Electrostriction of lead zirconate titanate/polyurethane composites

Author name used in this publication: K. S. LamAuthor name used in this publication: Y. ZhouAuthor name used in this publication: Y. W. WongAuthor name used in this publication: F. G. Shin2004-2005 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

End-to-End Delay Distribution Analysis for Stochastic Admission Control in Multi-hop Wireless Networks

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Scheduling in Dense Small Cells with Successive Interference Cancellation

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Power-efficient photonic BPSK coded ultrawideband signal generation

We experimentally demonstrate a power-efficient BPSK coded ultrawideband (UWB) signal generator. The 2.5 Gb/s BPSK coded signal is achieved through optical switching based on two intensity modulators driven by complementary microwave signals. © 2011 Optical Society of America.published_or_final_versionThe Optical Fiber Communication Conference and Exposition (OFC/NFOEC 2011) and the National Fiber Optic Engineers Conference, Los Angeles, CA., 8-10 March 2011. In OFC/NFOEC 2011 Proceeding

Cost-effective approaches for high-resolution bioimaging by time-stretched confocal microscopy at 1um

Session: Optics Imaging Algorithms and Analysis IIOptical imaging based on time-stretch process has recently been proven as a powerful tool for delivering ultra-high frame rate (< 1MHz) which is not achievable by the conventional image sensors. Together with the capability of optical image amplification for overcoming the trade-off between detection sensitivity and speed, this new imaging modality is particularly valuable in high-throughput biomedical diagnostic practice, e.g. imaging flow cytometry. The ultra-high frame rate in time-stretch imaging is attained by two key enabling elements: dispersive fiber providing the time-stretch process via group-velocity-dispersion (GVD), and electronic digitizer. It is well-known that many biophotonic applications favor the spectral window of 1μm. However, reasonably high GVD (< 0.1 ns/nm) in this range can only be achieved by using specialty single-mode fiber (SMF) at 1μm. Moreover, the ultrafast detection has to rely on the state-of- the-art digitizer with significantly wide-bandwidth and high sampling rate (e.g. <10 GHz, <40 GS/s). These stringent requirements imply the prohibitively high-cost of the system and hinder its practical use in biomedical diagnostics. We here demonstrate two cost-effective approaches for realizing time-stretch confocal microscopy at 1μm: (i) using the standard telecommunication SMF (e.g. SMF28) to act as a few-mode fiber (FMF) at 1μm for the time-stretch process, and (ii) implementing the pixel super-resolution (SR) algorithm to restore the high-resolution (HR) image when using a lower-bandwidth digitizer. By using a FMF (with a GVD of 0.15ns/nm) and a modified pixel-SR algorithm, we can achieve time-stretch confocal microscopy at 1μm with cellular resolution ( 3μm) at a frame rate 1 MHz.© (2012) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.published_or_final_versio

Capacity of Hybrid Wireless Networks with Long-Range Social Contacts Behavior

Hybrid wireless network is composed of both ad hoc transmissions and cellular transmissions. Under the L-maximum-hop routing policy, flow is transmitted in the ad hoc mode if its source and destination are within L hops away; otherwise, it is transmitted in the cellular mode. Existing works study the hybrid wireless network capacity as a function of L so as to find the optimal L to maximize the network capacity. In this paper, we consider two more factors: traffic model and base station access mode. Different from existing works, which only consider the uniform traffic model, we consider a traffic model with social behavior. We study the impact of traffic model on the optimal routing policy. Moreover, we consider two different access modes: one-hop access (each node directly communicates with base station) and multi-hop access (node may access base station through multiple hops due to power constraint). We study the impact of access mode on the optimal routing policy. Our results show that: 1) the optimal L does not only depend on traffic pattern, but also the access mode; 2) one-hop access provides higher network capacity than multi-hop access at the cost of increasing transmitting power; and 3) under the one-hop access mode, network capacity grows linearly with the number of base stations; however, it does not hold with the multi-hop access mode, and the number of base stations has different effects on network capacity for different traffic models.postprin

Tuning the electrical properties of La[sub 0.75]Ca[sub 0.25]MnO₃ thin films by ferroelectric polarization, ferroelectric-field effect, and converse piezoelectric effect

2006-2007 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Novel application of magnetoresistive sensors for high-voltage transmission-line monitoring

High-voltage transmission lines are responsible for transmission of electric power. Their sag and electric current are important parameters for transmission-line monitoring. In this paper, a simple and promising method based on magnetoresistive sensors is proposed for transmission-line monitoring. This is a noncontact method and its installation is simple without the need for power cut. The method involves measuring emanated magnetic field from a line conductor at the ground level and, then, calculating the source position and current inversely. A proof-of-concept laboratory setup was constructed and a series of experiments were carried out for demonstration. This method can handle complicated transmission-line configuration by integrating the stochastic optimization approach into the inverse electromagnetic calculation. It was tested with the computational simulation of a 500 kV transmission-line configuration. The result shows the feasibility of using this transmission-line monitoring method in reality. © 2011 IEEE.published_or_final_versio

