219 research outputs found

    НАБР Π₯ΠΠœΠ˜Π” АБУ ЗАЙД: Π–Π˜Π—ΠΠ•ΠΠΠ«Π™ ПУВЬ И ΠžΠ‘ΠΠžΠ’ΠΠ«Π• Π’Π—Π“Π›Π―Π”Π«

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    The article is dedicated to Nasr Hamid Abu Zayd (1943–2010) β€”Β an Egyptian thinker, one of the leading liberal theologians of Islam, professorΒ at Cairo University. The work traces in detail the life and scientifi cpaths of Nasr Abu Zayd, including the process of the so-called β€œAbu ZaydΒ case”, which had resonance not only in the Muslim, but also in the WesternΒ world, and caused the emigration of the thinker from his native country.Β The author also analyzes the main ideas of Abu Zayd, which resulted inΒ criticism of adherents of traditional views and gave reason for accusing theΒ thinker of apostasy.Данная ΡΡ‚Π°Ρ‚ΡŒΡ посвящСна творчСству Насра Π₯Π°ΠΌΠΈΠ΄Π° Абу Π—Π°ΠΉΠ΄Π° (1943–2010) β€” СгипСтского мыслитСля, профСссора ΠšΠ°ΠΈΡ€ΡΠΊΠΎΠ³ΠΎ унивСрситСт ΠΈ ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΈΠ· Π²Π΅Π΄ΡƒΡ‰ΠΈΡ… Π»ΠΈΠ±Π΅Ρ€Π°Π»ΡŒΠ½Ρ‹Ρ… Ρ‚Π΅ΠΎΠ»ΠΎΠ³ΠΎΠ² ислама. Π’ Ρ€Π°Π±ΠΎΡ‚Π΅ подробно исслСдуСтся ΠΆΠΈΠ·Π½Π΅Π½Π½Ρ‹ΠΉ ΠΈ Π½Π°ΡƒΡ‡Π½Ρ‹ΠΉ ΠΏΡƒΡ‚ΡŒ Насра Абу Π—Π°ΠΉΠ΄Π°, Π² Ρ‚ΠΎΠΌ числС описываСтся судСбный процСсс ΠΏΠΎ Ρ‚Π°ΠΊ Π½Π°Π·Ρ‹Π²Π°Π΅ΠΌΠΎΠΌΡƒ Β«Π΄Π΅Π»Ρƒ Абу Π—Π°ΠΉΠ΄Π°Β», Π²Ρ‹Π·Π²Π°Π²ΡˆΠ΅ΠΌΡƒ рСзонанс Π½Π΅ Ρ‚ΠΎΠ»ΡŒΠΊΠΎ Π² ΠΌΡƒΡΡƒΠ»ΡŒΠΌΠ°Π½ΡΠΊΠΎΠΌ, Π½ΠΎ ΠΈ Π² Π·Π°ΠΏΠ°Π΄Π½ΠΎΠΌ ΠΌΠΈΡ€Π΅ ΠΈ ΠΏΠΎΡΠ»ΡƒΠΆΠΈΠ²ΡˆΠ΅ΠΌΡƒ ΠΏΡ€ΠΈΡ‡ΠΈΠ½ΠΎΠΉ эмиграции мыслитСля ΠΈΠ· Ρ€ΠΎΠ΄Π½ΠΎΠΉ страны. Π’Π°ΠΊΠΆΠ΅ Π°Π²Ρ‚ΠΎΡ€Β Π°Π½Π°Π»ΠΈΠ·ΠΈΡ€ΡƒΠ΅Ρ‚ основныС ΠΈΠ΄Π΅ΠΈ Абу Π—Π°ΠΉΠ΄Π°, повлСкшиС ΠΊΡ€ΠΈΡ‚ΠΈΠΊΡƒ со стороны ΠΏΡ€ΠΈΠ²Π΅Ρ€ΠΆΠ΅Π½Ρ†Π΅Π² Ρ‚Ρ€Π°Π΄ΠΈΡ†ΠΈΠΎΠ½Π½Ρ‹Ρ… взглядов ΠΈ ΡΡ‚Π°Π²ΡˆΠΈΠ΅ ΠΏΠΎΠ²ΠΎΠ΄ΠΎΠΌ для обвинСния ΡƒΡ‡Π΅Π½ΠΎΠ³ΠΎ Π² вСроотступничСствС

    ВлияниС Π²Π½ΡƒΡ‚Ρ€Π΅Π½Π½ΠΈΡ… ΠΏΡ€ΠΎΡ‚ΠΈΠ²ΠΎΡ€Π΅Ρ‡ΠΈΠΉ Π² экономикС БША Π½Π° Π³Π»ΠΎΠ±Π°Π»ΡŒΠ½ΡƒΡŽ Ρ„ΠΈΠ½Π°Π½ΡΠΈΠ°Π»ΠΈΠ·Π°Ρ†ΠΈΡŽ ΠΈ экспансию Ρ„ΠΈΠΊΡ‚ΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΊΠ°ΠΏΠΈΡ‚Π°Π»Π°

