ESTIMATING THE CONTRIBUTION OF THE FARGODOME TO THE AREA ECONOMY

Tourism has become an important economic sector in many parts of the world, and many regions, states, and local areas are increasingly looking to expenditures by visitors as a potential source of economic growth. Some communities have developed facilities to host sports events or other forms of entertainment to attract out-of-town visitors. Thus, the multi-purpose sports arena/auditorium has joined the industrial park as a community economic development initiative. This paper estimates the economic contribution of a multi-purpose sports and auditorium facility located in Fargo, North Dakota. Since opening its doors in December of 1992, the FARGODOME has hosted a wide variety of sporting events (e.g., college and high school football, rodeo, professional basketball), concerts, trade shows, and other forms of entertainment (e.g., ice shows, circuses, motor sports events). The purpose of this study was to estimate the contribution that FARGODOME event attendees and participants make to the Fargo area economy. The assessment process included (1) determining the residency and expenditure patterns of event attendees and participants, (2) estimating the aggregate direct economic contribution to the area economy by combining event attendee attributes and expenditures with FARGODOME records of the number of events held at the facility and attendance at each, and (3) estimating the secondary economic impacts associated with the FARGODOME's direct economic contribution. Event attendees' and participants' (e.g., exhibitors, athletes, and accompanying persons) place of residence and expenditures were obtained through intercept surveys of attendees/participants at selected FARGODOME events. The expenditures made directly by the FARGODOME to local entities (i.e., for payroll, benefits, utilities, etc.) were added to the attendees'/participants' expenditures outside the facility to arrive at the total direct economic impact (contribution) to the Fargo area. Then, the North Dakota Input-Output Model was used to estimate the secondary (multiplier) effects resulting from FARGODOME activities. Economic impacts will be reported using indicators such as gross business volume (gross receipts) of various economic sectors (e.g., retail trade), personal income, and employment.economic impacts, visitor spending, sports events, Public Economics, Resource /Energy Economics and Policy,

Numerical Simulations Reproduce Field Observations Showing Transient Weakening During Shear Zone Formation by Diffusional Hydrogen Influx and H2O Inflow

Exposures on Holsnøy island (Bergen Arcs, Norway) indicate fluid infiltration through fractures into a dry, metastable granulite, which triggered a kinetically delayed eclogitization, a transient weakening during fluid-rock interaction, and formation of shear zones that widened during shearing. It remains unclear whether the effects of grain boundary-assisted aqueous fluid inflow on the duration of granulite hydration were influenced by a diffusional hydrogen influx accompanying the fluid inflow. To better estimate the fluid infiltration efficiencies and the parameter interdependencies, a 1D numerical model of a viscous shear zone is utilized and validated using measured mineral phase abundance distributions and H2O-contents in nominally anhydrous minerals of the original granulite assemblage to constrain the hydration by aqueous fluid inflow and diffusional hydrogen influx, respectively. Both hydrations are described with a diffusion equation and affect the effective viscosity. Shear zone kinematics are constrained by the observed shear strain and thickness. The model fits the phase abundance and H2O-content profiles if the effective hydrogen diffusivity is approximately one order of magnitude higher than the diffusivity for aqueous fluid inflow. The observed shear zone thickness is reproduced if the viscosity ratio between dry granulite and deforming, reequilibrating eclogite is ∼104 and that between dry granulite and hydrated granulite is ∼102. The results suggest shear velocities <10−2 cm/a, hydrogen diffusivities of ∼10−13±1 m2/s, and a shearing duration of <10 years. This study successfully links and validates field data to a shear zone model and highlights the importance of hydrogen diffusion for shear zone widening and eclogitization

Numerical Simulations Reproduce Field Observations Showing Transient Weakening During Shear Zone Formation by Diffusional Hydrogen Influx and H₂O Inflow

Exposures on Holsnøy island (Bergen Arcs, Norway) indicate fluid infiltration through fractures into a dry, metastable granulite, which triggered a kinetically delayed eclogitization, a transient weakening during fluid-rock interaction, and formation of shear zones that widened during shearing. It remains unclear whether the effects of grain boundary-assisted aqueous fluid inflow on the duration of granulite hydration were influenced by a diffusional hydrogen influx accompanying the fluid inflow. To better estimate the fluid infiltration efficiencies and the parameter interdependencies, a 1D numerical model of a viscous shear zone is utilized and validated using measured mineral phase abundance distributions and H2O-contents in nominally anhydrous minerals of the original granulite assemblage to constrain the hydration by aqueous fluid inflow and diffusional hydrogen influx, respectively. Both hydrations are described with a diffusion equation and affect the effective viscosity. Shear zone kinematics are constrained by the observed shear strain and thickness. The model fits the phase abundance and H2O-content profiles if the effective hydrogen diffusivity is approximately one order of magnitude higher than the diffusivity for aqueous fluid inflow. The observed shear zone thickness is reproduced if the viscosity ratio between dry granulite and deforming, reequilibrating eclogite is ∼104 and that between dry granulite and hydrated granulite is ∼102. The results suggest shear velocities <10−2 cm/a, hydrogen diffusivities of ∼10−13±1 m2/s, and a shearing duration of <10 years. This study successfully links and validates field data to a shear zone model and highlights the importance of hydrogen diffusion for shear zone widening and eclogitization

