Effects of heavy modes on vacuum stability in supersymmetric theories

We study the effects induced by heavy fields on the masses of light fields in supersymmetric theories, under the assumption that the heavy mass scale is much higher than the supersymmetry breaking scale. We show that the square-masses of light scalar fields can get two different types of significant corrections when a heavy multiplet is integrated out. The first is an indirect level-repulsion effect, which may arise from heavy chiral multiplets and is always negative. The second is a direct coupling contribution, which may arise from heavy vector multiplets and can have any sign. We then apply these results to the sGoldstino mass and study the implications for the vacuum metastability condition. We find that the correction from heavy chiral multiplets is always negative and tends to compromise vacuum metastability, whereas the contribution from heavy vector multiplets is always positive and tends on the contrary to reinforce it. These two effects are controlled respectively by Yukawa couplings and gauge charges, which mix one heavy and two light fields respectively in the superpotential and the Kahler potential. Finally we also comment on similar effects induced in soft scalar masses when the heavy multiplets couple both to the visible and the hidden sector.Comment: LaTex, 24 pages, no figures; v2 some comments and references adde

Gene copy number variation throughout the Plasmodium falciparum genome

BACKGROUND: Gene copy number variation (CNV) is responsible for several important phenotypes of the malaria parasite Plasmodium falciparum, including drug resistance, loss of infected erythrocyte cytoadherence and alteration of receptor usage for erythrocyte invasion. Despite the known effects of CNV, little is known about its extent throughout the genome. RESULTS: We performed a whole-genome survey of CNV genes in P. falciparum using comparative genome hybridisation of a diverse set of 16 laboratory culture-adapted isolates to a custom designed high density Affymetrix GeneChip array. Overall, 186 genes showed hybridisation signals consistent with deletion or amplification in one or more isolate. There is a strong association of CNV with gene length, genomic location, and low orthology to genes in other Plasmodium species. Sub-telomeric regions of all chromosomes are strongly associated with CNV genes independent from members of previously described multigene families. However, approximately 40% of CNV genes were located in more central regions of the chromosomes. Among the previously undescribed CNV genes, several that are of potential phenotypic relevance are identified. CONCLUSION: CNV represents a major form of genetic variation within the P. falciparum genome; the distribution of gene features indicates the involvement of highly non-random mutational and selective processes. Additional studies should be directed at examining CNV in natural parasite populations to extend conclusions to clinical settings

Correction to: A multilevel longitudinal study of obsessive compulsive symptoms in adolescence: male gender and emotional stability as protective factors

Erratum/corrigendum to: Stavropoulos V, Moore KA, Lazaratou H, Dikeos D, Gomez R. A multilevel longitudinal study of obsessive compulsive symptoms in adolescence: male gender and emotional stability as protective factors. Ann Gen Psychiatry. 2017;16:42. https://doi.org/10.1186/s12991-017-0165-z

FLASHING: Project Overview

This paper describes the overview of the FLASHING (Finest Legacy Acquisitions of SiO-/ H$_2$O-maser Ignitions by the Nobeyama Generation) project promoted using the 45 m telescope of Nobeyama Radio Observatory, which aims to intensively monitor H$_2$O (22 GHz) and SiO (43 GHz) masers associated with so-called "water fountain" sources. Here we show scientific results on the basis of the data taken in for the first five seasons of FLASHING, from 2018 December to 2023 April). We have found the evolution of the H$_2$O maser spectra, such as new spectral components breaking the record of the jet's top speed and/or systematic velocity drifts in the spectrum indicating acceleration or deceleration of the maser gas clumps. For the 43 GHz SiO maser emission, we have found its new detection in a source while its permanent disappearance in other source. Our finding may imply that the jets from these water fountains can be accelerated or decelerated, and show how cicumstellar envelopes have been destroyed.Comment: 31 pages, 22 figures, to be published in the Publications of the Astronomical Society of Japa

Subcellular heterogeneity of ryanodine receptor properties in ventricular myocytes with low T-tubule density

Rationale: In ventricular myocytes of large mammals, not all ryanodine receptor (RyR) clusters are associated with T-tubules (TTs); this fraction increases with cellular remodeling after myocardial infarction (MI). Objective: To characterize RyR functional properties in relation to TT proximity, at baseline and after MI. Methods: Myocytes were isolated from left ventricle of healthy pigs (CTRL) or from the area adjacent to a myocardial infarction (MI). Ca2+ transients were measured under whole-cell voltage clamp during confocal linescan imaging (fluo-3) and segmented according to proximity of TTs (sites of early Ca2+ release, F>F50 within 20 ms) or their absence (delayed areas). Spontaneous Ca2+ release events during diastole, Ca2+ sparks, reflecting RyR activity and properties, were subsequently assigned to either category. Results: In CTRL, spark frequency was higher in proximity of TTs, but spark duration was significantly shorter. Block of Na+/Ca2+ exchanger (NCX) prolonged spark duration selectively near TTs, while block of Ca2+ influx via Ca2+ channels did not affect sparks properties. In MI, total spark mass was increased in line with higher SR Ca2+ content. Extremely long sparks (>47.6 ms) occurred more frequently. The fraction of near-TT sparks was reduced; frequency increased mainly in delayed sites. Increased duration was seen in near-TT sparks only; Ca2+ removal by NCX at the membrane was significantly lower in MI. Conclusion: TT proximity modulates RyR cluster properties resulting in intracellular heterogeneity of diastolic spark activity. Remodeling in the area adjacent to MI differentially affects these RyR subpopulations. Reduction of the number of sparks near TTs and reduced local NCX removal limit cellular Ca2+ loss and raise SR Ca2+ content, but may promote Ca2+ waves

