A linear magnetic-geared permanent magnet machine for wave energy generation

This paper presents a new linear magnetic-geared permanent magnet (PM) machine for wave energy generation. In order to match the low speed of wave motion with the high-speed machine design, a linear PM machine is artfully integrated with a linear magnetic gear (MG). Namely, the low-speed mover of the gear is coupled to the buoy directly and reciprocates with the waves, while two sets of PMs, which function as the high-speed mover of the gear and the translator of the machine respectively, are integrated into a tubular iron core. By using the finite element method, the characteristics and performances of the proposed machine are analyzed and verified.published_or_final_versionThe 2010 International Conference on Electrical Machines and Systems (ICEMS), Incheon, Korea, 10-13 October 2010. In Proceedings of the International Conference on Electrical Machines and Systems, 2010, p. 1538-154

A linear doubly-salient HTS machine for wave energy conversion

This paper proposes a linear doubly-salient high-temperature superconductor (HTS) machine for wave energy conversion, which is composed of a tubular stator and a tubular translator. Since the translator is a simple iron core with salient poles, it is so robust that it can be directly coupled with the reciprocating buoy. The stator consists of an iron core with salient poles, DC HTSfield windings and 3-phase HTS concentrated armature windings. By using the finite element analysis, the proposed machine is quantitatively compared with its permanent magnet and copperwinding counterparts. Hence, it validates that its performance, especially the power density, can be improved greatly. © 2011 IEEE.published_or_final_versio

A linear stator permanent magnet vernier HTS machine for wave energy conversion

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Design and analysis of linear stator permanent magnet vernier machines

In Poster Session GP: Permanent Magnet Motor II: poster no. GP-10This paper presents a new class of linear permanent magnet (PM) vernier machines which is suitable for low speed and high thrust force applications. The machine is composed of a tubular stator and a tubular translator. The stator consists of an iron core with salient teeth wound with 3-phase armature windings and PMs mounted on the surface of stator teeth. The translator is designed as a simple tubular iron core with salient teeth so that it is very robust to transmit high thrust force. By using the finite element method, the characteristics and performances of the proposed machine are analyzed and verified. © 2011 IEEE.published_or_final_versionThe IEEE International Magnetic Conference (INTERMAG2011), Taipei, Taiwan, 25-29 April 2011. In IEEE Transactions on Magnetics, 2011, v. 47 n. 10, p. 4219-422

Comparison of linear primary permanent magnet vernier machine and linear vernier hybrid machine

This journal issue contain selected papers from the 2014 IEEE International Magnetics (INTERMAG) ConferenceGQ - Electrical Machines for industrial and automotive applicationspublished_or_final_versio

The interplay between fluorescence and phosphorescence with luminescent gold(i) and gold(iii) complexes bearing heterocyclic arylacetylide ligands

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Clinical significance of VEGF-A, -C and -D expression in esophageal malignancies

Vascular endothelial growth factors ( VEGF)- A, - C and - D are members of the proangiogenic VEGF family of glycoproteins. VEGF-A is known to be the most important angiogenic factor under physiological and pathological conditions, while VEGF-C and VEGF-D are implicated in the development and sprouting of lymphatic vessels, so called lymphangiogenesis. Local tumor progression, lymph node metastases and hematogenous tumor spread are important prognostic factors for esophageal carcinoma ( EC), one of the most lethal malignancies throughout the world. We found solid evidence in the literature that VEGF expression contributes to tumor angiogenesis, tumor progression and lymph node metastasis in esophageal squamous cell carcinoma ( SCC), and many authors could show a prognostic value for VEGF-assessment. In adenocarcinoma (AC) of the esophagus angiogenic properties are acquired in early stages, particularly in precancerous lesions like Barrett's dysplasia. However, VEGF expression fails to give prognostic information in AC of the esophagus. VEGF-C and VEGF-D were detected in SCC and dysplastic lesions, but not in normal mucosa of the esophagus. VEGF-C expression might be associated with lymphatic tumor invasion, lymph node metastases and advanced disease in esophageal SCC and AC. Therapeutic interference with VEGF signaling may prove to be a promising way of anti-angiogenic co-treatment in esophageal carcinoma. However, concrete clinical data are still pending

High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines.

Hundreds of genetically characterized cell lines are available for the discovery of genotype-specific cancer vulnerabilities. However, screening large numbers of compounds against large numbers of cell lines is currently impractical, and such experiments are often difficult to control. Here we report a method called PRISM that allows pooled screening of mixtures of cancer cell lines by labeling each cell line with 24-nucleotide barcodes. PRISM revealed the expected patterns of cell killing seen in conventional (unpooled) assays. In a screen of 102 cell lines across 8,400 compounds, PRISM led to the identification of BRD-7880 as a potent and highly specific inhibitor of aurora kinases B and C. Cell line pools also efficiently formed tumors as xenografts, and PRISM recapitulated the expected pattern of erlotinib sensitivity in vivo

Characterizations of how species mediate ecosystem properties require more comprehensive functional effect descriptors

The importance of individual species in mediating ecosystem process and functioning is generally accepted, but categorical descriptors that summarize species-specific contributions to ecosystems tend to reference a limited number of biological traits and underestimate the importance of how organisms interact with their environment. Here, we show how three functionally contrasting sediment-dwelling marine invertebrates affect fluid and particle transport - important processes in mediating nutrient cycling - and use high-resolution reconstructions of burrow geometry to determine the extent and nature of biogenic modification. We find that individual functional effect descriptors fall short of being able to adequately characterize how species mediate the stocks and flows of important ecosystem properties and that, in contrary to common practice and understanding, they are not substitutable with one another because they emphasize different aspects of species activity and behavior. When information derived from these metrics is combined with knowledge of how species behave and modify their environment, however, detailed mechanistic information emerges that increases the likelihood that a species functional standing will be appropriately summarized. Our study provides evidence that more comprehensive functional effect descriptors are required if they are to be of value to those tasked with projecting how altered biodiversity will influence future ecosystems

Cyclic Nucleotide-Gated Channels Contribute to Thromboxane A2-Induced Contraction of Rat Small Mesenteric Arteries

Background: Thromboxane A 2 (TxA 2)-induced smooth muscle contraction has been implicated in cardiovascular, renal and respiratory diseases. This contraction can be partly attributed to TxA2-induced Ca 2+ influx, which resulted in vascular contraction via Ca 2+-calmodulin-MLCK pathway. This study aims to identify the channels that mediate TxA2-induced Ca 2+ influx in vascular smooth muscle cells. Methodology/Principal Findings: Application of U-46619, a thromboxane A2 mimic, resulted in a constriction in endothelium-denuded small mesenteric artery segments. The constriction relies on the presence of extracellular Ca 2+, because removal of extracellular Ca 2+ abolished the constriction. This constriction was partially inhibited by an L-type Ca 2+ channel inhibitor nifedipine (0.5–1 mM). The remaining component was inhibited by L-cis-diltiazem, a selective inhibitor for CNG channels, in a dose-dependent manner. Another CNG channel blocker LY83583 [6-(phenylamino)-5,8-quinolinedione] had similar effect. In the primary cultured smooth muscle cells derived from rat aorta, application of U46619 (100 nM) induced a rise in cytosolic Ca 2+ ([Ca 2+]i), which was inhibited by L-cis-diltiazem. Immunoblot experiments confirmed the presence of CNGA2 protein in vascular smooth muscle cells. Conclusions/Significance: These data suggest a functional role of CNG channels in U-46619-induced Ca 2+ influx and contraction of smooth muscle cells