Tolerability and Safety Profile of Cariprazine in Treating Psychotic Disorders, Bipolar Disorder and Major Depressive Disorder: A Systematic Review with Meta-Analysis of Randomized Controlled Trials

BACKGROUND: Cariprazine is a novel antipsychotic agent recently approved for treating schizophrenia and bipolar mania in the USA. The sample sizes of published randomized controlled trials (RCTs) of the drug are small; previous meta-analyses included few RCTs and did not specifically investigate the tolerability/safety profile of cariprazine. OBJECTIVE: Our objective was to conduct a meta-analysis of published RCTs to systematically review the tolerability and safety of cariprazine versus placebo. METHODS: We searched the clinical trial registers (the metaRegister of controlled trials, ClinicalTrials.gov and the World Health Organization International Clinical Trials Registry Platform) and electronic databases (PubMed, Embase, PsycINFO and Cochrane library) up to June 2016 to identify phase II/III RCTs of cariprazine in patients with schizophrenia, bipolar disorder or major depressive disorder. We conducted a meta-analysis to investigate outcomes, including risks of discontinuation due to adverse events (AEs), extrapyramidal side effects (EPS) or related events, metabolic syndrome and cardiovascular-related events. RESULTS: We included nine RCTs, with a total of 4324 subjects. The risk of discontinuation due to AEs for cariprazine was similar to that for placebo (risk ratio [RR] 1.13, 95 % confidence interval [CI] 0.77-1.66). Cariprazine was associated with higher risks of EPS-related events than was placebo, including risk of akathisia (RR 3.92, 95 % CI 2.83-5.43), tremor (RR 2.41, 95 % CI 1.53-3.79) and restlessness (RR 2.17, 95 % CI 1.38-3.40). The cariprazine treatment group was more likely to have clinically significant weight gain (RR 1.68, 95 % CI 1.12-2.52). No statistically significant differences in results were found in other metabolic parameters or cardiovascular-related events. CONCLUSION: There was a statistically significant higher risk of EPS-related AEs and a slight increase in mean body weight with cariprazine. There were no statistically significant effects on prolactin level or cardiovascular parameters. EPSs were the main short-term adverse reactions reported in the limited number of patients studied. Further clinical and post-marketing pharmacovigilance studies are needed to investigate the long-term safety of cariprazine

Incident heart failure and myocardial infarction in sodium-glucose cotransporter 2 versus dipeptidyl peptidase-4 inhibitor users

Objectives To compare the rates of major cardiovascular adverse events in sodium-glucose cotransporter-2 inhibitors (SGLT2I) and dipeptidyl-peptidase-4 inhibitors (DPP4I) users in a Chinese population. Background SGLT2I and DPP4I are increasingly prescribed for type 2 diabetes mellitus patients. However, few population-based studies are comparing their effects on incident heart failure or myocardial infarction. Methods This was a population-based retrospective cohort study using the electronic health record database in Hong Kong, including type 2 diabetes mellitus patients receiving either SGLT2I or DPP4I between January 1st, 2015, to December 31st, 2020. Propensity-score matching was performed in a 1:1 ratio based on demographics, past comorbidities, non-SGLT2I/DPP4I medications with nearest-neighbor matching (caliper=0.1). Univariable and multivariable Cox models were used to identify significant predictors for new onset heart failure, new onset myocardial infarction, cardiovascular mortality, and all-cause mortality. Sensitivity analyses with competing risk models and multiple propensity score matching approaches were conducted. Subgroup age and gender analyses were presented. Results A total of 41994 patients (58.89% males, median admission age at 58 years old, interquartile rage [IQR]: 51.2-65.3) were included in the study cohorts with a median follow-up duration of 5.6 years (IQR: 5.32-5.82). After adjusting for significant demographics, past comorbidities, medication prescriptions and biochemical results, SGLT2I users have a significantly lower risk for myocardial infarction (hazard ratio [HR]: 0.34, 95% confidence interval [CI]: [0.28, 0.41], P < 0.0001), cardiovascular mortality (HR: 0.53, 95% CI: [0.38, 0.74], P = 0.0002) and all-cause mortality (HR: 0.21, 95% CI: [0.18, 0.25], P= 0.0001) under multivariable Cox regression. However, the risk for heart failure is comparable (HR: 0.87, 95% CI: [0.73, 1.04], P= 0.1343). Conclusions SGLT2 inhibitors are protective against adverse cardiovascular events compared to DPP4I. The prescription of SGLT2I is preferred especially for males and patients aged 65 or older to prevent cardiovascular risks