785 research outputs found
Large Extra Dimensions at Linear Colliders
In this talk, I first present the motivation for theories wherein extra
spacetime dimensions can be compactified to have large magnitudes. In
particular, I discuss the Arkani-Hamed, Dimopoulos, Dvali (ADD) scenario. I
present the constraints that have been derived on these models from current
experiments and the expectations from future colliders. I concentrate
particularly on the possibilities of probing these extra dimensions at future
linear colliders.Comment: Talk given at the Third International Workshop on Electron-Electron
Interactions at TeV Energies (e- e- 99), Santa Cruz, California, 10-12 Dec
1999. 7 pages, LaTeX, style files attache
Spin configuration of top quark pair production with large extra dimensions at photon-photon colliders
Top quark pair production at photon-photon colliders is studied in low scale
quantum gravity scenario. From the dependence of the cross sections on the spin
configuration of the top quark and anti-quark, we introduce a new observable,
top spin asymmetry. It is shown that there exists a special top spin basis
where with the polarized parent electron beams the top spin asymmetry vanishes
in the standard model but retains substantial values with the large extra
dimension effects. We also present lower bounds of the quantum gravity scale
from total cross sections with various combinations of the laser,
electron beam, and top quark pair polarizations. The measurements of the top
spin state with unpolarized initial beams are
shown to be most effective, enhancing by about 5% the bounds with respect
to totally unpolarized case.Comment: 18 pages, 4 figures, ReVTe
Patients with refractory cytomegalovirus (CMV) infection following allogeneic haematopoietic stem cell transplantation are at high risk for CMV disease and non-relapse mortality
AbstractPre-emptive therapy is an effective approach for cytomegalovirus (CMV) control; however, refractory CMV still occurs in a considerable group of recipients after allogeneic haematopoietic stem cell transplantation (allo-HSCT). Until now, hardly any data have been available about the clinical characteristics and risk factors of refractory CMV, or its potential harmful impact on the clinical outcome following allo-HSCT. We studied transplant factors affecting refractory CMV in the 100 days after allo-HSCT, and the impact of refractory CMV on the risk of CMV disease and non-relapse mortality (NRM). We retrospectively studied 488 consecutive patients with CMV infection after allo-HSCT. Patients with refractory CMV in the 100 days after allo-HSCT had a higher incidence of CMV disease and NRM than those without refractory CMV (11.9% vs. 0.8% and 17.1% vs. 8.3%, respectively). Multivariate analysis showed that refractory CMV infection in the 100 days after allo-HSCT was an independent risk factor for CMV disease (hazard ratio (HR) 10.539, 95% CI 2.467â45.015, p 0.001), and that refractory CMV infection within 60â100 days after allo-HSCT was an independent risk factor for NRM (HR 8.435, 95% CI 1.511â47.099, p 0.015). Clinical factors impacting on the risk of refractory CMV infection included receiving transplants from human leukocyte antigen-mismatched family donors (HR 2.012, 95% CI 1.603â2.546, p <0.001) and acute graft-versus-host disease (HR 1.905, 95% CI 1.352â2.686, p <0.001). We conclude that patients with refractory CMV infection during the early stage after allo-HSCT are at high risk for both CMV disease and NRM
Direct Signals for Large Extra Dimensions in the Production of Fermion Pairs at Linear Colliders
We analyze the potentiality of the new generation of linear
colliders to search for large extra dimensions via the production of fermion
pairs in association with Kaluza-Klein gravitons (G), i.e. . This process leads to a final state exhibiting a significant amount
of missing energy in addition to acoplanar lepton or jet pairs. We study in
detail this reaction using full tree level contibutions due to the graviton
emission and the standard model backgrounds. After choosing the cuts to enhance
the signal, we show that a linear collider with a center-of-mass energy of 500
GeV will be able to probe quantum gravity scales from 0.96(0.86) up to 4.1(3.3)
TeV at 2(5) level, depending on the number of extra dimensions.Comment: 19 pages, 5 figures. Using RevTex, axodraw.sty. Discussion was
extended. No changes in the results. Accepted for publication by Phys. Rev.
