Notched graphite polymimide composites at room and notched graphite polymide composites at room and elevated temperatures

The fracture behavior in graphite/polyimide (Gr/PI) Celion 6000/PMR-15 composites was characterized. Emphasis was placed on the correlation between the observed failure modes and the deformation characteristics of center-notched Gr/Pl laminates. Crack tip damage growth, fracture strength and notch sensitivity, and the associated characterization methods were also examined. Special attention was given to nondestructive evaluation of internal damage and damage growth, techniques such as acoustic emission, X-ray radiography, and ultrasonic C-scan. Microstructural studies using scanning electron microscopy, photomicrography, and the pulsed nuclear magnetic resonance technique were employed as well. All experimental procedures and techniques are described and a summary of representative results for Gr/Pl laminates is given

Twentieth century light curves and the nucleus of comet P/Tempel 2

Observations of P/Tempel 2 from 1899 to 1988 corresponding to 13 apparitions are analyzed in order to estimate the perihelion asymmetry of the gas production curve for different periods of its evolution. Using the correlation found by Festou et al. (1990) between the perihelion asymmetries and the delay in perihelion passage due to the action of nongravitational forces, we estimate the mass of the comet to be M approximately equals 1.6 plus or minus 0.5 x 10(exp 14) kg. Assuming a volume of 500 cu km, based on nuclear observations, a density of 0.3 plus or minus 0.1 g/cu cm is obtained

Implementing circular economy strategies in buildings - from theory to practice

Population growth, along with a rapid urban expansion, is imposing a heavy pressure on the planet’s finite resources. It is widely acknowledged that the building industry consumes large amounts of raw materials while generating waste and emissions. To set apart economic growth from environmental repercussions, the Circular Economy (CE) arose as an innovative paradigm that can offer a fast-track towards a sustainable built environment. This paper will tackle a research gap that academia and policymakers often highlighted, which is how can we apply CE to assets that are predominantly meant to be demolished and their resources wasted when they reach their end-of-life. Globally, the paradigm aims at erasing the waste concept, relying on renewable and regenerative sources, and keeping the materials, components, and systems in use at their highest value as long as possible. The concept’s implementation would attempt to consider the built environment as a closed-loop system wherein resources are viewed as a scarce commodity. Although the CE seems straightforward, translating the circular thinking to the building level might be a hardship. The following paper will attempt to shed light on how to promote CE in buildings that will ultimately lead to healthier, more efficient, and more sustainable cities on a broader scale. The proposed framework considers CE implementation strategies throughout the building’s lifecycle and mainly deals with three innovative aspects: wise resource management, building design approaches, and digitalization of the building industry. In this sense, this study will explore these game-changing factors that are considered paramount to concretize the concept in practice and provide a smooth pathway for CE uptake in buildings.This research was funded by University of Minho, grant number UMINHO/BID/2020/7

Selection criteria for building materials and components in line with the circular economy principles in the built environment: a review of current trends

A growing concern is given to the environmental impacts caused by the construction industry. Waste generation, resource consumption, and greenhouse gas emissions are the main drawbacks of the rapid urbanization that the world is witnessing. As a response to these pressing issues, policymakers and academia are exploring the concept of Circular Economy (CE) to manage resources better and achieve resource efficiency while eliminating waste. One of the strategies to implement CE in the built environment is to select the appropriate building materials and components from the early stages to carry out the concept's principles along the value chain and create a closed-loop system. Therefore, this study aims at identifying selection criteria for building elements according to CE principles through a review of the latest research. Results have shown that little has been concretely achieved in terms of a paradigm shift to CE since the main focus of the literature is still the use of recycled products and the recyclability of building materials and components at their end-of-life. Although the present study is solely focused on the technical aspect of building materials and components, it outlines current adopted criteria to bring about a circular built environment and highlights the need for a more innovative approach to attain higher circularity levels.This research was funded by University of Minho, grant number UMINHO/BID/2020/71

