The sele sentence completion questionnaire: a new instrument for the assessment of personal meaning in research on aging

In this paper, the SELE-instrumenits presented. The SELE-instrument is a sentence completion test and an accompanying coding scheme, which is designed to study cognitions about self and life. The related theoretical construct is the personal meaning system, which encompasses different meaning domains, like "self", "activities" and "social relations", as well as evaluations and time perspectives. It is argued that especially in aging research. it is necessarv to use more oven instruments in studying self-and-life-cognitions. A short history of sentence completion instruments in psychology, is presented in order to better understand the specific contents of the SELE-instrument. The SELE provides sentence stems in the first form singular ("I") combination with verbal factors, which express different combinations of evaluation and time perspective, to which the respondents have to react in their own words. The SELE-instrumenits thus a semi-structured questionnaire, which can be used in large-scale research. The sentence completions are coded with an extensive coding scheme, which is hierarchially and dimensionally organized. Some figures on the coding reliability as well as on the validity and stability of the instrument are presented. The different uses to which the SELE-instrument as been put are described shortly.En este articulo se presenta el instrumento SELE. Este instrumento, que consta de un cuestionario de frases incompletas y un esquema de codificación de respuestas, está diseñado para el estudio de las cogniciones sobre el self y la vida. El constructo teórico al que se aproxima es el sistema de significado personal, sistema que comprende tanto diferentes dominios de significado (por ejemplo el "self", "actividades" o "relaciones sociales") como evaluaciones y perspectivas temporales. Se argumenta que, especialmente en la investigación en envejecimiento, es necesario utilizar instrurnentos de carácter más abierto para el estudio de cogniciones relacionadas con el self y la vida. Por otra parte, para entender mejor los contenidos específicos del SELE, se presenta una breve historia de los instrumentos de frases incompletas en Psicologia. El SELE proporciona estimulos en forma de frases incompletas a los que la persona tiene que contestar en sus propias palabras. Estos estímulos comienzan con un sujeto en primera persona del singular ("Yo") seguido por una forma verbal que expresa diferentes combinaciones de perspectiva temporal y evaluación. Debido a este formato, el SELE es un cuestionario semiestructurado que puede ser utilizado en investigaciones a gran escala. Las respuestas se categorizan mediante un exhaustivo sistema de codificación que está organizado tanto jerárquica como dimensionalmente. En el articulo se presentan algunos resultados en relación con la fiabilidad, la validez y la estabilidad del cuestionario, asi como también se describen brevemente los diferentes usos a los que ha estado dirigido el SELE

The sele sentence completion questionnaire: a new instrument for the assessment of personal meaning in research on aging

In this paper, the SELE-instrumenits presented. The SELE-instrument is a sentence completion test and an accompanying coding scheme, which is designed to study cognitions about self and life. The related theoretical construct is the personal meaning system, which encompasses different meaning domains, like "self", "activities" and "social relations", as well as evaluations and time perspectives. It is argued that especially in aging research. it is necessarv to use more oven instruments in studying self-and-life-cognitions. A short history of sentence completion instruments in psychology, is presented in order to better understand the specific contents of the SELE-instrument. The SELE provides sentence stems in the first form singular ("I") combination with verbal factors, which express different combinations of evaluation and time perspective, to which the respondents have to react in their own words. The SELE-instrumenits thus a semi-structured questionnaire, which can be used in large-scale research. The sentence completions are coded with an extensive coding scheme, which is hierarchially and dimensionally organized. Some figures on the coding reliability as well as on the validity and stability of the instrument are presented. The different uses to which the SELE-instrument as been put are described shortly.En este articulo se presenta el instrumento SELE. Este instrumento, que consta de un cuestionario de frases incompletas y un esquema de codificación de respuestas, está diseñado para el estudio de las cogniciones sobre el self y la vida. El constructo teórico al que se aproxima es el sistema de significado personal, sistema que comprende tanto diferentes dominios de significado (por ejemplo el "self", "actividades" o "relaciones sociales") como evaluaciones y perspectivas temporales. Se argumenta que, especialmente en la investigación en envejecimiento, es necesario utilizar instrurnentos de carácter más abierto para el estudio de cogniciones relacionadas con el self y la vida. Por otra parte, para entender mejor los contenidos específicos del SELE, se presenta una breve historia de los instrumentos de frases incompletas en Psicologia. El SELE proporciona estimulos en forma de frases incompletas a los que la persona tiene que contestar en sus propias palabras. Estos estímulos comienzan con un sujeto en primera persona del singular ("Yo") seguido por una forma verbal que expresa diferentes combinaciones de perspectiva temporal y evaluación. Debido a este formato, el SELE es un cuestionario semiestructurado que puede ser utilizado en investigaciones a gran escala. Las respuestas se categorizan mediante un exhaustivo sistema de codificación que está organizado tanto jerárquica como dimensionalmente. En el articulo se presentan algunos resultados en relación con la fiabilidad, la validez y la estabilidad del cuestionario, asi como también se describen brevemente los diferentes usos a los que ha estado dirigido el SELE

