Overvalued ideas and their impact on treatment outcome Idéias supervalorizadas e seu impacto no resultado do tratamento

BACKGROUND: The presence of overvalued ideas (OVI) in patients with obsessive-compulsive disorder (OCD) has been theoretically linked to poorer treatment outcome. However, to date there have not been any quantitative measures of overvalued ideas. Therefore, the relationship between OVI and outcome has been primarily hypothetical. Rudimentary assessments have been attempted by asking patients to rate their strength of belief from 1 to 10, clinically rating the fixity of beliefs from 1 to 5, and rating patients on item 11 (insight) on the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). The purpose of this study was to determine the relationship between OVI, degree of severity of OCD symptoms, and improvement. METHOD: Twenty patients with OCD participated in the study. All patients were treated with six days a week of 90 minutes of exposure and response prevention (ERP) and selective serotonin re-uptake inhibitors. No changes in medication were made during the course of treatment and all patients had been on their respective medications for at least three months prior to entering the study. Assessment scales consisted of the Overvalued Ideas Scale (OVIS), Y-BOCS, Beck Depression Inventory, and the Beck Anxiety Inventory. RESULTS: The results indicated that overvalued ideas did not necessarily correlate with severity of symptoms on the Y-BOCS. The higher the score on the OVIS, the less change on the Y-BOCS score. CONCLUSION: Overvalued ideas appear to be an important predictor of poor outcome.<br>INTRODUÇÃO: A existência de idéias superestimadas (IS) em pacientes com transtorno obsessivo-compulsivo (TOC) vem sendo teoricamente relacionada a resultado insatisfatório do tratamento. Como até o momento não existem medidas quantitativas das idéias superestimadas, a relação entre IS e resultado fica restrita ao campo hipotético. Houve algumas tentativas de avaliações simples. Era pedido aos pacientes que avaliassem a intensidade de suas convicções, em uma escala de 1 a 10. A seguir, fazia-se a avaliação clínica da fixidez das convicções de 1 a 5, e os pacientes eram classificados segundo o item 11 (insight) da Escala Yale-Brown de Sintomas Obsessivo-compulsivos (Y-BOCS). A proposta deste estudo era determinar a relação existente entre IS, gravidade dos sintomas do TOC e melhora. MÉTODO: Vinte pacientes com DOC participaram do estudo. Todos eles foram submetidos ao tratamento de prevenção de exposição e reação (PER), durante seis dias por semana, com sessões de 90 minutos, e medicados com inibidores seletivos de recaptação de serotonina. Os medicamentos não foram alterados durante o curso do tratamento. Antes de entrar no estudo, todos os pacientes já recebiam tratamento medicamentoso há, pelo menos, três meses. As escalas de avaliação usadas foram Escala de Idéias Superestimadas (OVIS), Y-BOCS, Inventário Beck para Depressão e Inventário Beck para Ansiedade. RESULTADOS: Os resultados indicaram que idéias superestimadas não se correlacionavam necessariamente com a gravidade dos sintomas, medidos pela Y-BOCS. Quanto maior o grau medido pela OVIS, menor era a variação na Y-BOCS. CONCLUSÃO: Idéias superestimadas parecem ser um importante fator de predição de um resultado insatisfatório para o tratamento

Data from: Life-history plasticity in female threespine stickleback

The postglacial adaptive radiation of the threespine stickleback fish (Gasterosteus aculeatus) has been widely used to investigate the roles of both adaptive evolution and plasticity in behavioral and morphological divergence from the ancestral condition represented by present-day oceanic stickleback. These phenotypes tend to exhibit high levels of ecotypic differentiation. Population divergence in life history has also been well studied, but in contrast to behavior and morphology, the extent and importance of plasticity has been much less well studied. In this review, we summarize what is known about life-history plasticity in female threespine stickleback, considering four traits intimately associated with reproductive output: age/size at maturation, level of reproductive effort, egg size and clutch size. We envision life-history plasticity in an iterative, ontogenetic framework, in which females may express plasticity repeatedly across each of several time frames. We contrast the results of laboratory and field studies because, for most traits, these approaches give somewhat different answers. We provide ideas on what the cues might be for observed plasticity in each trait and, when possible, we inquire about the relative costs and benefits to expressed plasticity. We end with an example of how we think plasticity may play out in stickleback life history given what we know of plasticity in the ancestor