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    The financialization genesis of the global economy centered in the United States is on the bifurcation point nowβ€” a fictive capital’ expansion is damaging with the social capital regeneration mechanism disaster. The method of identifying and estimating the fictive capital’ extension is absent for now. The fictive capital exists as a metaphor on the science papers but not as an institutional basis of the capital flows directions. The paper aims to update the configuration of the global financial system, its dependence on the performance of US corporations and banks; to identify the sources of vulnerability of world finance and global liquidity from the fictitious capital of American financial markets. The methodology is theoretical pattern’ of financial capital movements and its real statistical market indicators comparison. The empirical base is statistical data about the financial flows and financial results especially about the US as a global financial center. Based on the results the authors have revealed an origin of fictive capital on the US bank sector by the justification for the conclusion of liquidity above the profitable as the purpose of financial operations. This conclusion is confirmed with the scale of off-balance sheet transactions of banks. Besides the regression between the prices of derivative’ basis assets and stock indexes has been shown. Also, the market capitalization of American companies is not sensitive to change in market liquidity indicators. The authors concluded that global financialization is supported by significant internal contradictions in the US economy. The source of contradictions is the financial mechanism for withdrawing liquidity from the sphere of production and circulation into the sphere of financial markets. Capital investment using instruments of the US financial market entails the threat of losing their liquidity. Forecasting the dynamics of the global economy without taking into account the role of fictitious capital, which is emerging in the American financial markets, leads to global vulnerability and may cause the next financial crisis.Π­Π²ΠΎΠ»ΡŽΡ†ΠΈΡ процСсса финансиализации глобальной экономики с Ρ†Π΅Π½Ρ‚Ρ€ΠΎΠΌ Π² БША подошла ΠΊ Ρ‚ΠΎΡ‡ΠΊΠ΅ Π±ΠΈΡ„ΡƒΡ€ΠΊΠ°Ρ†ΠΈΠΈ β€” экспансия Ρ„ΠΈΠΊΡ‚ΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΊΠ°ΠΏΠΈΡ‚Π°Π»Π° ΡƒΠ³Ρ€ΠΎΠΆΠ°Π΅Ρ‚ Π½Π°Ρ€ΡƒΡˆΠ΅Π½ΠΈΠ΅ΠΌ ΠΌΠ΅Ρ…Π°Π½ΠΈΠ·ΠΌΠΎΠ² общСствСнного воспроизводства ΠΊΠ°ΠΏΠΈΡ‚Π°Π»Π°. Однако сСгодня отсутствуСт Ρ‡Π΅Ρ‚ΠΊΠΈΠΉ ΠΌΠ΅Ρ‚ΠΎΠ΄ ΠΈΠ΄Π΅Π½Ρ‚ΠΈΡ„ΠΈΠΊΠ°Ρ†ΠΈΠΈ ΠΌΠ°ΡΡˆΡ‚Π°Π±ΠΎΠ² распространСния Ρ„ΠΈΠΊΡ‚ΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΊΠ°ΠΏΠΈΡ‚Π°Π»Π°, ΠΎΠ½ ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΡƒΠ΅Ρ‚ΡΡ Π² Π½Π°ΡƒΡ‡Π½Ρ‹Ρ… исслСдованиях ΠΊΠ°ΠΊ ΠΌΠ΅Ρ‚Π°Ρ„ΠΎΡ€Π°, Π° Π½Π΅ Π² качСствС Π½ΠΎΠ²ΠΎΠΉ ΠΈΠ½ΡΡ‚ΠΈΡ‚ΡƒΡ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠΉ основы двиТСния