144 research outputs found

    Analytical method for designing grating compensated dispersion-managed soliton systems

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    This paper was published in Journal of Optical Society of America B and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: http://www.opticsinfobase.org/abstract.cfm?URI=JOSAB-21-4-706. Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law. © 2004 The Optical Society.Peer reviewedPublisher PD

    Expression of disease-causing lamin A mutants impairs the formation of DNA repair foci

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    A-type lamins are components of the nuclear lamina. Mutations in the gene encoding lamin A are associated with a range of highly degenerative diseases termed laminopathies. To evaluate sensitivity to DNA damage, GFP-tagged lamin A cDNAs with disease-causing mutations were expressed in HeLa cells. The inner nuclear membrane protein emerin was mislocalised upon expression of the muscular dystrophy mutants G232E, Q294P or R386K, which aberrantly assembled into nuclear aggregates, or upon expression of mutants causing progeria syndromes in vivo (lamin A del50, R471C, R527C and L530P). The ability of cells expressing these mutants to form DNA repair foci comprising phosphorylated H2AX in response to mild doses of cisplatin or UV irradiation was markedly diminished, unlike the nearly normal response of cells expressing wild-type GFP-lamin A or disease-causing H222P and R482L mutants. Interestingly, mutants that impaired the formation of DNA repair foci mislocalised ATR (for 'ataxia telangiectasia-mutated and Rad3-related') kinase, which is a key sensor in the response to DNA damage. Our results suggest that a subset of lamin A mutants might hinder the response of components of the DNA repair machinery to DNA damage by altering interactions with chromatin

    RESEARCH TRENDS IN GLOBAL OUTPUT OF COSMIC RAYS: A SCIENTOMETRIC ANALYSIS

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    This paper attempts to highlight the publication status and growth of global cosmic rays research output of Web of Science during 2004-2013. A total of 20395 publications were published on cosmic rays during this period. The average number of publications per year is 2039.5 and the highest number of publications 2565 was published in 2009. The scientometric parameters studied in this paper include forms of publications, annual growth rate, relative growth rate and doubling time of publications, authorship pattern, identification of most prolific authors, country wise distribution of publications, identification of highly productive institutions, language wise distribution of publications and highly preferred source titles for publications

    MAPPING OF GLOBAL NATURAL HAZARDS RESEARCH PRODUCTIVITY DURING 2006-2015

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    This paper examines with scientometric tools a total of 7659 publications on natural hazards indexed in web of science database during the period 2006-2015. The average number of publications published per year was 765.9. The highest number of publications (1264) was recorded in the year 2015. The relative growth rates (RGR) has decreased from 2007 (0.72) to 2015 (0.18) in the span of 10 years. The doubling time (DT) has gradually increased from 0.96 in 2007 to 3.85 in 2015. The exponential growth of publications was observed during the study period. Majority of publications were found in English language. Authors from USA have contributed maximum number of publications compared to the other countries and India stood 8th rank in terms of productivity in this period. A total of 7274 different institutions were involved in the productivity, among them Harvard University, USA contributed highest number of 110 articles. The subject Geology contributed the largest share (22.93%) among subjects followed by Environmental science ecology (19.66%), water resources (15.45%) and Meteorology atmospheric sciences (12.43%) etc since the natural hazards are delt by many disciplines

    Supercontinuum Generation in a Silicon Nanowire Embedded Photonic Crystal Fiber for Optical Coherence Tomography Applications

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    KSN wishes to thank CSIR [No: 03(1264)/12/EMR-11] and DST [No: SR/FTP/PS-66/2009], Government of India, for the financial support through the project.Postprin

    Combination and Compression of Multiple Optical Pulses in Nonlinear Fibers with the Exponentially Decreasing Dispersion

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    ACKNOWLEDGMENT This work was supported by the National Natural Science Foundation of China (No. Project 61675008).Peer reviewedPostprin

    9-Aminoacridin-10-ium 4-aminobenzoate dihydrate

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    The asymmetric unit of the title hydrated salt, C13H11N2 +.-C7H6NO2-.2H2O, consists of two independent 9-aminoacridinium cations, two 4-aminobenzoate anions and four water molecules. Both 9-aminoacridinium cations are essentially planar, with maximum deviations of 0.034 (1) and 0.025 (2) A ° , and are protonated at the pyridine N atoms. The 4-aminobenzoate anions are approximately planar, with dihedral angles of 9.16 (19) and 5.4 (2)° between the benzene ring and the carboxylate group. In the crystal, the two independent anions are connected by N—H...O hydrogen bonds, forming a layer parallel to (100). The layers are connected through the cations by N—H...N and N—H...O hydrogen bonds. The water molecules, which form O—H...O hydrogen-bonded chains along the b-axis direction, connect the anions and the cations by O—H...O, N—H...O and C— H...O hydrogen bonds. The crystal structure also features n–n interactions [centroid–centroid distances = 3.6343 (9)– 3.8366 (10) A °] and a C—H...n interaction

    Exact states in waveguides with periodically modulated nonlinearity

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    Partial financial support has been provided by the Research Grants Council (Hong Kong) contract HKU 17200815.Peer reviewedPostprin
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