M5 spikes and operators in the HVZ membrane theory

In this note we study some aspects of the so-called dual ABJM theory introduced by Hanany, Vegh & Zaffaroni. We analyze the spectrum of chiral operators, and compare it with the spectrum of functions on the mesonic moduli space M=C^2\times C^2/Z_k, finding expected agreement for the coherent branch. A somewhat mysterious extra branch of dimension N^2 opens up at the orbifold fixed point. We also study BPS solutions which represent M2/M5 intersections. The mesonic moduli space suggests that there should be two versions of this spike: one where the M5 lives in the orbifolded C^2 and another where it lives in the unorbifolded one. While expectedly the first class turns out to be like the ABJM spike, the latter class looks like a collection of stacks of M5 branes with fuzzy S^3 profiles. This shows hints of the appearance of the global SO(4) at the non-abelian level which is otherwise not present in the bosonic potential. We also study the matching of SUGRA modes with operators in the coherent branch of the moduli space. As a byproduct, we present some formulae for the laplacian in conical CY_4 of the form C^n\times CY_{4-n}.Comment: 22 pages, 1 figure. Published version with corrected typos

Inflation, moduli (de)stabilization and supersymmetry breaking

We study the cosmological inflation from the viewpoint of the moduli stabilization. We study the scenario that the superpotential has a large value during the inflation era enough to stabilize moduli, but it is small in the true vacuum. This scenario is discussed by using a simple model, one type of hybrid models.Comment: 17 pages, 7 figure

The Beta Ansatz: A Tale of Two Complex Structures

Brane tilings, sometimes called dimer models, are a class of bipartite graphs on a torus which encode the gauge theory data of four-dimensional SCFTs dual to D3-branes probing toric Calabi-Yau threefolds. An efficient way of encoding this information exploits the theory of dessin d’enfants, expressing the structure in terms of a permutation triple, which is in turn related to a Belyi pair, namely a holomorphic map from a torus to a P1 with three marked points. The procedure of a-maximization, in the context of isoradial embeddings of the dimer, also associates a complex structure to the torus, determined by the R-charges in the SCFT, which can be compared with the Belyi complex structure. Algorithms for the explicit construction of the Belyi pairs are described in detail. In the case of orbifolds, these algorithms are related to the construction of covers of elliptic curves, which exploits the properties of Weierstraß elliptic functions. We present a counter example to a previous conjecture identifying the complex structure of the Belyi curve to the complex structure associated with R-charges

Osmoregulators proline and glycine betaine counteract salinity stress in canola

Salt inundation leads to increased salinization of arable land in many arid and semi-arid regions. Until genetic solutions are found farmers and growers must either abandon salt-affected fields or use agronomic treatments that alleviate salt stress symptoms. Here, field experiments were carried out to study the effect of the osmoregulators proline at 200 mg L-1 and glycine betaine at 400 mg L-1 in counteracting the harmful effect of soil salinity stress on canola plants grown in Egypt. We assessed growth characteristics, yield and biochemical constituents. Results show first that all growth characters decreased with increasing salinity stress but applied osmoregulators alleviated these negative effects. Second, salinity stress decreased photosynthetic pigments, K and P contents, whilst increasing proline, soluble sugars, ascorbic acid, Na and Cl contents. Third, application of osmoregulators without salt stress increased photosynthetic pigments, proline, soluble sugars, N, K and P contents whilst decreasing Na and Cl contents. It is concluded that the exogenously applied osmoregulators glycine betaine and proline can fully or partially counteract the harmful effect of salinity stress on growth and yield of canola.© INRA and Springer-Verlag, France 2012

Node overlap removal by growing a tree

Node overlap removal is a necessary step in many scenarios including laying out a graph, or visualizing a tag cloud. Our contribution is a new overlap removal algorithm that iteratively builds a Minimum Spanning Tree on a Delaunay triangulation of the node centers and removes the node overlaps by ”growing” the tree. The algorithm is simple to implement yet produces high quality layouts. According to our experiments it runs several times faster than the current state-of-the-art methods