Triangular Fuzzy Matrices

In this paper, some elementary operations on triangular fuzzy numbers are defined. we also define some operations on triangular fuzzy matrices such as trace and triangular fuzzy determinant. Using elementary operations. Some important properties of TFMS are presented. The concept of adjoints on TFM is discussed and some of their properties are. some special types of TFMs are defined and a number of properties of these TFMS are presented

A PERSPECTIVE REVIEW ON APPLICATIONS OF NANOPARTICLE MEDIATED DRUG DELIVERY TO THE CNS

Delivery of drugs into the brain is one of the most interesting and challenging areas of research. The blood-brain barrier (BBB) is a highly selective semipermeable membrane that separates blood from the brain in the central nervous system. It acts as a barrier to protect the brain from microbes, neurotoxins and other chemical substances and also blocks the entry of many drugs into the brain. An estimated 6.8 billion people die every year from CNS diseases like Parkinson’s disease, Alzheimer’s disease, sclerosis, brain stroke, dementia and others. According to WHO, one billion people are affected worldwide, about 50 million suffer from epilepsy and 24 million suffer from Alzheimer and other dementias. This indicates the importance of the delivery of drugs into the brain for treating various neurological diseases and psychological disorders. In drug targeting, a concept was introduced by Dr. Paul Ehrlich as a ‘magic bullet’ that gave tremendous hope for the researches to deliver drugs into the brain. This review discuses about various drug targeting strategies and applications of nanotechnology in designing drug delivery systems with the ability to cross through the BBB for treating neurological diseases

IDENTIFICATION OF BIOACTIVE COMPOUNDS BY GAS CHROMATOGRAPHY-MASS SPECTROMETRY ANALYSIS OF SYZYGIUM JAMBOS (L.) COLLECTED FROM WESTERN GHATS REGION COIMBATORE, TAMIL NADU

Objective: The aim of this study was to investigate the presence of bioactive compounds in the methanolic leaf extract of Syzygium jambos.Methods: Collected leaves were shade dried and made into fine powder, extracted with methanol, and the methanolic extract was prepared and analyzed for the presence of bioactive compounds by gas chromatography-mass spectrometry (GC-MS). The mass spectrum of the chromatography was matched with NIST and WILEY Libraries.Results: The GC-MS analysis revealed the presence of 45 active compounds in the extract. From the GC-MS investigation, 1-Deoxy-d-mannitol3-methyl-2-methylsulfanyl-5-nitro-6-pyridin-4-ylpyrimidin-4-one, 3-Pentadecylphenol, 2-biphenylene carboxylic acid, Quinoline-3-carboxylic acid, and Stigmast-5-en-3-ol are important phytoconstituents which have antipyretic and antiparasitic activities.Conclusion: The present investigation revealed preliminary information on phytocompounds presented in S. jambos leaf extract which is very useful for the human community.Keywords: Syzygium jambos, Gas chromatography-mass spectrometry analysis, 1-Deoxy-d-mannitol, Phytoconstituents, Methanolic leaf extrac

Comparison of Thrombolysis in Myocardial Infarction Score and Heart Score in risk stratification of acute myocardial infarction patients, prognostic accuracy and arrhythmia incidence

Background: To compare TIMI & HEART SCORE for their risk stratification in Acute Myocardial Infarction Patients,  prognostic accuracy and Arrhythmia incidence.Methods: This observational study is conducted in a Tertiary care hospital over a period of 2 years from August 2017 to July 2019. A total of 100 patients presented to ER with Chest Pain are selected for study. Patients were monitored for a period of one month in ICCU.Results: In present study out of 61 cases with TIMI score ≥5, mortality of 11.5%(7 cases, p value 0.028). Heart score more than 6  constitutes high risk group, out of which mortality was observed in 7.45% cases (p=0.48). Most of the arrhythmias (70.49%) in present study observed in patients with TIMI score ≥5 (High risk group) which is statistically significant with p value 0.002. Most of the arrhythmias in present study observed in patients with HS ≥8 which is not statistically significant with p value 0.135.Conclusions: In present study, overall mortality rate was 7% and these patients who died constitutes to high risk group with TIMI. HEART SCORE identified more patients as low risk compared to TIMI SCORE. TIMI SCORE is a good predictor of arrhythmia incidence

