63 research outputs found
FORMULATION AND EVALUATION OF ORAL FLOATING BEADS OF TRAMODOL HYDROCHLORIDE
Aim of present work was to formulate and evaluate oral floating beads of Tramadol hydrochloride. Floating beads were fabricated using modified ionotropic gelation technique using various natural and synthetic polymers in different proportion. In the formulated batches BT1 to BT11 not have ability to extend drug release for 12 hours. In formulated batch BT 12 (Sodium alginate 6%: Carbapol 940 1.2 %) show in vitro release for 12 hours (100.26 ± 0.66% ). It also has floating lag time and floating time immediate, and floating duration more than 12 hours. In kinetic model fitting it follows Korsemeyers Peppas equation. Also it was found stable after 6 months in accelerated stability study. From all the formulation of oral floating beads of Tramadol Hydrochloride; it was concluded that, among all different polymer ratio Sodium Alginate 6% and CaCl2 3% (2:1 ratio) gives best results. Among different polymers Carbapol 940 gives retarded drug release for 12 hours. The optimized batch was found to be stable after 6 Months in accelerated stability studies. Key Words: Ionotropic gelation, Tramadol Hydrochloride, floating beads, Carbapol 94
PREPARATION AND CHARACTERIZATION OF ZIRCONIA BASED THICK FILM RESISTOR AS A AMMONIA GAS SENSOR
Genetic Patterns of Domestication in Pigeonpea (Cajanus cajan (L.) Millsp.) and Wild Cajanus Relatives
Pigeonpea (Cajanus cajan) is an annual or short-lived perennial food legume of acute regional importance, providing significant protein to the human diet in less developed regions of Asia and Africa. Due to its narrow genetic base, pigeonpea improvement is increasingly reliant on introgression of valuable traits from wild forms, a practice that would benefit from knowledge of its domestication history and relationships to wild species. Here we use 752 single nucleotide polymorphisms (SNPs) derived from 670 low copy orthologous genes to clarify the evolutionary history of pigeonpea (79 accessions) and its wild relatives (31 accessions). We identified three well-supported lineages that are geographically clustered and congruent with previous nuclear and plastid sequence-based phylogenies. Among all species analyzed Cajanus cajanifolius is the most probable progenitor of cultivated pigeonpea. Multiple lines of evidence suggest recent gene flow between cultivated and non-cultivated forms, as well as historical gene flow between diverged but sympatric species. Evidence supports that primary domestication occurred in India, with a second and more recent nested population bottleneck focused in tropical regions that is the likely consequence of pigeonpea breeding. We find abundant allelic variation and genetic diversity among the wild relatives, with the exception of wild species from Australia for which we report a third bottleneck unrelated to domestication within India. Domesticated C. cajan possess 75% less allelic diversity than the progenitor clade of wild Indian species, indicating a severe “domestication bottleneck” during pigeonpea domestication
Fungal planet description sheets : 371–399
Novel species of fungi described in the present study include the following from Australia: Neoseptorioides
eucalypti gen. & sp. nov. from Eucalyptus radiata leaves, Phytophthora gondwanensis from soil, Diaporthe
tulliensis from rotted stem ends of Theobroma cacao fruit, Diaporthe vawdreyi from fruit rot of Psidium guajava,
Magnaporthiopsis agrostidis from rotted roots of Agrostis stolonifera and Semifissispora natalis from Eucalyptus
leaf litter. Furthermore, Neopestalotiopsis egyptiaca is described from Mangifera indica leaves (Egypt), Roussoella
mexicana from Coffea arabica leaves (Mexico), Calonectria monticola from soil (Thailand), Hygrocybe jackmanii
from littoral sand dunes (Canada), Lindgomyces madisonensis from submerged decorticated wood (USA), Neofabraea
brasiliensis from Malus domestica (Brazil), Geastrum diosiae from litter (Argentina), Ganoderma wiiroense
on angiosperms (Ghana), Arthrinium gutiae from the gut of a grasshopper (India), Pyrenochaeta telephoni from the
screen of a mobile phone (India) and Xenoleptographium phialoconidium gen. & sp. nov. on exposed xylem tissues
of Gmelina arborea (Indonesia). Several novelties are introduced from Spain, namely Psathyrella complutensis on
loamy soil, Chlorophyllum lusitanicum on nitrified grasslands (incl. Chlorophyllum arizonicum comb. nov.), Aspergillus
citocrescens from cave sediment and Lotinia verna gen. & sp. nov. from muddy soil. Novel foliicolous taxa from South
Africa include Phyllosticta carissicola from Carissa macrocarpa, Pseudopyricularia hagahagae from Cyperaceae
and Zeloasperisporium searsiae from Searsia chirindensis. Furthermore, Neophaeococcomyces is introduced as
a novel genus, with two new combinations, N. aloes and N. catenatus. Several foliicolous novelties are recorded
from La RĂ©union, France, namely Ochroconis pandanicola from Pandanus utilis, Neosulcatispora agaves gen. &
sp. nov. from Agave vera-cruz, Pilidium eucalyptorum from Eucalyptus robusta, Strelitziana syzygii from Syzygium
jambos (incl. Strelitzianaceae fam. nov.) and Pseudobeltrania ocoteae from Ocotea obtusata (Beltraniaceae emend.).
Morphological and culture characteristics along with ITS DNA barcodes are provided for all taxa.http://www.ingentaconnect.com/content/nhn/pimjam2016Forestry and Agricultural Biotechnology Institute (FABI)Microbiology and Plant Patholog
- …