A Research Survey of Electronic Commerce Innovation: Evidence from the Literature

The development of technology has ignited many innovations in business management, especially in the electronic commerce area. The essential example, that is, online stores and online shopping, is a critical evolution and innovation from traditional brick-and-mortar stores to clicks and mortar. Following previous research (Van Oorschot et al.), this present study adopted bibliometric and keyword analysis to review the main characteristics of electronic commerce innovations. Focused on the academic sources, the research data used in this study were searched for and collected from the Web of Science (WoS), a renowned academic database which covers the most influential research journals in electronic commerce. Based on a combination of several keywords related to “innovation” and “electronic commerce,” the keyword search in the WoS was conducted in May 2019. As a result, a total of 334 research articles related to electronic commerce innovations were collected. Derived from the bibliometric analysis, some keywords that were seldom used in the earlier decade (2000-2009), but which rapidly grew in use in the recent decade (2010-2018) were found, including m-commerce, platforms, social commerce, online review, and co-creation. In addition, the top 10 influential articles listed in each of the two decades were identified. The results show some of the research trajectories in EC innovations. In the first decade (2000-2009), the top 10 papers focused on traditional IT adoption, such as self-service technology, enterprise resource planning systems, and the adoption of general attitude-intention theories such as the technology acceptance model. In the recent decade (2010-2018), researchers have shown more diverse interest in innovative EC applications, such as RFID applications, cloud computing, crowdsourcing, etc. Accompanying these EC innovation contexts, in addition to general attitude-intention theories, more theories such as signaling theory, have been adopted

Case report: Hemophagocytic lymphohistiocytosis complicated by multiple organ dysfunction syndrome following aseptic encephalitis

Hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially life-threatening condition caused by excessive immune activation. Secondary HLH is usually triggered by infection, most often from viral infection or malignancy. Here, we present a case of secondary HLH, complicated by multiple organ dysfunction syndrome triggered by critical aseptic encephalitis. A 27-year-old man without any underlying disease presented to our hospital with fever, disturbance of consciousness, and generalized seizures. The patient was diagnosed with aseptic encephalitis with super-refractory status epilepticus. Although antiseizure medications and immunoglobulins were administered, the patient developed multiple organ dysfunction syndrome. HLH was later diagnosed based on hypertriglyceridemia, hyperferritinemia, splenomegaly, cytopenia, and phagocytosis of nucleated cells, as shown by a blood smear of bone marrow aspiration. Treatment with pulse steroid therapy and plasmapheresis was initiated rather than chemotherapy because of the patient’s critical condition. However, the patient died of profound shock and multiple organ failure. Diagnosis of HLH is challenging in patients with severe infections because of similar clinical manifestations and laboratory findings. The early recognition of HLH provides patients with the opportunity to receive appropriate treatment, which can lead to increased survival and remission rates

Wolfberry genomes and the evolution of Lycium (Solanaceae)

AbstractWolfberry Lycium, an economically important genus of the Solanaceae family, contains approximately 80 species and shows a fragmented distribution pattern among the Northern and Southern Hemispheres. Although several herbaceous species of Solanaceae have been subjected to genome sequencing, thus far, no genome sequences of woody representatives have been available. Here, we sequenced the genomes of 13 perennial woody species of Lycium, with a focus on Lycium barbarum. Integration with other genomes provides clear evidence supporting a whole-genome triplication (WGT) event shared by all hitherto sequenced solanaceous plants, which occurred shortly after the divergence of Solanaceae and Convolvulaceae. We identified new gene families and gene family expansions and contractions that first appeared in Solanaceae. Based on the identification of self-incompatibility related-gene families, we inferred that hybridization hotspots are enriched for genes that might be functioning in gametophytic self-incompatibility pathways in wolfberry. Extremely low expression of LOCULE NUBER (LC) and COLORLESS NON-RIPENING (CNR) orthologous genes during Lycium fruit development and ripening processes suggests functional diversification of these two genes between Lycium and tomato. The existence of additional flowering locus C-like MADS-box genes might correlate with the perennial flowering cycle of Lycium. Differential gene expression involved in the lignin biosynthetic pathway between Lycium and tomato likely illustrates woody and herbaceous differentiation. We also provide evidence that Lycium migrated from Africa into Asia, and subsequently from Asia into North America. Our results provide functional insights into Solanaceae origins, evolution and diversification.</jats:p