APOPTOTIC INDUCTION POTENTIALS OF BACOPA MONERI AGAINST ORAL CANCER CELL LINE

Aim: To assess the apoptotic induction potentials of Bacopa monnieri against oral cancer cell.Objective: This research is done to find the apoptotic induction potentials of B. monnieri against oral cancer cell line.Background: The apoptosis is a process of programed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cellchanges and death. The initiation of apoptosis is tightly regulated by activation mechanisms, because once apoptosis has begun, it inevitably leadsto the death of the cell. The two best-understood activation mechanisms are the intrinsic pathway (also called the mitochondrial pathway) and theextrinsic pathway.Methods: The apoptotic induction potential of B. monnieri was studied on KB cell line by investigating the activation of caspase 3 and caspase 9.Reason: Oral cancer is a growing concern due to the changes in lifestyle. The treatment for this disease has been degraded the patient's health bycausing various side effects. An effective treatment for the long run is necessary. Usable of herbal plants can serve to be a possible and very effective remedy.Results: Apoptotic induction potentials of B. monnieri against oral cancer cell line were studied.Conclusion: Caspase 3 and caspase 9 was activated thus proving the apoptotic potential of B. monnieri.Keywords: Bacopa monnieri, oral cancer, apoptotic induction

IN VITRO ANTIOXIDANT AND ANTICANCER ACTIVITY OF ULVA LACTUCA L.USING MOLT-3 CELL LINE

Objective: The aim of the present investigation was to determine the in vitro antioxidant and anticancer activity of the ethanol extract of Ulva lactuca L. Methods: The present study was to investigate the antioxidant and anticancer activity of U. lactuca L. The extract of U. lactuca L. was extracted by ethanol and subject to analysis. An in vitro antioxidant activity of the ethanol extract of U. lactuca L. was performed by 1, 1-diphenyl-2-picrylhydrazyl free radical scavenging assay. Simultaneously anticancer activity was also performed using blood cancer (MOLT-3) cell line, and the species showed a strong selective cell proliferation inhibition of the cancer cell line. Results: The scavenging activity was measured and determined to be 78.5%. This might be due to high polyphenolic compounds and flavonoid contents of the extract, which showed maximum growth inhibition of 74.4%. Conclusion: Thus, the study concludes that the constituents of seaweeds can act as potent in treating various diseases and can be used as an alternative for therapeutic treatment

Knowledge And Awareness on Iron Deficiency Anaemia Among Women - A Questionnaire Based Survey

Iron deficiency anaemia is one of the major health problems faced by women. Several factors such as age, sex, socio-economic status, educational level play prominent roles in influencing the health status.Iron deficiency anaemia may result in slow growth and development, fatigue, stillbirth etc.But the knowledge and awareness towards it was significantly low.The main purpose of this study was to evaluate the knowledge and awareness of women towards iron deficiency anaemia. A questionnaire based survey was conducted among 100 female participants. Questionnaire was distributed through a survey link. Results were collected and analysed using IBM SPSS Statistical Analyzer (23.0 version). Frequency distribution and descriptive analysis were carried out. Pearson Chi square test was done. P value less than or equal to 0.05 was considered to be statistically significant.The results of the study showed that the knowledge and awareness of women carried according to their level of education. Participants who are educated were found to have re knowledge and awareness compared to the participants who are not educated. Therefore, it is of utmost importance for women to gain adequate knowledge on iron deficiency anaemia to make lifestyle modifications for healthy living.Saveetha Dental Colleg

Role of artificial intelligence in drug development

In the last decade, artificial intelligence (AI) has revolutionised the field of drug research. Staff abilities (55 percent), data structure (52 percent), and resources were all factors in AI deployment (49 percent ). Nearly 60% of respondents said they expected to hire more people in the next two years to assist AI usage or adoption in drug development. AI in areas like as drug research and development, drug repurposing, boosting pharmaceutical productivity, and clinical trials, among others, minimises human effort and allows for the achievement of objectives in a short amount of time. On the one hand, AI techniques used in drug development bring the drug development process and the use of various models closer to medicinal chemists, while on the other hand, AI methods used in drug development bring the drug development process and the use of various models closer to mathematicians