Smoke-free legislation and hospitalizations for childhood asthma

<b>BACKGROUND:</b> Previous studies have shown that after the adoption of comprehensive smoke-free legislation, there is a reduction in respiratory symptoms among workers in bars. However, it is not known whether respiratory disease is also reduced among people who do not have occupational exposure to environmental tobacco smoke. The aim of our study was to determine whether the ban on smoking in public places in Scotland, which was initiated in March 2006, influenced the rate of hospital admissions for childhood asthma.<br></br> <b>METHODS:</b> Routine hospital administrative data were used to identify all hospital admissions for asthma in Scotland from January 2000 through October 2009 among children younger than 15 years of age. A negative binomial regression model was fitted, with adjustment for age group, sex, quintile of socioeconomic status, urban or rural residence, month, and year. Tests for interactions were also performed. <br></br> <b>RESULTS:</b> Before the legislation was implemented, admissions for asthma were increasing at a mean rate of 5.2% per year (95% confidence interval [CI], 3.9 to 6.6). After implementation of the legislation, there was a mean reduction in the rate of admissions of 18.2% per year relative to the rate on March 26, 2006 (95% CI, 14.7 to 21.8; P<0.001). The reduction was apparent among both preschool and school-age children. There were no significant interactions between hospital admissions for asthma and age group, sex, urban or rural residence, region, or quintile of socioeconomic status. <b>CONCLUSIONS:</b> In Scotland, passage of smoke-free legislation in 2006 was associated with a subsequent reduction in the rate of respiratory disease in populations other than those with occupational exposure to environmental tobacco smoke. (Funded by NHS Health Scotland.

Approximating Tverberg Points in Linear Time for Any Fixed Dimension

Let P be a d-dimensional n-point set. A Tverberg-partition of P is a partition of P into r sets P_1, ..., P_r such that the convex hulls conv(P_1), ..., conv(P_r) have non-empty intersection. A point in the intersection of the conv(P_i)'s is called a Tverberg point of depth r for P. A classic result by Tverberg implies that there always exists a Tverberg partition of size n/(d+1), but it is not known how to find such a partition in polynomial time. Therefore, approximate solutions are of interest. We describe a deterministic algorithm that finds a Tverberg partition of size n/4(d+1)^3 in time d^{O(log d)} n. This means that for every fixed dimension we can compute an approximate Tverberg point (and hence also an approximate centerpoint) in linear time. Our algorithm is obtained by combining a novel lifting approach with a recent result by Miller and Sheehy (2010).Comment: 14 pages, 2 figures. A preliminary version appeared in SoCG 2012. This version removes an incorrect example at the end of Section 3.

Scheduling of space to ground quantum key distribution

Satellite-based platforms are currently the only feasible way of achieving intercontinental range for quantum communication, enabling thus the future global quantum internet. Recent demonstrations by the Chinese spacecraft Micius have spurred an international space race and enormous interest in the development of both scientific and commercial systems. Research efforts so far have concentrated upon in-orbit demonstrations involving a single satellite and one or two ground stations. Ultimately satellite quantum key distribution should enable secure network communication between multiple nodes, which requires efficient scheduling of communication with the set of ground stations. Here we present a study of how satellite quantum key distribution can service many ground stations taking into account realistic constraints such as geography, operational hours, and most importantly, weather conditions. The objective is to maximise the number of keys a set of ground stations located in the United Kingdom could share while simultaneously reflecting the communication needs of each node and its relevance in the network. The problem is formulated as a mixed-integer linear optimisation program and solved to a desired optimality gap using a state of the art solver. The approach is presented using a simulation run throughout six years to investigate the total number of keys that can be sent to ground stations

Pulse variational quantum eigensolver on cross-resonance based hardware

State-of-the-art noisy digital quantum computers can only execute short-depth quantum circuits. Variational algorithms are a promising route to unlock the potential of noisy quantum computers since the depth of the corresponding circuits can be kept well below hardware-imposed limits. Typically, the variational parameters correspond to virtual $R_Z$ gate angles, implemented by phase changes of calibrated pulses. By encoding the variational parameters directly as hardware pulse amplitudes and durations we succeed in further shortening the pulse schedule and overall circuit duration. This decreases the impact of qubit decoherence and gate noise. As a demonstration, we apply our pulse-based variational algorithm to the calculation of the ground state of different hydrogen-based molecules (H$_2$, H$_3$ and H$_4$) using IBM cross-resonance-based hardware. We observe a reduction in schedule duration of up to $5\times$ compared to CNOT-based Ans\"atze, while also reducing the measured energy. In particular, we observe a sizable improvement of the minimal energy configuration of H$_3$ compared to a CNOT-based variational form. Finally, we discuss possible future developments including error mitigation schemes and schedule optimizations, which will enable further improvements of our approach paving the way towards the simulation of larger systems on noisy quantum devices

