Recht und Verfassung im Mittelalter

Kern describes how law was perceived in the middle ages. Law does not have to be issued by the state, but it has to be old and good

The salience of comparison standards and the activation of social norms: consequences for judgments of happiness and their communications

'Zwei Untersuchungen wurden durchgeführt, in denen Berichte über das eigene subjektive Wohlbefinden beeinflußt werden a) durch die Augenfälligkeit eines Vergleichsstandards und b) durch die Aktivierung einer sozialen Norm im Kontext der Urteilsabgabe. Wir fanden, daß sich die Versuchspersonen in Anwesenheit einer anderen Person, der es vergleichsweise schlechter ging, als glücklicher einschätzten. Dieser Kontrasteffekt trat verstärkt auf, wenn die Aufmerksamkeit der Vpn beim Ausfüllen des Fragebogens durch ein natürliches Sitzarrangement auf die Vergleichsperson gerichtet war. Die Ergebnisse des zweiten Experiments, in dem die Darbietungsform der Befragung (anonym vs. offen) und der offensichtliche Gesundheitszustand der Vergleichsperson (körperbehindert oder nicht) variiert wurde, zeigen, daß solche vergleichende Urteile nicht geäußert werden, wenn die Antworten dem körperbehinderten Versuchsteilnehmer gegenüber offen geäußert werden müssen. Zusammengenommen machen beide Untersuchungen deutlich, daß kognitive und kommunikative Prozesse gleichermaßen beachtet werden müssen, um die Determinanten von Urteilen des subjektiven Wohlbefindens zu verstehen.' (Autorenreferat)'Two studies were conducted in which subjects' reports of their own happiness were influenced a) by the salience of comparison standards and b) by the social norm that was activated in the context of communicating those judgments. It was found that the presence of another person who was relatively worse off led to more positive judgments of the subjects' own happiness. This contrast effect was increased when subjects' attention was directed toward the comparison person by a natural seating arrangement at the time the questionnaire had to be filled out. The results of the second study in which the mode of administration (private vs. public) and the apparent state of health of the comparison person were varied (physically handicapped or not), show that such contrastive judgments may not be uttered when the judgment has to be reported to the handicapped confederate. Taken together, these studies demonstrate how both cognitive and communicative mechanisms must be taken into account to understand the determinants of judgments of subjective well-being.' (author's abstract

Paleoclimate of the subtropical Andes during the latest Miocene, Lauca T Basin, Chile

Uplift of the Andean Cordillera during the Miocene and Pliocene produced large-scale changes in regional atmospheric circulation that impacted local ecosystems. The Lauca Basin (northern Chilean Altiplano) contains variably fluvial and lacustrine sedimentary sequences spanning the interval from 8.7 to 2.3 Ma. Field samples were collected from paleo-lacustrine sediments in the basin. Sediments were dated using detrital zircon geochronology on volcanic tuffs, yielding an age range between ~5.57 and 5.44 Ma. These new age constraints provided an opportunity to evaluate changes in the Lauca Basin ecosystem across this dynamic Miocene-Pliocene transition. We employed multiple proxies (lithofacies analysis, diatoms, pollen, and oxygen stable isotopes of authigenic carbonates) to interpret ancient lacustrine and terrestrial paleoenvironments. Alternations among mudstone, carbonate, and evaporitic facies indicate lake-level variability through time. The diatom assemblage is characterized by meso- to hypersaline and alkaline-tolerant taxa typical of shallow lakes. The δ18O values ranged from −8.96 to −2.22‰ indicating fluctuations in water balance. Pollen taxa in the outcrop are typical of a transitional stage between seasonal cloud forest and open grassland. Together, these proxies indicate that the Lauca paleolake sediments were deposited under a wetter-than-modern climate with high temporal variability. Our results refine previous studies in the Lauca Basin and are consistent with other regional studies suggesting that the South American summer monsoon at the Miocene-Pliocene transition was more intense than it is at present

Large-Mass Ultra-Low Noise Germanium Detectors: Performance and Applications in Neutrino and Astroparticle Physics

A new type of radiation detector, a p-type modified electrode germanium diode, is presented. The prototype displays, for the first time, a combination of features (mass, energy threshold and background expectation) required for a measurement of coherent neutrino-nucleus scattering in a nuclear reactor experiment. The device hybridizes the mass and energy resolution of a conventional HPGe coaxial gamma spectrometer with the low electronic noise and threshold of a small x-ray semiconductor detector, also displaying an intrinsic ability to distinguish multiple from single-site particle interactions. The present performance of the prototype and possible further improvements are discussed, as well as other applications for this new type of device in neutrino and astroparticle physics (double-beta decay, neutrino magnetic moment and WIMP searches).Comment: submitted to Phys. Rev.

A 1.8 million year history of Amazon vegetation

During the Pleistocene, long-term trends in global climate were controlled by orbital cycles leading to high amplitude glacial-interglacial variability. The history of Amazonian vegetation during this period is largely unknown since no continuous record from the lowland basin extends significantly beyond the last glacial stage. Here we present a paleoenvironmental record spanning the last 1800 kyr based on palynological data, biome reconstructions, and biodiversity metrics from a marine sediment core that preserves a continuous archive of sediments from the Amazon River. Tropical rainforests dominated the Amazonian lowlands during the last 1800 ka interchanging with surrounding warm-temperate rainforests and tropical seasonal forests. Between 1800 and 1000 ka, rainforest biomes were present in the Amazon drainage basin, along with extensive riparian wetland vegetation. Tropical rainforest expansion occurred during the relatively warm Marine Isotope Stages 33 and 31 (ca. 1110 to 1060 ka), followed by a contraction of both forests and wetlands until ca. 800 ka. Between 800 and 400 ka, low pollen concentration and low diversity of palynological assemblages renders difficult the interpretation of Amazonian vegetation. A strong synchronicity between vegetation changes and glacial-interglacial global climate cycles was established around 400 ka. After 400 ka, interglacial vegetation was dominated by lowland tropical rainforest in association with warmer temperatures and higher CO2. During cooler temperatures and lower CO2 of glacial stages, tropical seasonal forests expanded, presumably towards eastern Amazonia. While this study provides no evidence supporting a significant expansion of savanna or steppe vegetation within the Amazonian lowlands during glacial periods, there were changes in the rainforest composition in some parts of the basin towards a higher proportion of deciduous elements, pointing to less humid conditions and/or greater seasonality of precipitation. Nevertheless, rainforest persisted during both glacial and interglacial periods. These findings confirm the sensitivity of tropical lowland vegetation to changes in CO2, temperature, and moisture availability and the most suitable conditions for tropical rainforests occurred during the warmest stages of the Mid Pleistocene Transition and during the interglacial stages of the past 400 kyr

AUGMENT : a phase III study of lenalidomide plus rituximab versus placebo plus rituximab in relapsed or refractory indolent lymphoma

PURPOSE Patients with indolent non-Hodgkin lymphoma typically respond well to first-line immunochemotherapy. At relapse, single-agent rituximab is commonly administered. Data suggest the immunomodulatory agent lenalidomide could increase the activity of rituximab. METHODS A phase III, multicenter, randomized trial of lenalidomide plus rituximab versus placebo plus rituximab was conducted in patients with relapsed and/or refractory follicular or marginal zone lymphoma. Patients received lenalidomide or placebo for 12 cycles plus rituximab once per week for 4 weeks in cycle 1 and day 1 of cycles 2 through 5. The primary end point was progression-free survival per independent radiology review. RESULTS A total of 358 patients were randomly assigned to lenalidomide plus rituximab (n = 178) or placebo plus rituximab (n = 180). Infections (63% v 49%), neutropenia (58% v 23%), and cutaneous reactions (32% v 12%) were more common with lenalidomide plus rituximab. Grade 3 or 4 neutropenia (50% v 13%) and leukopenia (7% v 2%) were higher with lenalidomide plus rituximab; no other grade 3 or 4 adverse event differed by 5% or more between groups. Progression-free survival was significantly improved for lenalidomide plus rituximab versus placebo plus rituximab, with a hazard ratio of 0.46 (95% CI, 0.34 to 0.62; P < .001) and median duration of 39.4 months (95% CI, 22.9 months to not reached) versus 14.1 months (95% CI, 11.4 to 16.7 months), respectively. CONCLUSION Lenalidomide improved efficacy of rituximab in patients with recurrent indolent lymphoma, with an acceptable safety profile

Trans-Amazon Drilling Project (TADP): origins and evolution of the forests, climate, and hydrology of the South American tropics

This article presents the scientific rationale for an ambitious ICDP drilling project to continuously sample Late Cretaceous to modern sediment in four different sedimentary basins that transect the equatorial Amazon of Brazil, from the Andean foreland to the Atlantic Ocean. The goals of this project are to document the evolution of plant biodiversity in the Amazon forests and to relate biotic diversification to changes in the physical environment, including climate, tectonism, and the surface landscape. These goals require long sedimentary records from each of the major sedimentary basins across the heart of the Brazilian Amazon, which can only be obtained by drilling because of the scarcity of Cenozoic outcrops. The proposed drilling will provide the first long, nearly continuous regional records of the Cenozoic history of the forests, their plant diversity, and the associated changes in climate and environment. It also will address fundamental questions about landscape evolution, including the history of Andean uplift and erosion as recorded in Andean foreland basins and the development of west-to-east hydrologic continuity between the Andes, the Amazon lowlands, and the equatorial Atlantic. Because many modern rivers of the Amazon basin flow along the major axes of the old sedimentary basins, we plan to locate drill sites on the margin of large rivers and to access the targeted drill sites by navigation along these rivers

Anthrax Toxins Inhibit Neutrophil Signaling Pathways in Brain Endothelium and Contribute to the Pathogenesis of Meningitis

Anthrax meningitis is the main neurological complication of systemic infection with Bacillus anthracis approaching 100% mortality. The presence of bacilli in brain autopsies indicates that vegetative bacteria are able to breach the blood-brain barrier (BBB). The BBB represents not only a physical barrier but has been shown to play an active role in initiating a specific innate immune response that recruits neutrophils to the site of infection. Currently, the basic pathogenic mechanisms by which B. anthracis penetrates the BBB and causes anthrax meningitis are poorly understood.Using an in vitro BBB model, we show for the first time that B. anthracis efficiently invades human brain microvascular endothelial cells (hBMEC), the single cell layer that comprises the BBB. Furthermore, transcriptional profiling of hBMEC during infection with B. anthracis revealed downregulation of 270 (87%) genes, specifically key neutrophil chemoattractants IL-8, CXCL1 (Gro alpha) and CXCL2 (Gro beta), thereby strongly contrasting hBMEC responses observed with other meningeal pathogens. Further studies using specific anthrax toxin-mutants, quantitative RT-PCR, ELISA and in vivo assays indicated that anthrax toxins actively suppress chemokine production and neutrophil recruitment during infection, allowing unrestricted proliferation and dissemination of the bacteria. Finally, mice challenged with B. anthracis Sterne, but not the toxin-deficient strain, developed meningitis.These results suggest a significant role for anthrax toxins in thwarting the BBB innate defense response promoting penetration of bacteria into the central nervous system. Furthermore, establishment of a mouse model for anthrax meningitis will aid in our understanding of disease pathogenesis and development of more effective treatment strategies