Ki67 expression levels are a better marker of reduced melanoma growth following MEK inhibitor treatment than phospho-ERK levels

The loss of tumour phospho-extracellular responsive kinase (pERK) positivity is the major treatment biomarker for mitogen-activated protein kinase/extracellular responsive kinase (MEK) inhibitors. Here, we demonstrate that there is a poor correlation between pERK inhibition and the anti-proliferative effects of MEK inhibitors in melanoma cells. We suggest that Ki67 is a better biomarker for future clinical studies

Non-global Structure of the O({\alpha}_s^2) Dijet Soft Function

High energy scattering processes involving jets generically involve matrix elements of light- like Wilson lines, known as soft functions. These describe the structure of soft contributions to observables and encode color and kinematic correlations between jets. We compute the dijet soft function to O({\alpha}_s^2) as a function of the two jet invariant masses, focusing on terms not determined by its renormalization group evolution that have a non-separable dependence on these masses. Our results include non-global single and double logarithms, and analytic results for the full set of non-logarithmic contributions as well. Using a recent result for the thrust constant, we present the complete O({\alpha}_s^2) soft function for dijet production in both position and momentum space.Comment: 55 pages, 8 figures. v2: extended discussion of double logs in the hard regime. v3: minor typos corrected, version published in JHEP. v4: typos in Eq. (3.33), (3.39), (3.43) corrected; this does not affect the main result, numerical results, or conclusion

An improved observable for the forward-backward asymmetry in B -> K* l+ l- and Bs -> phi l+ l-

We study the decay B -> K* l+ l- in the QCD factorization approach and propose a new integrated observable whose dependence on the form factors is almost negligible, consequently the non--perturbative error is significantly reduced and indeed its overall theoretical error is dominated by perturbative scale uncertainties. The new observable we propose is the ratio between the integrated forward--backward asymmetry in the [4,6] GeV^2 and [1,4] GeV^2 dilepton invariant mass bins. This new observable is particularly interesting because, when compared to the location of the zero of the FBA spectrum, it is experimentally easier to measure and its theoretical uncertainties are almost as small; moreover it displays a very strong dependence on the phase of the Wilson coefficient C_10 that is otherwise only accessible through complicated CP violating asymmetries. We illustrate the new physics sensitivity of this observable within the context of few extensions of the Standard Model, namely the SM with four generations, an MSSM with non--vanishing source of flavor changing neutral currents in the down squark sector and a Z' model with tree level flavor changing couplings.Comment: 19 pages, 7 figure

Factorization at Subleading Power and Irreducible Uncertainties in Bˉ→Xsγ\bar B\to X_s\gamma Decay

Using methods from soft-collinear and heavy-quark effective theory, a systematic factorization analysis is performed for the $\bar B\to X_s\gamma$ photon spectrum in the endpoint region $m_b-2E_\gamma={\cal O}(\Lambda_{\rm QCD})$. It is proposed that, to all orders in $1/m_b$, the spectrum obeys a novel factorization formula, which besides terms with the structure $H\,J\otimes S$ familiar from inclusive $\bar B\to X_u l\,\bar\nu$ decay distributions contains "resolved photon" contributions of the form $H\,J\otimes S\otimes\bar J$ and $H\,J\otimes S\otimes\bar J\otimes\bar J$. Here $S$ and $\bar J$ are new soft and jet functions, whose form is derived. These contributions arise whenever the photon couples to light partons instead of coupling directly to the effective weak interaction. The new contributions appear first at order $1/m_b$ and are related to operators other than $Q_{7\gamma}$ in the effective weak Hamiltonian. They give rise to non-vanishing $1/m_b$ corrections to the total decay rate, which cannot be described using a local operator product expansion. A systematic analysis of these effects is performed at tree level in hard and hard-collinear interactions. The resulting uncertainty on the decay rate defined with a cut $E_\gamma>1.6$ GeV is estimated to be approximately $\pm 5$. It could be reduced by an improved measurement of the isospin asymmetry $\Delta_{0-}$ to the level of $\pm 4$. We see no possibility to reduce this uncertainty further using reliable theoretical methods.Comment: 63 pages, 11 Figures, Journal Versio

Spin canting across core/shell Fe3O4/MnxFe3−xO4 nanoparticles

Magnetic nanoparticles (MNPs) have become increasingly important in biomedical applications like magnetic imaging and hyperthermia based cancer treatment. Understanding their magnetic spin configurations is important for optimizing these applications. The measured magnetization of MNPs can be significantly lower than bulk counterparts, often due to canted spins. This has previously been presumed to be a surface effect, where reduced exchange allows spins closest to the nanoparticle surface to deviate locally from collinear structures. We demonstrate that intraparticle effects can induce spin canting throughout a MNP via the Dzyaloshinskii-Moriya interaction (DMI). We study ~7.4 nm diameter, core/shell Fe3O4/MnxFe3−xO4 MNPs with a 0.5 nm Mn-ferrite shell. Mössbauer spectroscopy, x-ray absorption spectroscopy and x-ray magnetic circular dichroism are used to determine chemical structure of core and shell. Polarized small angle neutron scattering shows parallel and perpendicular magnetic correlations, suggesting multiparticle coherent spin canting in an applied field. Atomistic simulations reveal the underlying mechanism of the observed spin canting. These show that strong DMI can lead to magnetic frustration within the shell and cause canting of the net particle moment. These results illuminate how core/shell nanoparticle systems can be engineered for spin canting across the whole of the particle, rather than solely at the surface