ParaDime: A Framework for Parametric Dimensionality Reduction

ParaDime is a framework for parametric dimensionality reduction (DR). In parametric DR, neural networks are trained to embed high-dimensional data items in a low-dimensional space while minimizing an objective function. ParaDime builds on the idea that the objective functions of several modern DR techniques result from transformed inter-item relationships. It provides a common interface to specify the way these relations and transformations are computed and how they are used within the losses that govern the training process. Through this interface, ParaDime unifies parametric versions of DR techniques such as metric MDS, t-SNE, and UMAP. Furthermore, it allows users to fully customize each aspect of the DR process. We show how this ease of customization makes ParaDime suitable for experimenting with interesting techniques, such as hybrid classification/embedding models or supervised DR, which opens up new possibilities for visualizing high-dimensional data

ÖKONOMISCHE ANALYSE REDUZIERTER BODENBEARBEITUNG IN ABHÄNGIGKEIT VON DER STICKSTOFFDÜNGUNG UNTER BESONDERER BERÜCKSICHTIGUNG DES PRODUKTIONSRISIKOS

Verfahren reduzierter Bodenbearbeitung können den Einsatz von Betriebsmitteln und Maschinen reduzieren und somit zu Kostensenkungen bei landwirtschaftlichen Produktionsverfahren beitragen. Unsicherheiten bezüglich möglicher Ertragseinbußen können jedoch eine Ursache für die geringe Akzeptanz reduzierter Bodenbearbeitungssysteme sein. Auf der Basis von Ergebnissen aus einem Langzeitversuch wurden die Ertragseffekte und deren ökonomische Auswirkungen unter Berücksichtigung von Risikoaspekten analysiert. Da die Bodenbearbeitung auch die Mineralisierung von Pflanzennährstoffen bestimmt, wurden auch Wechselwirkungen mit der Stickstoffdüngung untersucht. Anhand der Ergebnisse aus 12 Jahren wurde festgestellt, dass eine reduzierte Bodenbearbeitung vielfach eine höhere Stickstoffdüngung nötig macht, um einen gleichen Erfolg zu erzielen. Risikoaverse Landwirte würden pflügende Bodenbearbeitung bevorzugen.Reduzierte Bodenbearbeitung, Stickstoffdüngung, Risikoanalyse, Environmental Economics and Policy,

Standards und Indikatoren für die Entwicklung von Kompetenzen in der Lehrerbildung

In diesem Papier werden für die Schulpraktika im Lehramtsstudium, für das Referendariat und schließlich für die professionelle Lehrkraft Handlungsstandards in sechs zentralen Dimensionen dargestellt: 1) Handeln als Lehrperson 2) die Schule als Lern- und Lebensraum 3) Unterrichtsbeobachtung und –evaluation 4) Unterrichtsplanung, -durchführung und –analyse 5) Klassenführung 6) Leistungsmessung In einer spiralcurricularen Darstellung wird der Weg der professionellen Entwicklung, beginnend bei den ersten Handlungserfahrungen als Lehrperson, anhand von Regelstandards entwickelt. Dazu werden jeweils Indikatoren aufgeführt, an denen man die Erreichung des jeweiligen Standards beobachten kann. Ein theoretischer Teil führt in die erziehungswissenschaftliche Diskussion rund um das Thema Lehrerbildungsstandards ein und verankert die vorliegenden sowie die dazugehörigen Indikatoren in der aktuellen Unterrichtsqualitätsforschung

Analysis of camber formation, suppression and control in hot rolling of wedge-shaped slabs by utilizing fem and analytical concepts

Reducing wedge without generating camber is still a big challenge for today’s process automation systems for hot strip mills. Therefore, detailed transient 3D-models of the underlying severely asymmetric flat hot rolling processes have been developed by the authors with the help of the commercial FEM-package ©Abaqus Explicit. By utilizing suitably positioned edging rolls, the corresponding lateral force acting on the strip induces a lateral material flow inside the roll gap, leading to stress-redistributions such that the outgoing camber-curvature is drastically reduced. Systematic parameter studies performed so far revealed how the lateral edging force and the resulting strip camber-curvature depend on characteristic rolling parameters, such as slab width, thickness, initial wedge and thickness reduction. To understand the underlying highly non-linear elasto-viscoplastic forming processes inside the strip or slab in more detail, and to develop fast simulation-tools, semi-analytical model reduction approaches have been developed. This enables a quantitative analysis of the induced lateral material flow and the occurring stress-redistributions inside the roll bite. By introducing a lateral material transfer parameter directly correlated to the camber-curvature, an analytical relation could be derived for the bending moment (and external work) that has to be applied to eliminate the camber of the strip or slab. These analytical predictions, although based on rough simplifications, correspond quite satisfactorily with those attained by 3D-FEM simulations