финансовых ΠΏΠΎΡ‚ΠΎΠΊΠΎΠ². ЦСль исслСдования— актуализация ΠΊΠΎΠ½Ρ„ΠΈΠ³ΡƒΡ€Π°Ρ†ΠΈΠΈ ΠΌΠΈΡ€ΠΎΠ²ΠΎΠΉ финансовой систСмы, Π΅Π΅ зависимости ΠΎΡ‚ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΎΠ² Π΄Π΅ΡΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΠΈ ΠΊΠΎΡ€ΠΏΠΎΡ€Π°Ρ†ΠΈΠΉ ΠΈ Π±Π°Π½ΠΊΠΎΠ² БША, выявлСниС источников уязвимости ΠΌΠΈΡ€ΠΎΠ²Ρ‹Ρ… финансов ΠΈ глобальной ликвидности ΠΎΡ‚ Ρ„ΠΈΠΊΡ‚ΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΊΠ°ΠΏΠΈΡ‚Π°Π»Π° амСриканских финансовых Ρ€Ρ‹Π½ΠΊΠΎΠ². ΠœΠ΅Ρ‚ΠΎΠ΄ΠΎΠ»ΠΎΠ³ΠΈΡ‡Π΅ΡΠΊΠΎΠΉ основой исслСдования стало сопоставлСниС тСорСтичСски установлСнных закономСрностСй повСдСния финансового ΠΊΠ°ΠΏΠΈΡ‚Π°Π»Π° с фактичСскими Π΄Π°Π½Π½Ρ‹ΠΌΠΈ ΠΎ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π°Ρ… ΡΠΎΠ²Π΅Ρ€ΡˆΠ΅Π½ΠΈΡ ΠΎΠΏΠ΅Ρ€Π°Ρ†ΠΈΠΉ Ρ€Ρ‹Π½ΠΎΡ‡Π½Ρ‹ΠΌΠΈ Π°Π³Π΅Π½Ρ‚Π°ΠΌΠΈ. Π‘Π°Π·Π° исслСдования β€” статистичСскиС Π΄Π°Π½Π½Ρ‹Π΅ ΠΎ Π΄Π²ΠΈΠΆΠ΅Π½ΠΈΠΈ финансовых ΠΏΠΎΡ‚ΠΎΠΊΠΎΠ² ΠΈ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π°Ρ… финансовых ΠΎΠΏΠ΅Ρ€Π°Ρ†ΠΈΠΉ Π² глобальной экономикС с ΡƒΠΏΠΎΡ€ΠΎΠΌ Π½Π° Π΄Π°Π½Π½Ρ‹Π΅ статистики БША ΠΊΠ°ΠΊ Ρ†Π΅Π½Ρ‚Ρ€Π° ΠΌΠΈΡ€ΠΎΠ²ΠΎΠΉ финансовой систСмы. Π’ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π΅ обоснования Π²Ρ‹Π²ΠΎΠ΄Π° ΠΎ ΠΏΡ€Π΅ΠΎΠ±Π»Π°Π΄Π°Π½ΠΈΠΈ Ρ†Π΅Π»ΠΈ максимизации ликвидности Π½Π°Π΄ максимизациСй ΠΏΡ€ΠΈΠ±Ρ‹Π»ΡŒΠ½ΠΎΡΡ‚ΠΈ банковских ΠΎΠΏΠ΅Ρ€Π°Ρ†ΠΈΠΉ Π°Π²Ρ‚ΠΎΡ€Ρ‹ выявили источники Ρ„ΠΈΠΊΡ‚ΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΊΠ°ΠΏΠΈΡ‚Π°Π»Π° Π² Π΄Π΅ΡΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΠΈ банковского сСктора БША. ΠœΠ°ΡΡˆΡ‚Π°Π±Ρ‹ забалансовых ΠΎΠΏΠ΅Ρ€Π°Ρ†ΠΈΠΉ Π±Π°Π½ΠΊΠΎΠ² ΠΏΠΎΠ΄Ρ‚Π²Π΅Ρ€ΠΆΠ΄Π°ΡŽΡ‚ Π΄Π°Π½Π½Ρ‹ΠΉ Π²Ρ‹Π²ΠΎΠ΄. Показана Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡ‚ΡŒ Ρ†Π΅Π½ базисных Π°ΠΊΡ‚ΠΈΠ²ΠΎΠ² Ρ‚ΠΎΠ²Π°Ρ€Π½Ρ‹Ρ… Π΄Π΅Ρ€ΠΈΠ²Π°Ρ‚ΠΈΠ²ΠΎΠ² ΠΎΡ‚ Π±ΠΈΡ€ΠΆΠ΅Π²Ρ‹Ρ… индСксов, Π° Ρ‚Π°ΠΊΠΆΠ΅ ΡƒΡΡ‚ΠΎΠΉΡ‡ΠΈΠ²ΠΎΡΡ‚ΡŒ Ρ€Ρ‹Π½ΠΎΡ‡Π½ΠΎΠΉ ΠΊΠ°ΠΏΠΈΡ‚Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ амСриканских ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΉ ΠΊ измСнСниям уровня ликвидности ΠΈΡ… Π°ΠΊΡ†ΠΈΠΉ. Π‘Π΄Π΅Π»Π°Π½ Π²Ρ‹Π²ΠΎΠ΄, Ρ‡Ρ‚ΠΎ глобальная финансиализация поддСрТиваСтся сущСствСнными Π²Π½ΡƒΡ‚Ρ€Π΅Π½Π½ΠΈΠΌΠΈ противорСчиями Π² экономикС БША. Π˜ΡΡ‚ΠΎΡ‡Π½ΠΈΠΊΠΎΠΌ ΠΏΡ€ΠΎΡ‚ΠΈΠ²ΠΎΡ€Π΅Ρ‡ΠΈΠΉ являСтся финансовый ΠΌΠ΅Ρ…Π°Π½ΠΈΠ·ΠΌ Π²Ρ‹Π²ΠΎΠ΄Π° ликвидности ΠΈΠ· сфСры производства ΠΈ обращСния Π² сфСру финансовых Ρ€Ρ‹Π½ΠΊΠΎΠ². Π Π°Π·ΠΌΠ΅Ρ‰Π΅Π½ΠΈΠ΅ ΠΊΠ°ΠΏΠΈΡ‚Π°Π»ΠΎΠ² с использованиСм инструмСнтов финансового Ρ€Ρ‹Π½ΠΊΠ° БША Π²Π»Π΅Ρ‡Π΅Ρ‚ ΡƒΠ³Ρ€ΠΎΠ·Ρƒ ΠΏΠΎΡ‚Π΅Ρ€ΠΈ ΠΈΡ… ликвидности, Π° ΠΏΡ€ΠΎΠ³Π½ΠΎΠ·ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ глобальной экономики Π±Π΅Π· ΡƒΡ‡Π΅Ρ‚Π° Ρ€ΠΎΠ»ΠΈ Ρ„ΠΈΠΊΡ‚ΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΊΠ°ΠΏΠΈΡ‚Π°Π»Π°, Π·Π°Ρ€ΠΎΠΆΠ΄Π°ΡŽΡ‰Π΅Π³ΠΎΡΡ Π½Π° амСриканских финансовых Ρ€Ρ‹Π½ΠΊΠ°Ρ…, ΠΏΡ€ΠΈΠ²ΠΎΠ΄ΠΈΡ‚ ΠΊ глобальной уязвимости ΠΈ ΠΌΠΎΠΆΠ΅Ρ‚ ΡΡ‚Π°Ρ‚ΡŒ ΠΏΡ€ΠΈΡ‡ΠΈΠ½ΠΎΠΉ ΠΎΡ‡Π΅Ρ€Π΅Π΄Π½ΠΎΠ³ΠΎ финансового кризиса

