Urinary Phthalate Metabolite Concentrations and Cancer Mortality in NHANES, 1999-2006

Four in ten people in the US will be diagnosed with cancer during their lifetime. Environmental exposures are important determinants of cancer risk, causing as many as 19% of cancers worldwide. Phthalates are a group of chemicals used to increase the flexibility of plastics and vinyl in household materials such as food packaging, plastic toys, wood finishes and adhesives. Some phthalates may act as endocrine disruptors with hypothesized links to endometriosis, breast cancer, and reproductive outcomes. However, no research yet exists on phthalate exposure and all-cancer mortality. We investigated the relationship between seven urinary phthalate metabolites among 5,205 adults in National Health and Nutrition Examination Survey (NHANES), from 1999 to 2006 with mortality data through 2011. Urinary phthalate metabolites were measured in spot urine samples using HPLC-MS/MS and HPLC-ESI-MS/MS. Cox proportional hazard regressions were conducted to calculate hazard ratios and 95 percent confidence intervals for all-cancer mortality, stratified by gender. Mean creatinine adjusted metabolite concentrations ranged from 0.03 – 3.86 ug/mg in males and 0.07 – 4.37 ug/mg in females. Age-adjusted and multivariate Cox proportional hazard models did not yield statistically significant results for any metabolites. Hazard ratios in the multivariate model for continuous, creatinine adjusted, log transformed metabolite concentrations, ranged from 0.90 to 1.27 in men and 0.86 to 1.07 in women. There was no evidence for a dose-response relationship in the quartile analyses, with p-values for trend above 0.12. This research contributes to the limited cancer literature on phthalate exposure that helps direct future regulations on plasticizers in consumer products

Induced pseudoscalar form factor of the nucleon at two-loop order in chiral perturbation theory

We calculate the imaginary part of the induced pseudoscalar form factor of the nucleon $G_P(t)$ in the framework of two-loop heavy baryon chiral perturbation theory. The effect of the calculated three-pion continuum on the pseudoscalar constant $g_P = (m_\mu/2M) G_P(t=-0.877m_\mu^2)$ measurable in ordinary muon capture $\mu^-p\to \nu_\mu n$ turns out to be negligibly small. Possible contributions from counterterms at two-loop order are numerically smaller than the uncertainty of the dominant pion-pole term proportional to the pion-nucleon coupling constant $g_{\pi N}= 13.2\pm 0.2$. We conclude that a sufficiently accurate representation of the induced pseudoscalar form factor of the nucleon at low momentum transfers $t$ is given by the sum of the pion-pole term and the Adler-Dothan-Wolfenstein term: $G_P(t) = 4g_{\pi N} M f_\pi/ (m_\pi^2 -t)- 2g_A M^2 /3$, with $= (0.44 \pm 0.02)$ fm$^2$ the axial mean square radius of the nucleon.Comment: 6 pages, 2 figures, accepted for publication in Physical Review

A wave-envelope of sound propagation in nonuniform circular ducts with compressible mean flows

An acoustic theory is developed to determine the sound transmission and attenuation through an infinite, hard-walled or lined circular duct carrying compressible, sheared, mean flows and having a variable cross section. The theory is applicable to large as well as small axial variations, as long as the mean flow does not separate. The technique is based on solving for the envelopes of the quasi-parallel acoustic modes that exist in the duct instead of solving for the actual wave, thereby reducing the computation time and the round-off error encountered in purely numerical techniques. The solution recovers the solution based on the method of multiple scales for slowly varying duct geometry. A computer program was developed based on the wave-envelope analysis for general mean flows. Results are presented for the reflection and transmission coefficients as well as the acoustic pressure distributions for a number of conditions: both straight and variable area ducts with and without liners and mean flows from very low to high subsonic speeds are considered

Transmission of sound through nonuniform circular ducts with compressible mean flows

An acoustic theory is developed to determine the sound transmission and attenuation through an infinite, hard-walled or lined, circular duct carrying compressible, sheared, mean flows and having a variable cross section. The theory is applicable to large as well as small axial variations, as long as the mean flow does not separate. Although the theory is described for circular ducts, it is applicable to other duct configurations - annular, two dimensional, and rectangular. The theory is described for the linear problem, but the technique is general and has the advantage of being applicable to the nonlinear case as well as the linear case. The technique is based on solving for the envelopes of the quasi-parallel acoustic modes that exist in the duct instead of solving for the actual wave. A computer program was developed. The mean flow model consists of a one dimensional flow in the core and a quarter-sine profile in the boundary layer. Results are presented for the reflection and transmission coefficients in ducts with varying slopes and carrying different mean flows

On the electron-induced isotope fractionation in low temperature ³²O₂/³⁶O₂ ices—ozone as a case study

The formation of six ozone isotopomers and isotopologues, 16O16O16O, 18O18O18O, 16O16O18O, 18O18O16O, 16O18O16O, and 18O16O18O, has been studied in electron-irradiated solid oxygen 16O2 and 18O2 (1 : 1) ices at 11 K. Significant isotope effects were found to exist which involved enrichment of 18O-bearing ozone molecules. The heavy 18O18O18O species is formed with a factor of about six higher than the corresponding 16O16O16O isotopologue. Likewise, the heavy 18O18O16O species is formed with abundances of a factor of three higher than the lighter 16O16O18O counterpart. No isotope effect was observed in the production of 16O18O16O versus 18O16O18O. Such studies on the formation of distinct ozone isotopomers and isotopologues involving non-thermal, non-equilibrium chemistry by irradiation of oxygen ices with high energy electrons, as present in the magnetosphere of the giant planets Jupiter and Saturn, may suggest that similar mechanisms may contribute to the 18O enrichment on the icy satellites of Jupiter and Saturn such as Ganymede, Rhea, and Dione. In such a Solar System environment, energetic particles from the magnetospheres of the giant planets may induce non-equilibrium reactions of suprathermal and/or electronically excited atoms under conditions, which are quite distinct from isotopic enrichments found in classical, thermal gas phase reactions

General Relativistic Description of the Observed Galaxy Power Spectrum: Do We Understand What We Measure?

We extend the general relativistic description of galaxy clustering developed in Yoo, Fitzpatrick, and Zaldarriaga (2009). For the first time we provide a fully general relativistic description of the observed matter power spectrum and the observed galaxy power spectrum with the linear bias ansatz. It is significantly different from the standard Newtonian description on large scales and especially its measurements on large scales can be misinterpreted as the detection of the primordial non-Gaussianity even in the absence thereof. The key difference in the observed galaxy power spectrum arises from the real-space matter fluctuation defined as the matter fluctuation at the hypersurface of the observed redshift. As opposed to the standard description, the shape of the observed galaxy power spectrum evolves in redshift, providing additional cosmological information. While the systematic errors in the standard Newtonian description are negligible in the current galaxy surveys at low redshift, correct general relativistic description is essential for understanding the galaxy power spectrum measurements on large scales in future surveys with redshift depth z>3. We discuss ways to improve the detection significance in the current galaxy surveys and comment on applications of our general relativistic formalism in future surveys.Comment: accepted for publication in Physical Review