GYNOCARE Update: Modern Strategies to Improve Diagnosis and Treatment of Rare Gynecologic Tumors—Current Challenges and Future Directions

More than 50% of all gynecologic tumors can be classified as rare (defined as an incidence of ≤6 per 100,000 women) and usually have a poor prognosis owing to delayed diagnosis and treatment. In contrast to almost all other common solid tumors, the treatment of rare gynecologic tumors (RGT) is often based on expert opinion, retrospective studies, or extrapolation from other tumor sites with similar histology, leading to difficulty in developing guidelines for clinical practice. Currently, gynecologic cancer research, due to distinct scientific and technological challenges, is lagging behind. Moreover, the overall efforts for addressing these challenges are fragmented across different European countries and indeed, worldwide. The GYNOCARE, COST Action CA18117 (European Network for Gynecological Rare Cancer Research) programme aims to address these challenges through the creation of a unique network between key stakeholders covering distinct domains from concept to cure: basic research on RGT, biobanking, bridging with industry, and setting up the legal and regulatory requirements for international innovative clinical trials. On this basis, members of this COST Action, (Working Group 1, “Basic and Translational Research on Rare Gynecological Cancer”) have decided to focus their future efforts on the development of new approaches to improve the diagnosis and treatment of RGT. Here, we provide a brief overview of the current state-of-the-art and describe the goals of this COST Action and its future challenges with the aim to stimulate discussion and promote synergy across scientists engaged in the fight against this rare cancer worldwide

Numerical evaluation of hydrodynamic characteristics of planing hulls by using a hybrid method

The hydrodynamic characteristics of the planing hulls in particular at the planing regime are completely different from the conventional hull forms and the determination of these characteristics is more complicated. In the present study, calm water hydrodynamic characteristics of planing hulls are investigated using a hybrid method. The hybrid method combines the dynamic trim and sinkage from the Zarnick approach with the Savitsky method in order to calculate the total resistance of the planing hull. Since the obtained dynamic trim and sinkage values by using the original Zarnick approach are not in good agreement with experimental data, an improvement is applied to the hybrid method using a reduction function proposed by Garme. The numerical results obtained by the hybrid and improved hybrid method are compared with each other and available experimental data. The results indicate that the improved hybrid method gives better results compared to the hybrid method, especially for the dynamic trim and resistance. Although the results have some discrepancies with experimental data in terms of resistance, trim and sinkage, the improved hybrid method becomes appealing particularly for the preliminary design stage of the planing hulls

Bruksizm ve Implant Basarisi: Literat�r derleme | Bruxism and dental implants success: A literature review

ÖzetAMAÇ: Derlememizin amacı implant destekli rehabilitasyonlarda meydana gelen farklı komplikasyonlara bruksizmin risk faktörü olarak etkisinin literatürlerle sistematik olarak değerlendirilmesidir.MATERYAL METOD: 10 Mart 2014’te elektronik arama moturunda, İngiliz literatüründeki bruksizm dental implant komplikasyon iliskisini konu alan calışmalar aşağıda açıklanan arama stratejileri dahilinde araştırılmıştır. Literatürler PICO arama kriterlerine uygun olarak incelendi: P, populasyon/problem; I, müdahale/yapılan tedavi; C, karşılaştırma; O, sonuç. BULGULAR: Derlememize 14 makale dahil edilmiştir. Biyolojik açıdan, bruksizmin 9 çalışmadaki sonuçları çıkarım yapmak için yeterli bulunmamıştır. Mekanik komplikasyonlara gelince 5 çalışmada bruksizmle ilgili pozitif ilişki ortaya konmuştur.SONUÇ: Bruksizm dental implantlar etrafındaki biyolojik komplikasyonlar için risk faktörü oluşturmazken mekanik komplikasyonların oluşmasında potansiyel oluşturabilir.Anahtar kelimelerDental implant; bruksizm; mekanik-biyolojik komplikasyonla

Vertical motions prediction in irregular waves using a time domain approach for hard chine displacement hull

