Review of the safety, efficacy and patient acceptability of the levonorgestrel-releasing intrauterine system

The levonorgestrel-containing intrauterine system is an extremely effective, reversible and safe form of long-term yet reversible birth control. In view of its efficacy, it is a safer alternative to permanent contraceptive methods such as sterilization. It is especially useful in situations where use of estrogen-containing contraceptives is contraindicated. While menstrual disturbances are a common side effect, proper counseling improves compliance. In addition to its contraceptive effect, the levonorgestrel intrauterine system offers potential therapeutic benefits in other clinical contexts, including menorrhagia, symptomatic fibroids, endometriosis, and endometrial protection

Classification of Subjects as Slow or Rapid Inactivators of Isoniazid Oral Administration of a Slow-release. Preparation of Isoniazid and Determination of the Ratio of Acetyisoniazid to Isoniazid in Urine

A simple method for classifying subjects as slow or rapid inactivators of isoniazid has beenevaluated on large numbers of patients. The method consists of determining the ratio of acetylisoniazid to isoniazid in a 24-26 h. urine collection following the oral administration of a slow-release preparation of isoniazid 30 mg./kg. body-weight. In a group of 101 patients, there was 100 per cent agreement between the classification based on this method and that based on a standard method, consisting of estimation of the serum isoniazid concentration, 4½ h. after an intramuscular dose of ordinary isoniazid 3 mg./kg. body-weight. Subsequent studies in other patients have confirmed that the method is efficient, and demonstrated that the classification is highly reproducible

A Modified Method for the Estimation of Acetylisoniazid in Urine

The method of Venkataraman et al. (1968) for the direct estimation of acetylisoniazid in urine has been modified to make it suitable for application to urine specimens containing sugar. The urine is first extracted with a mixture of chloroform and n-butanol, the organic phase re-extracted with dilute sulphuric acid, and the original method then applied to the acid extract. With the modified method, recoveries of acetylisoniazid were quantitative, both in the presence and the absence of glucose. Interference due to hydrazones and isonicotinyl glycine was substantially reduced by the modification, while that due to isoniazid remained the same. There was little or no interference from isonicotinic acid, with either the original or the modified method

Genetic parameters for early growth traits in Lates calcarifer (Bloch)

Genetic parameters for early growth traits such as body length at 21st, 50th and 80th day and bodv weight at 50th and 80th day were estimated using the data from a sample of 497 progeny s or pair matings in Lates calcarifer. The progeny were produced by the induction of spawning using reproductive hormone LHRH-a. The heritability (hz), genetic and phenotypic correlations were estimated using single pair matings model of analysis of variance and covariance. The efficient of variation ranged from 21.57 to 37.95 for body length and 64.98 to 89.41 for body weight. The hZ estimates ranged from 0.15 to 0.96 and 0.50 to 0.77 for body length and body weight respectively. The pooled data estimates of h2 are higher than the single environment data estimates and the h2 increased along with the age. The genetic and phenotypic correlations between body length and weight were found to be high, positive and significant in 50 day and 80 day old fingerlings of L. calcarifer

Cleidocranial dysplasia in son and father: Report of two rare cases with review of literature

Cleidocranial dysplasia (CCD) is a rare autosomal dominant skeletal disease, which is caused by mutation in the gene on 6p21 encoding transcription factor CBFA1, i.e runt-related transcription factor 2 (RUNX2). The disease is characterized by a persistently open anterior fontanelle and skull sutures, hypoplastic or aplastic clavicles, dental abnormalities, short stature, a wide pubic symphysis and a variety of other skeletal changes. A major finding of CCD is hypoplasia or aplasia of clavicular bones resulting in the ability of the patient to approximate the shoulders. Delayed closure of the anterior fontanelle and of metopic sutures causes frontal bossing. We report a rare case of CCD in a 15-year-old boy and in his father and emphasize the importance of clinical and radiographic findings in CCD

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Not AvailableA captive broodstock of the grey mullet Mugil cephalus has been successfully developed at Muttukadu experimental station of the Central Institute of Brackishwater Aquaculture. A stock of 72 sub-adult and adult fish in the size range of 290-450 mm/300-1,200 g procured from the commercial catches were maintained in 100 tonne capacity RCC tanks hom January '96. During 1996, about 20% of the stock, both males and females attained final maturity. In 1997, about 60% of the females and 80% of the males attained final maturity In mature females ova diameter of the matured oocytes ranged from 525 to 614 pa and the mature males were in oozing stage.Not Availabl

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Not AvailableGenetic parameters for early growth traits such as body length at 21st, 50th and 80th day and bodv weight at 50th and 80th day were estimated using the data from a sample of 497 progeny s or pair matings in Lates calcarifer. The progeny were produced by the induction of spawning using reproductive hormone LHRH-a. The heritability (hz), genetic and phenotypic correlations were estimated using single pair matings model of analysis of variance and covariance. The efficient of variation ranged from 21.57 to 37.95 for body length and 64.98 to 89.41 for body weight. The hZ estimates ranged from 0.15 to 0.96 and 0.50 to 0.77 for body length and body weight respectively. The pooled data estimates of h2 are higher than the single environment data estimates and the h2 increased along with the age. The genetic and phenotypic correlations between body length and weight were found to be high, positive and significant in 50 day and 80 day old fingerlings of L. calcarifer.Not Availabl

Cleidocranial dysplasia in son and father: Report of two rare cases with review of literature

Cleidocranial dysplasia (CCD) is a rare autosomal dominant skeletal disease, which is caused by mutation in the gene on 6p21 encoding transcription factor CBFA1, i.e runt-related transcription factor 2 (RUNX2). The disease is characterized by a persistently open anterior fontanelle and skull sutures, hypoplastic or aplastic clavicles, dental abnormalities, short stature, a wide pubic symphysis and a variety of other skeletal changes. A major finding of CCD is hypoplasia or aplasia of clavicular bones resulting in the ability of the patient to approximate the shoulders. Delayed closure of the anterior fontanelle and of metopic sutures causes frontal bossing. We report a rare case of CCD in a 15-year-old boy and in his father and emphasize the importance of clinical and radiographic findings in CCD

Not Available

Not AvailableGenetic parameters for early growth traits such as body length at 21st, 50th and 80th day and bodv weight at 50th and 80th day were estimated using the data from a sample of 497 progeny s or pair matings in Lates calcarifer. The progeny were produced by the induction of spawning using reproductive hormone LHRH-a. The heritability (hz), genetic and phenotypic correlations were estimated using single pair matings model of analysis of variance and covariance. The efficient of variation ranged from 21.57 to 37.95 for body length and 64.98 to 89.41 for body weight. The hZ estimates ranged from 0.15 to 0.96 and 0.50 to 0.77 for body length and body weight respectively. The pooled data estimates of h2 are higher than the single environment data estimates and the h2 increased along with the age. The genetic and phenotypic correlations between body length and weight were found to be high, positive and significant in 50 day and 80 day old fingerlings of L. calcarifer.Not Availabl

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