Roles of myo-inositol in maintaining women’s reproductive health. Increase effectiveness of in vitro fertilization techniques

Roles of myo-inositol in maintaining women’s reproductive health. Increase effectiveness of in vitro fertilization techniques O.A. Gromova1, I.Yu. Torshin1, A.G. Kalacheva2, N.K. Tetruashvili3 1 IPI RAN, Moscow, Russian Federation 2 FSBEI HE IvSMA MOН Russia, Ivanovo, Russian Federation 3 V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Moscow, Russian Federation Myo-inositol is an essential component of human metabolome: for at least 120 inositol phosphate-dependent proteins, there is reliable information about their specific participation in maintaining of reproductive system functioning, embryo development, fetal brain neuroprotection, and insulin signaling cascade activity. Accordingly, metabolic disorders of the myo-inositol lead to insulin resistance, cell resistance to gonadotropin-releasing hormone, follicle-stimulating and luteinizing hormones, ovulation disorders, inhibition of oocyte maturation. An involvement of myo-inositol phospho derivatives in intracellular signal transmission from reproductive hormones receptors determines effectiveness of myo-inositol drug action on normalizing processes of reproductive hormone levels and ovulation. Use of the myo-inositol is effective in the treatment of polycystic ovarian syndrome and reduces a risk of folate-resistant developmental malformations. It is also promising to use the myo-inositol for in vitro fertilization (IVF) preparation. Meta-analyzes of randomized trials have confirmed myo-inositol efficacy (2–4 g/day, at least 3 months) in increasing of frequency of pregnancy in infertile women who undergo induction of ovulation or in vitro embryo transplantation. The data cited above indicate importance of establishing availability of myo-inositol to patients undergoing the IVF, as myo-inositol level in the blood is an important biomarker of women’s somatic and reproductive health. An effective method of correcting reproductive disorders in women is the use of myo-inositol (especially in combination with folates). Key words: myo-inositol, folates, menstrual cycle, pregravid preparation, oocyte quality, Myofert. For citation: Gromova O.A., Torshin I.Yu., Kalacheva A.G., Tetruashvili N.K. Roles of myo-inositol in maintaining women’s reproductive health. Increase effectiveness of in vitro fertilization techniques. Russian journal of Woman and Child Health. 2018;1(1):–95.<br

Myo-inositol: micronutrient for “fine tuning” of the female reproductive sphere

Myo-inositol: micronutrient for “fine tuning” of the female reproductive sphere I.Yu. Torshin1, O.A. Gromova1, A.G. Kalacheva2, N.K. Tetruashvili3, V.I. Demidov2 1 Federal Research Center “Computer Science and Control” of the Russian Academy&nbsp; &nbsp;of Sciences, Moscow, Russian Federation 2 Ivanovo State Medical Academy, Ivanovo, Russian Federation 3 V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Moscow,&nbsp; &nbsp;Russian Federation Myo-inositol is necessary for the synthesis of signal molecules of inositol phosphates involved in effect mediation of reproductive hormones. Insufficiency of myo-inositol is associated with menstrual irregularities, infertility, polycystic ovaries and congenital malformations of the fetus. Myo-inositol supplement improves the formation of ovulatory cycles, mature oocytes, the probability of pregnancy; reduce the risk of folate-resistant malformations, gestational diabetes, and fetal macrosomia. Myo-inositol favorably affects the lipid profile of the blood; prevents excessive weight gain during pregnancy, counteracts the formation of glucose tolerance and insulin resistance in women with menstrual irregularities, reduces chronic inflammation in the atherogenic profile of the blood. Myo-inositol supports antitumor immunity. The level of myo-inositol in the body decreases with the use of nephrotoxic medicinal products. Myo-inositol dependence increases with kidney pathology (pyelonephritis, glomerulonephritis, diabetic nephropathy, nephropathy of pregnancy, renal form of hypertension, etc.), with hyperglycaemic type of nutrition. Key words: myo-inositol, ovulation, hormonal receptors, polycystic ovary, folate-resistant developmental defects, Miofert. For citation: Torshin I.Yu., Gromova O.A., Kalacheva A.G. et al. Myo-inositol: micronutrient for “fine tuning” of the female reproductive sphere. Russian Journal of Woman and Child Health. 2018;1(2):148–155.<br

VARIOUS WAYS OF THE ORGANIC ZINC SALTS ADMINISTRATION WITH A COLOSTRUM IN FREQUENTLY AND PROTRACTEDLY SICK CHILDREN

We studied the efficiency of the organic zinc salts combined with colostrum during 60 days in a group of 74 children with frequent acute respiratory infections. The patients (4–6 years old) were subdivided into 3 groups: children slowly dissolving in mouth the drug lozenges (n = 30), children swallowing one (n = 18) and the children on standard therapy without zinc (control, n = 26). In groups of children with zinc administration, a significant improvement compared with the control was observed: medium scores for the therapy effectiveness were 5,7, 4,7 and 2,7 for the three groups accordingly (p &lt; 0,002 for both groups zinc administration). We have also observed the dependence of the treatmente ffectiveness on the extent of the zinc deficit prior to the clinical trial. Patients with low levels of zinc at the start of the study (activity of alkaline phosphatase 95 IU/L) were characterized by low efficiency of the therapy (2–4 points). At the same time, the treatment of patients with higher initial levels of zinc (activity of apase 95–110 mmol/l at the start of the study) was more successful (5–7 points, OR = 6,0, 95%, CI = 1,0–37,0, p = 0,04). Thus, zinc administration can be used to alleviate symptoms and reduce the duration of the acute respiratory infections.Key words: zinc, acute respiratory infections, children