How fluid infiltrates dry crustal rocks during progressive eclogitization and shear zone formation: insights from H2O contents in nominally anhydrous minerals

Granulites from Holsnøy (Bergen Arcs, Norway) maintained a metastable state until fluid infiltration triggered the kinetically delayed eclogitization. Interconnected hydrous eclogite-facies shear zones are surrounded by unreacted granulites. Macroscopically, the granulite–eclogite interface is sharp and there are no significant compositional changes in the bulk chemistry, indicating the fluid composition was quickly rock buffered. To better understand the link between deformation, fluid influx, and fluid–rock interaction one cm-wide shear zone at incipient eclogitization is studied here. Granulite and eclogite consist of garnet, pyroxene, and plagioclase. These nominally anhydrous minerals (NAMs) can incorporate H2O in the form of OH groups. H2O contents increase from granulite to eclogite, as documented in garnet from ~ 10 to ~ 50 µg/g H2O, pyroxene from ~ 50 to ~ 310 µg/g H2O, and granulitic plagioclase from ~ 10 to ~ 140 µg/g H2O. Bowl-shape profiles are characteristic for garnet and pyroxene with lower H2O contents in grain cores and higher at the rims, which suggest a prograde water influx into the NAMs. Omphacite displays a H2O content range from ~ 150 to 425 µg/g depending on the amount of hydrous phases surrounding the grain. The granulitic plagioclase first separates into a hydrous, more albite-rich plagioclase and isolated clinozoisite before being replaced by new fine-grained phases like clinozoisite, kyanite and quartz during ongoing fluid infiltration. Results indicate a twofold fluid influx with different mechanisms to act simultaneously at different scales and rates. Fast and more pervasive proton diffusion is recorded by NAMs that retain the major element composition of the granulite-facies equilibration where hydrogen decorates pre-existing defects in the crystal lattice and leads to OH increase. Contemporaneously, slower grain boundary-assisted aqueous fluid influx enables element transfer and results in progressive formation of new minerals, e.g., hydrous phases. Both mechanisms lead to bulk H2O increase from ~ 450 to ~ 2500 µg/g H2O towards the shear zone and convert the system from rigid to weak. The incorporation of OH groups reduces the activation energy for creep, promotes formation of smaller grain sizes (phase separation of plagioclase), and synkinematic metamorphic mineral reactions. These processes are part of the transient weakening, which enhance the sensitivity of the rock to deform

Contemporary NSTEMI management: the role of the hospitalist.

Non-ST-segment elevation myocardial infarction (NSTEMI) is defined as elevated cardiac biomarkers of necrosis in the absence of persistent ST-segment elevation in the setting of anginal symptoms or other acute event. It carries a poorer prognosis than most ST-segment elevation events, owing to the typical comorbidity burden of the older NSTEMI patients as well as diverse etiologies that add complexity to therapeutic decision-making. It may result from an acute atherothrombotic event (\u27Type 1\u27) or as the result of other causes of mismatch of myocardial oxygen supply and demand (\u27Type 2\u27). Regardless of type and other clinical factors, the hospital medicine specialist is increasingly responsible for managing or coordinating the care of these patients. Following published guidelines for risk stratification and basing anti-anginal, anticoagulant, antiplatelet, other pharmacologic therapies, and overall management approach on that individualized patient risk assessment can be expected to result in better short- and long-term clinical outcomes, including near-term readmission and recurrent events. We present here a review of the evidence basis and expert commentary to assist the hospitalist in achieving those improved outcomes in NSTEMI. Given that the Society for Hospital Medicine cites care of patients with acute coronary syndrome as a core competency for hospitalists, it is essential that those specialists stay current on optimal NSTEMI care

Hypoglycemia After Administration of Somatostatin Analog (SMS 201-995) in Metastatic Carcinoid

SMS 201-995 (Sandoz Pharmaceuticals. East Hanover NJ) is a synthetic peptide analog of native somatostatin that has been used to relieve .symptoms caused by neuroendocrine tumors. Reports have described an insulin suppressive effect of SMS 201-995 that results in elevations of blood glucose. We report a patient with a metastatic small bowel carcinoid and renal failure in whom mild symptomatic hypoglycemia occurred 30 to 60 minutes after SMS 201-995 administration. No increase in insulin or decreases in glucagon. Cortisol, or catecholamines were observed during these hypoglycemic episodes. Elevated levels of growth hormone fell gradually following SMS 201-995 administration and did not temporally correspond to the 30- to 60-minute nadir of blood glucose. However SMS 201-995 levels peaked during this 30- to 60-minute period. As clinical experience with this drug broadens, patients whose glucose control is dependent on counter-regulatory hormones should be monitored for the possibility of hypoglycemia