    Π›ΠΈΠ±Π΅Ρ€Π°Π»ΡŒΠ½Π°Ρ (прогрСссивная) исламская тСология Π² соврСмСнной Π“Π΅Ρ€ΠΌΠ°Π½ΠΈΠΈ: основныС Ρ„ΠΈΠ³ΡƒΡ€Ρ‹

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    The article discusses the manifestations of liberal Islam that are currently observed in Germany. The questions to what extent Islam has adapted to the new environment and values, and what methods and practices are proposed by German Muslims in order to make Islamic traditional norms compatible with fundamental Western values are raised. As examples are taken the concept of β€œEuroIslam” by Bassam Tibi, as well as the activities of German Islamic activists Seyran Atesh, Rabeya MΓΌller and Halima Krausen are taken as exampl.Π’ ΡΡ‚Π°Ρ‚ΡŒΠ΅ ΠΈΡΡΠ»Π΅Π΄ΡƒΡŽΡ‚ΡΡ проявлСния Π»ΠΈΠ±Π΅Ρ€Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ ислама, Π½Π°Π±Π»ΡŽΠ΄Π°Π΅ΠΌΡ‹Π΅ Π² настоящСС врСмя Π² Π“Π΅Ρ€ΠΌΠ°Π½ΠΈΠΈ. ΠŸΠΎΠ΄Π½ΠΈΠΌΠ°Π΅Ρ‚ΡΡ вопрос ΠΎ Ρ‚ΠΎΠΌ, Π² ΠΊΠ°ΠΊΠΎΠΉ ΠΌΠ΅Ρ€Π΅ ислам адаптировался ΠΊ Π½ΠΎΠ²ΠΎΠΉ срСдС ΠΈ цСнностям ΠΈ ΠΊΠ°ΠΊΠΈΠ΅ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹ ΠΈ ΠΏΡ€Π°ΠΊΡ‚ΠΈΠΊΠΈ ΠΏΡ€Π΅Π΄Π»Π°Π³Π°ΡŽΡ‚ΡΡ Π½Π΅ΠΌΠ΅Ρ†ΠΊΠΈΠΌΠΈ ΠΌΡƒΡΡƒΠ»ΡŒΠΌΠ°Π½Π°ΠΌΠΈ для Ρ‚ΠΎΠ³ΠΎ, Ρ‡Ρ‚ΠΎΠ±Ρ‹ исламскиС Ρ‚Ρ€Π°Π΄ΠΈΡ†ΠΈΠΎΠ½Π½Ρ‹Π΅ Π½ΠΎΡ€ΠΌΡ‹ Π½Π΅ вступали Π² ΠΊΠΎΠ½Ρ„Ρ€ΠΎΠ½Ρ‚Π°Ρ†ΠΈΡŽ с ΠΎΡΠ½ΠΎΠ²ΠΎΠΏΠΎΠ»Π°Π³Π°ΡŽΡ‰ΠΈΠΌΠΈ Π·Π°ΠΏΠ°Π΄Π½Ρ‹ΠΌΠΈ цСнностями. Π’ качСствС ΠΏΡ€ΠΈΠΌΠ΅Ρ€ΠΎΠ² Ρ€Π°ΡΡΠΌΠ°Ρ‚Ρ€ΠΈΠ²Π°ΡŽΡ‚ΡΡ концСпция «Свроислама» Бассама Π’ΠΈΠ±ΠΈ, Π° Ρ‚Π°ΠΊΠΆΠ΅ Π΄Π΅ΡΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ Π½Π΅ΠΌΠ΅Ρ†ΠΊΠΈΡ… исламских активисток Π² Π»ΠΈΡ†Π΅ Π‘Π΅ΠΉΡ€Π°Π½ ΠΡ‚Π΅Ρˆ, Π Π°Π±Π΅ΠΉΠΈ ΠœΡŽΠ»Π»Π΅Ρ€ ΠΈ Π₯Π°Π»ΠΈΠΌΡ‹ ΠšΡ€Π°ΡƒΠ·Π΅Π½

    ΠŸΠ΅Ρ€ΠΈΠΎΡΡ‚ΠΈΠ½ ΠΊΠ°ΠΊ ΠΏΡ€Π΅Π΄ΠΈΠΊΡ‚ΠΎΡ€ Π½Π΅ΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»ΠΈΡ€ΡƒΠ΅ΠΌΠΎΠ³ΠΎ тСчСния астмы ΠΈ сниТСния ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»Π΅ΠΉ Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΈ Π»Π΅Π³ΠΊΠΈΡ… Ρƒ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² Ρ€Π°Π·Π½Ρ‹Ρ… возрастных Π³Ρ€ΡƒΠΏΠΏ