Optical vortex generation from molecular chromophore arrays

The generation of light endowed with orbital angular momentum, frequently termed optical vortex light, is commonly achieved by passing a conventional beam through suitably constructed optical elements. This Letter shows that the necessary phase structure for vortex propagation can be directly produced through the creation of twisted light from the vacuum. The mechanism is based on optical emission from a family of chromophore nanoarrays that satisfy specific geometric and symmetry constraints. Each such array can support pairs of electronically delocalized doubly degenerate excitons whose azimuthal phase progression is responsible for the helical wave front of the emitted radiation. The exciton symmetry dictates the maximum magnitude of topological charge; detailed analysis secures the conditions necessary to deliver optical vortices of arbitrary order

How genomics has informed our understanding of the pathogenesis of osteoporosis

Osteoporosis is a skeletal disorder characterized by compromised bone strength that predisposes a person to an increased risk of fracture. Osteoporosis is a complex trait that involves multiple genes, environmental factors, and gene-gene and gene-environment interactions. Twin and family studies have indicated that between 25% and 85% of the variation in bone mass and other skeletal phenotypes is heritable, but our knowledge of the underlying genes is limited. Bone mineral density is the most common assessment for diagnosing osteoporosis and is the most often used quantitative value in the design of genetic studies. In recent years, our understanding of the pathophysiology of osteoporosis has been greatly facilitated by advances brought about by the Human Genome Project. Genetic approaches ranging from family studies of monogenic traits to association studies with candidate genes, to whole-genome scans in both humans and animals have identified a small number of genes that contribute to the heritability of bone mass. Studies with transgenic and knockout mouse models have revealed major new insights into the biology of many of these identified genes, but much more needs to be learned. Ultimately, we hope that by revealing the underlying genetics and biology driving the pathophysiology of osteoporosis, new and effective treatment can be developed to combat and possibly cure this devastating disease. Here we review the rapidly evolving field of the genomics of osteoporosis with a focus on important gene discoveries, new biological/physiological paradigms that are emerging, and many of the unanswered questions and hurdles yet to be overcome in the field

Live Imaging of Type I Collagen Assembly Dynamics in Osteoblasts Stably Expressing GFP and mCherry-Tagged Collagen Constructs

Type I collagen is the most abundant extracellular matrix protein in bone and other connective tissues and plays key roles in normal and pathological bone formation as well as in connective tissue disorders and fibrosis. Although much is known about the collagen biosynthetic pathway and its regulatory steps, the mechanisms by which it is assembled extracellularly are less clear. We have generated GFPtpz and mCherry-tagged collagen fusion constructs for live imaging of type I collagen assembly by replacing the α2(I)-procollagen N-terminal propeptide with GFPtpz or mCherry. These novel imaging probes were stably transfected into MLO-A5 osteoblast-like cells and fibronectin-null mouse embryonic fibroblasts (FN-null-MEFs) and used for imaging type I collagen assembly dynamics and its dependence on fibronectin. Both fusion proteins co-precipitated with α1(I)-collagen and remained intracellular without ascorbate but were assembled into α1(I) collagen-containing extracellular fibrils in the presence of ascorbate. Immunogold-EM confirmed their ultrastuctural localization in banded collagen fibrils. Live cell imaging in stably transfected MLO-A5 cells revealed the highly dynamic nature of collagen assembly and showed that during assembly the fibril networks are continually stretched and contracted due to the underlying cell motion. We also observed that cell-generated forces can physically reshape the collagen fibrils. Using co-cultures of mCherry- and GFPtpz-collagen expressing cells, we show that multiple cells contribute collagen to form collagen fiber bundles. Immuno-EM further showed that individual collagen fibrils can receive contributions of collagen from more than one cell. Live cell imaging in FN-null-MEFs expressing GFPtpz-collagen showed that collagen assembly was both dependent upon and dynamically integrated with fibronectin assembly. These GFP-collagen fusion constructs provide a powerful tool for imaging collagen in living cells and have revealed novel and fundamental insights into the dynamic mechanisms for the extracellular assembly of collagen