A prospective study on prevalence and characteristics of hematologic effects associated with subclinical hypothyroidism

Background: Distinctive types of iron deficiency have been accounted for patients with obvious hypothyroidism with a predominance of up to 47%. Regardless of the fact that vitamin B12, folic corrosive and iron fixations are ordinary, weakness that standardizes in light of thyroxine substitution is found in up to 25% of hypothyroid patients.Methods: Briefly, 50 women with SCH were enrolled in the study. Patients between 18 and 65 years old, with TSH levels more than 5.0 mIU/L, the patients selected has a history of hypothyroidism for more than a year and were on oral levothyroxine. A total of 50 participants were enrolled in the study. Blood samples were collected from 50 selected hypothyroid patients on the basis of a history of a hypothyroidism, persistent Anemia, of these patients all were females.Results: In present study 25 cases of age group 41-65 years  there were almost 10 patients having high thyroid stimulating factor (Tsh) that is more than (0.3-5.0U/Ml), Constitute to be 40% cases in this age category. Hence patients with high age may slower the response towards a levothyroxine hormone and hence have the high risk of developing anemia.Conclusions: Thyroid dysfunctions have an immediate impact on hemoglobin levels and these progressions should be considered in therapeutic consideration by medical practitioner

Development and Evaluation of Palmyrah (Borassus Flabellifer L.) Fruit Pulp

Palmyrah(Borassus flabellifer L) fruit pulp is available abundantly and has high potential for food in rural areas, useful for pharmaceutical and cosmetic applications, however, the main hindrance for these pulp is lack of mechanisation and availability of pulp in sufficient quantity at one place. The pulp of this fruit is usually used by rural communities where the processors use manual pulping, which are not only time-consuming but yields seasonal during July and August in India. Therefore, the objective of this work was to develop and evaluate the efficiency of fruit pulp extractor. The pulper was developed to be compact and easy to operate, consisting of main housing with stainless steel teeth on rotating shaft and pulping performed by beating and shearing. The performance evaluation of the machine was carried out with different rpm (320, 360, 410) input capacity(8,10 and 12 kg) for fixed time of operation is 6 minutes.. The pulp weight was evaluated during the pulping process period. The highest pulping efficiency (84.78%) and pulp recovery (33.9%) was obtained rpm of 410, with 6 minutes of pulping, and batch capacity of 10 kg of fruits which resulted in a capacity of 50 kg fruits per hour. This high efficiency makes this mechanized effective for pulping palmyrah fruits and, thus, it can replace manual pulping, especially in rural communities involved with the palmyrah fruit pulping. &nbsp

Optimization of osmotic dehydration in dragon fruit (Hylocereus Polyrhizus) slices using response surface methodology

Dragon fruit (Hylocereus polyrhizus) is emerging as a super crop because of its several health and therapeutic benefits and ease of cultivation even in degraded land. Using response surface approach, the process parameters for osmotic dehydration of dragon fruit slices included process temperature, syrup concentration and process time. Slices of size 20 x 20 x 5 mm were dipped into sugar syrup with a syrup to dragon fruit slice ratio of 4:1 (w/w). After osmotic dehydration, the initial moisture content of dragon fruit samples was reduced to 27.5-68.49% (wb), demonstrating water loss, solid gain, and mass reduction in the range of 18.01-65.9%, 6.3-17.9% and 9.31-50.6%, respectively. After statistical analysis of the data on water loss, solid gain, and weight reduction, it was shown that regression equations of second order provided the greatest match for all the experimental data. With a syrup to fruit ratio of 4:1 and a syrup concentration of 65.3° Brix at a syrup temperature of 56.5°C, a maximum water loss of 58.2% and a minimum solid gain of 7.7% were expected to occur in 240 minutes of osmotic dehydration

Modelling and simulation of fluid flow through a circular cylinder with high reynolds number: a COMSOL multiphysics study

In this study, we intend to investigate the steady-state and laminar �ow of a viscous �uid through a circular cylinder �xed between two parallel plates keeping the aspect ratio of 1 : 5 from cylinder radius to height of the channel. �e two-dimensional, in�compressible �uid �ow problem has been simulated using COMSOL Multiphysics 5.4 which implements �nite element’s procedure. �e �ow pattern will be investigated by using the Reynolds number from 100 to 1000. �e reattachment length formed at the back of the cylinder and drag force when the �uid comes to strike with the front surface of the cylinder is expressed in terms of Reynolds numbers. We propose to calculate the velocity and the pressure before and after the cylinder. For this purpose, two�line graphs before and after the cylinder will be drawn to check the impact of cylinder on both velocity and pressure. It was found that the percentage change in the velocity as well as pressure before to after the cylinder is changing their behaviours at Re � 700. �e study is important because the empirical equations between the vortex’s lengths formed along the cylinder using the linear regression process obtained in this study may be used for future implementatio

