Moore on degrees of responsibility

In his latest book Mechanical Choices, Michael Moore provides an explication and defence of the idea that responsibility comes in degrees. His account takes as its point of departure the view that free action and free will consist in the holding of certain counterfactuals. In this paper, I argue that Moore’s view faces several familiar counterexamples, all of which serve to motivate Harry Frankfurt’s classic insight that whether and to what extent one is responsible for one’s action has more to do with what actually caused that action than with what one could or couldn’t have done instead. I then go on to sketch an alternative approach to degrees of responsibility that takes seriously this insight. I’ll argue that Moore ought to be sympathetic to this approach, inasmuch as it combines two familiar Moorean ideas: the idea that causal contribution comes in degrees, and the idea that acting freely is compatible with, and indeed entails, the fact that one’s action was caused by prior states of affairs

Responsibility and iterated knowledge

I defend an iterated knowledge condition on responsibility for outcomes: one is responsible for a consequence of one's action only if one was in a position to know that, for all one was in a position to know, one's action would have that consequence

Retailer Compliance as a Predictor of Youth Smoking Participation and Consumption

Ninety per cent of smokers report having their first whole cigarette before the age of 19. Thus, it is important to have policies such as youth access laws which may prevent youth from becoming future smokers. In Canada, the Tobacco Act prohibits retailers from furnishing tobacco products to individuals under the age of 18. For such laws to be effective, however, it is important that retailers comply with them. The objective of this study was to examine the effect of retailer compliance on youth smoking behaviour. Data on individual smoking behaviour in conjunction with provincial retailer compliance rates and cigarette prices for the years 1999-2005 were employed to examine the effects of retailer compliance on youth smoking participation and consumption. Both price and retailer compliance were significant predictors of smoking participation. Price elasticity of demand for the overall sample was estimated to be -0.54. Our results which are consistent with previous research indicate that retailer compliance must be considered when examining the effects of youth access laws. This research confirmed that youth access laws can be an important component of a successful public policy approach to youth smoking prevention.youth smoking; two-part model; retailer compliance

Analysis of vertebrate genomes suggests a new model for clade B serpin evolution

BACKGROUND: The human genome contains 13 clade B serpin genes at two loci, 6p25 and 18q21. The three genes at 6p25 all conform to a 7-exon gene structure with conserved intron positioning and phasing, however, at 18q21 there are two 7-exon genes and eight genes with an additional exon yielding an 8-exon structure. Currently, it is not known how these two loci evolved, nor which gene structure arose first – did the 8-exon genes gain an exon, or did the 7-exon genes lose one? Here we use the genomes of diverse vertebrate species to plot the emergence of clade B serpin genes and to identify the point at which the two genomic structures arose. RESULTS: Analysis of the chicken genome indicated the presence of a single clade B serpin gene locus, containing orthologues of both human loci and both genomic structures. The frog genome and the genomes of three fish species presented progressively simpler loci, although only the 7-exon structure could be identified. The Serpinb12 gene contains seven exons in the frog genome, but eight exons in chickens and humans, indicating that the additional exon evolved in this gene. CONCLUSION: We propose a new model for clade B serpin evolution from a single 7-exon gene (either Serpinb1 or Serpinb6). An additional exon was gained in the Serpinb12 gene between the tetrapoda and amniota radiations to produce the 8-exon structure. Both structures were then duplicated at a single locus until a chromosomal breakage occurred at some point along the mammalian lineage resulting in the two modern loci

