Emotional Intelligence and Disordered Eating: Efficacy of Analysis Via Ecological Momentary Assessment

The proposed presentation will provide background information on and preliminary baseline data from an ongoing pilot study of the use of EMA to assess the association between emotional intelligence and disordered eating. Participants will complete baseline surveys inquiring about disordered eating behaviors, emotional intelligence, and daily stressors, and receive text message prompts over two weeks asking about eating behaviors, stressors, and emotional intelligence. The study will ultimately address the following questions: does emotional intelligence predict occurrences of disordered eating symptoms and other eating behaviors over a subsequent two-week period and is ecological momentary assessment technology a feasible means of assessing day-to-day fluctuations in the presentation of disordered eating symptoms

Second-scale rotational coherence and dipolar interactions in a gas of ultracold polar molecules

Ultracold polar molecules combine a rich structure of long-lived internal states with access to controllable long-range anisotropic dipole–dipole interactions. In particular, the rotational states of polar molecules confined in optical tweezers or optical lattices may be used to encode interacting qubits for quantum computation or pseudo-spins for simulating quantum magnetism. As with all quantum platforms, the engineering of robust coherent superpositions of states is vital. However, for optically trapped molecules, the coherence time between rotational states is typically limited by inhomogeneous differential light shifts. Here we demonstrate a rotationally magic optical trap for 87Rb133Cs molecules that supports a Ramsey coherence time of 0.78(4) s in the absence of dipole–dipole interactions. This is estimated to extend to >1.4 s at the 95% confidence level using a single spin-echo pulse. In our trap, dipolar interactions become the dominant mechanism by which Ramsey contrast is lost for superpositions that generate oscillating dipoles. By changing the states forming the superposition, we tune the effective dipole moment and show that the coherence time is inversely proportional to the strength of the dipolar interaction. Our work unlocks the full potential of the rotational degree of freedom in molecules for quantum computation and quantum simulation

Momentary fluctuations in emotional intelligence and stress predict changes in disordered eating

Low emotional intelligence and symptoms of disordered eating are connected, however, whether daily fluctuations in emotional intelligence predict daily changes in disordered eating symptoms has not been examined, nor has stress been explored as a potential moderator of this relationship. Participants were undergraduate students ( = 100). Participants completed baseline questionnaires, then responded to random ecological momentary assessment prompts 3 times daily for 2 weeks. Results indicated that when individuals had higher momentary emotional intelligence, they had lower disordered eating at the same time point (within subjects estimate = -0.30,  \u3c .001) and following time point (within subjects estimate = -0.08,  = 0.03). Momentary stress moderated the relationship between baseline emotional intelligence and momentary disordered eating (b = -0.02,  \u3c .01). Changes in emotional intelligence predict day-to-day changes in disordered eating, and stress moderates the connection between emotional intelligence and disordered eating

Oncostatin M Receptor as a Therapeutic Target for Radioimmune Therapy in Synovial Sarcoma

Synovial sarcoma (SS) is a pediatric muscle cancer that primarily affects adolescents and young adults and has few treatment options. Complicating the treatment of synovial sarcoma is the low mutational burden of SS. Inflammatory pathways have been identified as being upregulated in some SS, leading to the discovery of upregulated oncostatin M receptor (OSMR). It was found that OSMR is upregulated in SS by RNAseq analysis and quantitative PCR, highlighting its potential in the treatment of SS. Also, OSMR is upregulated in mouse models for synovial sarcoma as demonstrated by western blot and immunohistochemistry, and the protein is present in both primary and metastatic sites of disease. Using a radioimmune therapy drug model, targeted therapy was synthesized for use in OSMR expressing SS and it was demonstrated that this drug is stable, while capable of efficient OSMR binding and isotope capture. Finally, this antibody conjugate exhibited ideal pharmacokinetics and targeted sites of disease in our mouse model and was taken up in both primary and metastatic diseased tissue. This suggests OSMR as an ideal target for therapy and this radioimmune therapy provides a novel treatment option for a disease with few therapy choices

Arctic science education using public museum collections from the University of Alaska Museum: An evolving and expanding landscape

Alaska faces unique challenges in STEM (science, technology, engineering and mathematics) education, including limited accessibility to resources and learning opportunities, and a lack of place-based education resources. Museum education programs, traditionally focused on public outreach through docent-led tours, are playing an increasingly important role in both formal and informal aspects of STEM education to help address these challenges. The University of Alaska Museum (UAM) stands as a model in the Arctic region exemplifying how public natural history museum collections can be utilized to create active place-based learning experiences with the aim of increasing engagement in STEM literacy, and building connections between museums and communities. These efforts take many forms, including the development of teaching materials involving physical objects and/or online data from the open-access database ARCTOS, training pre-service teachers, and implementing citizen science projects. Because many UAM specimens and objects are from Alaska, they are easily incorporated into place-based education, thereby demonstrating how the Arctic environment is unique at local and regional scales. Here, we showcase several programs that are either unique to UAM, or part of larger national projects, and include exemplar teaching modules in order to provide learning opportunities in the Arctic region and other rural settings.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author