Early Intervention for Children at High Risk of Developmental Disability in Low- and Middle-Income Countries:A Narrative Review

In low- and middle-income countries (LMICs), while neonatal mortality has fallen, the number of children under five with developmental disability remains unchanged. The first thousand days are a critical window for brain development, when interventions are particularly effective. Early Childhood Interventions (ECI) are supported by scientific, human rights, human capital and programmatic rationales. In high-income countries, it is recommended that ECI for high-risk infants start in the neonatal period, and specialised interventions for children with developmental disabilities as early as three months of age; more data is needed on the timing of ECI in LMICs. Emerging evidence supports community-based ECI which focus on peer support, responsive caregiving and preventing secondary morbidities. A combination of individual home visits and community-based groups are likely the best strategy for the delivery of ECI, but more evidence is needed to form strong recommendations, particularly on the dosage of interventions. More data on content, impact and implementation of ECI in LMICs for high-risk infants are urgently needed. The development of ECI for high-risk groups will build on universal early child development best practice but will likely require tailoring to local contexts

IT Value in Public Administrations: a Model Proposal for E-Procurement

Recent studies have affirmed the necessity of a discontinuity in the method of investigating the value produced in organisations by IT. Existing studies have in common a prevailing (when not exclusive) attention paid to the private sector, as testified by the frequent use of income or financial indicators to measure benefits. These approaches however cannot be directly applied to public utility organisations like public administrations. Taking into account this scenario, the present exploratory work looks at the analysis of IT investments in the public sector by identifying a viable approach to research in this domain. To move towards this objective, procurement management has been taken as the field to be observed, and an Italian publich Local Healthcare Agency which has managed several e-procurement projects has been analysed. This case represents a valuable context for examination and discussion because the outcomes of each project were evaluated in details. A riche IT Value Model devoted to the private secotr has been adopted and discussed, and later some resulting adaptations are suggested, together with some hints and limitations.Recent studies have affirmed the necessity of a discontinuity in the method of investigating the value produced in organisations by IT. Existing studies have in common a prevailing (when not exclusive) attention paid to the private sector, as testified by the frequent use of income or financial indicators to measure benefits. These approaches however cannot be directly applied to public utility organisations like public administrations. Taking into account this scenario, the present exploratory work looks at the analysis of IT investments in the public sector by identifying a viable approach to research in this domain. To move towards this objective, procurement management has been taken as the field to be observed, and an Italian publich Local Healthcare Agency which has managed several e-procurement projects has been analysed. This case represents a valuable context for examination and discussion because the outcomes of each project were evaluated in details. A riche IT Value Model devoted to the private secotr has been adopted and discussed, and later some resulting adaptations are suggested, together with some hints and limitations.Monograph's chapter

Superpixel-based Two-view Deterministic Fitting for Multiple-structure Data

This paper proposes a two-view deterministic geometric model fitting method, termed Superpixel-based Deterministic Fitting (SDF), for multiple-structure data. SDF starts from superpixel segmentation, which effectively captures prior information of feature appearances. The feature appearances are beneficial to reduce the computational complexity for deterministic fitting methods. SDF also includes two original elements, i.e., a deterministic sampling algorithm and a novel model selection algorithm. The two algorithms are tightly coupled to boost the performance of SDF in both speed and accuracy. Specifically, the proposed sampling algorithm leverages the grouping cues of superpixels to generate reliable and consistent hypotheses. The proposed model selection algorithm further makes use of desirable properties of the generated hypotheses, to improve the conventional fit-and-remove framework for more efficient and effective performance. The key characteristic of SDF is that it can efficiently and deterministically estimate the parameters of model instances in multi-structure data. Experimental results demonstrate that the proposed SDF shows superiority over several state-of-the-art fitting methods for real images with single-structure and multiple-structure data.Comment: Accepted by European Conference on Computer Vision (ECCV

Biomimetic surface functionalization of clinically relevant metals used as orthopaedic and dental implants