VARIOUS WAYS OF THE ORGANIC ZINC SALTS ADMINISTRATION WITH A COLOSTRUM IN FREQUENTLY AND PROTRACTEDLY SICK CHILDREN

We studied the efficiency of the organic zinc salts combined with colostrum during 60 days in a group of 74 children with frequent acute respiratory infections. The patients (4–6 years old) were subdivided into 3 groups: children slowly dissolving in mouth the drug lozenges (n = 30), children swallowing one (n = 18) and the children on standard therapy without zinc (control, n = 26). In groups of children with zinc administration, a significant improvement compared with the control was observed: medium scores for the therapy effectiveness were 5,7, 4,7 and 2,7 for the three groups accordingly (p &lt; 0,002 for both groups zinc administration). We have also observed the dependence of the treatmente ffectiveness on the extent of the zinc deficit prior to the clinical trial. Patients with low levels of zinc at the start of the study (activity of alkaline phosphatase 95 IU/L) were characterized by low efficiency of the therapy (2–4 points). At the same time, the treatment of patients with higher initial levels of zinc (activity of apase 95–110 mmol/l at the start of the study) was more successful (5–7 points, OR = 6,0, 95%, CI = 1,0–37,0, p = 0,04). Thus, zinc administration can be used to alleviate symptoms and reduce the duration of the acute respiratory infections.Key words: zinc, acute respiratory infections, children

Deficit of magnesium and states of hypercoagulation: Intellectual analysis of data obtained from a sample of patients aged 18-50 years from medical and preventive facilities in Russia

The states characterized by pronounced hypercoagulable components (deep vein thrombosis, cardio-and cerebro-vascular pathologies) are caused by multiple pathophysiological factors, including insufficient supply of magnesium (Mg) and other micronutrients. Aim: to present results of analysis of the Institute of Microelements Data Base (IMDB) performed from point of view of interrelationships of Mg deficit and hypercoagulable states in adults treated in medico-preventive facilities of Central, Northwestern, Northern, and Siberian federal districts of Russia. Methods. The analysis was realized as analysis of data obtained in a cross-sectional study. In the cohort of patients (n=1453) formed from the IMBD adequacy of Mg supply was assessed by magnesium levels in blood plasma (Mg BP) (0.69±0.15 mmol / L) and estimates of daily Mg consumption according to dietary diaries (Mg D) (185±90 mg / day). Results. Mg supply was adequate (Mg BP >0.80 mmol / L, Mg D >300 mg / day) in not more than 6 % of patients. Presence of "Hypercoagulation" label in data base was associated with greater number of chronic diseases (2.3±2.1 and 0.83±0.8 with and without this label, respectively, p=0.0006) and elevated risk of the presence on 4 comorbid pathologies (odds ratio [OR] 18, 95 % confidence interval [CI] 10-25, p=0.0006). Mg deficit (Mg BP <0.70 mmol / L) was associated with hypercoagulable states (OR 5.42, 95 % CI 1.83-16, p=0.0006), neurologic pathologies (partial epilepsy, vertigo, alcohol dependence syndrome, obsessive-compulsive disorder) and pathologies related to chronic inflammation (ulcerative colitis, allergy, ischemic heart disease). Blood hypercoagulation was associated with prescription of drugs capable to provoke hypercoagulable states and simultaneously Mg deficit: androgens and anabolic steroids (OR 4.00, 95 % CI 1.88-8.50, p=0.00008), immunodepressants (OR 5.16, 95 %CI 1.96-13.58, p=0.0002), tetracyclic antidepressants (OR 4.47, 95 %CI 1.54-13, p=0.0026), estrogen containing oral contraceptives (OR 3.3, 95 %CI 1.5-6.2, p=0.0028), and antibiotics (OR 1.80, 95 %CI 1-3.36, p=0.058). Lowered Mg BP levels were associated with augmented sensation of pain, lowering of efficacy of analgesia, and with more pronounced cutaneous lesions. Conclusion. Thus, regular intake of magnesium preparations is indicated for the vast majority of adult patients in medico-preventive facilities especially to those with hypercoagulation and polypragmasy. © 2018 Media Sphera Publishing Group.All right reserved

ИСПОЛЬЗОВАНИЕ РАЗЛИЧНЫХ СПОСОБОВ ПРИЕМА БИОУСВОЯЕМЫХ ОРГАНИЧЕСКИХ СОЛЕЙ ЦИНКА С ЭКСТРАКТОМ МОЛОЗИВА У ЧАСТО И ДЛИТЕЛЬНО БОЛЕЮЩИХ ДЕТЕЙ