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    Introduction. Uncontrolled bronchial asthma (BA) increases risk of hospitalizations, future exacerbations and decreases quality of life; factors improving the probability to achieve BA control are under study.Methods and materials. The open prospective study included 104 patients of three groups: children (6β€”11 years, n=38), adolescents (14β€”17 years, n = 35) and adults (25 β€” 50 years, n = 31). Inclusion criteria: BA duration >12 month, uncontrolled asthma, absence of acute respiratory infection for 14 days. Clinical history, respiratory function and sampling (serum and nasal brushings) for periostin assay were performed on Visit 1. Maintenance therapy correction and triggers avoiding recommendations were made. Two further visits 6 months apart were done. Statistical processing included ANOVA (Kruskall β€” Wallis test) and Pearson correlation test. Differences were considered significant when p<0.05.Results. 75 % of Β«ChildrenΒ» group,70.6 % of Β«AdolescentsΒ» and 53.6 % of Β«AdultsΒ» had achieved BA control. Obesity, non-atopic phenotype, FEV1 <65 % of predicted were risk factors of uncontrolled BA. Serum periostin levels were highest in uncontrolled BA subgroup, Me [Q25; Q75] =32.9 [28.6; 39.1] ng/ml. Nasal periostin levels were highest in Β«AdolescentΒ» group: 9.8 [4.8; 11.2] ng/ml. Nasal periostin and low FEV1 had moderate reverse correlation (r=β€”0.61).Conclusion. Serum and nasal periostin levels could indicate treatment efficacy and prognose future risks of BA control loss.Π’Π²Π΅Π΄Π΅Π½ΠΈΠ΅. НСконтролируСмая Π±Ρ€ΠΎΠ½Ρ…ΠΈΠ°Π»ΡŒΠ½Π°Ρ астма (БА) ΠΏΠΎΠ²Ρ‹ΡˆΠ°Π΅Ρ‚ риск госпитализаций, Π±ΡƒΠ΄ΡƒΡ‰ΠΈΡ… обострСний ΠΈ сниТаСт качСство ΠΆΠΈΠ·Π½ΠΈ; Ρ„Π°ΠΊΡ‚ΠΎΡ€Ρ‹, ΠΎΠΏΡ€Π΅Π΄Π΅Π»ΡΡŽΡ‰ΠΈΠ΅ Π²Π΅Ρ€ΠΎΡΡ‚Π½ΠΎΡΡ‚ΡŒ достиТСния контроля, Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎ ΠΈΠ·ΡƒΡ‡Π°ΡŽΡ‚ΡΡ.ΠœΠ΅Ρ‚ΠΎΠ΄Ρ‹ ΠΈ ΠΌΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Ρ‹. Π’ ΠΎΡ‚ΠΊΡ€Ρ‹Ρ‚ΠΎΠ΅ проспСктивноС исслСдованиС Π²ΠΊΠ»ΡŽΡ‡ΠΈΠ»ΠΈ 104 ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚Π° Ρ‚Ρ€Π΅Ρ… Π³Ρ€ΡƒΠΏΠΏ: Π΄Π΅Ρ‚ΠΈ (6 β€” 11 Π»Π΅Ρ‚, n = 38), подростки (14β€”17 Π»Π΅Ρ‚, n = 35), взрослыС (25 β€” 50 Π»Π΅Ρ‚, n = 31). ΠšΡ€ΠΈΡ‚Π΅Ρ€ΠΈΠΈ Π²ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΡ: стаТ Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π° БА >12 мСсяцСв, нСконтролируСмая астма, >14 Π΄Π½Π΅ΠΉ Π±Π΅Π· острой рСспираторной ΠΈΠ½Ρ„Π΅ΠΊΡ†ΠΈΠΈ. На Π²ΠΈΠ·ΠΈΡ‚Π΅ 1 выполняли сбор Π°Π½Π°ΠΌΠ½Π΅Π·Π°, исслСдованиС Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΈ внСшнСго дыхания (Π€Π’Π”), взятиС сыворотки ΠΊΡ€ΠΎΠ²ΠΈ ΠΈ назального Π±Ρ€Π°Ρˆ-Π±ΠΈΠΎΠΏΡ‚Π°Ρ‚Π° для исслСдования пСриостина. ΠšΠΎΡ€Ρ€Π΅ΠΊΡ‚ΠΈΡ€ΠΎΠ²Π°Π»ΠΈ Π±Π°Π·ΠΈΡΠ½ΡƒΡŽ Ρ‚Π΅Ρ€Π°ΠΏΠΈΡŽ ΠΈ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½Ρ‹Π΅ Ρ„Π°ΠΊΡ‚ΠΎΡ€Ρ‹ риска Π½Π΅ΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»ΠΈΡ€ΡƒΠ΅ΠΌΠΎΠΉ БА. Π‘ ΠΈΠ½Ρ‚Π΅Ρ€Π²Π°Π»ΠΎΠΌ 6 мСсяцСв ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π΅Ρ‰Π΅ 2 Π²ΠΈΠ·ΠΈΡ‚Π°. БтатистичСская ΠΎΠ±Ρ€Π°Π±ΠΎΡ‚ΠΊΠ° Π²ΠΊΠ»ΡŽΡ‡Π°Π»Π° Π² сСбя ANOVA (ΠΊΡ€ΠΈΡ‚Π΅Ρ€ΠΈΠΉ ΠšΡ€Π°ΡΠΊΠ΅Π»Π° β€” Уоллиса) ΠΈ коэффициСнт ΠŸΠΈΡ€ΡΠΎΠ½Π°. Различия считали Π·Π½Π°Ρ‡ΠΈΠΌΡ‹ΠΌΠΈ ΠΏΡ€ΠΈ Ρ€<0,05.Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. ΠšΠΎΠ½Ρ‚Ρ€ΠΎΠ»Ρ БА достигли 75 % ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² Π³Ρ€ΡƒΠΏΠΏΡ‹ Β«Π”Π΅Ρ‚ΠΈΒ», 70,6 % ΠΈΠ· Π³Ρ€ΡƒΠΏΠΏΡ‹ Β«ΠŸΠΎΠ΄Ρ€ΠΎΡΡ‚ΠΊΠΈΒ» ΠΈ 53,6 % ΠΈΠ· Π³Ρ€ΡƒΠΏΠΏΡ‹ «ВзрослыС». Π€Π°ΠΊΡ‚ΠΎΡ€Ρ‹ риска нСдостиТСния контроля: ΠΎΠΆΠΈΡ€Π΅Π½ΠΈΠ΅, нСатопичСский Ρ„Π΅Π½ΠΎΡ‚ΠΈΠΏ, объСм Ρ„ΠΎΡ€ΠΌΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π²Ρ‹Π΄ΠΎΡ…Π° Π·Π° 1 с (ΠžΠ€Π’1) <65 % ΠΎΡ‚ Π½ΠΎΡ€ΠΌΡ‹. ΠšΠΎΠ½Ρ†Π΅Π½Ρ‚Ρ€Π°Ρ†ΠΈΡ пСриостина сыворотки Π·Π½Π°Ρ‡ΠΈΠΌΠΎ Π²Ρ‹ΡˆΠ΅ Ρƒ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ², Π½Π΅ Π΄ΠΎΡΡ‚ΠΈΠ³ΡˆΠΈΡ… контроля БА, Me [Q25; Q75]=32,9 [28,6; 39,1] Π½Π³/ΠΌΠ». ΠΠ°Π·Π°Π»ΡŒΠ½Ρ‹Π΅ ΠΊΠΎΠ½Ρ†Π΅Π½Ρ‚Ρ€Π°Ρ†ΠΈΠΈ пСриостина Π±Ρ‹Π»ΠΈ ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡŒΠ½Ρ‹ΠΌΠΈ Π² Π³Ρ€ΡƒΠΏΠΏΠ΅ Β«ΠŸΠΎΠ΄Ρ€ΠΎΡΡ‚ΠΊΠΈΒ»: 9,8 [4,8; 11,2] Π½Π³/ΠΌΠ». Π£Ρ€ΠΎΠ²Π΅Π½ΡŒ назального пСриостина ΠΈ Π½ΠΈΠ·ΠΊΠΈΠΉ ΠžΠ€Π’1 ΠΈΠΌΠ΅ΡŽΡ‚ ΡƒΠΌΠ΅Ρ€Π΅Π½Π½ΡƒΡŽ ΠΎΠ±Ρ€Π°Ρ‚Π½ΡƒΡŽ ΠΊΠΎΡ€Ρ€Π΅Π»ΡΡ†ΠΈΡŽ (r= β€”0,61).Π—Π°ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠ΅. Π‘ΠΎΠ΄Π΅Ρ€ΠΆΠ°Π½ΠΈΠ΅ пСриостина Π² сывороткС ΠΈ Π² назальном эпитСлии ΠΌΠΎΠΆΠ΅Ρ‚ ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΠΎΠ²Π°Ρ‚ΡŒΡΡ для ΠΎΡ†Π΅Π½ΠΊΠΈ эффСктивности лСчСния ΠΈ долгосрочных рисков ΠΏΠΎΡ‚Π΅Ρ€ΠΈ контроля БА

