A scalable readout system for a superconducting adiabatic quantum optimization system

We have designed, fabricated and tested an XY-addressable readout system that is specifically tailored for the reading of superconducting flux qubits in an integrated circuit that could enable adiabatic quantum optimization. In such a system, the flux qubits only need to be read at the end of an adiabatic evolution when quantum mechanical tunneling has been suppressed, thus simplifying many aspects of the readout process. The readout architecture for an $N$-qubit adiabatic quantum optimization system comprises $N$ hysteretic dc SQUIDs and $N$ rf SQUID latches controlled by $2\sqrt{N} + 2$ bias lines. The latching elements are coupled to the qubits and the dc SQUIDs are then coupled to the latching elements. This readout scheme provides two key advantages: First, the latching elements provide exceptional flux sensitivity that significantly exceeds what may be achieved by directly coupling the flux qubits to the dc SQUIDs using a practical mutual inductance. Second, the states of the latching elements are robust against the influence of ac currents generated by the switching of the hysteretic dc SQUIDs, thus allowing one to interrogate the latching elements repeatedly so as to mitigate the effects of stochastic switching of the dc SQUIDs. We demonstrate that it is possible to achieve single qubit read error rates of $<10^{-6}$ with this readout scheme. We have characterized the system-level performance of a 128-qubit readout system and have measured a readout error probability of $8\times10^{-5}$ in the presence of optimal latching element bias conditions.Comment: Updated for clarity, final versio

Uncertainty-principle noise in vacuum-tunneling transducers

The fundamental sources of noise in a vacuum-tunneling probe used as an electromechanical transducer to monitor the location of a test mass are examined using a first-quantization formalism. We show that a tunneling transducer enforces the Heisenberg uncertainty principle for the position and momentum of a test mass monitored by the transducer through the presence of two sources of noise: the shot noise of the tunneling current and the momentum fluctuations transferred by the tunneling electrons to the test mass. We analyze a number of cases including symmetric and asymmetric rectangular potential barriers and a barrier in which there is a constant electric field. Practical configurations for reaching the quantum limit in measurements of the position of macroscopic bodies with such a class of transducers are studied

Functional consequences of seven novel mutations in the CYP11B1 Gene: four mutations associated with nonclassic and three mutations causing classic 11 -Hydroxylase Deficiency

Context: Steroid 11β-hydroxylase (CYP11B1) deficiency (11OHD) is the second most common form of congenital adrenal hyperplasia (CAH). Cases of nonclassic 11OHD are rare compared with the incidence of nonclassic 21-hydroxylase deficiency. Objective: The aim of the study was to analyze the functional consequences of seven novel CYP11B1 mutations (p.M88I, p.W116G, p.P159L, p.A165D, p.K254_A259del, p.R366C, p.T401A) found in three patients with classic 11OHD, two patients with nonclassic 11OHD, and three heterozygous carriers for CYP11B1 mutations. Methods: We conducted functional studies employing a COS7 cell in vitro expression system comparing wild-type (WT) and mutant CYP11B1 activity. Mutants were examined in a computational three-dimensional model of the CYP11B1 protein. Results: All mutations (p.W116G, p.A165D, p.K254_A259del) found in patients with classic 11OHD have absent or very little 11β-hydroxylase activity relative to WT. The mutations detected in patients with nonclassic 11OHD showed partial functional impairment, with one patient being homozygous (p.P159L; 25% of WT) and the other patient compound heterozygous for a novel mild p.M88I (40% of WT) and the known severe p.R383Q mutation. The two mutations detected in heterozygous carriers (p.R366C, p.T401A) also reduced CYP11B1 activity by 23 to 37%, respectively. Conclusion: Functional analysis results allow for the classification of novel CYP11B1 mutations as causative for classic and nonclassic 11OHD, respectively. Four partially inactivating mutations are predicted to result in nonclassic 11OHD. These findings double the number of mild CYP11B1 mutations previously described as associated with mild 11OHD. Our data are important to predict phenotypic expression and provide important information for clinical and genetic counseling i

Measurement of the ground-state flux diagram of three coupled qubits as a first step towards the demonstration of adiabatic quantum computation

The ground state susceptibility of a system consisting of three flux-qubits was measured in the complete three dimensional flux space around the common degeneracy point of the qubits. The system's Hamiltonian could be completely reconstructed from measurements made far away from the common degeneracy point. The subsequent measurements made around this point show complete agreement with the theoretical predictions which follow from this Hamiltonian. The ground state anti-crossings of the system could be read-out directly from these measurements. This allows one to determine the ground-state flux diagram, which provides the solution for the non-polynomial optimization problem MAXCUT encoded in the Hamiltonian of the three-flux-qubit system. Our results show that adiabatic quantum computation can be demonstrated with this system provided that the energy gap and/or the speed of the read-out is increased.Comment: accepted for publication by Europhysics Letter

Sources of pro-cyclicality in east Asian financial systems

Procyclicality is a normal feature of economic systems, but financial sector weaknesses can exacerbate it sufficiently to pose a threat to macroeconomic and financial stability. These include shortcomings in bank risk management and governance, in supervision and in terms of dependence on volatile sources of funds. The paper tests econometrically for the importance of such features leading to pro-cyclicality in the financial systems of 11 East Asian countries. This analysis makes it possible to identify specific policy measures for East Asian countries that could limit the extent to which financial systems exacerbate pro-cyclicality

Predicting Climate-Driven Coastlines With a Simple and Efficient Multiscale Model

Ocean-basin-scale climate variability produces shifts in wave climates and water levels affecting the coastlines of the basin. Here we present a hybrid shoreline change?foredune erosion model (A COupled CrOss-shOre, loNg-shorE, and foreDune evolution model, COCOONED) intended to inform coastal planning and adaptation. COCOONED accounts for coupled longshore and cross-shore processes at different timescales, including sequencing and clustering of storm events, seasonal, interannual, and decadal oscillations by incorporating the effects of integrated varying wave action and water levels for coastal hazard assessment. COCOONED is able to adapt shoreline change rates in response to interactions between longshore transport, cross-shore transport, water level variations, and foredune erosion. COCOONED allows for the spatial and temporal extension of survey data using global data sets of waves and water levels for assessing the behavior of the shoreline at multiple time and spatial scales. As a case study, we train the model in the period 2004?2014 (11 years) with seasonal topographic beach profile surveys from the North Beach Sub-cell (NBSC) of the Columbia River Littoral Cell (Washington, USA).We explore the shoreline response and foredune erosion along 40 km of beach at several timescales during the period 1979?2014 (35 years), revealing an accretional trend producing reorientation of the beach, cross-shore accretional, and erosional periods through time (breathing) and alternating beach rotations that are correlated with climate indices.J. A. A. Antolínez and F. J. Méndez acknowledge the support of the Spanish “Ministerio de Economia y Competitividad” under Grant BIA2014-59643-R

Challenging Perceptions of Disability through Performance Poetry Methods: The "Seen but Seldom Heard" Project.

This paper considers performance poetry as a method to explore lived experiences of disability. We discuss how poetic inquiry used within a participatory arts-based research framework can enable young people to collectively question society’s attitudes and actions towards disability. Poetry will be considered as a means to develop a more accessible and effective arena in which young people with direct experience of disability can be empowered to develop new skills that enable them to tell their own stories. Discussion of how this can challenge audiences to critically reflect upon their own perceptions of disability will also be developed