There is a transition from compressive to tensile stress at a processing pressure around 2 mTorr. The transition occurs at different pressures for thin films of different thickness. The degree of c-axis orientation was not affected by the target–substrate distance as it was varied in between 30 and 70 mm

Young and Intermediate-age Distance Indicators

Distance measurements beyond geometrical and semi-geometrical methods, rely mainly on standard candles. As the name suggests, these objects have known luminosities by virtue of their intrinsic proprieties and play a major role in our understanding of modern cosmology. The main caveats associated with standard candles are their absolute calibration, contamination of the sample from other sources and systematic uncertainties. The absolute calibration mainly depends on their chemical composition and age. To understand the impact of these effects on the distance scale, it is essential to develop methods based on different sample of standard candles. Here we review the fundamental properties of young and intermediate-age distance indicators such as Cepheids, Mira variables and Red Clump stars and the recent developments in their application as distance indicators.Comment: Review article, 63 pages (28 figures), Accepted for publication in Space Science Reviews (Chapter 3 of a special collection resulting from the May 2016 ISSI-BJ workshop on Astronomical Distance Determination in the Space Age

INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese

The single nucleotide polymorphism (SNP) rs7566605 in the upstream region of the insulin-induced gene 2 (INSIG2) is associated with the obesity phenotype in many Caucasian populations. In Japanese, this association with the obesity phenotype is not clear. To investigate the relationship between rs7566605 and obesity in Japanese, we genotyped rs7566605 from severely obese subjects [n = 908, body mass index (BMI) ≥ 30 kg/m2] and normal-weight control subjects (n = 1495, BMI < 25 kg/m2). A case–control association analysis revealed that rs7566605 was significantly associated with obesity in Japanese. The P value in the minor allele recessive mode was 0.00020, and the odds ratio (OR) adjusted for gender and age was 1.61 [95% confidential interval (CI) = 1.24–2.09]. Obesity-associated phenotypes, which included the level of BMI, plasma glucose, hemoglobin A1c, total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, and blood pressure, were not associated with the rs7566605 genotype. Thus, rs7566605 in the upstream region of the INSIG2 gene was found to be associated with obesity, i.e., severe obesity, in Japanese

Hyperleptinemia Is Required for the Development of Leptin Resistance

Leptin regulates body weight by signaling to the brain the availability of energy stored as fat. This negative feedback loop becomes disrupted in most obese individuals, resulting in a state known as leptin resistance. The physiological causes of leptin resistance remain poorly understood. Here we test the hypothesis that hyperleptinemia is required for the development of leptin resistance in diet-induced obese mice. We show that mice whose plasma leptin has been clamped to lean levels develop obesity in response to a high-fat diet, and the magnitude of this obesity is indistinguishable from wild-type controls. Yet these obese animals with constant low levels of plasma leptin remain highly sensitive to exogenous leptin even after long-term exposure to a high fat diet. This shows that dietary fats alone are insufficient to block the response to leptin. The data also suggest that hyperleptinemia itself can contribute to leptin resistance by downregulating cellular response to leptin as has been shown for other hormones