2,509 research outputs found
Predictability, surprise, attention, and conditioning
Role of attention in Pavlovian conditioning, and use of auditory and visual stimuli to condition rat
Attention-like processes in classical conditioning
Conditioned emotional response studies using rats already trained to press bar for food suppl
Dispersive Soft Ferrite Models For Time Domain Simulation And their application To Accelerator Component Modeling
On the asymptotic behaviour of solutions to the fractional porous medium equation with variable density
We are concerned with the long time behaviour of solutions to the fractional
porous medium equation with a variable spatial density. We prove that if the
density decays slowly at infinity, then the solution approaches the
Barenblatt-type solution of a proper singular fractional problem. If, on the
contrary, the density decays rapidly at infinity, we show that the minimal
solution multiplied by a suitable power of the time variable converges to the
minimal solution of a certain fractional sublinear elliptic equation.Comment: To appear in DCDS-
Renormalizing Partial Differential Equations
In this review paper, we explain how to apply Renormalization Group ideas to
the analysis of the long-time asymptotics of solutions of partial differential
equations. We illustrate the method on several examples of nonlinear parabolic
equations. We discuss many applications, including the stability of profiles
and fronts in the Ginzburg-Landau equation, anomalous scaling laws in
reaction-diffusion equations, and the shape of a solution near a blow-up point.Comment: 34 pages, Latex; [email protected]; [email protected]
The determinants of vulnerability to currency crises: country-specific factors versus regional factors
We investigate the determinants of exchange market pressures (EMP) for some new EU member states at both the national and regional levels, where macroeconomic and financial variables are considered as potential sources. The regional common factors are extracted from these variables by using dynamic factor analysis. The linear empirical analysis, in general, highlights the importance of country-specific factors to defend themselves against vulnerability in their external sectors. Yet, given a significant impact of the common component in credit on EMP, a contagion effect is apparent through the conduit of credit market integration across these countries under investigation
Predictive gaze cues affect face evaluations: The effect of facial emotion
When we see someone change their direction of gaze, we spontaneously follow their eyes because we expect people to look at interesting objects. Bayliss and Tipper (2006) examined the consequences of observing this expectancy being either confirmed or violated by faces producing reliable or unreliable gaze cues. Participants viewed different faces that would consistently look at the target, or consistently look away from the target: The faces that consistently looked towards targets were subsequently chosen as being more trustworthy than the faces that consistently looked away from targets. The current work demonstrates that these gaze contingency effects are only detected when faces create a positive social context by smiling, but not in the negative context when all the faces held angry or neutral expressions. These data suggest that implicit processing of the reward contingencies associated with gaze cues relies on a positive emotional expression to maintain expectations of a favourable outcome of joint attention episodes
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Cationic Peptide Exposure Enhances Pulsed-Electric-Field-Mediated Membrane Disruption
Background: The use of pulsed electric fields (PEFs) to irreversibly electroporate cells is a promising approach for destroying undesirable cells. This approach may gain enhanced applicability if the intensity of the PEF required to electrically disrupt cell membranes can be reduced via exposure to a molecular deliverable. This will be particularly impactful if that reduced PEF minimally influences cells that are not exposed to the deliverable. We hypothesized that the introduction of charged molecules to the cell surfaces would create regions of enhanced transmembrane electric potential in the vicinity of each charged molecule, thereby lowering the PEF intensity required to disrupt the plasma membranes. This study will therefore examine if exposure to cationic peptides can enhance a PEF’s ability to disrupt plasma membranes. Methodology/Principal Findings We exposed leukemia cells to 40 μs PEFs in media containing varying concentrations of a cationic peptide, polyarginine. We observed the internalization of a membrane integrity indicator, propidium iodide (PI), in real time. Based on an individual cell’s PI fluorescence versus time signature, we were able to determine the relative degree of membrane disruption. When using 1–2 kV/cm, exposure to >50 μg/ml of polyarginine resulted in immediate and high levels of PI uptake, indicating severe membrane disruption, whereas in the absence of peptide, cells predominantly exhibited signatures indicative of no membrane disruption. Additionally, PI entered cells through the anode-facing membrane when exposed to cationic peptide, which was theoretically expected. Conclusions/Significance: Exposure to cationic peptides reduced the PEF intensity required to induce rapid and irreversible membrane disruption. Critically, peptide exposure reduced the PEF intensities required to elicit irreversible membrane disruption at normally sub-electroporation intensities. We believe that these cationic peptides, when coupled with current advancements in cell targeting techniques will be useful tools in applications where targeted destruction of unwanted cell populations is desired
Self-similarity and long-time behavior of solutions of the diffusion equation with nonlinear absorption and a boundary source
This paper deals with the long-time behavior of solutions of nonlinear
reaction-diffusion equations describing formation of morphogen gradients, the
concentration fields of molecules acting as spatial regulators of cell
differentiation in developing tissues. For the considered class of models, we
establish existence of a new type of ultra-singular self-similar solutions.
These solutions arise as limits of the solutions of the initial value problem
with zero initial data and infinitely strong source at the boundary. We prove
existence and uniqueness of such solutions in the suitable weighted energy
spaces. Moreover, we prove that the obtained self-similar solutions are the
long-time limits of the solutions of the initial value problem with zero
initial data and a time-independent boundary source
Asymptotic expansions of the solutions of the Cauchy problem for nonlinear parabolic equations
Let be a solution of the Cauchy problem for the nonlinear parabolic
equation and
assume that the solution behaves like the Gauss kernel as . In
this paper, under suitable assumptions of the reaction term and the initial
function , we establish the method of obtaining higher order
asymptotic expansions of the solution as . This paper is a
generalization of our previous paper, and our arguments are applicable to the
large class of nonlinear parabolic equations
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