Quisqualate- and NMDA-sensitive [ 3 H]glutamate binding in primate brain

Excitatory amino acids (EAA) such as glutamate and aspartate are probably the neurotransmitters of a majority of mammalian neurons. Only a few previous studies have been concerned with the distribution of the subtypes of EAA receptor binding in the primate brain. We examined NMDA- and quisqualate-sensitive [ 3 H]glutamate binding using quantitative autoradiography in monkey brain (Macaca fascicularis) . The two types of binding were differentially distributed. NMDA-sensitive binding was most dense in dentate gyrus of hippocampus, stratum pyramidale of hippocampus, and outer layers of cerebral cortex. Quisqualate-sensitive binding was most dense in dentate gyrus of hippocampus, inner and outer layers of cerebral cortex, and molecular layer of cerebellum. In caudate nucleus and putamen, quisqualate- and NMDA-sensitive binding sites were nearly equal in density. However, in globus pallidus, substantia nigra, and subthalamic nucleus, quisqualate-sensitive binding was several-fold greater than NMDA-sensitive binding. In thalamus, [ 3 H]glutamate binding was generally low for both subtypes of binding except for the anterior ventral, lateral dorsal, and pulvinar nuclei. In the brainstem, low levels of binding were found, and strikingly the red nucleus and pons, which are thought to receive glutamatergic projections, had approximately 1/20 the binding observed in cerebral cortex. These results demonstrate that NMDA- and quisqualate-sensitive [ 3 H]glutamate binding are observed in all regions of primate brain, but that in some regions one subtype predominates over the other. In addition, certain areas thought to receive glutamatergic projections have low levels of both types of binding.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/50225/1/490270412_ftp.pd

Edoxaban: an update on the new oral direct factor Xa inhibitor.

Edoxaban is a once-daily oral anticoagulant that rapidly and selectively inhibits factor Xa in a concentration-dependent manner. This review describes the extensive clinical development program of edoxaban, including phase III studies in patients with non-valvular atrial fibrillation (NVAF) and symptomatic venous thromboembolism (VTE). The ENGAGE AF-TIMI 48 study (N = 21,105; mean CHADS2 score 2.8) compared edoxaban 60 mg once daily (high-dose regimen) and edoxaban 30 mg once daily (low-dose regimen) with dose-adjusted warfarin [international normalized ratio (INR) 2.0-3.0] and found that both regimens were non-inferior to warfarin in the prevention of stroke and systemic embolism in patients with NVAF. Both edoxaban regimens also provided significant reductions in the risk of hemorrhagic stroke, cardiovascular mortality, major bleeding and intracranial bleeding. The Hokusai-VTE study (N = 8,292) in patients with symptomatic VTE had a flexible treatment duration of 3-12 months and found that following initial heparin, edoxaban 60 mg once daily was non-inferior to dose-adjusted warfarin (INR 2.0-3.0) for the prevention of recurrent VTE, and also had a significantly lower risk of bleeding events. Both studies randomized patients at moderate-to-high risk of thromboembolic events and were further designed to simulate routine clinical practice as much as possible, with edoxaban dose reduction (halving dose) at randomisation or during the study if required, a frequently monitored and well-controlled warfarin group, a well-monitored transition period at study end and a flexible treatment duration in Hokusai-VTE. Given the phase III results obtained, once-daily edoxaban may soon be a key addition to the range of antithrombotic treatment options

Widening of Hydrous Shear Zones During Incipient Eclogitization of Metastable Dry and Rigid Lower Crust— Holsnøy, Western Norway

The partially eclogitized crustal rocks on Holsnøy in the Bergen Arcs, Norway, indicate that eclogitization is caused by the interplay of brittle and ductile deformation promoted by fluid infiltration and fluid-rock interaction. Eclogitization generated an interconnected network of millimeterto- kilometer-wide hydrous eclogite-facies shear zones, which presumably caused transient weakening of the mechanically strong lower crust. To decipher the development of those networks, we combine detailed lithological and structural mapping of two key outcrops with numerical modeling. Both outcrops are largely composed of preserved granulite with minor eclogite-facies shear zones, thus representing the beginning phases of eclogitization and ductile deformation. We suggest that deformation promoted fluidrock interaction and eclogitization, which gradually consumed the granulite until fluid-induced reactions were no longer significant. The shear zones widen during progressive deformation. To identify the key parameters that impact shear zone widening, we generated scale-independent numerical models, which focus on different processes affecting the shear zone evolution: (i) rotation of the shear zones caused by finite deformation, (ii) mechanical weakening due to a limited amount of available fluid, and (iii) weakening and further hydration of the shear zones as a result of continuous and unlimited fluid supply. A continuous diffusion-type fluid infiltration, with an effective diffusion coefficient around 2 10 16 m s D , coupled with deformation is prone to develop structures similar to the ones mapped in field. Our results suggest that the shear zones formed under a continuous fluid supply, causing shear zone widening, rather than localization, during progressive deformation