Videodensitometric methods for cardiac output measurements

Cardiac output is often measured by indicator dilution techniques, usually based on dye or cold saline injections. Developments of more stable ultrasound contrast agents (UCA) are leading to new noninvasive indicator dilution methods. However, several problems concerning the interpretation of dilution curves as detected by ultrasound transducers have arisen. This paper presents a method for blood flow measurements based on UCA dilution. Dilution curves are determined by real-time densitometric analysis of the video output of an ultrasound scanner and are automatically fitted by the Local Density Random Walk model. A new fitting algorithm based on multiple linear regression is developed. Calibration, that is, the relation between videodensity and UCA concentration, is modelled by in vitro experimentation. The flow measurement system is validated by in vitro perfusion of SonoVue contrast agent. The results show an accurate dilution curve fit and flow estimation with determination coefficient larger than 0.95 and 0.99, respectively

On Counteracting Byzantine Attacks in Network Coded Peer-to-Peer Networks

Random linear network coding can be used in peer-to-peer networks to increase the efficiency of content distribution and distributed storage. However, these systems are particularly susceptible to Byzantine attacks. We quantify the impact of Byzantine attacks on the coded system by evaluating the probability that a receiver node fails to correctly recover a file. We show that even for a small probability of attack, the system fails with overwhelming probability. We then propose a novel signature scheme that allows packet-level Byzantine detection. This scheme allows one-hop containment of the contamination, and saves bandwidth by allowing nodes to detect and drop the contaminated packets. We compare the net cost of our signature scheme with various other Byzantine schemes, and show that when the probability of Byzantine attacks is high, our scheme is the most bandwidth efficient.Comment: 26 pages, 9 figures, Submitted to IEEE Journal on Selected Areas in Communications (JSAC) "Mission Critical Networking

Identification of ultrasound-contrast-agent dilution systems for ejection fraction measurements

Left ventricular ejection fraction is an important cardiac-efficiency measure. Standard estimations are based on geometric analysis and modeling; they require time and experienced cardiologists. Alternative methods make use of indicator dilutions, but they are invasive due to the need for catheterization. This study presents a new minimally invasive indicator dilution technique for ejection fraction quantification. It is based on a peripheral injection of an ultrasound contrast agent bolus. Left atrium and left ventricle acoustic intensities are recorded versus time by transthoracic echocardiography. The measured curves are corrected for attenuation distortion and processed by an adaptive Wiener deconvolution algorithm for the estimation of the left ventricle impulse response, which is interpolated by a monocompartment exponential model for the ejection fraction assessment. This technique measures forward ejection fraction, which excludes regurgitant volumes. The feasibility of the method was tested on a group of 20 patients with left ventricular ejection fractions going from 10% to 70%. The results are promising and show a 0.93 correlation coefficient with echographic bi-plane ejection fraction measurements. A more extensive validation as well as an investigation on the method applicability for valve insufficiency and right ventricular ejection fraction quantification will be an object of future study

Creep curve measurement to support wear and adhesion modelling, using a continuously variable creep twin disc machine

Predictive modelling of wear and adhesion at rolling-sliding contacts such as a railway rail and wheel depends on understanding the relationship between slip and shear force at the contact surface, i.e. the creep verses force curve. This paper describes a new approach to creep curve measurement using a twin disc machine running with a continuous programmed variation of creep, enabling an entire creep curve to be defined in a single experiment. The work focuses on very low levels of creep, ranging from zero to 1%, and shows clear correlation between the creep curve gradient and the full slip friction coefficient for dry and lubricated contacts. Comparison of data generated using the new approach with that generated using multiple tests each at a single creep level shows good agreement. Comparison is also made between the twin disc data and results for full size three dimensional rail-wheel contacts to examine how two and three dimensional contact adhesion data are related. The data generated has application in wear and rolling contact fatigue modelling, but the original motivation for the research was generation of creep curves to support prediction of low adhesion conditions at the rail-wheel interface based upon monitored running conditions prior to brake application. The range of contact conditions investigated includes those experienced in service and during driver training, with the correlation found between creep curve gradient (measurable prior to braking) and full slip friction coefficient (not measurable until brakes are applied) representing a key finding

Towards an engineering model for curve squeal

Curve squeal is a strong tonal noise that may arise when a railway vehicle negotiates a curve. The wheel/rail contact model is the central part of prediction models, describing the frictional instability occurring in the contact during squeal. A previously developed time-domain squeal model considers the wheel and rail dynamics, and the wheel/rail contact is solved using Kalker’s nonlinear transient CONTACT algorithm with Coulomb friction. In this paper, contact models with different degree of simplification are compared to CONTACT within the previously developed squeal model in order to determine a suitable contact algorithm for an engineering curve squeal model. Kalker’s steady-state FASTSIM is evaluated, and, without further modification, shows unsatisfying results. An alternative transient single-point contact algorithm named SPOINT is formulated with the friction model derived from CONTACT. Comparing with the original model results, the SPOINT implementation results are promising and similar to results from CONTACT

Localization of beta-catenin in Type II Diabetic murine corneal epithelial tissue before and after injury

The Center for Disease Control estimates that 9% of Americans have Type II Diabetes (CDC, 2020), which is a major risk factor for blindness. The delayed wound healing displayed in Type II Diabetes can cause corneal ulcers and persistent epithelial defects, among other conditions. While corneal transplants can be effective, they are not always available or appropriate. The protein Β-catenin plays an important role in the adherens junction, acting as a bridge between E-cadherin and a-catenin to indirectly anchor actin to E-cadherin. In healthy, unwounded epithelium, adherens junctions are generally localized to apical regions of tissue, and are maintained to attach cells together, which helps maintain epithelial integrity and cell shape. After wounding, adherens junctions are rearranged, with some Β-catenin being trafficked into the cytoplasm for degradation. This promotes cell migration and wound closure. This thesis investigates the localization of Β-catenin in the Type II Diabetic murine cornea before and after wounding. Our results indicated that epithelium from unwounded Type II Diabetic corneas showed apical localization of Β-catenin, but there was a lesser amount compared to control. After wounding, tissue was found to have an increase of Β-catenin at the wound edge in basal regions of the epithelium, but the extent of that increase varied by time after injury. With the exception of the 2-hour wound, however, a smaller amount of Β-catenin was found at the wound edge of Type II Diabetic mice, compared to control. In summary, there were many differences between the corneas of Type II diabetic and control corneas.2021-06-08T00:00:00

Comparison of Wheel-Rail Contact Modelling in Multibody System Online Simulation

The wheel-rail contact modelling is always an interesting topic in rail vehicle system dynamics simulation. Many contact models have been developed for different purposes, and each model has its own pros and cons for different applications. In multibody system (MBS) simulation of rail vehicles, the efficiency and accuracy of the wheel-rail contact model are of importance. It is the aim of this paper to compare in MBS online simulation one classical approach (Hertz theory+FASTSIM), one approximated non-Hertzian approach and the ‘exact’ solver CONTACT and show the influences of the contact modelling on the results of vehicle dynamics simulations