Concepts liés à la réduction des méfaits dans la lutte au tabagisme

L’arrêt tabagique complet demeure le résultat le plus souhaitable sur le plan de la santé publique en ce qui a trait à la « réduction des méfaits ». Le présent article a pour but de présenter, à partir de la documentation scientifique internationale, les trois principales approches en matière de réduction des méfaits du tabac : réduction de la consommation tabagique, substitution et modification de produits, examen de l’efficacité de ces approches et définition des difficultés qu’elles présentent.From the standpoint of public health, smoking cessation remains the most desirable outcome of any “harm reduction” effort. The goal of this article is to present the three primary approaches to tobacco harm reduction, based on the international scientific literature; these are: smoking reduction, product replacement and product modification. This article also reviews the current knowledge of the effectiveness of these approaches, as well as the difficulties associated with each of them.El cese tabáquico completo sigue siendo el resultado más deseable en salud pública en cuanto a la “reducción de los daños”. El presente artículo tiene como objetivo exponer, a partir de la documentación científica internacional, los tres enfoques principales en materia de reducción de daños producidos por el tabaco: reducción del consumo tabáquico; sustitución y modificación de productos; examen de la eficacia de los enfoques y definición de las dificultades que ellos presentan

The roll-your-own cigarette market in Canada: a cross-sectional exploratory study

<p>Abstract</p> <p>Background</p> <p>Even though the use and prevalence of roll-your-own cigarettes (RYO) has been declining over the past decades, RYO remains important. Given the paucity of research examining RYO use, there is a need to better understand the current and potential future context of RYO use.</p> <p>Methods</p> <p>Data from the 2002 Canadian Tobacco Use Monitoring Survey (CTUMS) were used to examine RYO tobacco use among 23,341 Canadians aged 15 and older. Logistic regression models were conducted to examine factors which differentiate smokers who smoke RYO tobacco all of the time, most of the time or sometimes from smokers who do not smoke RYO tobacco.</p> <p>Results</p> <p>We found that 17% (n = 925,000) of current smokers in Canada reported smoking RYO. When compared to manufactured cigarette (MC) smokers, RYO users were heavier smokers, more addicted to nicotine, and less likely to consider quitting smoking. Lower income smokers were more likely to smoke RYO tobacco compared to smokers with high income. Conversely, smokers who had completed secondary school or university were less likely to smoke RYO tobacco compared to smokers who had not completed secondary school.</p> <p>Conclusion</p> <p>This study demonstrates that RYO tobacco use is not a negligible problem within Canada and provides valuable new insight for developing future tobacco control initiatives for this population of smokers.</p

Retailer Compliance as a Predictor of Youth Smoking Participation and Consumption

Ninety per cent of smokers report having their first whole cigarette before the age of 19. Thus, it is important to have policies such as youth access laws which may prevent youth from becoming future smokers. In Canada, the Tobacco Act prohibits retailers from furnishing tobacco products to individuals under the age of 18. For such laws to be effective, however, it is important that retailers comply with them. The objective of this study was to examine the effect of retailer compliance on youth smoking behaviour. Data on individual smoking behaviour in conjunction with provincial retailer compliance rates and cigarette prices for the years 1999-2005 were employed to examine the effects of retailer compliance on youth smoking participation and consumption. Both price and retailer compliance were significant predictors of smoking participation. Price elasticity of demand for the overall sample was estimated to be -0.54. Our results which are consistent with previous research indicate that retailer compliance must be considered when examining the effects of youth access laws. This research confirmed that youth access laws can be an important component of a successful public policy approach to youth smoking prevention

The major human and mouse granzymes are structurally and functionally divergent

Approximately 2% of mammalian genes encode proteases. Comparative genomics reveals that those involved in immunity and reproduction show the most interspecies diversity and evidence of positive selection during evolution. This is particularly true of granzymes, the cytotoxic proteases of natural killer cells and CD8+ T cells. There are 5 granzyme genes in humans and 10 in mice, and it is suggested that granzymes evolve to meet species-specific immune challenge through gene duplication and more subtle alterations to substrate specificity. We show that mouse and human granzyme B have distinct structural and functional characteristics. Specifically, mouse granzyme B is 30 times less cytotoxic than human granzyme B and does not require Bid for killing but regains cytotoxicity on engineering of its active site cleft. We also show that mouse granzyme A is considerably more cytotoxic than human granzyme A. These results demonstrate that even “orthologous” granzymes have species-specific functions, having evolved in distinct environments that pose different challenges