13 research outputs found
Correlation functions in a c=1 boundary conformal field theory
We obtain exact results for correlation functions of primary operators in the
two-dimensional conformal field theory of a scalar field interacting with a
critical periodic boundary potential. Amplitudes involving arbitrary bulk
discrete primary fields are given in terms of SU(2) rotation coefficients while
boundary amplitudes involving discrete boundary fields are independent of the
boundary interaction. Mixed amplitudes involving both bulk and boundary
discrete fields can also be obtained explicitly. Two- and three-point boundary
amplitudes involving fields at generic momentum are determined, up to
multiplicative constants, by the band spectrum in the open-string sector of the
theory.Comment: 33 pages, 6 figure
Tall tales from de Sitter space II: Field theory dualities
We consider the evolution of massive scalar fields in (asymptotically) de
Sitter spacetimes of arbitrary dimension. Through the proposed dS/CFT
correspondence, our analysis points to the existence of new nonlocal dualities
for the Euclidean conformal field theory. A massless conformally coupled scalar
field provides an example where the analysis is easily explicitly extended to
'tall' background spacetimes.Comment: 31 pages, 2 figure
A new twist on dS/CFT
We stress that the dS/CFT correspondence should be formulated using unitary
principal series representations of the de Sitter isometry group/conformal
group, rather than highest-weight representations as originally proposed. These
representations, however, are infinite-dimensional, and so do not account for
the finite gravitational entropy of de Sitter space in a natural way. We then
propose to replace the classical isometry group by a q-deformed version. This
is carried out in detail for two-dimensional de Sitter and we find that the
unitary principal series representations deform to finite-dimensional unitary
representations of the quantum group. We believe this provides a promising
microscopic framework to account for the Bekenstein-Hawking entropy of de
Sitter space.Comment: 21 pages, revtex, v2 references adde
Boundary Liouville theory at c=1
The c=1 Liouville theory has received some attention recently as the
Euclidean version of an exact rolling tachyon background. In an earlier paper
it was shown that the bulk theory can be identified with the interacting c=1
limit of unitary minimal models. Here we extend the analysis of the c=1-limit
to the boundary problem. Most importantly, we show that the FZZT branes of
Liouville theory give rise to a new 1-parameter family of boundary theories at
c=1. These models share many features with the boundary Sine-Gordon theory, in
particular they possess an open string spectrum with band-gaps of finite width.
We propose explicit formulas for the boundary 2-point function and for the
bulk-boundary operator product expansion in the c=1 boundary Liouville model.
As a by-product of our analysis we also provide a nice geometric interpretation
for ZZ branes and their relation with FZZT branes in the c=1 theory.Comment: 37 pages, 1 figure. Minor error corrected, slight change in result
(1.6
Of Bounces, Branes and Bounds
Some recent studies have considered a Randall-Sundrum-like brane world
evolving in the background of an anti-de Sitter Reissner-Nordstrom black hole.
For this scenario, it has been shown that, when the bulk charge is
non-vanishing, a singularity-free ``bounce'' universe will always be obtained.
However, for the physically relevant case of a de Sitter brane world, we have
recently argued that, from a holographic (c-theorem) perspective, such brane
worlds may not be physically viable. In the current paper, we reconsider the
validity of such models by appealing to the so-called ``causal entropy bound''.
In this framework, a paradoxical outcome is obtained: these brane worlds are
indeed holographically viable, provided that the bulk charge is not too small.
We go on to argue that this new finding is likely the more reliable one.Comment: 15 pages, Revtex; references added and very minor change
Reissner-Nordstrom-de Sitter black hole, planar coordinates and dS/CFT
We discuss the Reissner-Nordstrom-de Sitter black holes in the context of
dS/CFT correspondence by using static and planar coordinates. The boundary
stress tensor and the mass of the solutions are computed. Also, we investigate
how the RG flow is changed for different foliations. The Kastor-Traschen
multi-black hole solution is considered as well as AdS counterparts of these
configurations. In particular, we find that in planar coordinates the black
holes appear like punctures in the dual boundary theory.Comment: 30 pages, 3 eps figures, JHEP style v2: new references added,
misprints correcte
Dwelling on de Sitter
A careful reduction of the three-dimensional gravity to the Liouville
description is performed, where all gauge fixing and on-shell conditions come
from the definition of asymptotic de Sitter spaces. The roles of both past and
future infinities are discussed and the conditions space-time evolution imposes
on both Liouville fields are explicited. Space-times which correspond to
non-equivalent profiles of the Liouville field at past and future infinities
are shown to exist. The qualitative implications of this for any tentative dual
theory are presented.Comment: RevTeX 4, 8 pages, v3: Small clarifications on sections III and IV
and references added/corrected, v4: typo
Nebulised racemic adrenaline in the treatment of acute bronchiolitis in infants and toddlers.
Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility.
Contains fulltext :
80628.pdf (publisher's version ) (Closed access)We report a prostate cancer genome-wide association follow-on study. We discovered four variants associated with susceptibility to prostate cancer in several European populations: rs10934853[A] (OR = 1.12, P = 2.9 x 10(-10)) on 3q21.3; two moderately correlated (r2 = 0.07) variants, rs16902094[G] (OR = 1.21, P = 6.2 x 10(-15)) and rs445114[T] (OR = 1.14, P = 4.7 x 10(-10)), on 8q24.21; and rs8102476[C] (OR = 1.12, P = 1.6 x 10(-11)) on 19q13.2. We also refined a previous association signal on 11q13 with the SNP rs11228565[A] (OR = 1.23, P = 6.7 x 10(-12)). In a multivariate analysis using 22 prostate cancer risk variants typed in the Icelandic population, we estimated that carriers in the top 1.3% of the risk distribution are at a 2.5 times greater risk of developing the disease than members of the general population
Genetic correction of PSA values using sequence variants associated with PSA levels.
Item does not contain fulltextMeasuring serum levels of the prostate-specific antigen (PSA) is the most common screening method for prostate cancer. However, PSA levels are affected by a number of factors apart from neoplasia. Notably, around 40% of the variability of PSA levels in the general population is accounted for by inherited factors, suggesting that it may be possible to improve both sensitivity and specificity by adjusting test results for genetic effects. To search for sequence variants that associate with PSA levels, we performed a genome-wide association study and follow-up analysis using PSA information from 15,757 Icelandic and 454 British men not diagnosed with prostate cancer. Overall, we detected a genome-wide significant association between PSA levels and single-nucleotide polymorphisms (SNPs) at six loci: 5p15.33 (rs2736098), 10q11 (rs10993994), 10q26 (rs10788160), 12q24 (rs11067228), 17q12 (rs4430796), and 19q13.33 [rs17632542 (KLK3: I179T)], each with P(combined) <3 x 10(-10). Among 3834 men who underwent a biopsy of the prostate, the 10q26, 12q24, and 19q13.33 alleles that associate with high PSA levels are associated with higher probability of a negative biopsy (odds ratio between 1.15 and 1.27). Assessment of association between the six loci and prostate cancer risk in 5325 cases and 41,417 controls from Iceland, the Netherlands, Spain, Romania, and the United States showed that the SNPs at 10q26 and 12q24 were exclusively associated with PSA levels, whereas the other four loci also were associated with prostate cancer risk. We propose that a personalized PSA cutoff value, based on genotype, should be used when deciding to perform a prostate biopsy