8,004 research outputs found

    Using Action Research to Facilitate School Improvement

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    This study describes a joint project between a mid-sized urban school district and local university. Specifically, district and university personnel collaborated to provide action research training for building leadership teams. A multi-method approach was used to identify the barriers and facilitators of the use of action research training as a method for teachers to create school improvement. A content analysis of the action research plans that were a summative product of the training is provided. Findings include the importance of both technical research skills and attention to the provision of time as a resource for those involved with school improvement efforts

    Active contractility in actomyosin networks

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    Contractile forces are essential for many developmental processes involving cell shape change and tissue deformation. Recent experiments on reconstituted actomyosin networks, the major component of the contractile machinery, have shown that active contractility occurs above a threshold motor concentration and within a window of crosslink concentration. We present a microscopic dynamic model that incorporates two essential aspects of actomyosin self-organization: the asymmetric load response of individual actin filaments and the correlated motor-driven events mimicking myosin-induced filament sliding. Using computer simulations we examine how the concentration and susceptibility of motors contribute to their collective behavior and interplay with the network connectivity to regulate macroscopic contractility. Our model is shown to capture the formation and dynamics of contractile structures and agree with the observed dependence of active contractility on microscopic parameters including the contractility onset. Cooperative action of load-resisting motors in a force-percolating structure integrates local contraction/buckling events into a global contractile state via an active coarsening process, in contrast to the flow transition driven by uncorrelated kicks of susceptible motors.Comment: 15 pages, 4 main figures, 4 supplementary figure

    Self-synchronization and dissipation-induced threshold in collective atomic recoil lasing

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    Networks of globally coupled oscillators exhibit phase transitions from incoherent to coherent states. Atoms interacting with the counterpropagating modes of a unidirectionally pumped high-finesse ring cavity form such a globally coupled network. The coupling mechanism is provided by collective atomic recoil lasing, i.e., cooperative Bragg scattering of laser light at an atomic density grating, which is self-induced by the laser light. Under the rule of an additional friction force, the atomic ensemble is expected to undergo a phase transition to a state of synchronized atomic motion. We present the experimental investigation of this phase transition by studying the threshold behavior of this lasing process

    A stochastic model of Min oscillations in Escherichia coli and Min protein segregation during cell division

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    The Min system in Escherichia coli directs division to the centre of the cell through pole-to-pole oscillations of the MinCDE proteins. We present a one dimensional stochastic model of these oscillations which incorporates membrane polymerisation of MinD into linear chains. This model reproduces much of the observed phenomenology of the Min system, including pole-to-pole oscillations of the Min proteins. We then apply this model to investigate the Min system during cell division. Oscillations continue initially unaffected by the closing septum, before cutting off rapidly. The fractions of Min proteins in the daughter cells vary widely, from 50%-50% up to 85%-15% of the total from the parent cell, suggesting that there may be another mechanism for regulating these levels in vivo.Comment: 19 pages, 12 figures (25 figure files); published at http://www.iop.org/EJ/journal/physbi

    The non-Gaussian tail of cosmic-shear statistics

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    Due to gravitational instability, an initially Gaussian density field develops non-Gaussian features as the Universe evolves. The most prominent non-Gaussian features are massive haloes, visible as clusters of galaxies. The distortion of high-redshift galaxy images due to the tidal gravitational field of the large-scale matter distribution, called cosmic shear, can be used to investigate the statistical properties of the LSS. In particular, non-Gaussian properties of the LSS will lead to a non-Gaussian distribution of cosmic-shear statistics. The aperture mass (MapM_{\rm ap}) statistics, recently introduced as a measure for cosmic shear, is particularly well suited for measuring these non-Gaussian properties. In this paper we calculate the highly non-Gaussian tail of the aperture mass probability distribution, assuming Press-Schechter theory for the halo abundance and the `universal' density profile of haloes as obtained from numerical simulations. We find that for values of MapM_{\rm ap} much larger than its dispersion, this probability distribution is closely approximated by an exponential, rather than a Gaussian. We determine the amplitude and shape of this exponential for various cosmological models and aperture sizes, and show that wide-field imaging surveys can be used to distinguish between some of the currently most popular cosmogonies. Our study here is complementary to earlier cosmic-shear investigations which focussed more on two-point statistical properties.Comment: 9 pages, 5 figures, submitted to MNRA

    On the monotone stability approach to BSDEs with jumps: Extensions, concrete criteria and examples

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    We show a concise extension of the monotone stability approach to backward stochastic differential equations (BSDEs) that are jointly driven by a Brownian motion and a random measure for jumps, which could be of infinite activity with a non-deterministic and time inhomogeneous compensator. The BSDE generator function can be non convex and needs not to satisfy global Lipschitz conditions in the jump integrand. We contribute concrete criteria, that are easy to verify, for results on existence and uniqueness of bounded solutions to BSDEs with jumps, and on comparison and a-priori LL^{\infty}-bounds. Several examples and counter examples are discussed to shed light on the scope and applicability of different assumptions, and we provide an overview of major applications in finance and optimal control.Comment: 28 pages. Added DOI https://link.springer.com/chapter/10.1007%2F978-3-030-22285-7_1 for final publication, corrected typo (missing gamma) in example 4.1

    The Camassa-Holm equation as the long-wave limit of the improved Boussinesq equation and of a class of nonlocal wave equations

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    In the present study we prove rigorously that in the long-wave limit, the unidirectional solutions of a class of nonlocal wave equations to which the improved Boussinesq equation belongs are well approximated by the solutions of the Camassa-Holm equation over a long time scale. This general class of nonlocal wave equations model bidirectional wave propagation in a nonlocally and nonlinearly elastic medium whose constitutive equation is given by a convolution integral. To justify the Camassa-Holm approximation we show that approximation errors remain small over a long time interval. To be more precise, we obtain error estimates in terms of two independent, small, positive parameters ϵ\epsilon and δ\delta measuring the effect of nonlinearity and dispersion, respectively. We further show that similar conclusions are also valid for the lower order approximations: the Benjamin-Bona-Mahony approximation and the Korteweg-de Vries approximation.Comment: 24 pages, to appear in Discrete and Continuous Dynamical System

    Coarse-grained model of entropic allostery

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    Many signaling functions in molecular biology require proteins to bind to substrates such as DNA in response to environmental signals such as the simultaneous binding to a small molecule. Examples are repressor proteins which may transmit information via a conformational change in response to the ligand binding. An alternative entropic mechanism of "allostery" suggests that the inducer ligand changes the intramolecular vibrational entropy, not just the mean static structure. We present a quantitative, coarse-grained model of entropic allostery, which suggests design rules for internal cohesive potentials in proteins employing this effect. It also addresses the issue of how the signal information to bind or unbind is transmitted through the protein. The model may be applicable to a wide range of repressors and also to signaling in trans-membrane proteins
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