    Outlier detection and classification in sensor data streams for proactive decision support systems

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    A paper has a deal with the problem of quality assessment in sensor data streams accumulated by proactive decision support systems. The new problem is stated where outliers need to be detected and to be classified according to their nature of origin. There are two types of outliers defined; the first type is about misoperations of a system and the second type is caused by changes in the observed system behavior due to inner and external influences. The proposed method is based on the data-driven forecast approach to predict the values in the incoming data stream at the expected time. This method includes the forecasting model and the clustering model. The forecasting model predicts a value in the incoming data stream at the expected time to find the deviation between a real observed value and a predicted one. The clustering method is used for taxonomic classification of outliers. Constructive neural networks models (CoNNS) and evolving connectionists systems (ECS) are used for prediction of sensors data. There are two real world tasks are used as case studies. The maximal values of accuracy are 0.992 and 0.974, and F1 scores are 0.967 and 0.938, respectively, for the first and the second tasks. The conclusion contains findings how to apply the proposed method in proactive decision support systems

    Russia’s economy innovative development in conditions of the import substitution

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    Β© 2018, Universidad del Zulia. All rights reserved. The article aims to investigate Russia’s economy innovative development in conditions of the import substitution. The analysis of the nomenclature of import-substituting products was carried out using the official list of priority and critical types of products, services and software in terms of import substitution and national security. As a result, the model of catching-up development which was being objectively criticized earlier, has once again taken up the leading position in the economic agenda of the state. In conclusion, the sanctions pressure exerted on Russia has affected both the current macroeconomic situation and the system of its promising technological development

    The use of screening methods as element array system improvement public health

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    The priority pollutants of the environment in industrial cities are such reproductive toxic substances as benzo(a)pyrene, formaldehyde, phenol and nitrogen dioxide [1]. Chemical substances, which a person confronts in the course of professional activity, may cause mutagenic and genotoxic effects and hereditary disorders. The exposure to physical factors of production environment may result in pathology. The study of harmful factor impact on the reproductive health of workers, the development of study screening methods and prevention activities is an important one. The tiered screening system was used, including socio-sanitary, physical, chemical, clinical, biochemical and cytogenetic studies. 318 men were observed - the workers of the machine-building enterprise who deal with harmful chemical and physical factors during their work and 148 workers without a contact (control group). Questionnaire screening showed that almost 70% of respondents work in contact with a chemical factor, 2/3 of respondents work in a noisy atmosphere, about 40% work with local vibration, at that 8.5% of the patients consulted a doctor concerning reproductive function disorders. The measurements of physical factors at workplaces revealed the excess of maximum permissible levels of noise and local vibration. The exceeding of maximum permissible concentrations (MPC) of benz(a)pyrene, mineral oil aerosols, nitrogen dioxide, epichlorohydrin were also revealed in the working area. The results of testosterone, lutropin and follitropin levels showed that abnormalities were found among 25.5% of the employees, including 21% of workers exposed to a local vibration. The mathematical model is developed for the estimation of reproductive disorder occurrence probability, significantly influencing factors were determined. These factors are presented by vibration impact, the experienced diseases, the activator of which could have the affinity for seminiferous epithelium, the changes of testosterone levels, the miscarriages among women in history. The noise at workplaces (87.7 + 4.5 dB) significantly affects the blood levels of testosterone (r = 0,51, p < 0.04), which may be associated with the influence on Leydig cells and hypothalamic-hypophysial system. The impact of reprotoxicants (benz(a)pyrene, mineral oil aerosols, nitrogen dioxide), may cause reproductive health damage. In order to study the reproductive health status, to determine risk groups and the development of preventive measures it is advisable to use a multi-level screening system, including questioning, the hygienic assessment of industrial environmental factors, hormonal status determination, mathematical modeling

    Application of magnesium drugs and their influence on the indicators of connective tissue dysplasia in patients with varicose veins

