Timing of Spermarche and Menarche are Associated with Physical Activity and Sedentary Behavior Among Korean Adolescents

OBJECTIVES: This study examined the timing of menarche and spermarche and their associations with physical activity (PA) and sedentary behavior (SB) after controlling for body mass index (BMI). METHODS: Multiple logistic regression analyses were conducted to determine whether the timing of menarche in girls and spermarche in boys is associated with PA and SB independent of BMI in a nationally representative sample of Korean adolescents (13–18 years; N = 74,186). RESULTS: After controlling for age, family economic status, and BMI, early timing of spermarche among boys was associated with a higher likelihood of engaging in PA and a lower likelihood of engaging in SB for < 2 hours during weekdays. By contrast, boys with late timing of spermarche were less likely to engage in PA and more likely to engage in SB for < 2 hours. Among girls, early or late timing of menarche was associated with a higher likelihood of engaging in PA and a lower likelihood of engaging in SB. CONCLUSION: Timing of menarche in girls and spermarche in boys could be a marker for PA and SB among Korean adolescents. To promote PA and discourage SB among Korean adolescents, school-based, grade-specific interventions can be tailored by the absence or presence of menarche/spermarche

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells

The major-histocompatibility-complex-(MHC)-class-I-related molecule MR1 can present activating and non-activating vitamin-B-based ligands to mucosal-associated invariant T cells (MAIT cells). Whether MR1 binds other ligands is unknown. Here we identified a range of small organic molecules, drugs, drug metabolites and drug-like molecules, including salicylates and diclofenac, as MR1-binding ligands. Some of these ligands inhibited MAIT cells ex vivo and in vivo, while others, including diclofenac metabolites, were agonists. Crystal structures of a T cell antigen receptor (TCR) from a MAIT cell in complex with MR1 bound to the non-stimulatory and stimulatory compounds showed distinct ligand orientations and contacts within MR1, which highlighted the versatility of the MR1 binding pocket. The findings demonstrated that MR1 was able to capture chemically diverse structures, spanning mono- and bicyclic compounds, that either inhibited or activated MAIT cells. This indicated that drugs and drug-like molecules can modulate MAIT cell function in mammals

A systematic review evaluating the psychometric properties of measures of social inclusion

Introduction: Improving social inclusion opportunities for population health has been identified as a priority area for international policy. There is a need to comprehensively examine and evaluate the quality of psychometric properties of measures of social inclusion that are used to guide social policy and outcomes. Objective: To conduct a systematic review of the literature on all current measures of social inclusion for any population group, to evaluate the quality of the psychometric properties of identified measures, and to evaluate if they capture the construct of social inclusion. Methods: A systematic search was performed using five electronic databases: CINAHL, PsycINFO, Embase, ERIC and Pubmed and grey literature were sourced to identify measures of social inclusion. The psychometric properties of the social inclusion measures were evaluated against the COSMIN taxonomy of measurement properties using pre-set psychometric criteria. Results: Of the 109 measures identified, twenty-five measures, involving twenty-five studies and one manual met the inclusion criteria. The overall quality of the reviewed measures was variable, with the Social and Community Opportunities Profile-Short, Social Connectedness Scale and the Social Inclusion Scale demonstrating the strongest evidence for sound psychometric quality. The most common domain included in the measures was connectedness (21), followed by participation (19); the domain of citizenship was covered by the least number of measures (10). No single instrument measured all aspects within the three domains of social inclusion. Of the measures with sound psychometric evidence, the Social and Community Opportunities Profile-Short captured the construct of social inclusion best. Conclusions: The overall quality of the psychometric properties demonstrate that the current suite of available instruments for the measurement of social inclusion are promising but need further refinement. There is a need for a universal working definition of social inclusion as an overarching construct for ongoing research in the area of the psychometric properties of social inclusion instruments

Interface potential of calcium phosphate in simulated body fluid

Calcium phosphate ceramics are used in the substitution of injured or damaged bones. Nevertheless, the behaviour of these materials, and in particular, the mechanisms guiding their interface response in physiological environment is still unknown. This work describes the construction of hydroxyapatite and tricalcium phosphate electrodes used to determine the interface potential behaviour of these materials in a simulated body fluid, in a pH range corresponding to the Variation observed in human body injuries, at ambient and physiological temperatures. These measurements are associated with the adsorption/desorption of ions from the materials. The results show that hydroxyapatite and tricalcium phosphate have similar behaviour in that they reach an interface potential equilibrium state faster when the solution pH is decreased and the temperature increased. This behaviour may be attributed to their ability to form a calcium-rich layer and is relevant to their quality as implantable materials. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.19242329233

Biological assessment of porous-implant hydroxyapatite combined with periosteal grafting in maxillary defects

Purpose: To investigate the use of porous hydroxyapatite (HA) combined with periosteal graft to repair an induced maxillary bone defect. Materials and Methods: A defect was produced in the premaxillary bone of rats. Four groups were used: 1) those treated with the mucoperiosteal graft from the premaxilla; 2) those treated with HA combined with mucoperiosteal graft from the premaxilla; 3) those treated with HA combined with periosteal graft from the femur; and 4) those treated with periosteal graft from the femur. Results: The radiographic aspects from all groups showed no signs of bone formation after 2 weeks. After 16 weeks, there was evidence of points of radiolucency inside the HA implants. Cell proliferation occurred from the periosteum covering the defect. Bone tissue grew from the defect margin to inside the defect in all cases. Mature bone was seen around the HA implants after 8 and 16 weeks. Conclusion: The periosteal graft provides satisfactory support to the HA implant, allowing the growth of new bone. (C) 2007 American Association of Oral and Maxillofacial Surgeons.65584785

The competing effect of ammonia in the synthesis of iron oxide/silica nanoparticles in microemulsion/sol-gel system

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Combined microemulsion/sol-gel processes may be used to prepare composite nanoparticles. In this work, iron oxide/silica nanoparticles were synthesized in such a combined system, having ammonium hydroxide acting in both processes: as precipitating agent in the synthesis of iron oxide and as catalyst in the sol-gel process of silica. The nanoparticles were synthesized in microemulsions containing tetraethoxysilane (TEOS) and composed by Triton X-100/hexyl alcohol/cyclohexane/aqueous solution, with different amounts of ammonium hydroxide. Powder materials were obtained after centrifugation, washing and drying, and they were analyzed as synthesized and after heating at 350, 500 and 1000 degrees C. The influence of base quantity was evaluated in relation to the size of the particles and the iron oxide phase synthesized. TEM analysis showed that nanometric iron oxide particles were formed and that they were percolated by a net of amorphous silica. The higher amount of ammonia seems to have induced TEOS condensation process instead of iron oxide particles' growth, indicating that the quantity of base influenced both the microemulsion system and the sal-gel process, but with minor influence over the iron oxide composition, as evidenced by FT-IR and DRX. (C) 2013 Elsevier B.V. All rights reserved.422136142Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq