食道癌ESD後の異時性多発病変の発症にADH1BとALDH2上の２つのSNPが関連する。

広島大学(Hiroshima University)博士(医学)Doctor of Philosophy in Medical Sciencedoctora

A Project Support System Using Stepwise-Particularized Software Process Descriptions

This article proposes a project support system which employs process descriptions as vehicles of exchanging activity plans between a project manager and developers. The system provides cooperative specification of actual, detailed and executable process descriptions to project staffs, and stepwise particularizes process descriptions according to the project progress. Also, by handling the detailed process descriptions, the system generates candidates of more effective project plans and makes it possible to control individual processes of staffs in advance. This article also proposes the graphical process representation method which is formal but intuitive and comprehensible

Guiding optical flows by photonic crystal slabs made of dielectric cylinders

We investigate the electromagnetic propagation in two-dimensional photonic crystals, formed by parallel dielectric cylinders embedded a uniform medium. The frequency band structure is computed using the standard plane-wave expansion method, while the propagation and scattering of the electromagnetic waves are calculated by the multiple scattering theory. It is shown that within partial bandgaps, the waves tend to bend away from the forbidden directions. Such a property may render novel applications in manipulating optical flows. In addition, the relevance with the imaging by flat photonic crystal slabs will also be discussed.Comment: 5 pages, 5 figure

Sarcomere Imaging by Quantum Dots for the Study of Cardiac Muscle Physiology

We here review the use of quantum dots (QDs) for the imaging of sarcomeric movements in cardiac muscle. QDs are fluorescence substances (CdSe) that absorb photons and reemit photons at a different wavelength (depending on the size of the particle); they are efficient in generating long-lasting, narrow symmetric emission profiles, and hence useful in various types of imaging studies. Recently, we developed a novel system in which the length of a particular, single sarcomere in cardiomyocytes can be measured at ~30 nm precision. Moreover, our system enables accurate measurement of sarcomere length in the isolated heart. We propose that QDs are the ideal tool for the study of sarcomere dynamics during excitation-contraction coupling in healthy and diseased cardiac muscle

Water wave propagation and scattering over topographical bottoms

Here I present a general formulation of water wave propagation and scattering over topographical bottoms. A simple equation is found and is compared with existing theories. As an application, the theory is extended to the case of water waves in a column with many cylindrical steps