Optimization of robust and LQR control parameters for half car model using genetic algorithm

To test the performance of the half car system, two types of controller are used, namely Robust H-infinity control and LQR control. Robust H-infinity and LQR controller is designed to control the suspension system and to reduce the vibrations in the car and to improve handling. A half car model is considered in this research to study the effects in passenger owing to different road profiles. The weights of Robust H-infinity and LQR controller are obtained using Genetic Algorithm on a half car model with two different types of usually existing road disturbance.The design parameters of both the active controller varies with various road profiles. This proves that particular design parameters in Robust and LQR controller do not have the ability to adapt to the variations in road surface. Furthermore, active controllers significantly improve the performance of the system in all aspects when compared to passive system. © 2019 SERSC

Effect of surfactant treatment on thermal stability and mechanical properties of CNT/polybenzoxazine nanocomposites

The mechanical and thermo-mechanical properties of polybenzoxazine nanocomposites containing multi-walled carbon nanotubes (MWCNTs) functionalized with surfactant are studied. The results are specifically compared with the corresponding properties of epoxy-based nanocomposites. The CNTs bring about significant improvements in flexural strength, flexural modulus, storage modulus and glass transition temperature, T g, of CNT/polybenzoxazine nanocomposites at the expense of impact fracture toughness. The surfactant treatment has a beneficial effect on the improvement of these properties, except the impact toughness, through enhanced CNT dispersion and interfacial interaction. The former four properties are in general higher for the CNT/polybenzoxazine nanocomposites than the epoxy counterparts, and vice versa for the impact toughness. The addition of CNTs has an ameliorating effect of lowering the coefficient of thermal expansion (CTE) of polybenzoxazine nanocomposites in both the regions below and above T g, whereas the reverse is true for the epoxy nanocomposites. This observation has a particular implication of exploiting the CNT/polybenzoxazine nanocomposites in applications requiring low shrinkage and accurate dimensional control. © 2012 Elsevier Ltd

Mechanical and thermal properties of Benzoxazine resin containing multiwalled carbon nanotubes

The mechanical and thermal properties of Benzoxazine epoxy system containing multiwalled carbon nanotubes (MWCNTs) are studied. The CNTs bring about significant improvements in flexural strength and modulus. The thermo-mechanical properties are characterized using the dynamic mechanical analysis (DMA), thermo-gravimetric analysis (TGA) and thermo-mechanical analysis (TMA). The results show that the storage modulus and glass transition temperature increase with increasing CNT content. The addition of CNTs has an ameliorating effect of lowering the coefficient of thermal expansion in both the regions below and above glass transition temperature. This observation has a particular implication on using the Benzoxazine epoxy nanocomposites requiring low shrinkage and accurate dimensional control. The mechanical and thermal properties of CNT-Benzoxazine nanocomposites are compared with those of typical epoxy nanocomposites containing similar CNTs

Analysis of active suspension control policies for vehicle using robust controllers

Better ride comfort and controllability of vehicles are pursued by automotive industries by considering the use of suspension system which plays a very important role in handling and ride comfort characteristics. This paper presents the design of an active suspension of quarter car system using Robust H-infinity, Robust H2, Robust Mu-synthesis controllers with passive suspension technique. Parametric uncertainties were also considered to model the non linearities associated in the system. Numerical simulation was performed to the designed controller. Results shows that inspite of introducing uncertainties, the designed active controller improves ride comfort and road holding of the car when compared to the traditional passive suspension system. © 2019 SERSC

ACE I/D gene polymorphism in diabetic nephropathy: Clinical implications

Diabetic nephropathy (DN) is a major microvascular complication accounting for about 30% of End-Stage Renal Disease (ESRD) cases. An insertion/deletion (I/D) polymorphism of the gene encoding angiotensin-I converting enzyme (ACE) is reported to be a candidate gene predisposing to diabetic nephropathy. Accordingly, we investigated the ACE I/D gene polymorphism in 52 Type 2 diabetes mellitus (T2DM) cases suffering from nephropathy as assessed by 24 hrs urinary protein levels. 50 age and sex matched healthy subjects served as controls. ACE I/D genotyping was carried out by polymerase chain reaction (PCR) amplification using allele specific primers. The frequencies of ACE DD, ID and II genotypes in the diabetic nephropathy patients were 38.5% , 50% and 11.5% and in the control subjects, 22%, 38% and 40% respectively. There was an increase of 16.5% in the frequency of DD genotype in the patients compared to controls. The frequency of D allele in the patients was 63% which was found to be statistically significant (p< 0.05, Odds ratio=2.6) compared to 41% in the controls. These results indicate that Type 2 diabetic patients with D allele (those with DD & ID genotypes) have more than two fold risk of developing nephropathy. Clinical implications of ACE genotyping in planning for patient’s management have been discussed