Near-Infrared H2 and Continuum Survey of Extended Green Objects

The Spitzer GLIMPSE survey has revealed a number of "Extended Green Objects" (EGOs) which display extended emission at 4.5 micron. These EGOs are potential candidates for high mass protostellar outflows. We have used high resolution (< 1") H2 1-0 S(1) line, K, and H-band images from the United Kingdom Infrared Telescope to study 34 EGOs to investigate their nature. We found that 12 EGOs exhibit H2 outflows (two with chains of H2 knotty structures; five with extended H2 bipolar structures; three with extended H2 lobes; two with pairs of H2 knots). In the 12 EGOs with H2 outflows, three of them exhibit similar morphologies between the 4.5 micron and H2 emission. However, the remaining 9 EGOs show that the H2 features are more extended than the continuum features, and the H2 emission is seldom associated with continuum emission. Furthermore, the morphologies of the near-infrared continuum and 4.5 micron emission are similar to each other for those EGOs with K-band emission, implying that at least a part of the IRAC-band continuum emission of EGOs comes from scattered light from the embedded YSOs.Comment: accepted for publication in ApJ

Polycomb group proteins EZH2 and EED directly regulate androgen receptor in advanced prostate cancer

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149265/1/ijc32118.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149265/2/ijc32118_am.pd

Synthesis, self-assembly, and immunological activity of α-galactose-functionalized dendron–lipid amphiphiles

Nanoassemblies presenting multivalent displays of biologically active carbohydrates are of significant interest for a wide array of biomedical applications ranging from drug delivery to immunotherapy. In this study, glycodendron–lipid hybrids were developed as a new and tunable class of dendritic amphiphiles. A modular synthesis was used to prepare dendron–lipid hybrids comprising distearylglycerol and 0 through 4th generation polyester dendrons with peripheral protected amines. Following deprotection of the amines, an isothiocyanate derivative of C-linked α-galactose (α-Gal) was conjugated to the dendron peripheries, affording amphiphiles with 1 to 16 α-Gal moieties. Self-assembly in water through a solvent exchange process resulted in vesicles for the 0 through 2nd generation systems and micelles for the 3rd and 4th generation systems. The critical aggregation concentrations decreased with increasing dendron generation, suggesting that the effects of increasing molar mass dominated over the effects of increasing the hydrophilic weight fraction. The binding of the assemblies to Griffonia simplicifolia Lectin I (GSL 1), a protein with specificity for α-Gal was studied by quantifying the binding of fluorescently labeled assemblies to GSL 1-coated beads. It was found that binding was enhanced for amphiphiles containing higher generation dendrons. Despite their substantial structural differences with the natural ligands for the CD1d receptor, the glycodendron–lipid hybrids were capable of stimulating invariant natural killer T (iNKT) cells, a class of innate-like T cells that recognize lipid and glycolipid antigens presented by CD1d and that are implicated in a wide range of diseases and conditions including but not limited to infectious diseases, diabetes and cancer

Emission Mechanism of "Green Fuzzies" in High-mass Star Forming Regions

The Infrared Array Camera (IRAC) on the Spitzer Space Telescope has revealed that a number of high-mass protostars are associated with extended mid-infrared emission, particularly prominent at 4.5-micron. These are called "Green Fuzzy" emission or "Extended Green Objects". We present color analysis of this emission toward six nearby (d=2-3 kpc) well-studied high-mass protostars and three candidate high-mass protostars identified with the Spitzer GLIMPSE survey. In our color-color diagrams most of the sources show a positive correlation between the [3.6]-[4.5] and [3.5]-[5.8] colors along the extinction vector in all or part of the region. We compare the colors with those of scattered continuum associated with the low-mass protostar L 1527, modeled scattered continuum in cavities, shocked emission associated with low-mass protostars, modeled H2 emission for thermal and fluorescent cases, and modeled PAH emission. Of the emission mechanisms discussed above, scattered continuum provides the simplest explanation for the observed linear correlation. In this case, the color variation within each object is attributed to different foreground extinctions at different positions. Alternative possible emission mechanisms to explain this correlation may be a combination of thermal and fluorescent H2 emission in shocks, and a combination of scattered continuum and thermal H2 emission, but detailed models or spectroscopic follow-up are required to further investigate this possibility. Our color-color diagrams also show possible contributions from PAHs in two objects. However, none of our sample show clear evidence for PAH emission directly associated with the high-mass protostars, several of which should be associated with ionizing radiation. This suggests that those protostars are heavily embedded even at mid-infrared wavelengths.Comment: 32 pages, 14 figures, 3 tables, accepted for publication in Astrophysical Journa

The Complete Chloroplast Genome Sequence of Date Palm (Phoenix dactylifera L.)

BACKGROUND: Date palm (Phoenix dactylifera L.), a member of Arecaceae family, is one of the three major economically important woody palms--the two other palms being oil palm and coconut tree--and its fruit is a staple food among Middle East and North African nations, as well as many other tropical and subtropical regions. Here we report a complete sequence of the data palm chloroplast (cp) genome based on pyrosequencing. METHODOLOGY/PRINCIPAL FINDINGS: After extracting 369,022 cp sequencing reads from our whole-genome-shotgun data, we put together an assembly and validated it with intensive PCR-based verification, coupled with PCR product sequencing. The date palm cp genome is 158,462 bp in length and has a typical quadripartite structure of the large (LSC, 86,198 bp) and small single-copy (SSC, 17,712 bp) regions separated by a pair of inverted repeats (IRs, 27,276 bp). Similar to what has been found among most angiosperms, the date palm cp genome harbors 112 unique genes and 19 duplicated fragments in the IR regions. The junctions between LSC/IRs and SSC/IRs show different features of sequence expansion in evolution. We identified 78 SNPs as major intravarietal polymorphisms within the population of a specific cp genome, most of which were located in genes with vital functions. Based on RNA-sequencing data, we also found 18 polycistronic transcription units and three highly expression-biased genes--atpF, trnA-UGC, and rrn23. CONCLUSIONS: Unlike most monocots, date palm has a typical cp genome similar to that of tobacco--with little rearrangement and gene loss or gain. High-throughput sequencing technology facilitates the identification of intravarietal variations in cp genomes among different cultivars. Moreover, transcriptomic analysis of cp genes provides clues for uncovering regulatory mechanisms of transcription and translation in chloroplasts