Science and the Liberal Arts at Ursinus College

Science trend: Moving beyond industrialism • Founders\u27 Day address: Small colleges nurture young scientists well • Physics mentor changed a life • Complex world a challenge for scientists • In government, chemist finds his niche • Ursinus helps non standard student bloom • Ursinus let him explore inner space • Finding the problem is scientist\u27s hardest task • Most wanted: Insatiable curiosity • Real research: Practical or esoteric? • Flexibility is a matter of degree • Liberal arts education prepares minds • The way to encourage young scientistshttps://digitalcommons.ursinus.edu/founders_programs/1053/thumbnail.jp

P2RX7 Purinoceptor: A Therapeutic Target for Ameliorating the Symptoms of Duchenne Muscular Dystrophy

open access articleDuchenne muscular dystrophy (DMD) is the most common inherited muscle disease, leading to severe disability and death in young men. Death is caused by the progressive degeneration of striated muscles aggravated by sterile inflammation. The pleiotropic effects of the mutant gene also include cognitive and behavioral impairments and low bone density. Current interventions in DMD are palliative only as no treatment improves the long-term outcome. Therefore, approaches with a translational potential should be investigated, and key abnormalities downstream from the absence of the DMD product, dystrophin, appear to be strong therapeutic targets. We and others have demonstrated that DMD mutations alter ATP signaling and have identified P2RX7 purinoceptor up-regulation as being responsible for the death of muscles in the mdx mouse model of DMD and human DMD lymphoblasts. Moreover, the ATP–P2RX7 axis, being a crucial activator of innate immune responses, can contribute to DMD pathology by stimulating chronic inflammation. We investigated whether ablation of P2RX7 attenuates the DMD model mouse phenotype to assess receptor suitability as a therapeutic target

REC : revista de estudios del currículum

Resumen basado en el de la revistaEste artículo explora la introducción de la enseñanza del arte y de la educación física como temas especiales de enseñanza en el currículum de la escolarización de masas durante los siglos XIX y XX. Se explica por qué estas asignaturas nucleares de la enseñanza, el arte y la educación física, se difundieron más lentamente que otras por los sistemas educativos no occidentales.CataluñaBiblioteca del Ministerio de Educación y Formación Profesional; Calle San Agustín, 5; 28014 Madrid; Tel. +34917748000; [email protected]

The net cost of biofuels in Thailand--An economic analysis

Biofuels are expected to represent a growing portion of liquid fuel consumption in Thailand due to environmental and social considerations in conjunction with policy goals supporting their domestic production and consumption. This paper reviews the economic costs associated with biofuel policy implementation in Thailand in the short term target year of 2011. Internal (production) and external (environmental, social, etc.) costs and benefits are evaluated, and, where possible, monetized. Domestic production of biofuel is calculated to be 9.5 billion THB (317 million USD) more expensive than importing the equivalent amount of petroleum. The environmental benefits from GHG savings as well as losses due to increased ground level ozone formation and government expenditure to support the biofuel industry yield a total "net cost" of 8.6 billion THB or 121 THB (4.04 USD) per capita for the year 2011. This result is contextualized with the (non-monetized) consideration that although biofuels are somewhat more expensive in the short term, their domestic production allows virtually all of the money to stay within the Thai economy as opposed to being sent abroad. This fact, coupled with significant uncertainty in future petroleum prices, could strongly influence the direction of Thai policy with respect to biofuels.Economic analysis Biofuels Thailand