Quantum Cohesion Oscillation of Electron Ground State in Low Temperature Laser Plasma

The development of radically new technological and economically efficient methods for obtaining chemical products and for producing new materials with specific properties requires the study of physical and chemical processes proceeding at temperature of 10(exp 3) to 10(exp 4) K, temperature range of low temperature plasma. In our paper, by means of Wigner matrix of quantum statistical theory, a formula is derived for the energy of quantum coherent oscillation of electron ground state in laser plasma at low temperature. The collective behavior would be important in ion and ion-molecule reactions

Multiphoton Process and Anomalous Potential of Cell Membrane by Laser Radiation

In this paper, by the use of quantum biology and quantum optics, the laser induced potential variation of cell membrane has been studied. Theoretically, we have found a method of calculating the monophoton and multiphoton processes in the formation of the anomalous potential of cell membrane. In contrast with the experimental results, our numerical result is in the same order. Therefore, we have found the possibility of cancer caused by the laser induced anomalous cell potential

Correlation and consistency between two detection methods for serum 25 hydroxyvitamin D levels in human venous blood and capillary blood

IntroductionThe study assessed the correlation and concordance of 25-hydroxyvitamin D [25(OH)D] levels in capillary and venous plasma collected simultaneously after vitamin D3 supplementation in 42 healthy adults. They were randomly divided into three groups by random number table method. Group A took 1,000 IU vitamin D3 daily, group B took 10,000 IU vitamin D3 every 10 days, and group C took 30,000 IU vitamin D3 every 30 days until the end of the 12th month. Venous blood serum 25(OH)D level was detected by chemiluminescence immunoassay (CLIA) and mass spectrometry (LC-MS) at day 1, day 14, day 28, month 6, and month 12 respectively, the capillary blood serum 25(OH)D level was detected by chemiluminescence immunoassay (CLIA) at the same time. Pearson correlation analysis and linear regression analysis were employed to investigate the relationship and transformation equation between the findings of the two samples and the results obtained from different detection methods within the same sample. The Bland-Altman method, Kappa analysis, and receiver operating characteristic (ROC) curve were utilized for assessing consistency, sensitivity, and specificity.ResultsThe three groups all reached a stable peak at 6 months, and the average levels of the three groups were 49.21, 42.50 and 43.025 nmol/L, respectively. The average levels of group A were higher than those of group B and group C (P < 0.001). The mean values of serum 25(OH)D measured by LC-MS and CLIA in 42 healthy adults were 45.32 nmol/L and 49.88 nmol/L, respectively, and the mean values of 25(OH)D measured by LC-MS in capillary blood were 52.03 nmol/L, and the difference was statistically significant (P < 0.001). Pearson correlation analysis showed that the linear fitting formula of scatter data was as follows: venous 25(OH)D concentration (nmol/L) = 1.105 * capillary 25(OH)D concentration −7.532 nmol/L, R2 = 0.625. Good agreement was observed between venous and corrected capillary 25(OH)D levels in clinical diagnosis (Kappa value 0.75). The adjusted serum 25(OH)D in capillary blood had a high clinical predictive value.ConclusionsThe agreement between the two methods is good when the measured 25(OH)D level is higher. Standardized capillary blood chemiluminescence method can be used for 25(OH)D detection

Pathogenic Role of microRNA in Rheumatoid Arthritis

Rheumatoid arthritis (RA) being a chronic inflammatory disease can be affected by both genetic and environmental factors. Abnormal functioning of immune response is the main underlying cause of RA. A growing number of studies on related diseases uncovered that microRNA (miRNA) may influence the pathogenesis of RA, such as the promotion of proliferation of fibroblast-like synoviocytes and secretion of cytokines by highly expressed miRNAs. A large number of studies have reported the aberrant expressions of miRNAs during the entire phase of RA, from the preclinical to terminal stages. These dynamic changes can be potentially developed as a bio-marker for predicting the risk, diagnosis and clinical management of RA. This chapter aims to summarize and discuss miRNAs’ roles and mechanisms in the process of RA development, differential diagnosis from other diseases, clinical management and refractory RA. Therefore, miRNA demonstrates future perspectives of diagnosis and treatment of clinical RA under the support of newly discovered theoretical basis

The muscle nutritional components analysis of golden pompano (Trachinotus blochii) in different mariculture area, growth stages, and genders

Golden pompano (Trachinotus blochii) is an economically important fish which exhibits sexual size dimorphism and is widely cultivated in the southern seas of China. To evaluate the nutritional composition of T. blochii of different mariculture areas, growth stages, and genders, the moisture, ash, amino acids, and fatty acids in the muscle were measured using national standard biochemical assay. The analysis found 16 kinds of amino acids in the muscle of T. blochii. The EAA contents of fish from Guangdong (GD) and Guangxi (GX) were significantly lower than those of Hainan (HN) and Fujian (FJ) (p < 0.05). The unsaturated fatty acids were higher in T. blochii cultured in HN and FJ (p < 0.05). Within the same sea area, the contents of TAA, EAA, DAA, and PUFA increased with growth in T. blochii, but the differences were not significant (p > 0.05). EAA/TAA and EAA/NEAA conformed to the ideal FAO/WHO model. The AAS, CS, and EAAI scores of amino acids within groups gradually increased with growth. The TAA, EAA and PUFA contents in females were higher than in males (p > 0.05). The slightly higher amounts of amino acids and fatty acids in female T. blochii indicated females had higher nutritional value. In conclusion, the HN and FJ groups, the later growth stages, and the female T. blochii had generally higher nutritional values than their respective counterparts. These results provide fundamental data supporting all-female T. blochii breeding and culture, and optimized marketing body size

