329 research outputs found
Charge Transfer Induced Molecular Hole Doping into Thin Film of Metal-Organic-Frameworks
Despite the highly porous nature with significantly large surface area, metal
organic frameworks (MOFs) can be hardly used in electronic, and optoelectronic
devices due to their extremely poor electrical conductivity. Therefore, the
study of MOF thin films that require electron transport or conductivity in
combination with the everlasting porosity is highly desirable. In the present
work, thin films of Co3(NDC)3DMF4 MOFs with improved electronic conductivity
are synthesized using layer-by-layer and doctor blade coating techniques
followed by iodine doping. The as-prepared and doped films are characterized
using FE-SEM, EDX, UV/Visible spectroscopy, XPS, current-voltage measurement,
photoluminescence spectroscopy, cyclic voltammetry, and incident photon to
current efficiency measurements. In addition, the electronic and semiconductor
property of the MOF films are characterized using Hall Effect measurement,
which reveals that in contrast to the insulator behavior of the as-prepared
MOFs, the iodine doped MOFs behave as a p-type semiconductor. This is caused by
charge transfer induced hole doping into the frameworks. The observed charge
transfer induced hole doping phenomenon is also confirmed by calculating the
densities of states of the as-prepared and iodine doped MOFs based on density
functional theory. Photoluminescence spectroscopy demonstrate an efficient
interfacial charge transfer between TiO2 and iodine doped MOFs, which can be
applied to harvest solar radiations.Comment: Main paper (19 pages, 6 figures) and supplementary information (15
pages, 10 figures), accepted in ACS Appl. Materials & Interface
Successful Treatment of Pure Red Cell Aplasia with Rituximab in Patients after ABO-Compatible Allogeneic Hematopoietic Stem Cell Transplantation
Pure red cell aplasia (PRCA) following allogeneic hematopoietic stem cell transplantation (HSCT) has been mostly reported in situations involving major ABO incompatibility between donor and recipient. Conventional treatments such as plasma exchange, erythropoietin, and steroid are often unsatisfactory. Rituximab has been reported to be highly effective for PRCA following major ABO-incompatible allogeneic HSCT. A 49-year-old woman with PRCA following ABO-matched allogeneic HSCT for acute lymphoblastic leukemia, refractory to erythropoietin treatment, received 4 doses of rituximab 375 mg/m2 weekly. After the 3rd dose of rituximab, she exhibited a striking rise in her reticulocyte count with an increase in her hemoglobin level. To our knowledge, this is the first case of PRCA following major ABO-compatible allogeneic HSCT resolving completely after rituximab treatment
Molecular genetic study of novel biomarkers for early diagnosis of oral squamous cell carcinoma
Objectives: Early detection and treatment of an oral squamous cell carcinoma (OSCC) is critical because of its
rapid growth, frequent lymph-node metastasis, and poor prognosis. However, no clinically-valuable methods of
early diagnosis exist, and genetic analysis of OSCCs has yielded no biomarkers.
Study
D
esign: We investigated the expression of genes associated with inflammation in OSCCs via a quantitative
reverse transcriptase polymerase chain reaction (qRT-PCR) analysis of microarray data. Tumor and normal tissues
from five patients with an OSCC were used for microarray analysis. Differentially-expressed genes, identified using permutation, local pooled error (LPE), t-tests, and significance analysis of microarrays (SAM), were selected
as candidate genetic markers.
Results: Two groups corresponding to tissue identity were evident, implying that their differentially-expressed
genes represented biological differences between tissues. Fifteen genes were identified using the Student’s paired
t-test (
p<
0.05)
and the SAM, with a false discovery rate of less than 0.02. Based on gene expression, these 15
genes can be used to classify an OSCC. A genetic analysis of functional networks and ontologies, validated by
using a qRT-PCR analysis of the tissue samples, identified four genes, ADAM15, CDC7, IL12RB2 and TNFRSF8,
that demonstrated excellent concordance with the microarray data.
Conclusions: Our study demonstrated that four genes (ADAM15, CDC7, IL12RB2 and TNFRSF8) had potential
as novel biomarkers for the diagnosis and the treatment of an OSCC
THE POSSIBILITY OF CLASSIFYING V1 AND V2 SUB-TECHNIQUES OF A SINGLE IMU SENSOR THROUGH COMPARISON OF MOTION-SPECIFIC DATA(PITCH, YAW AND ROLL ANGLE VALUES-ORIENTATION ANGLE VALUE) IN XC SKI
The purpose of this study is to confirm whether the single IMU sensor module(LGE developing and providing for the experiments) that attached to the pelvis can distinguish the motion of the sub-techniques (V1, V2, V2A) with the accuracy of commercial XSENS(equipment consisting of 17 sensors) in freestyle(skate) xc skiing. Therefore, one elite male xc skier with eleven years experience was investigated by measuring the three-directional rotation angle for each of the three sub-techniques used in XC ski freestyle. Through this method, we could found not only the difference of motion patterns of each sub-techniques but also the possibility for replacement of multiple sensor system by a single IMU sensor module from LGE. Thus, it is expected that a single LGE IMU sensor module could be applied to repetitive and periodic sports such as XC ski
A Case of Disseminated and Fulminant Plasmacytomas That Developed during Bortezomib Treatment
Multiple myeloma is an incurable and slow growing plasma cell neoplasm. The introduction of new drugs has increased the number of treatment options. Bortezomib, the first-in-class proteasome inhibitor, has been shown to have a significant antitumor activity in the treatment of relapse/refractory patients with multiple myeloma. Additionally, plasmacytomas have shown significant response to bortezomib. In this case report, we describe a patient who developed disseminated and fulminant extramedullary plasmacytomas during combination chemotherapy treatment with bortezomib within a short period, after having shown clinical improvement
Ectopic overexpression of the aluminum-induced protein gene from Panax ginseng enhances heavy metal tolerance in transgenic Arabidopsis
Aluminum (Al), one of the most abundant metals in agricultural soils, significantly limits crop growth and productivity in acidic soil by inhibiting root elongation. Al ions, especially Al3+, have a toxic effect on both plant and animal cells under low-pH conditions. We first isolated and characterized aluminum-induced protein (AIP) cDNA from a 4-year-old root of Panax ginseng Meyer. This cDNA encodes an open reading frame of 711 bp with a deduced amino acid sequence of 236 residues. The calculated molecular mass of the mature protein is approximately 58.9 kDa with a predicated isoelectric point of 5.13. The Panax ginsengAIP (PgAIP) contains a domain also present in wheat aluminum-induced protein 7 (Wali7) and shares homology with the AIPs of other species, including Codonopis and Arabidopsis. The PgAIP gene was abundantly expressed in the plant’s leaves and was up-regulated by Al exposure. The functional role of PgAIP in Al tolerance was further validated through its overexpression in Arabidopsis. Transgenic Arabidopsis plants overexpressing the PgAIP gene showed enhanced Al tolerance in terms of root growth when compared to wild-type plants, suggesting PgAIP is important in plant defense against Al toxicity. Confocal analysis of CFP-tagging PgAIP in Arabidopsis showed subcellular localization in the plasma membrane. Our results suggest that PgAIP in the plasma membrane plays an important role in the protection of plant cells against heavy metal exposure
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