Kaluza-Klein gravitino production with a single photon at e^+ e^- colliders
In a supersymmetric large extra dimension scenario, the production of
Kaluza-Klein gravitinos accompanied by a photino at e^+ e^- colliders is
studied. We assume that a bulk supersymmetry is softly broken on our brane such
that the low-energy theory resembles the MSSM. Low energy supersymmetry
breaking is further assumed as in GMSB, leading to sub-eV mass shift in each KK
mode of the gravitino from the corresponding graviton KK mode. Since the
photino decays within a detector due to its sufficiently large inclusive decay
rate into a photon and a gravitino, the process e^+ e^- -> photino + gravitino
yields single photon events with missing energy. Even if the total cross
section can be substantial at sqrt(s)=500 GeV, the KK graviton background of
e^+ e^- -> photon + graviton is kinematically advantageous and thus much
larger. It is shown that the observable, sigma(e^-_L)-sigma(e^-_R), can
completely eliminate the KK graviton background but retain most of the KK
gravitino signal, which provides a unique and robust method to probe the
supersymmetric bulk.Comment: Reference added and typos correcte
Testing the Nature of Kaluza-Klein Excitations at Future Lepton Colliders
With one extra dimension, current high precision electroweak data constrain
the masses of the first Kaluza-Klein excitations of the Standard Model gauge
fields to lie above TeV. States with masses not much larger than
this should be observable at the LHC. However, even for first excitation masses
close to this lower bound, the second set of excitations will be too heavy to
be produced thus eliminating the possibility of realizing the cleanest
signature for KK scenarios. Previous studies of heavy and production
in this mass range at the LHC have demonstrated that very little information
can be obtained about their couplings to the conventional fermions given the
limited available statistics and imply that the LHC cannot distinguish an
ordinary from the degenerate pair of the first KK excitations of the
and . In this paper we discuss the capability of lepton colliders
with center of mass energies significantly below the excitation mass to resolve
this ambiguity. In addition, we examine how direct measurements obtained on and
near the top of the first excitation peak at lepton colliders can confirm these
results. For more than one extra dimension we demonstrate that it is likely
that the first KK excitation is too massive to be produced at the LHC.Comment: 38 pages, 10 Figs, LaTex, comments adde
in NonCommutative Standard Model
We study the top quark decay to b quark and W boson in the NonCommutative
Standard Model (NCSM). The lowest contribution to the decay comes from the
terms quadratic in the matrix describing the noncommutative (NC) effects while
the linear term is seen to identically vanish because of symmetry. The NC
effects are found to be significant only for low values of the NC
characteristic scale.Comment: 11 page Latex file containing 2 eps figures (redrawn). More
discussion included. To appear in PR
Modeling manufacturing processes using a genetic programming-based fuzzy regression with detection of outliers
Fuzzy regression (FR) been demonstrated as a promising technique for modeling manufacturing processes where availability of data is limited. FR can only yield linear type FR models which have a higher degree of fuzziness, but FR ignores higher order or interaction terms and the influence of outliers, all of which usually exist in the manufacturing process data. Genetic programming (GP), on the other hand, can be used to generate models with higher order and interaction terms but it cannot address the fuzziness of the manufacturing process data. In this paper, genetic programming-based fuzzy regression (GP-FR), which combines the advantages of the two approaches to overcome the deficiencies of the commonly used existing modeling methods, is proposed in order to model manufacturing processes. GP-FR uses GP to generate model structures based on tree representation which can represent interaction and higher order terms of models, and it uses an FR generator based on fuzzy regression to determine outliers in experimental data sets. It determines the contribution and fuzziness of each term in the model by using experimental data excluding the outliers. To evaluate the effectiveness of GP-FR in modeling manufacturing processes, it was used to model a non-linear system and an epoxy dispensing process. The results were compared with those based on two commonly used FR methods, Tanka's FR and Peters' FR. The prediction accuracy of the models developed based on GP-FR was shown to be better than that of models based on the other two FR methods
Genome-wide meta-analysis identifies eight new susceptibility loci for cutaneous squamous cell carcinoma
Cutaneous squamous cell carcinoma (SCC) is one of the most common cancers in the United States. Previous genome-wide association studies (GWAS) have identified 14 single nucleotide polymorphisms (SNPs) associated with cutaneous SCC. Here, we report the largest cutaneous SCC meta-analysis to date, representing six international cohorts and totaling 19,149 SCC cases and 680,049 controls. We discover eight novel loci associated with SCC, confirm all previously associated loci, and perform fine mapping of causal variants. The novel SNPs occur within skin-specific regulatory elements and implicate loci involved in cancer development, immune regulation, and keratinocyte differentiation in SCC susceptibility
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