Antipsychotic dose escalation as a trigger for Neuroleptic Malignant Syndrome (NMS): literature review and case series report

Background: “Neuroleptic malignant syndrome” (NMS) is a potentially fatal idiosyncratic reaction to any medication which affects the central dopaminergic system. Between 0.5% and 1% of patients exposed to antipsychotics develop the condition. Mortality rates may be as high as 55% and many risk factors have been reported. Although rapid escalation of antipsychotic dose is thought to be an important risk factor, to date it has not been the focus of a published case series or scientifically defined. <p/>Aims: To identify cases of NMS and review risk factors for its development with a particular focus on rapid dose escalation in the 30 days prior to onset. <p/>Methodology: A review of the literature on rapid dose escalation was undertaken and a pragmatic definition of “rapid dose escalation” was made. NMS cases were defined using DSM-IV criteria and systematically identified within a secondary care mental health service. A ratio of titration rate was calculated for each NMS patient and “rapid escalators” and “non rapid escalators” were compared. <p/>Results: 13 cases of NMS were identified. A progressive mean dose increase 15 days prior to the confirmed episode of NMS was observed (241.7mg/day during days 1-15 to 346.9mg/day during days 16-30) and the mean ratio of dose escalation for NMS patients was 1.4. Rapid dose escalation was seen in 5/13 cases and non rapid escalators had markedly higher daily cumulative antipsychotic dose compared to rapid escalators. <p/>Conclusions: Rapid dose escalation occurred in less than half of this case series (n=5, 38.5%), although there is currently no consensus on the precise definition of rapid dose escalation. Cumulative antipsychotic dose – alongside other known risk factors - may also be important in the development of NMS

Nanosatellite experiments to enable future space-based QKD missions

We present a programme for establishing the space worthiness of highly-miniaturised, polarisation-entangled, photon pair sources using CubeSat nanosatellites. Once demonstrated, the photon pair sources can be deployed on more advanced satellites that are equipped with optical links to establish a global space-based quantum key distribution network. In doing so, this work will also bring experimental tests of the overlap between quantum and relativistic regimes closer to realisation

Functional polymorphisms in the P2X7 receptor gene are associated with stress fracture injury

Context: Military recruits and elite athletes are susceptible to stress fracture injuries. Genetic predisposition has been postulated to have a role in their development. The P2X7 receptor (P2X7R) gene, a key regulator of bone remodelling, is a genetic candidate that may contribute to stress fracture predisposition. Objective: To evaluate the putative contribution of P2X7R to stress fracture injury in two separate cohorts, military personnel and elite athletes. Methods: In 210 Israeli Defence Forces (IDF) military conscripts, stress fracture injury was diagnosed (n=43) based on symptoms and a positive bone scan. In a separate cohort of 518 elite athletes, self-reported medical imaging scan-certified stress fracture injuries were recorded (n=125). Non-stress fracture controls were identified from these cohorts who had a normal bone scan or no history or symptoms of stress fracture injury. Study participants were genotyped for functional SNPs within the P2X7R gene using proprietary fluorescence-based competitive allele-specific PCR assay. Pearson Chi-square (χ2) tests, corrected for multiple comparisons, were used to assess associations in genotype frequencies. Results: The variant allele of P2X7R SNP rs3751143 (Glu496Ala- loss of function) was associated with stress fracture injury, while the variant allele of rs1718119 (Ala348Thr- gain of function) was associated with a reduced occurrence of stress fracture injury in military conscripts (P<0.05). The association of the variant allele of rs3751143 with stress fractures was replicated in elite athletes (P<0.05), whereas the variant allele of rs1718119 was also associated with reduced multiple stress fracture cases in elite athletes (P<0.05). Conclusions: The association between independent P2X7R polymorphisms with stress fracture prevalence supports the role of a genetic predisposition in the development of stress fracture injury