Potential of Core-Collapse Supernova Neutrino Detection at JUNO

JUNO is an underground neutrino observatory under construction in Jiangmen, China. It uses 20kton liquid scintillator as target, which enables it to detect supernova burst neutrinos of a large statistics for the next galactic core-collapse supernova (CCSN) and also pre-supernova neutrinos from the nearby CCSN progenitors. All flavors of supernova burst neutrinos can be detected by JUNO via several interaction channels, including inverse beta decay, elastic scattering on electron and proton, interactions on C12 nuclei, etc. This retains the possibility for JUNO to reconstruct the energy spectra of supernova burst neutrinos of all flavors. The real time monitoring systems based on FPGA and DAQ are under development in JUNO, which allow prompt alert and trigger-less data acquisition of CCSN events. The alert performances of both monitoring systems have been thoroughly studied using simulations. Moreover, once a CCSN is tagged, the system can give fast characterizations, such as directionality and light curve

Detection of the Diffuse Supernova Neutrino Background with JUNO

As an underground multi-purpose neutrino detector with 20 kton liquid scintillator, Jiangmen Underground Neutrino Observatory (JUNO) is competitive with and complementary to the water-Cherenkov detectors on the search for the diffuse supernova neutrino background (DSNB). Typical supernova models predict 2-4 events per year within the optimal observation window in the JUNO detector. The dominant background is from the neutral-current (NC) interaction of atmospheric neutrinos with 12C nuclei, which surpasses the DSNB by more than one order of magnitude. We evaluated the systematic uncertainty of NC background from the spread of a variety of data-driven models and further developed a method to determine NC background within 15\% with {\it{in}} {\it{situ}} measurements after ten years of running. Besides, the NC-like backgrounds can be effectively suppressed by the intrinsic pulse-shape discrimination (PSD) capabilities of liquid scintillators. In this talk, I will present in detail the improvements on NC background uncertainty evaluation, PSD discriminator development, and finally, the potential of DSNB sensitivity in JUNO

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts

Investigating the Success Factors for the Acceptance of Mobile Healthcare Technology

This study provides a theoretical and empirical analysis to explain factors influencing the elder persons’ adoption of mobile healthcare devices. The proposed model was extended from two wellknown intention-based theories: the theory of reasoned action and the technology acceptance model. Other individual differences and technological characteristics factors were integrated. As a result, the proposed model accounted for 67% high of the variance explained in behavioral intention, thus providing researchers and practitioners with an in-depth understanding of the introduction of new healthcare technology devices

Networking for Educational Innovations: A Bibliometric Survey of International Publication Patterns

The emergence of networking has been viewed as a critical educational innovation. To highlight some innovations in educational networking (EN) research, this paper provides a bibliometric overview of international EN research from 2000 to 2018. Based on a keyword search, a total of 1005 journal articles with 13,803 citations were obtained. Through careful bibliometric analyses, three main results were concluded. (1) The growth of EN articles and authors was up by 1.5 times from the first decade (2000&ndash;2009) to the current one (2010&ndash;2018). (2) The most influential journals (over 300 citations) were identified. The research scope covers education technology, higher education, education policy, and even AIDS (acquired immune deficiency syndrome) education. (3) Based on some popular bibliometric indicators, the changes of research trends can be seen from the comparison of the main streams, which are identified from the most influential articles. Classification of the main research streams was presented, providing a typological understanding of the EN literature. In the first decade of research, the two articles which ranked first in terms of overall citations and average citations are Horvat et al. (2003) (232 times) and Coburn and Russell (2008) (17.6 times), respectively. In the last decade, the article by Roblyer et al. (2010) received both the highest number of citations (407) and average citations (45.2). Finally, the main ideas of highly-cited articles were categorized into three research streams. While the EN research of the earlier decade focused on interpersonal relationships, that of the recent decade emphasized on some innovative networking approaches, such as social media for learning, and network-based methodologies. Further discussions are provided