Nuclear Threats from Small States

That are the policy implications regarding proliferation and counterproliferation of nuclear weapons among Third World states? How does deterrence operate outside the parameters of superpower confrontation as defined by the cold war\u27s elaborate system of constraints enforced by concepts like mutual assured destruction, and counter-value and counter-force targeting? How can U.S. policymakers devise contingencies for dealing with nuclear threats posed by countries like North Korea, Libya, Iraq, Iran, and Syria? These are some of the unsettling but nevertheless important questions addressed by the author. Mr. Jerome Kahan examines the likelihood that one or more of these countries will use nuclear weapons before the year 2000. He also offers a framework that policymakers and planners might use in assessing U.S. interests in preempting the use of nuclear weapons or in retaliating for their use. Ironically, with the end of the cold war, it is imperative that defense strategists, policymakers, and military professionals think about the unthinkable.https://press.armywarcollege.edu/monographs/1895/thumbnail.jp

Relationships Between the Performance of Time/Frequency Standards and Navigation/Communication Systems

The relationship between system performance and clock or oscillator performance is discussed. Tradeoffs discussed include: short term stability versus bandwidth requirements; frequency accuracy versus signal acquisition time; flicker of frequency and drift versus resynchronization time; frequency precision versus communications traffic volume; spectral purity versus bit error rate, and frequency standard stability versus frequency selection and adjustability. The benefits and tradeoffs of using precise frequency and time signals are various levels of precision and accuracy are emphasized

Economic evaluation of ASCOT-BPLA: Antihypertensive treatment with an amlodipine-based regimen is cost-effective compared to an atenolol-based regimen

Copyright © 2010 BMJ Publishing Group Ltd & British Cardiovascular Society. Internal or personal use of this material is permitted. However, permission to reprint/republish this material must be obtained from the Publisher.Objective: To compare the cost effectiveness of an amlodipine-based strategy and an atenolol-based strategy in the treatment of hypertension in the UK and Sweden. Design: A prospective, randomised trial complemented with a Markov model to assess long-term costs and health effects. Setting: Primary care. Patients: Patients with moderate hypertension and three or more additional risk factors. Interventions: Amlodipine 5–10 mg with perindopril 4–8 mg added as needed or atenolol 50–100 mg with bendroflumethiazide 1.25–2.5 mg and potassium added as needed Main outcome measures: Cost per cardiovascular event and procedure avoided, and cost per quality-adjusted life-year gained. Results: In the UK, the cost to avoid one cardiovascular event or procedure would be €18 965, and the cost to gain one quality-adjusted life-year would be €21 875. The corresponding figures for Sweden were €13 210 and €16 856. Conclusions: Compared with the thresholds applied by NICE and in the Swedish National Board of Health and Welfare’s Guidelines for Cardiac Care, an amlodipine-based regimen is cost effective for the treatment of hypertension compared with an atenolol-based regimen in the population studied.The study was supported by the principal funding source, Pfizer, New York, USA

Optical System Design for the Next Generation Space Telescope

This report provides considerations and suggested approaches for design of the Optical Telescope Assembly and the segmented primary mirror of a Next Generation Space Telescope (NGST). Based on prior studies and hardware development, we provide data and design information on low-risk materials and hardware configurations most likely to meet low weight, low temperature and long-life requirements of the nominal 8-meter aperture NGST. We also provide preliminary data for cost and performance trades, and recommendations for technology development and demonstration required to support the system design effort

Integrable and superintegrable systems associated with multi-sums of products

We construct and study certain Liouville integrable, superintegrable, and non-commutative integrable systems, which are associated with multi-sums of products.Comment: 26 pages, submitted to Proceedings of the royal society

Technology Goes Home Evaluation – Executive Summary

Technology Goes Home (TGH) is an innovative program designed to bridge the digital divide by bringing technology into low-income families’ homes. This Boston Digital Bridge Foundation (BDBF) program strives to prepare adults for employment opportunities and to help children improve academic performance by offering computer training and equipment to families in Boston neighborhoods and schools. Classes are offered in groups, with parents and children learning together in order to strengthen families and build community as well as skills. Neighborhood programs are operated in six communities through Neighborhood Technology Collaboratives, coalitions of community-based organizations. These coalitions select participating families, and provide training, practice lab space and ongoing support. The TGH@school program uses a similar model through which parents and their children participate in technology training delivered by fourth-grade teachers. For the past year, the Center for Social Policy (CSP) staff have been engaged in a comprehensive evaluation of the program

An Update and Report Failure of Surgical Syndactyly Repair in Harlequin Ichthyosis.

Harlequin ichthyosis (HI) is a rare congenital skin disorder caused by irregular epidermal differentiation. Syndactyly in HI is associated with thick hyperkeratotic skin flexion and angulation deformity of the hand and fingers resulting in limited function of the upper extremity. Traditional syndactyly release is limited as full-thickness skin grafts typically used in reconstruction are composed of diseased skin and require donor sites in a patient predisposed for adverse wound healing. This case report is a follow-up to a previous viewpoint written about digital escharotomies in a newborn with HI and outlines a second and fourth webspace syndactyly release with a dermal substitute. Despite early evidence of adequate release and improved hand function, recurrence of syndactyly was observed within 4 months of surgical release. Our experience described within this case report may suggest the limitations and possible alternatives of surgical release of syndactyly in the HI population

One Family Scholar Project Evaluation: Executive Summary

The One Family Scholar Project provides resources and financial support to low-income and formerly homeless women who are pursuing educational goals. This unique project faces many challenges as it seeks to strike a balance between serving as a traditional scholarship program, which solely offers financial support, and operating as a supportive educational program designed to help women and families make life and system changes. By design, the Scholar Project is quite different from traditional financial support programs. The mission is to provide the supports necessary for low-income women to achieve academic and personal success. In order to do this, the project considers all aspects of a woman’s life, how that woman contributes to the larger community, and her potential for doing so in the future

A comparison of methods to adjust for continuous covariates in the analysis of randomised trials

BACKGROUND: Although covariate adjustment in the analysis of randomised trials can be beneficial, adjustment for continuous covariates is complicated by the fact that the association between covariate and outcome must be specified. Misspecification of this association can lead to reduced power, and potentially incorrect conclusions regarding treatment efficacy. METHODS: We compared several methods of adjustment to determine which is best when the association between covariate and outcome is unknown. We assessed (a) dichotomisation or categorisation; (b) assuming a linear association with outcome; (c) using fractional polynomials with one (FP1) or two (FP2) polynomial terms; and (d) using restricted cubic splines with 3 or 5 knots. We evaluated each method using simulation and through a re-analysis of trial datasets. RESULTS: Methods which kept covariates as continuous typically had higher power than methods which used categorisation. Dichotomisation, categorisation, and assuming a linear association all led to large reductions in power when the true association was non-linear. FP2 models and restricted cubic splines with 3 or 5 knots performed best overall. CONCLUSIONS: For the analysis of randomised trials we recommend (1) adjusting for continuous covariates even if their association with outcome is unknown; (2) keeping covariates as continuous; and (3) using fractional polynomials with two polynomial terms or restricted cubic splines with 3 to 5 knots when a linear association is in doubt