4 research outputs found
Effects of iron overload and exenatide on erythrocyte deformability in a rat model (conferenceObject)
WOS: 000360810100149
Effect of Exenatide on Liver in an Iron Overload Rat Model
Arslan, Mustafa/0000-0003-4882-5063WOS: 000360810100148
Exenatide reduces oxidative stress and cell death in testis in iron overload rat model
Glucagon-like peptide-1 (GLP-1) has been demonstrated to affect the
oxidative stress status in several in vitro, in vivo and clinical
studies. The aim of the present study was to evaluate the effect of a
GLP-1 analogue, exenatide, on oxidative stress parameters and apoptotic
markers in testicular cells in an iron overload rat model. To obtain
this model, the animals were randomly divided into three groups
(n=6/group). Rats in the control group received intraperitoneal
injections of saline. Intraperitoneal iron dextran (60 mg/kg/day) was
given to Group FE for 5 days a week for 4 weeks. The third group (Group
Fe +E) was given subcutaneous injections of 10 mu g/kg exenatide in two
divided doses for 4 weeks in addition to iron dextran. Testes of all
rats were immediately removed for immunohistochemical staining and to
measure the malondialdehyde level and superoxide dismutase enzyme
activity. A significant reduction was observed in caspase-8 and -3
enzyme staining in testicular stromal and endothelial cells in exenatide
injected iron overloaded rats when compared with controls. Oxidative
stress markers malondialdehyde levels and superoxide dismutase enzyme
activities were also significantly lower in exenatide-injected rats when
compared with controls. These findings indicate that exenatide may be
protective against the harmful effects of iron accumulation in testis.
Further studies are required to evaluate how exenatide reduces oxidative
stress and cell death in iron overloaded testis tissue