Production of 203^{203}Pb from enriched 205^{205}Tl using deuteron beams

International audienceLead-203 is a SPECT emitter that can be used in theranostic applications as an imaging counterpart of lead-212 which is intended to be used for alpha therapy as lead-212/bismuth-212 in-vivo generator. In our study, we explore the production of lead-203 using enriched thallium-205 target irradiated by a deuteron beam. Excitation functions of deuteron induced reactions leading to the formation of 204m,203m2+m1+g,202m,201m+gPb, 202Tl and 203m+gHg isotopes were determined experimentally in the energy range from 21 MeV to 34 MeV. Cross sections were measured using the stacked foils technique and a set of two monitor foils, natNi and natTi for beam intensity evaluation. The experimental excitation functions of the investigated reactions were compared with the published data and also with the TENDL-2021 nuclear database. From our experimental data, we calculated lead-203 thick target yield in the energy range between 30 MeV and 32.5 MeV to be 56.7 MBq/μAh ±6.1 MBq/μAh. This value is compatible with large batch production showing that deuteron beams can be used for a routine production process. However, special attention must be paid to 203Hg and other lead contaminants. •Deuteron induced reactions on thallium enriched to 205 (205Tl) up to 34 MeV.•Target preparation of 205Tl using the electrodeposition technique.•Stacked foil irradiation.•Production of 203Pb for nuclear medicine applications.•Comparison of thick target yields between proton and deuteron irradiation

Manufacture of Tl targets by electrodeposition for the study of excitation functions of 203Pb

International audienceNatural Tl targets were manufactured by electrochemical deposition on a foil gold backing. The electrochemical parameters were defined after several experiments and reverse pulse potential was chosen to avoid the formation of filaments and dendrites. Once these parameters were established, enriched 205Tl targets were manufactured on a gold foil backing to be used to measure the cross sections for 203Pb production by deuteron induced reactions. The production yield was calculated from our excitation functions and was found to be 54 MBq/µAh in the energy interval 32.5 MeV – 30 MeV

Production of Pb-203 from target manufacturing to chemical separation Tl/Pb

International audienceLead 212 (t1/2 = 10.6 h) and lead 203 (t1/2 = 51.9 h), can be used as a theranostic pair of isotopes for theranostic applications in nuclear medicine. 212Pb is obtained by decay of 224Ra and is used for alpha targeted therapy whereas 203Pb is produced by proton irradiation of a thallium target and allows for single photon emission computed tomography (SPECT) thanks to its 279.2 keV (80.9%) photons. Current production of Pb-203 uses natTl bombarded by a proton beam. In this work, we consider alternative production routes using enriched 205Tl deuteron beams in order to limit the level of 201Pb (t1/2 = 9.33h) impurities. Starting from cross section measurements, we have defined optimal production parameters and yields. In parallel, we have developed a manufacturing process of the target by electroplating as well as a separation chemical process using a Pb resin provided by Triskem. This scheme will allow us to produce 203Pb in the near future

Production of Pb-203 from target manufacturing to chemical separation Tl/Pb

International audienceLead 212 (t1/2 = 10.6 h) and lead 203 (t1/2 = 51.9 h), can be used as a theranostic pair of isotopes for theranostic applications in nuclear medicine. 212Pb is obtained by decay of 224Ra and is used for alpha targeted therapy whereas 203Pb is produced by proton irradiation of a thallium target and allows for single photon emission computed tomography (SPECT) thanks to its 279.2 keV (80.9%) photons. Current production of Pb-203 uses natTl bombarded by a proton beam. In this work, we consider alternative production routes using enriched 205Tl deuteron beams in order to limit the level of 201Pb (t1/2 = 9.33h) impurities. Starting from cross section measurements, we have defined optimal production parameters and yields. In parallel, we have developed a manufacturing process of the target by electroplating as well as a separation chemical process using a Pb resin provided by Triskem. This scheme will allow us to produce 203Pb in the near future

JRJC 2021- Journées de Rencontres Jeunes Chercheurs. Book of Proceedings

Journées de Rencontres Jeunes Chercheurs (JRJC2021). 17-23 octobre 2021, La Rochelle (France

JRJC 2021- Journées de Rencontres Jeunes Chercheurs. Book of Proceedings

Journées de Rencontres Jeunes Chercheurs (JRJC2021). 17-23 octobre 2021, La Rochelle (France

JRJC 2021- Journées de Rencontres Jeunes Chercheurs. Book of Proceedings

Journées de Rencontres Jeunes Chercheurs (JRJC2021). 17-23 octobre 2021, La Rochelle (France

JRJC 2021- Journées de Rencontres Jeunes Chercheurs. Book of Proceedings

Journées de Rencontres Jeunes Chercheurs (JRJC2021). 17-23 octobre 2021, La Rochelle (France

JRJC 2021- Journées de Rencontres Jeunes Chercheurs. Book of Proceedings

Journées de Rencontres Jeunes Chercheurs (JRJC2021). 17-23 octobre 2021, La Rochelle (France

JRJC 2021- Journées de Rencontres Jeunes Chercheurs. Book of Proceedings

Journées de Rencontres Jeunes Chercheurs (JRJC2021). 17-23 octobre 2021, La Rochelle (France