Automated Determination of Stellar Parameters from Simulated Dispersed Images for DIVA

We have assessed how well stellar parameters (T_eff, logg and [Fe/H]) can be retrieved from low-resolution dispersed images to be obtained by the DIVA satellite. Although DIVA is primarily an all-sky astrometric mission, it will also obtain spectrophotometric information for about 13 million stars (operational limiting magnitude V ~ 13.5 mag). Constructional studies foresee a grating system yielding a dispersion of ~200nm/mm on the focal plane (first spectral order). For astrometric reasons there will be no cross dispersion which results in the overlapping of the first to third diffraction orders. The one-dimensional, position related intensity function is called a DISPI (DISPersed Intensity). We simulated DISPIS from synthetic spectra (...) for a limited range of metallicites i.e. our results are for [Fe/H] in the range -0.3 to 1 dex. We show that there is no need to deconvolve these low resolution signals in order to obtain basic stellar parameters. Using neural network methods and by including simulated data of DIVA's UV telescope, we can determine T_eff to an average accuracy of about 2% for DISPIS from stars with 2000 K < T_eff < 20000 K and visual magnitudes of V=13 mag (end of mission data). logg can be determined for all temperatures with an accuracy better than 0.25 dex for magnitudes brighter than V=12 mag. For low temperature stars with 2000 K < T_eff < 5000 K and for metallicities in the range -0.3 to +1 dex a determination of [Fe/H] is possible (to better than 0.2 dex) for these magnitudes. Additionally we examined the effects of extinction E(B-V) on DISPIS and found that it can be determined to better than 0.07 mag for magnitudes brighter than V=14 mag if the UV information is included.Comment: 12 pages, 8 figures, Accepted for publication in A&

Horizontal Branch Stars: The Interplay between Observations and Theory, and Insights into the Formation of the Galaxy

We review HB stars in a broad astrophysical context, including both variable and non-variable stars. A reassessment of the Oosterhoff dichotomy is presented, which provides unprecedented detail regarding its origin and systematics. We show that the Oosterhoff dichotomy and the distribution of globular clusters (GCs) in the HB morphology-metallicity plane both exclude, with high statistical significance, the possibility that the Galactic halo may have formed from the accretion of dwarf galaxies resembling present-day Milky Way satellites such as Fornax, Sagittarius, and the LMC. A rediscussion of the second-parameter problem is presented. A technique is proposed to estimate the HB types of extragalactic GCs on the basis of integrated far-UV photometry. The relationship between the absolute V magnitude of the HB at the RR Lyrae level and metallicity, as obtained on the basis of trigonometric parallax measurements for the star RR Lyrae, is also revisited, giving a distance modulus to the LMC of (m-M)_0 = 18.44+/-0.11. RR Lyrae period change rates are studied. Finally, the conductive opacities used in evolutionary calculations of low-mass stars are investigated. [ABRIDGED]Comment: 56 pages, 22 figures. Invited review, to appear in Astrophysics and Space Scienc

The design and performance of the Gaia photometric system

The European Gaia astrometry mission is due for launch in 2011. Gaia will rely on the proven principles of the ESA Hipparcos mission to create an all-sky survey of about one billion stars throughout our Galaxy and beyond, by observing all objects down to 20 mag. Through its massive measurement of stellar distances, motions and multicolour photometry, it will provide fundamental data necessary for unravelling the structure, formation and evolution of the Galaxy. This paper presents the design and performance of the broad- and medium-band set of photometric filters adopted as the baseline for Gaia. The 19 selected passbands (extending from the UV to the far-red), the criteria and the methodology on which this choice has been based are discussed in detail. We analyse the photometric capabilities for characterizing the luminosity, temperature, gravity and chemical composition of stars. We also discuss the automatic determination of these physical parameters for the large number of observations involved, for objects located throughout the entire Hertzsprung-Russell diagram. Finally, the capability of the photometric system (PS) to deal with the main Gaia science case is outline

Pharmacokinetics, safety, and tolerability of a depot formulation of naltrexone in alcoholics: an open-label trial

BACKGROUND: Naltrexone is an effective medication for treatment of alcohol dependence, but its efficacy is limited by lack of adherence to the oral dosage form. A long-acting depot formulation of naltrexone may increase adherence. METHODS: A single site, 6-week open label study was conducted with 16 alcohol dependent subjects each receiving 300 mg of Naltrexone Depot by intramuscular injection. The main outcomes were safety and tolerability of the Naltrexone Depot formulation, blood levels of naltrexone and its main metabolite 6-beta naltrexol, and self-reported alcohol use. All subjects received weekly individual counseling sessions. RESULTS: The medication was well tolerated with 88% of subjects completing the 6-week trial. The most common side effect experienced was injection site complications. There were no serious adverse events. Subjects had naltrexone and 6-beta-naltrexol concentrations throughout the trial with mean values ranging from 0.58 ng/mL to 2.04 ng/mL and 1.51 ng/mL to 5.52 ng/mL, respectively, at each sampling time following administration. Compared to baseline, subjects had significantly reduced number of drinks per day, heavy drinking days and proportion of drinking days. CONCLUSION: Naltrexone Depot is safe and well tolerated in alcoholics and these findings support the further investigation of its utility in larger double-blind placebo controlled trials

A Model Analysis of Arterial Oxygen Desaturation during Apnea in Preterm Infants

Rapid arterial O2 desaturation during apnea in the preterm infant has obvious clinical implications but to date no adequate explanation for why it exists. Understanding the factors influencing the rate of arterial O2 desaturation during apnea () is complicated by the non-linear O2 dissociation curve, falling pulmonary O2 uptake, and by the fact that O2 desaturation is biphasic, exhibiting a rapid phase (stage 1) followed by a slower phase when severe desaturation develops (stage 2). Using a mathematical model incorporating pulmonary uptake dynamics, we found that elevated metabolic O2 consumption accelerates throughout the entire desaturation process. By contrast, the remaining factors have a restricted temporal influence: low pre-apneic alveolar causes an early onset of desaturation, but thereafter has little impact; reduced lung volume, hemoglobin content or cardiac output, accelerates during stage 1, and finally, total blood O2 capacity (blood volume and hemoglobin content) alone determines during stage 2. Preterm infants with elevated metabolic rate, respiratory depression, low lung volume, impaired cardiac reserve, anemia, or hypovolemia, are at risk for rapid and profound apneic hypoxemia. Our insights provide a basic physiological framework that may guide clinical interpretation and design of interventions for preventing sudden apneic hypoxemia