In situ immobilizing atomically dispersed Ru on oxygen-defective Co3O4 for efficient oxygen evolution

The synergistic regulation of the electronic structures of transition-metal oxide-based catalysts via oxygen vacancy defects and single-atom doping is efficient to boost their oxygen evolution reaction (OER) performance, which remains challenging due to complex synthetic procedures. Herein, a facile defect-induced in situ single-atom deposition strategy is developed to anchor atomically dispersed Ru single-atom onto oxygen vacancy-rich cobalt oxides (Ru/Co3O4–x) based on the spontaneous redox reaction between Ru3+ ions and nonstoichiometric Co3O4–x. Accordingly, the as-prepared Ru/Co3O4–x electrocatalyst with the coexistence of oxygen vacancies and Ru atoms exhibits excellent performances toward OER with a low overpotential of 280 mV at 10 mA cm–2, a small Tafel slope value of 86.9 mV dec–1, and good long-term stability in alkaline media. Furthermore, density functional theory calculations uncover that oxygen vacancy and atomically dispersed Ru could synergistically tailor electron decentralization and d-band center of Co atoms, further optimizing the adsorption of oxygen-based intermediates (*OH, *O, and *OOH) and reducing the reaction barriers of OER. This work proposes an available strategy for constructing electrocatalysts with abundant oxygen vacancies and atomically dispersed noble metal and presents a deep understanding of synergistic electronic engineering of transition-metal-based catalysts to boost oxygen evolution

3D-PRINTED NI-BASED ELECTRODES FOR HIGH-CURRENT DENSITY WATER-SPLITTING APPLICATION (HER AND OER)

Master'sMASTER OF ENGINEERING (CDE

Glycosylated cationic block co-beta-peptide as antimicrobial and anti-biofilm agents against Gram-positive bacteria

Antimicrobial resistance to last-resort antibiotics is a serious and chronic global problem. The treatment of bacterial infection is further hindered by the presence of biofilm and metabolically inactive persisters. Methicillin-resistant Staphylococcus aureus (MRSA) is a major pathogen causing high rates of mortality and morbidity. We report the synthesis of a new enantiomeric block co-beta-peptide, poly(amido-D-glucose)-block-poly(beta-L-lysine)) (PDGu-b-PBLK), with high yield and purity by one-shot one-pot anionic-ring opening (co)polymerization (AROP). The co-beta-peptide is bactericidal against replicating as well as biofilm and persisters MRSA, and also disperses biofilm biomass. It is active towards both community-acquired and hospital-associated MRSA strains which are resistant to multiple drugs including vancomycin and daptomycin. Its antibacterial activity is superior to vancomycin in established MRSA murine and human ex vivo skin infection models, with no acute in vivo toxicity in repeated dosing in mice at above therapeutic levels. The bacteria-activated surfactant-like effect of the copolymer, resulting from contact with bacterial envelope, induces high bactericidal activity with low toxicity and good biofilm dispersal. This new class of non-toxic molecule, effective against all bacterial sub-populations, has promising clinical potential. Besides Staphylococci, biofilms of many other Gram-positive pathogens (including Streptococci, Enterococci) are closely associated with recalcitrant infections and poor clinical outcomes of standard antibiotic treatment. Moreover, many biofilm-associated infections are polymicrobial, and targeting only one specific pathogen becomes less effective. Broad-spectrum dispersal of biofilm matrix against multiple Gram-positive genuses, and thereby removing the substrate for future microbial re-colonization and persistent infection, is of great interest for next generation antibiofilm agent development. Wall teichoic acid (WTA), an anionic glycopolymer abundantly present on the cell surface of Gram-positive bacteria, is a highly accessible but underexploited target. We identified that the block co-beta-peptide PDGu-b-PBLK targets WTA of Gram-positive bacteria and potentiates the beta-lactam antibiotic oxacillin against 4 hospital associated MRSA strains. It also disperses the biofilm of all tested Gram-positive bacteria (five species across two genuses). Its cationic block electrostatically interacts with anionic WTA on cell envelope, and the glycosylated block forms a non-fouling corona around the bacteria. This reduces physical interaction of bacteria with biofilm matrix, leading to biofilm dispersal. This co-beta-peptide, which is antibiotic-potentiating, and which disperses biofilms of a broad spectrum of Gram-positive pathogens by targeting a common cell envelope component, WTA, has promising potential for future development of clinical antibacterial and anti-biofilm strategies.Doctor of Philosoph

The mediating role of social connectedness in the effect of positive personality, alexithymia and emotional granularity on life satisfaction: Analysis based on a structural equation model

This study explored the predictive effect of positive personality, positive emotional granularity and alexithymia on individual life satisfaction among 318 Chinese undergraduate students. Online questionnaires were used to assess positive personality, alexithymia, social connectedness and life satisfaction. Participants were also asked to view a series of standardized film clips and rate them on a list of nonprimary emotions to compute their emotional granularity. The results indicated that positive personality and alexithymia could predict an individual&#39;s life satisfaction directly or indirectly through social connectedness. Positive emotional granularity could predict alexithymia. However, positive emotional granularity could not predict life satisfaction directly, but it could predict life satisfaction through the path of alexithymia-social connectedness. These results provide implications for enhancing the well-being of Chinese college students by cultivating their positive psychological qualities and strengthening their social bonding.</p