Determining significant parameters on health and well-being of building occupants towards re-engineered inclusive environment

People spend over 90% of their time in the buildings. A building is a place where people are spending more time doing activities, thus an inclusive environment of the buildings is very important to ensure that people are having a healthy life. An inclusive environment is important for the well-being of building occupants. Indoor environmental quality is one of the essential elements in creating an inclusive environment in which a poor quality of indoor environment affects the health of the occupants both physically and mentally, their performance, productivity, comfort, satisfaction, and well-being. Even though people are towards creating an inclusive environment but it is a limited study on the parameters of the inclusive environment. Thus, this paper is to study the parameters of the inclusive environment by focused on the element of the indoor environmental quality for building occupants based on literature reviews of articles between the year 2006 and 2016. Based on the content analysis, it has been discovered that there are various parameters of an inclusive environment which are visual comfort, thermal comfort, acoustic comfort, indoor air quality, buildings factors, occupants’ factors, and climate condition factors. The parameters can be very useful as guidelines and development of policy in providing inclusive environment for the healthy lifestyle of building occupants

Determining significant parameters on health and well-being of building occupants towards re-engineered inclusive environment

People spend over 90% of their time in the buildings. A building is a place where people are spending more time doing activities, thus an inclusive environment of the buildings is very important to ensure that people are having a healthy life. An inclusive environment is important for the well-being of building occupants. Indoor environmental quality is one of the essential elements in creating an inclusive environment in which a poor quality of indoor environment affects the health of the occupants both physically and mentally, their performance, productivity, comfort, satisfaction, and well-being. Even though people are towards creating an inclusive environment but it is a limited study on the parameters of the inclusive environment. Thus, this paper is to study the parameters of the inclusive environment by focused on the element of the indoor environmental quality for building occupants based on literature reviews of articles between the year 2006 and 2016. Based on the content analysis, it has been discovered that there are various parameters of an inclusive environment which are visual comfort, thermal comfort, acoustic comfort, indoor air quality, buildings factors, occupants’ factors, and climate condition factors. The parameters can be very useful as guidelines and development of policy in providing inclusive environment for the healthy lifestyle of building occupants

Gender differences in association between measures of central obesity and falls in community-dwelling middle-aged and older adults in Malaysia

Acknowledgements This study was partially funded by the Ministry of Higher Education Fundamental Research Grant Scheme (FRGS/1/2019/SKK02/UM/01/1). We would like to thank all MELoR investigators for helping in the data collection. The MELoR study is now the Transforming Cognitive Frailty to Later Life SelfSufficiency (AGELESS) study, which is funded by the Ministry of Higher Education Malaysia Long Term Research Grant Scheme.Peer reviewedPublisher PD

Bactericidal and Anti-biofilm Effects of Polyhexamethylene Biguanide in Models of Intracellular and Biofilm of Staphylococcus aureus Isolated from Bovine Mastitis

Staphylococcus aureus infection is a common cause of mastitis, reducing milk yield, affecting animal welfare and causing huge economic losses within the dairy industry. In addition to the problem of acquired drug resistance, bacterial invasion into udder cells and the formation of surface biofilms are believed to reduce antibiotic efficacy, leading to treatment failure. Here, we investigated the antimicrobial activities of enrofloxacin, an antibiotic that is commonly used in mastitis therapy and polyhexamethylene biguanide (PHMB), an antimicrobial polymer. The antimicrobial activities were tested against intracellular S. aureus in infected Mac-T cells (host cells). Also, fluorescein-tagged PHMB was used to study PHMB uptake and localization with S. aureus within the infected Mac-T cells. Anti-biofilm activities were tested by treating S. aureus biofilms and measuring effects on biofilm mass in vitro. Enrofloxacin and PHMB at 15 mg/L killed between 42 to 92 and 99.9% of intracellular S. aureus, respectively. PHMB-FITC entered and colocalized with the intracellular S. aureus, suggesting direct interaction of the drug with the bacteria inside the host cells. Enrofloxacin and PHMB at 15 mg/L reduced between 10 to 27% and 28 to 37% of biofilms’ mass, respectively. The half-maximal inhibitory concentrations (IC50) obtained from a cytotoxicity assay were 345 ± 91 and 21 ± 2 mg/L for enrofloxacin and PHMB, respectively; therefore, both compounds were tolerated by the host cells at high concentrations. These findings suggest that both antimicrobials are effective against intracellular S. aureus and can disrupt biofilm structures, with PHMB being more potent against intracellular S. aureus, highlighting the potential application of PHMB in mastitis therapy

