Polarization attractors in harmonic mode-locked fiber laser

We report on a polarimetry of harmonic mode-locked erbium-doped fiber laser with carbon nanotubes saturable absorber. We find new types of vector solitons with locked, switching and precessing states of polarization. The underlying physics presents interplay between birefringence of a laser cavity created by polarization controller along with light induced anisotropy caused by polarization hole burning

Design of ultrasonic testing device for fatigue damage of pressure vessels

The container fatigue damage detection device is researched and designed for the fatigue damage detection requirements of pressure vessels. The hardware design of the detection device, the corresponding detection technology and the functions realized are introduced. The new test performs ultrasonic nondestructive testing by driving five DC servo motors to drive the mechanical part of the test device. Research on the detection system and technology to automate the detection of fatigue damage in pressure vessels

Design of ultrasonic testing device for fatigue damage of pressure vessels

The container fatigue damage detection device is researched and designed for the fatigue damage detection requirements of pressure vessels. The hardware design of the detection device, the corresponding detection technology and the functions realized are introduced. The new test performs ultrasonic nondestructive testing by driving five DC servo motors to drive the mechanical part of the test device. Research on the detection system and technology to automate the detection of fatigue damage in pressure vessels

Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases

Bacterial quorum sensing (QS) is a cell-to-cell communication in which specific signals are activated to coordinate pathogenic behaviors and help bacteria acclimatize to the disadvantages. The QS signals in the bacteria mainly consist of acyl-homoserine lactone, autoinducing peptide, and autoinducer-2. QS signaling activation and biofilm formation lead to the antimicrobial resistance of the pathogens, thus increasing the therapy difficulty of bacterial diseases. Anti-QS agents can abolish the QS signaling and prevent the biofilm formation, therefore reducing bacterial virulence without causing drug-resistant to the pathogens, suggesting that anti-QS agents are potential alternatives for antibiotics. This review focuses on the anti-QS agents and their mediated signals in the pathogens and conveys the potential of QS targeted therapy for bacterial diseases

ChinaOpen: A Dataset for Open-world Multimodal Learning

This paper introduces ChinaOpen, a dataset sourced from Bilibili, a popular Chinese video-sharing website, for open-world multimodal learning. While the state-of-the-art multimodal learning networks have shown impressive performance in automated video annotation and cross-modal video retrieval, their training and evaluation have primarily been conducted on YouTube videos with English text. Their effectiveness on Chinese data remains to be verified. In order to support multimodal learning in the new context, we construct ChinaOpen-50k, a webly annotated training set of 50k Bilibili videos associated with user-generated titles and tags. Both text-based and content-based data cleaning are performed to remove low-quality videos in advance. For a multi-faceted evaluation, we build ChinaOpen-1k, a manually labeled test set of 1k videos, wherein each video is accompanied with a manually checked user title and a manually written caption. Besides, each test video is manually tagged to describe what visual entities / actions / scenes are present in the visual content. The original user tags are also manually checked. Moreover, with all the Chinese text translated into English, ChinaOpen-1k is also suited for evaluating models trained on English data. In addition to ChinaOpen, we propose Generative Video-to-text Transformer (GVT) for Chinese video captioning. We conduct an extensive evaluation of the state-of-the-art single-task / multi-task models on the new dataset, resulting in a number of novel findings and insights

Recombinant protein rMBP-NAP restricts tumor progression by triggering antitumor immunity in mouse metastatic lung cancer

Recombinant Helicobacter pylori neutrophil-activating protein fused with Maltose- binding protein (rMBP-NAP), a potential TLR2 ligand, was reported to possess immunomodulatory effects on in-situ tumor in our previous study. In present work, we attempt to elucidate the effect of rMBP-NAP at the local immune modulation in B16-F10-induced metastatic lung cancer. Our results demonstrated that growth of B16-F10 melanoma metastases in the lung was significantly arrested after rMBP-NAP treatment, along with marked reduction in metastatic lung nodules and significant increase in survival. The treatment induced both local and systemic immune responses, which associated with higher influx of CD4+/CD8+ T cells and drove toward Th1-like and cytotoxic immune environment. Moreover, rMBP-NAP also showed significant anti-angiogenic activity by reducing vascularization in lung tumor sections. In conclusion, rMBP-NAP could induce antitumor immunity through activating Th1 cells and producing pro-inflammatory cytokines, which are responsible for the effective cytotoxic immune response against cancer progression. Our findings indicate that rMBP-NAP might be a novel antitumor therapeutic strategy.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author