Comparison of a pediatric practice-based therapy and an interdisciplinary ambulatory treatment in social pediatric centers for migraine in children: a nation-wide randomized-controlled trial in Germany: \textquotedblmoma - modules on migraine activity\textquotedbl

BACKGROUND Migraine is common in childhood, peaks in adolescents and persists into adulthood in at least 40% of patients. There is need for early interventions to improve the burden of disease and, if possible, reduce chronification. The aim of the project is to compare two types of ambulatory treatment strategies regarding their effect on headache days and quality of life in 6 to 11 year old children with migraine: 1) the routine care in pediatricians' practices (intervention group A) and 2) a structured interdisciplinary multimodal intervention administered at social pediatric centers (intervention group B). METHODS The study is a nation-wide cluster-randomized study. Based on the postal codes the regions are randomly assigned to the two intervention-strategies. Children with migraine are recruited in the pediatric practices, as common outpatient-care in the German health-care system. Parents rate headache frequency, intensity and acute medication intake at a daily basis via a digital smartphone application specifically designed for the study. Migraine-related disability and quality of life are assessed every 3 months. Study duration is 9 months for every participant: 3 months of baseline at the pediatric practice (both groups); 3 months of intervention at the pediatric practice (intervention group A) or at the social pediatric center (intervention group B), respectively; 3 months of follow-up at the pediatric practice (both groups). DISCUSSION Results of the planned comparison of routine care in pediatric practices and interdisciplinary social pediatric centers will be relevant for treatment of children with migraine, both for the individual and for the health care system. TRIAL REGISTRATION The study was approved by the ethics committee at the Ludwig-Maximilians-University Munich (number 18-804) and was retrospectively registered on 27 April 2021 in the WHO approved German Clinical Trials Register (number DRKS00016698 )

Diminished impact of cytomegalovirus infection on graft vasculopathy development in the antiviral prophylaxis era – a retrospective study

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Cell Stress – a new journal for cellular pathophysiology

Launched by over a hundred high-carat founding editors, including five Nobel Laureates and more than 30 members of the National Academy of Sciences, Cell Stress emerges as a new online-only journal that focuses on disease-relevant cellular responses to endogenous and exogenous stress. Cell Stress is a peer-reviewed publishing platform for high-impact research in all areas of pathophysiology with a rigorous open access policy that allows maximal visibility and transparency for the publication of excellent science. Cell Stress thus offers readers and experts all over the world a common, peer-reviewed platform to develop and transfer technical and experimental knowledge, to understand cellular and organismal stress and, ultimately, to combat disease

Migraine and the development of additional psychiatric and pain disorders in the transition from adolescence to adulthood

Introduction: The transition from childhood to adolescence and from adolescence to adulthood are vulnerable phases in life. In these phases, late or insufficient treatment of diseases may lead to chronification and favor development of additional disorders. In adolescents, migraine often has a highly negative impact on school performance and everyday life. The hypothesis of the present study was that adolescents with migraine have a higher risk for developing additional disorders such as psychiatric disorders or other pain syndromes in the course of the disease. Materials and methods: In this study, we analyzed health insurance data of 56,597 German adolescents at the age of 15 years in the year 2006. By using the International Classification of Diseases (ICD 10), we determined a group with migraine diagnosis in the year 2006 and a control group without any headache diagnosis in 2006. We then compared both groups regarding the development of additional disorders (based on the ICD 10) during the following 10 years (2007 to 2016). Results: Adolescents with migraine had a 2.1 fold higher risk than persons without migraine diagnosis to develop an additional affective or mood disorder, a 1.8 fold higher risk to obtain neurotic, stress-related and somatoform disorders, a 1.8 fold higher risk to subsequently suffer from behavioral syndromes, a 1.6 higher risk to get back pain and a 1.5 fold higher risk for irritable bowel syndrome during the next 10 years. Conclusion: Adolescents with migraine are at risk for developing additional disorders later. Considering and addressing the patient’s risks and potential medical and psychosocial problems might improve the long-term outcome significantly