Titanium and its alloys or tantalum (Ta) are materials used in orthopaedic and dental implants due to their excellent mechanical properties and biocompatibility. However, their bioactivity and osteoconductivity is low. With a view to improving the bioactivity of these materials we hypothesised that the surface of Ta and TiAl6V4 can be functionalised with biomimetic, amorphous nano-sized calcium phosphate (CaP) apatite-like deposits, instead of creating uniform coatings, which can lead to flaking, delamination and poor adherence. We used Ta and TiAl6V4 metal discs with smooth and rough surfaces. Amorphous CaP apatite-like particles were deposited on the different surfaces by a biomimetic rapid two-step soaking method using concentrated simulated body fluid (SBF) solutions without a pre-treatment of the metal surfaces to induce CaP deposition. Immersion times in the second SBF solution of 48 and 18 h for Ta and TiAl6V4 respectively produced CaP deposits composed of amorphous globular nano-sized particles that also contained Mg, C and O. Longer immersion times produced more uniform coatings as well as an undesired calcite mineral phase. Prediction of in vivo behaviour by immersion in regular SBF showed that the obtained CaP deposits would act as a catalyst to rapidly form a Ca deficient CaP layer that also incorporates Mg. The amorphous CaP apatite-like deposits promoted initial attachment, proliferation and osteogenic differentiation of bone marrow derived mesenchymal stem cells. Finally, we used our method to functionalise 3D porous structures of titanium alloy made by selective laser sintering. Our study uses a novel and cost-effective approach to functionalise clinically relevant metal surfaces in order to increase the bioactivity of these materials, which could improve their clinical performance

Humoral Response Induced by Prime-Boost Vaccination with the ChAdOx1 nCoV-19 and mRNA BNT162b2 Vaccines in a Teriflunomide-Treated Multiple Sclerosis Patient.

Patients with multiple sclerosis (MS) are treated with drugs that may impact immune responses to SARS-CoV-2 vaccination. Evaluation of "prime-boost" (heterologous) vaccination regimens including a first administration of a viral vector-based vaccine and a second one of an mRNA-based vaccine in such patients has not yet been completed. Here, we present the anti-spike protein S humoral response, including the neutralizing antibody response, in a 54-year-old MS patient who had been treated with teriflunomide for the past 2 years and who received a heterologous ChAdOx1 nCoV-19/ BNT162b2 vaccination regimen. The results showed a very strong anti-S IgG response and a good neutralizing antibody response. These results show that teriflunomide did not prevent the development of a satisfactory humoral response in this MS patient after vaccination with a ChAdOx1 nCoV-19/ BNT162b2 prime-boost protocol

Specificity of drug transport mediated by CaMDR1: a major facilitator of Candida albicans

CaMDR1 encodes a major facilitator superfamily (MFS) protein inCandida albicans whose expression has been linked to azole resistance and which is frequently encountered in this human pathogenic yeast. In this report we have overexpressed CaMdr1p inSƒ9 insect cells and demonstrated for the first time that it can mediate methotrexate (MTX) and fluconazole (FLC) transport. MTX appeared to be a better substrate for CaMdr1p among these two tested drugs. Due to severe toxicity of these drugs to insect cells, further characterization of CaMdr1p as a drug transporter could not be done with this system. Therefore, as an alternative, CaMdr1p and Cdr1p, which is an ABC protein (ATP binding cassette) also involved in azole resistance inC. albicans, were independently expressed in a common hypersensitive host JG436 ofSaccharomyces cerevisiae. This allowed a better comparison between the functionality of the two export pumps. We observed that while both FLC and MTX are effluxed by CaMdr1p, MTX appeared to be a poor substrate for Cdr1p. JG436 cells expressing Cdr1p thus conferred resistance to other antifungal drugs but remained hypersensitive to MTX. Since MTX is preferentially transported by CaMdr1p, it can be used for studying the function of this MFS protein

Frameworks for logically classifying polynomial-time optimisation problems.

We show that a logical framework, based around a fragment of existential second-order logic formerly proposed by others so as to capture the class of polynomially-bounded P-optimisation problems, cannot hope to do so, under the assumption that P ≠ NP. We do this by exhibiting polynomially-bounded maximisation and minimisation problems that can be expressed in the framework but whose decision versions are NP-complete. We propose an alternative logical framework, based around inflationary fixed-point logic, and show that we can capture the above classes of optimisation problems. We use the inductive depth of an inflationary fixed-point as a means to describe the objective functions of the instances of our optimisation problems

Magneto-optical Kerr Effect Studies of Square Artificial Spin Ice

We report a magneto-optical Kerr effect study of the collective magnetic response of artificial square spin ice, a lithographically-defined array of single-domain ferromagnetic islands. We find that the anisotropic inter-island interactions lead to a non-monotonic angular dependence of the array coercive field. Comparisons with micromagnetic simulations indicate that the two perpendicular sublattices exhibit distinct responses to island edge roughness, which clearly influence the magnetization reversal process. Furthermore, such comparisons demonstrate that disorder associated with roughness in the island edges plays a hitherto unrecognized but essential role in the collective behavior of these systems.Comment: Physical Review B, Rapid Communications (in press