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    Π’ΠΠ Π˜ΠšΠžΠ—ΠΠžΠ• Π ΠΠ‘Π¨Π˜Π Π•ΠΠ˜Π• ВЕН /Π›Π•Πš Π’Π•Π Π€ΠΠ ΠœΠΠšΠžΠ’Π•Π ΠΠŸΠ˜Π―ΠœΠΠ“ΠΠ˜Π™ΠœΠΠ’Π Π˜ΠšΠ‘Π ΠœΠ•Π’ΠΠ›Π›ΠžΠŸΠ ΠžΠ’Π•Π˜ΠΠΠ—Π«ΠšΠžΠ›Π›ΠΠ“Π•ΠΠΠ—Π Π˜ΠΠ’Π•Π Π‘Π’Π˜Π¦Π˜ΠΠ›Π¬ΠΠΠ―Π–Π•Π›ΠΠ’Π˜ΠΠΠ—Π BΠ”Π˜Π‘ΠŸΠ›ΠΠ—Π˜Π― Π‘ΠžΠ•Π”Π˜ΠΠ˜Π’Π•Π›Π¬ΠΠžΠ™ ВКАНИЦСль. Π˜Π·ΡƒΡ‡Π΅Π½ΠΈΠ΅ влияния ΠΏΡ€ΠΈΠ΅ΠΌΠ° ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚ΠΎΠ² магния Π½Π° ΠΊΠΎΠ½Ρ†Π΅Π½Ρ‚Ρ€Π°Ρ†ΠΈΡŽ матриксных ΠΌΠ΅Ρ‚Π°Π»Π»ΠΎΠΏΡ€ΠΎΡ‚Π΅ΠΈΠ½Π°Π· ΠΈ ΠΈΠΎΠ½ΠΎΠ² магния Ρƒ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с Π²Π°Ρ€ΠΈΠΊΠΎΠ·Π½ΠΎΠΉ болСзнью Π²Π΅Π½ Π½ΠΈΠΆΠ½ΠΈΡ… конСчностСй. ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π» ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹. Π’ исслСдованиС Π²ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΎ 124 ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚Π° с Π²Π°Ρ€ΠΈΠΊΠΎΠ·Π½ΠΎΠΉ болСзнью Π²Π΅Π½ Π½ΠΈΠΆΠ½ΠΈΡ… конСчностСй (Π’Π‘Π’ΠΠš) классов Π‘2-Π‘6, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Ρ… Ρ€Π°Π·Π΄Π΅Π»ΠΈΠ»ΠΈ Π½Π° 4 Π³Ρ€ΡƒΠΏΠΏΡ‹. Π’ I-ΠΉ Π³Ρ€ΡƒΠΏΠΏΠ΅ ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΎΠΏΠ΅Ρ€Π°Ρ‚ΠΈΠ²Π½ΠΎΠ΅ Π»Π΅Ρ‡Π΅Π½ΠΈΠ΅ с ΠΏΠΎΡΠ»Π΅Π΄ΡƒΡŽΡ‰ΠΈΠΌ Π½Π°Π·Π½Π°Ρ‡Π΅Π½ΠΈΠ΅ΠΌ стандартного консСрвативного лСчСния (32 Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ°); Π²ΠΎ II-ΠΉ Π³Ρ€ΡƒΠΏΠΏΠ΅ послС ΠΎΠΏΠ΅Ρ€Π°Ρ†ΠΈΠΈ Π² Π΄ΠΎΠΏΠΎΠ»Π½Π΅Π½ΠΈΠ΅ ΠΊ консСрвативному Π»Π΅Ρ‡Π΅Π½ΠΈΡŽ Π½Π°Π·Π½Π°Ρ‡Π°Π»ΠΈ ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Ρ‹ магния (32 Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ°); Π² III-ΠΉ Π³Ρ€ΡƒΠΏΠΏΠ΅ ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ консСрвативноС Π»Π΅Ρ‡Π΅Π½ΠΈΠ΅ Π±Π΅Π· ΠΎΠΏΠ΅Ρ€Π°Ρ†ΠΈΠΈ (30 Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊ); Π² IV-ΠΉ Π³Ρ€ΡƒΠΏΠΏΠ΅ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚Ρ‹ ΠΏΠΎΠ»ΡƒΡ‡Π°Π»ΠΈ стандартноС консСрвативноС Π»Π΅Ρ‡Π΅Π½ΠΈΠ΅ ΠΈ ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Ρ‹ магния (30 Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊ). V-ю ΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»ΡŒΠ½ΡƒΡŽ Π³Ρ€ΡƒΠΏΠΏΡƒ составили 20 Π·Π΄ΠΎΡ€ΠΎΠ²Ρ‹Ρ… Π΄ΠΎΠ±Ρ€ΠΎΠ²ΠΎΠ»ΡŒΡ†Π΅Π², Π½Π΅ ΡΡ‚Ρ€Π°Π΄Π°ΡŽΡ‰ΠΈΡ… Π²Π°Ρ€ΠΈΠΊΠΎΠ·Π½ΠΎΠΉ болСзнью. ΠŸΠ°Ρ†ΠΈΠ΅Π½Ρ‚Π°ΠΌ II-ΠΉ ΠΈ IV-ΠΉ Π³Ρ€ΡƒΠΏΠΏ Π½Π°Π·Π½Π°Ρ‡Π°Π»ΠΈ магния ΠΎΡ€ΠΎΡ‚Π°Ρ‚ 500 ΠΌΠ³ 2 Ρ‚Π°Π±Π». 3 Ρ€Π°Π·Π° Π² дСнь Π² Ρ‚Π΅Ρ‡Π΅Π½ΠΈΠ΅ 3 мСс. Π‘ΠΎΠ΄Π΅Ρ€ΠΆΠ°Π½ΠΈΠ΅ Π² сывороткС ΠΊΡ€ΠΎΠ²ΠΈ матриксной ΠΌΠ΅Ρ‚Π°Π»Π»ΠΎΠΏΡ€ΠΎΡ‚Π΅ΠΈΠ½Π°Π·Ρ‹-1 (ММП-1), матриксной ΠΌΠ΅Ρ‚Π°Π»Π»ΠΎΠΏΡ€ΠΎΡ‚Π΅ΠΈΠ½Π°Π·Ρ‹-9 (ММП-9), Ρ‚ΠΊΠ°Π½Π΅Π²ΠΎΠ³ΠΎ ΠΈΠ½Π³ΠΈΠ±ΠΈΡ‚ΠΎΡ€Π° матриксной ΠΌΠ΅Ρ‚Π°Π»Π»ΠΎΠΏΡ€ΠΎΡ‚Π΅ΠΈΠ½Π°Π·Ρ‹-1 (ВИМП-1) опрСдСляли ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ количСствСнного Ρ‚Π²Π΅Ρ€Π΄ΠΎΡ„Π°Π·Π½ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡƒΠ½ΠΎΡ„Π΅Ρ€ΠΌΠ΅Π½Ρ‚Π½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π°. ΠšΠΎΠ½Ρ†Π΅Π½Ρ‚Ρ€Π°Ρ†ΠΈΡŽ ΠΈΠΎΠ½ΠΎΠ² магния опрСдСляли колоримСтричСским ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. Π£ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с Π’Π‘Π’ΠΠš отмСчался достовСрно мСньший ΡƒΡ€ΠΎΠ²Π΅Π½ΡŒ магния ΠΏΠΎ ΡΡ€Π°Π²Π½Π΅Π½ΠΈΡŽ с условно Π·Π΄ΠΎΡ€ΠΎΠ²Ρ‹ΠΌΠΈ Π΄ΠΎΠ±Ρ€ΠΎΠ²ΠΎΠ»ΡŒΡ†Π°ΠΌΠΈ, Π½Π΅ ΡΡ‚Ρ€Π°Π΄Π°ΡŽΡ‰ΠΈΠΌΠΈ Π²Π°Ρ€ΠΈΠΊΠΎΠ·Π½ΠΎΠΉ болСзнью: 35,5% срСди ΡΡ‚Ρ€Π°Π΄Π°ΡŽΡ‰ΠΈΡ… Π²Π°Ρ€ΠΈΠΊΠΎΠ·Π½ΠΎΠΉ болСзнью ΠΈΠΌΠ΅Π»ΠΈ Π΄Π΅Ρ„ΠΈΡ†ΠΈΡ‚ магния, Π² Ρ‚ΠΎ врСмя ΠΊΠ°ΠΊ всСго 15% ΠΈΠΌΠ΅Π»ΠΈ сниТСниС Π΄Π°Π½Π½ΠΎΠ³ΠΎ показатСля срСди Π·Π΄ΠΎΡ€ΠΎΠ²Ρ‹Ρ… Π΄ΠΎΠ±Ρ€ΠΎΠ²ΠΎΠ»ΡŒΡ†Π΅Π². На Ρ„ΠΎΠ½Π΅ ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠΌΠΎΠΉ Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠΉ Ρ‚Π΅Ρ€Π°ΠΏΠΈΠΈ ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Π°ΠΌΠΈ магния, ΠΎΡ‚ΠΌΠ΅Ρ‡Π°Π»ΠΎΡΡŒ ΡƒΠΌΠ΅Π½ΡŒΡˆΠ΅Π½ΠΈΠ΅ количСства ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с Π΄Π΅Ρ„ΠΈΡ†ΠΈΡ‚ΠΎΠΌ магния Π² Π³Ρ€ΡƒΠΏΠΏΠ°Ρ… с Π’Π‘Π’ΠΠš, сниТСниС ΠΊΠΎΠ½Ρ†Π΅Π½Ρ‚Ρ€Π°Ρ†ΠΈΠΈ ММП-9 ΠΈ ΠΏΠΎΠ²Ρ‹ΡˆΠ΅Π½ΠΈΠ΅ активности ВИМП-1. Π—Π°ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠ΅. ИсслСдованиС ΠΏΠΎΠ΄Ρ‚Π²Π΅Ρ€Π΄ΠΈΠ»ΠΎ ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ примСнСния ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚ΠΎΠ² магния, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Π΅ ΠΎΠ±Π»Π°Π΄Π°ΡŽΡ‚ Π²Ρ‹Ρ€Π°ΠΆΠ΅Π½Π½Ρ‹ΠΌ влияниСм Π½Π° процСссы Π΄Π΅Π³Ρ€Π°Π΄Π°Ρ†ΠΈΠΈ ΠΊΠΎΠ»Π»Π°Π³Π΅Π½Π° ΠΈ Π²Π½Π΅ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½ΠΎΠ³ΠΎ матрикса, ΡΠ½ΠΈΠΆΠ°ΡŽΡ‚ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ ММП-9, ΠΏΠΎΠ²Ρ‹ΡˆΠ°ΡŽΡ‚ ΠΊΠΎΠ½Ρ†Π΅Π½Ρ‚Ρ€Π°Ρ†ΠΈΡŽ ВИМП-1, Ρ‚Π΅ΠΌ самым влияя Π½Π° баланс ММП/ВИМП Ρƒ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с Π’Π‘Π’ΠΠš.Objective. To study the effect of magnesium drugs on the concentration of matrix metalloproteinases and magnesium ions in patients with varicose veins of the lower extremities. Methods. The study included 124 patients with varicose veins of the lower extremities, C2-C6, which were divided into 4 groups. In the 1st group, surgical treatment followed with the administering the standard conservative treatment (32 patient); in the 2nd group after the operation in addition to conservative treatment, magnesium drugs (32 patient) were prescribed; in the 3rd group, conservative treatment without surgery (30 patient) was performed; in the 4th group patients received standard conservative treatment and magnesium drugs (30 patient). The 5th control group consisted of 20 healthy volunteers who did not suffer from varicose veins disease. Patients of groups 2 and 4 were given magnesium orotate 500 mg 2 tablets 3 times a day for 3 months. The content of serum matrix metalloproteinase-1 (MMP-1), matrix metalloproteinase-9 (MMP-9), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) was determined by quantitative solid-phase enzyme immunoassay. The magnesium ion concentration was determined by colorimetric method. Results. In patients with varicose veins of lower extremities a significantly lower level of magnesium was registered compared to healthy volunteers not suffering from varicose veins: 35.5% of those with varicose veins had a magnesium deficiency, while only 15% had a decrease in this indicator among healthy volunteers. Against the background of additional therapy with magnesium drugs, there was a decrease in the number of patients with magnesium deficiency in groups with varicose veins of lower extremities, a decrease in MMP-9 concentration and an increase in TIMP-1 activity was also established. Conclusions. This study has confirmed the efficacy of magnesium drugs which have a pronounced effect on collagen degradation processes and extracellular matrix, reduce the activity of MMP-9, increase the concentration of TIMP-1, thereby affecting the MMP/TIMP balance in patients with varicose veins of lower extremities
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