456 research outputs found
Identifying sources of antibiotic resistance genes in the environment using the microbial Find, Inform, and Test framework
Introduction: Antimicrobial resistance (AMR) is an increasing public health concern for humans, animals, and the environment. However, the contributions of spatially distributed sources of AMR in the environment are not well defined. Methods: To identify the sources of environmental AMR, the novel microbial Find, Inform, and Test (FIT) model was applied to a panel of five antibiotic resistance-associated genes (ARGs), namely, erm(B), tet(W), qnrA, sul1, and intI1, quantified from riverbed sediment and surface water from a mixed-use region. Results: A one standard deviation increase in the modeled contributions of elevated AMR from bovine sources or land-applied waste sources [land application of biosolids, sludge, and industrial wastewater (i.e., food processing) and domestic (i.e., municipal and septage)] was associated with 34â80% and 33â77% increases in the relative abundances of the ARGs in riverbed sediment and surface water, respectively. Sources influenced environmental AMR at overland distances of up to 13 km. Discussion: Our study corroborates previous evidence of offsite migration of microbial pollution from bovine sources and newly suggests offsite migration from land-applied waste. With FIT, we estimated the distance-based influence range overland and downstream around sources to model the impact these sources may have on AMR at unsampled sites. This modeling supports targeted monitoring of AMR from sources for future exposure and risk mitigation efforts
Bailing Out the Milky Way: Variation in the Properties of Massive Dwarfs Among Galaxy-Sized Systems
Recent kinematical constraints on the internal densities of the Milky Way's
dwarf satellites have revealed a discrepancy with the subhalo populations of
simulated Galaxy-scale halos in the standard CDM model of hierarchical
structure formation. This has been dubbed the "too big to fail" problem, with
reference to the improbability of large and invisible companions existing in
the Galactic environment. In this paper, we argue that both the Milky Way
observations and simulated subhalos are consistent with the predictions of the
standard model for structure formation. Specifically, we show that there is
significant variation in the properties of subhalos among distinct host halos
of fixed mass and suggest that this can reasonably account for the deficit of
dense satellites in the Milky Way. We exploit well-tested analytic techniques
to predict the properties in a large sample of distinct host halos with a
variety of masses spanning the range expected of the Galactic halo. The
analytic model produces subhalo populations consistent with both Via Lactea II
and Aquarius, and our results suggest that natural variation in subhalo
properties suffices to explain the discrepancy between Milky Way satellite
kinematics and these numerical simulations. At least ~10% of Milky Way-sized
halos host subhalo populations for which there is no "too big to fail" problem,
even when the host halo mass is as large as M_host = 10^12.2 h^-1 M_sun.
Follow-up studies consisting of high-resolution simulations of a large number
of Milky Way-sized hosts are necessary to confirm our predictions. In the
absence of such efforts, the "too big to fail" problem does not appear to be a
significant challenge to the standard model of hierarchical formation.
[abridged]Comment: 12 pages, 3 figures; accepted by JCAP. Replaced with published
versio
Dark Energy from structure: a status report
The effective evolution of an inhomogeneous universe model in any theory of
gravitation may be described in terms of spatially averaged variables. In
Einstein's theory, restricting attention to scalar variables, this evolution
can be modeled by solutions of a set of Friedmann equations for an effective
volume scale factor, with matter and backreaction source terms. The latter can
be represented by an effective scalar field (`morphon field') modeling Dark
Energy.
The present work provides an overview over the Dark Energy debate in
connection with the impact of inhomogeneities, and formulates strategies for a
comprehensive quantitative evaluation of backreaction effects both in
theoretical and observational cosmology. We recall the basic steps of a
description of backreaction effects in relativistic cosmology that lead to
refurnishing the standard cosmological equations, but also lay down a number of
challenges and unresolved issues in connection with their observational
interpretation.
The present status of this subject is intermediate: we have a good
qualitative understanding of backreaction effects pointing to a global
instability of the standard model of cosmology; exact solutions and
perturbative results modeling this instability lie in the right sector to
explain Dark Energy from inhomogeneities. It is fair to say that, even if
backreaction effects turn out to be less important than anticipated by some
researchers, the concordance high-precision cosmology, the architecture of
current N-body simulations, as well as standard perturbative approaches may all
fall short in correctly describing the Late Universe.Comment: Invited Review for a special Gen. Rel. Grav. issue on Dark Energy, 59
pages, 2 figures; matches published versio
Qualitative theory testing as mixed-method research
While the concept of mixed-methods research is more usually associated with combining quantitative and qualitative approaches, this paper outlines a study that mixed methods by undertaking qualitative theory testing and derivation when examining the relationship between health promotion theory and hospital nursing practice. Thus, it is concerned with relating the metatheoretical aspects of the debate and not with the pragmatic aspects of the research and concomitant methods. A deductiveâinductiveâdeductive design, based on the theoryâresearchâtheory strategy of Meleis (1985), tested, revised and developed for nursing established health promotion theory using theory-testing criteria. To complement the methodological mix, the study also used the theory (i.e. a health-promotion taxonomy) as a framework to contextualise the findings rather than generate theory in the way associated with interpretative inquiry. While inconsistent with the traditional view linking theory testing with quantitative, objective epistemology, the process enabled a theoretically robust health-promotion taxonomy to be synthesised and advanced for use in nursing in relation to a paradigm of social thought
Reply to editorial and commentaries on Steele, Al-Mufti, Augustyn, Chandrajith, Coghlan, Coulson et al. (2018) "Cause of Cambrian explosion - Terrestrial or cosmic?"
No abstract availabl
Reply to commentary by R Duggleby (2019)
Duggleby (2018) has made a numerical analysis of some aspects of the wide range of phenomena we reviewed in Steele et al. (2018) and asserted " .that panspermia as proposed by Steele et al. (2018) is extremely implausible.â It seems to us that Duggleby has based his viewpoint on a quite narrow and specific model of Panspermia which he supposes to be active in the cosmos. Here we address both his conclusions and his numerical analysis. Our response therefore will be at two levels, his specific analysis and his general conclusions. In the specific section below we show that while Duggleby's numerical analysis appears in part correct it is, in the final analysis, quite irrelevant to Cosmic Panspermia. In the general response which follows we address his unsupported conclusion throughout his critique, namely that ⊠" none of the examples mentioned by Steele et al. (2018) is decisive enough to allow no other explanation.
The Plasma Environment of Comets
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138863/1/rog199129s2976.pd
Star clusters near and far; tracing star formation across cosmic time
© 2020 Springer-Verlag. The final publication is available at Springer via https://doi.org/10.1007/s11214-020-00690-x.Star clusters are fundamental units of stellar feedback and unique tracers of their host galactic properties. In this review, we will first focus on their constituents, i.e.\ detailed insight into their stellar populations and their surrounding ionised, warm, neutral, and molecular gas. We, then, move beyond the Local Group to review star cluster populations at various evolutionary stages, and in diverse galactic environmental conditions accessible in the local Universe. At high redshift, where conditions for cluster formation and evolution are more extreme, we are only able to observe the integrated light of a handful of objects that we believe will become globular clusters. We therefore discuss how numerical and analytical methods, informed by the observed properties of cluster populations in the local Universe, are used to develop sophisticated simulations potentially capable of disentangling the genetic map of galaxy formation and assembly that is carried by globular cluster populations.Peer reviewedFinal Accepted Versio
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