The impact of IEQ on occupants’ satisfaction in Malaysian buildings

This paper focuses on the importance of occupant satisfaction with indoor environmental quality in buildings as well as the effect of indoor environmental quality towards occupants’ satisfaction. This research applied post-occupancy evaluation as a method to indicate the building occupants’ needs, their satisfaction and comfort level. The research is based on a case study approach whereby a questionnaire survey was conducted among 25 organizations involved in managing office buildings. A total of 115 questionnaires were returned for evaluation of occupants’ overall satisfaction from aspects of indoor environmental quality in these buildings and to determine the occupants’ satisfaction level within these buildings. The findings revealed that indoor environment factors that could contribute to occupants’ satisfaction consists of lighting, air quality and aesthetic perception. These classifications were made based on the factor analysis done with 22 attributes of the indoor environment. The majority of occupants are satisfied with their health conditions and do not face any serious health problems. However, occupants highlighted that some environmental conditions, health effects, air movement, ventilation and air freshness are important criteria for their satisfaction and comfort. This study provides insights into how occupants perceive their indoor environment and comfort, and identify problems that could arise in buildings

Air quality modelling using chemometric techniques

The datasets of air quality parameters for three years (2012-2014) were applied. HACA gave the result of three different groups of similarity based on the characteristics of air quality parameters. DA shows all seven parameters (CO, O3, PM10, SO2, NOx, NO and NO2) gave the most significant variables after stepwise backward mode. PCA identifies the major source of air pollution is due to combustion of fossil fuels in motor vehicles and industrial activities. The ANN model shows a better prediction compared to the MLR model with R2 values equal to 0.819 and 0.773 respectively. This study presents that the chemometric techniques and modelling become an excellent tool in API assessment, air pollution source identification, apportionment and can be setbacks in designing an API monitoring network for effective air pollution resources management

Individually-tailored multifactorial intervention to reduce falls in the Malaysian Falls Assessment and Intervention Trial (MyFAIT): A randomized controlled trial

Objective: To determine the effectiveness of an individually-tailored multifactorial intervention in reducing falls among at risk older adult fallers in a multi-ethnic, middle-income nation in South-East Asia. Design: Pragmatic, randomized-controlled trial. Setting: Emergency room, medical outpatient and primary care clinic in a teaching hospital in Kuala Lumpur, Malaysia. Participants: Individuals aged 65 years and above with two or more falls or one injurious fall in the past 12 months. Intervention: Individually-tailored interventions, included a modified Otago exercise programme, HOMEFAST home hazards modification, visual intervention, cardiovascular intervention, medication review and falls education, was compared against a control group involving conventional treatment. Primary and secondary outcome measures: The primary outcome was any fall recurrence at 12-month follow-up. Secondary outcomes were rate of fall and time to first fall. Results: Two hundred and sixty-eight participants (mean age 75.3 ±7.2 SD years, 67% women) were randomized to multifactorial intervention (n = 134) or convention treatment (n = 134). All participants in the intervention group received medication review and falls education, 92 (68%) were prescribed Otago exercises, 86 (64%) visual intervention, 64 (47%) home hazards modification and 51 (38%) cardiovascular intervention. Fall recurrence did not differ between intervention and control groups at 12-months [Risk Ratio, RR = 1.037 (95% CI 0.613–1.753)]. Rate of fall [RR = 1.155 (95% CI 0.846–1.576], time to first fall [Hazard Ratio, HR = 0.948 (95% CI 0.782–1.522)] and mortality rate [RR = 0.896 (95% CI 0.335–2.400)] did not differ between groups. Conclusion: Individually-tailored multifactorial intervention was ineffective as a strategy to reduce falls. Future research efforts are now required to develop culturally-appropriate and affordable methods of addressing this increasingly prominent public health issue in middle-income nations

HEAVY METALS IN TUNA SPECIES MEAT AND POTENTIAL CONSUMER HEALTH RISK : A REVIEW

Marine fishes are one of the protein sources and they form a significant part of human diet around the world. In particular, tuna fisheries are considered as the largest and most specialized commercially important group of species among all commercial fishes. The preparing tuna methods such as cooking and canning might alter the level of heavy metals inside the meat. The heat that applied to the meat might be decreased the moisture content in tuna meat, thus give some effects to the heavy metal level. Other than that, the different composition and function of different parts of tuna can contribute to the various level of heavy metals analysed. The metal contamination in tuna species meat has put serious question to the safety level of fish intake to the community. It represent an abiding threat to human health as it has been linked to some adverse health effects such as mental retardation, kidney damage, and various types of cancer and even worse, death could occur.The following review articles presents the findings of the work carried out by the various researchers in the past on the heavy metal pollution in samples of Tuna species around the world

Metal concentration at surface water using multivariate analysis and human health risk assessment

This study defined the concentration of metals in Kerteh and Paka River water and their potential health risk towards human. 54 water samples were collected and analyzed using ICP-OES. Results revealed that most of the stations in Kerteh River gave the higher concentration of Cd, Cu, Zn, Co, Ni, As, Cr and Pb compared to Paka River. However As, Cr and Pb have exceeded the permissible limit of Malaysia standard for all stations in both rivers. Cd, Cu, Zn, Co and Ni were below than Malaysian standard permissible levels during the sampling period. The principal component analysis (PCA) revealed that both geogenic and anthropogenic sources were responsible to possible metals contamination in both rivers. Moreover, risk assessments for all metals were within the safe limits, except for As in the Kerteh River for both adult and child as well as to Paka River for both genders