7 research outputs found
A therapist-focused knowledge translation intervention for improving patient adherence in musculoskeletal physiotherapy practice
A kinematic analysis of relative stability of the lower extremities between subjects with and without chronic low back pain
Determinants of clinical practice guidelines’ utilization for the management of musculoskeletal disorders: a scoping review
Manganese and iron deficiency in Southern Ocean Phaeocystis antarctica populations revealed through taxon-specific protein indicators
Kinesins and cancer
Kinesins are a family of molecular motors that travel unidirectionally along microtubule tracks to fulfil their many roles in intracellular transport or cell division. Over the past few years kinesins that are involved in mitosis have emerged as potential targets for cancer drug development. Several compounds that inhibit two mitotic kinesins (EG5 (also known as KIF11) and centromere-associated protein E (CENPE)) have entered Phase I and II clinical trials either as monotherapies or in combination with other drugs. Additional mitotic kinesins are currently being validated as drug targets, raising the possibility that the range of kinesin-based drug targets may expand in the future