In this paper, the validation of the hybrid frequency-time domain method for the assessment of hard chine displacement hull from vertical motions is presented. Excitation and hydrodynamic coefficients in regular waves are obtained from the 3D panel method by Hydrostar® software, while coupled heave and pitch motions are calculated in the time domain by applying the Cummins equations. Experiments using a 1:15 scale model of a "low-drag" small craft are performed in irregular head and following waves at Froude numbers Fr: 0.2, 0.4, and 0.6 at University of Naples Federico II, Italy. Results obtained by hybrid frequency-time domain simulations for heave, pitch, and vertical accelerations at center of gravity and bow are compared with experimental data and showed high accuracy

Clinical and radiographic evaluation of early loaded maxillary anterior implants: Three-year follow-up

The aim of this study was to evaluate clinical and radiologic results up to 3 years in patients treated with early loading of anterior implants supporting single-tooth all-ceramic restorations. Twenty-four patients were treated with 29 screw-type implants in the anterior maxilla. The implants were evaluated by clinical and radiographic parameters. Clinical parameters Plaque Index (PI), Sulcus Bleeding Index (BI), peri-implant probing depth (PD), and marginal bone loss (MBL) were recorded. At the recall examinations, all implants were successfully integrated, demonstrating healthy peri-implant soft tissues as documented by standard clinical parameters. No biologic complications were observed. There was no statistically significant increase in MBL between the baseline and recall stages (P >.05). Early loaded maxillary anterior implants supporting single-tooth restorations reveal successful clinical and radiographic outcomes when treatment steps were performed

Effect of borderline glucose intolerance on fetal maternal outcome

Purpose of investigation: The aim of this study was to compare the maternal and neonatal adverse outcomes in pregnant women whose glucose challenge test (GCT) results were below 130 mg/dl and between 130-139 mg/dl. Materials and Methods: Three hundred and six women with 50-gram GCT results of 130-139 mg/dl and 305 women with 50-gram GCT results of < 130 mg/dl were recruited. Results: Higher pre-postpartum hemoglobin difference (p = 0.001), longer postpartum hospitalisation time (p = 0.001), and increased cesarean section rates (p = 0.01) were reported in the study group. There were no differences between two groups in rates of preeclampsia, polyhydramnios, ablatio placenta, and chorioamnionitis. Conclusions: The authors suggest that a GCT result between 130-139 mg/dl is not associated with higher maternal and neonatal morbidity. Results do not support a conclusion of high maternal and neonatal morbidity in the study group and give an impression that the 140 mg/dl threshold value is adequate for screening

Diet and nutritional interventions with the special role of myo-inositol in gestational diabetes mellitus management. An evidence-based critical appraisal

Background: Gestational Diabetes Mellitus (GDM), defined as glucose intolerance with onset or first recognition during pregnancy, represents one of the most common maternal-fetal complications during pregnancy and it is associated with poor perinatal outcomes. To date, GDM is a rising condition over the last decades coinciding with the ongoing epidemic of obesity and Type 2 Diabetes Mellitus (T2DM). Objective: The aim of this review is to discuss the role of diet and nutritional interventions in preventing GDM with the explanation of the special role of myo-inositol (MI) in this matter. Methods: We performed an overview of the most recent literature data on the subject with particular attention to the effectiveness of diet and nutritional interventions in the prevention of GDM with the special role of MI. Results: Nutritional intervention and physical activity before and during pregnancy are mandatory in women affected by GDM. Moreover, the availability of insulin-sensitizers such as different forms of inositol has dramatically changed the scenario, allowing the treatment of several metabolic diseases, such as those related to glucose dysbalance. Although the optimal dose, frequency, and form of MI administration need to be further investigated, diet supplementation with MI appears to be an attractive alternative for the GDM prevention as well as for the reduction of GDM-related complications. Conclusions: More studies should be conducted to prove the most effective nutritional intervention in GDM. Regarding the potential effectiveness of MI, further evidence in multicenter, randomized controlled trials is needed to draw firm conclusions