We studied the efficiency of the organic zinc salts combined with colostrum during 60 days in a group of 74 children with frequent acute respiratory infections. The patients (4–6 years old) were subdivided into 3 groups: children slowly dissolving in mouth the drug lozenges (n = 30), children swallowing one (n = 18) and the children on standard therapy without zinc (control, n = 26). In groups of children with zinc administration, a significant improvement compared with the control was observed: medium scores for the therapy effectiveness were 5,7, 4,7 and 2,7 for the three groups accordingly (p &lt; 0,002 for both groups zinc administration). We have also observed the dependence of the treatmente ffectiveness on the extent of the zinc deficit prior to the clinical trial. Patients with low levels of zinc at the start of the study (activity of alkaline phosphatase 95 IU/L) were characterized by low efficiency of the therapy (2–4 points). At the same time, the treatment of patients with higher initial levels of zinc (activity of apase 95–110 mmol/l at the start of the study) was more successful (5–7 points, OR = 6,0, 95%, CI = 1,0–37,0, p = 0,04). Thus, zinc administration can be used to alleviate symptoms and reduce the duration of the acute respiratory infections.Key words: zinc, acute respiratory infections, children.Изучена эффективность применения органических солей цинка в комплексе с молозивом в течение 60 дней. Обследованы 74 часто болеющих ребенка 4–6 лет, разделенных на 3 группы: дети, получавшие препарат цинка путем рассасывания (n=30); дети, принимавшие его внутрь (n=18), и дети, не получавшие данный препарат (контроль, n=26). В группах детей, принимавших препарат цинка, отмечено значительное улучшение по сравнению с контрольной группой (средние баллы эффективности терапии составили 5,7, 4,7 и 2,7 для трех групп соответственно [p&lt;0,002 для первой и второй групп]); установлена зависимость эффектов от уровня дефицита цинка, существовавшего до начала проведения клинического наблюдения. Так, пациенты с низкими уровнями цинка на момент начала исследования (активность щелочной фосфатазы &lt; 95 ммоль/л) характеризовались низкой эффективностью терапии (2–4 балла). В то же время, терапия пациентов с более высоким уровнем цинка (активность ЩФ 95–110 ммоль/л на момент начала исследования) была более успешной (5–7 баллов, OR = 6,0, 95% CI = 1,0–37,0, p = 0,04). Применение пищевой добавки, содержащей препарат цинка, оказалось эффективным для облегчения симптоматики и сокращения длительности течения ОРИ у часто болеющих детей.Ключевые слова: цинк, острые респираторные инфекции, дети.(Педиатрическая фармакология. – 2009; 6(1):37-42)

Analysis of 19.9 million publications from the PubMed/MEDLINE database using artificial intelligence methods: Approaches to the generalizations of accumulated data and the phenomenon of “fake news” [Анализ 19,9 млн публикаций базы данных PubMed/MEDLINE методами искусственного интеллекта: подходы к обобщению накопленных данных и феномен “fake news”]

Introduction. The English-language databases PubMed/MEDLINE and Embase are valuable information resources for finding original publications in basic and clinical medicine. Currently, there are no artificial intelligence systems to evaluate the quality of these publications. Aim. Development and testing of a system for sentiment analysis (i.e. analysis of emotional modality) of biomedical publications. Materials and methods. The technique of analysis of the “Big data” of biomedical publications was formulated on the basis of the topological theory of sentiment analysis. Algorithms have been developed that allow for the classification of texts from 16 sentiment classes with 90% accuracy (manipulative speech, research without positive results, propaganda, falsification of results, negative personal attitude, aggressive text, negative emotional background, etc.). Based on the algorithms, a scale for assessing the sentiment quality of research (β-score) is proposed. Results. Abstracts of 19.9 million publications registered in PubMed/MEDLINE over the past 50 years (1970–2019) were analyzed. It was shown that publications with low sentiment quality (the value of the β-score of the text is less than zero, which corresponds to the prevalence of manipulative and negative sentiments in the text) comprise only 18.5% (3.68 out of 19.9 million). The greatest values of the β-score were characterized by publications on sports medicine, systems biology, nutrition, on the use of applied mathematics and data mining in medicine. The rubrication of the entire array of publications by 27,840 headings (MESH-system of PubMed/MEDLINE) indicated an increase in the β-score by years (i.e., the positive dynamics of sentiment quality of the texts of publications) for 27,090 of the studied headings. The most intense positive dynamics was found for research in genetics, physiology, pharmacology, and gerontology. 249 headings with sharply negative dynamics of sentiment quality and with a pronounced increase in the manipulative sentiments characteristic of the tabloid press were highlighted. Separate assessments of international experts are presented that confirm the patterns identified. Conclusion. The proposed artificial intelligence system allows a researcher to make an effective assessment of the sentiment quality of biomedical research papers, filtering out potentially inappropriate publications disguised as “evidence-based”. Copyright © 2020, Farmakoekonomika. All rights reserved