Endkonturnahes selektives Lasersintern von keramischen Pulvern

In der aktuellen Forschung werden die Eigenschaften und Anwendungen von ultrakurzgepulster Laserstrahlung im selektiven Lasersintern von keramischen Pulvern untersucht. Die hohe Verschleißfestigkeit und Biokompatibilität prädestinieren Keramiken für vielfältige technische und medizinische Anwendungen. Hohe Rissneigung durch Temperaturgradienten im Sinterprozess, sowie die hohen Schmelztemperaturen sind dabei Herausforderungen und stehen im Fokus der Technologieentwicklung. Die Nutzung einer inversen Schichterzeugungskinematik ermöglicht einen effizienten Pulverauftrag. Kerninnovation ist die Anwendung des Ultrakurzpulslasers. Mit diesem gelingt es, sowohl Zirkonoxid als auch Aluminiumoxid in verschiedenen stofflichen Konfigurationen zu sintern, wobei stabile und teilweise glasierte Oberflächen sowie stapelbare Sinterschichten erfolgreich erzeugt werden.In current research, the properties and applications of ultra-short pulsed laser radiation in the selective laser sintering of ceramic powders are explored. The high wear resistance and biocompatibility of ceramics make them usable for a wide range of technical and medical applications. Challenges, such as a high propensity for cracking due to temperature gradients during the sintering process and the elevated melting temperatures, are central to technology development. The use of an inverse layer generation kinematics enables efficient powder application. The core innovation is the application of the ultrashort pulse laser. With this, it is possible to sinter both zirconia and alumina in various material configurations, successfully producing stable and partially glazed surfaces as well as stackable sintered layers

A Digital Health Intervention (SweetGoals) for Young Adults With Type 1 Diabetes: Protocol for a Factorial Randomized Trial

Background: Many young adults with type 1 diabetes (T1D) struggle with the complex daily demands of adherence to their medical regimen and fail to achieve target range glycemic control. Few interventions, however, have been developed specifically for this age group. Objective: In this randomized trial, we will provide a mobile app (SweetGoals) to all participants as a “core” intervention. The app prompts participants to upload data from their diabetes devices weekly to a device-agnostic uploader (Glooko), automatically retrieves uploaded data, assesses daily and weekly self-management goals, and generates feedback messages about goal attainment. Further, the trial will test two unique intervention components: (1) incentives to promote consistent daily adherence to goals, and (2) web health coaching to teach effective problem solving focused on personalized barriers to self-management. We will use a novel digital direct-to-patient recruitment method and intervention delivery model that transcends the clinic. Methods: A 2x2 factorial randomized trial will be conducted with 300 young adults ages 19-25 with type 1 diabetes and (Hb)A1c ≥ 8.0%. All participants will receive the SweetGoals app that tracks and provides feedback about two adherence targets: (a) daily glucose monitoring; and (b) mealtime behaviors. Participants will be randomized to the factorial combination of incentives and health coaching. The intervention will last 6 months. The primary outcome will be reduction in A1c. Secondary outcomes include self-regulation mechanisms in longitudinal mediation models and engagement metrics as a predictor of outcomes. Participants will complete 6- and 12-month follow-up assessments. We hypothesize greater sustained A1c improvements in participants who receive coaching and who receive incentives compared to those who do not receive those components. Results: Data collection is expected to be complete by February 2025. Analyses of primary and secondary outcomes are expected by December 2025. Conclusions: Successful completion of these aims will support dissemination and effectiveness studies of this intervention that seeks to improve glycemic control in this high-risk and understudied population of young adults with T1D.ISSN:1929-074

Long-term Visual Outcomes and Causes of Vision Loss in Chronic Central Serous Chorioretinopathy

To evaluate the long-term visual outcomes and causes of vision loss in chronic central serous chorioretinopathy (CSC). Retrospective, longitudinal study. A total of 133 participants (217 eyes) with chronic CSC. A retrospective review of clinical and multimodal imaging data of patients with chronic CSC managed by 3 of the authors between May 1977 and March 2018. Multimodal imaging comprised color photography, fluorescein angiography, indocyanine green angiography, fundus autofluorescence (FAF), and OCT. Best-corrected visual acuity (BCVA) at the final visit; change in BCVA between first visit and 1-, 5-, and 10-year follow-up visits; and causes of vision loss at final visit. Data from 6228 individual clinic visits were analyzed. Mean age of patients at the first visit was 60.7 years, and mean period of follow-up from first to last visit was 11.3 years. The cohort included 101 male patients (75.9%). At the final visit, 106 patients (79.7%) maintained driving-standard vision with BCVA of 20/40 or better in at least 1 eye, and 17 patients (12.8%) were legally blind with BCVA of 20/200 or worse in both eyes. Mean BCVA at first visit was not significantly different from mean BCVA at 1- or 5-year follow-up visits (both P ≥ 0.65) but was significantly better than the mean BCVA at the 10-year follow-up visit (P = 0.04). Seventy-nine percent of eyes with 20/40 or better vision at the first visit maintained the same level of vision at the 10-year follow-up visit. Ninety-two percent of eyes with 20/200 or worse vision at the first visit maintained the same level of vision at the 10-year follow-up visit. Cystoid macular degeneration, choroidal neovascularization (CNV), outer retinal disruption on OCT, and FAF changes were associated with poorer vision at the final visit (all P ≤ 0.001). Multivariable analysis revealed that greater age at first visit was associated with greater BCVA change at the 10-year follow-up visit (P = 0.001). Chronic CSC can be a sight-threatening disease leading to legal blindness. Age at presentation and outer retinal changes on multimodal imaging were associated with long-term BCVA changes and may be predictors of long-term visual outcomes