322 research outputs found
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In-Situ Preheating in Hybrid Layered Manufacturing for Tooling Elements
Solidification cracking of hard materials such as H13 tool steel is one of the major
problems in metal based Additive Manufacturing (AM) processes. Hybrid Layered
Manufacturing (HLM) is one of the metal based AM process which uses Metal Inert Gas (MIG)
cladding for addition and CNC milling for subtraction of material. In this work, an in-situ
induction heating based preheating system has been developed to solve the solidification
cracking problem. The Tungsten Inert Gas (TIG) and Induction heating methods are compared
and it has been found that the induction based preheating system can produce better
microstructure and sound products. In the experimental procedure, before deposition of a layer
the prebuild layer is preheated up to 350-5000C. Also the effect of in-situ preheating on the
microstructure of the deposited layers have been studied using Scanning Electron Microscope
(SEM).Mechanical Engineerin
Plasmacytoma of Bronchus Treated by Radical Radiotherapy-A Rare Case with Four and a Half Years Follow up
AbstractPlasmacytoma of the bronchus is a very rare plasma cell neoplasm affecting the bronchus. Here we report a case of plasmacytoma of the bronchus treated by radical radiotherapy in July 2002. The tumor responded very well to treatment and showed a slow but sustained regression in the size over two years. Presently, he has completed four and a half years of follow-up and is free of disease
Comprehensive characterization and validation of chromosome-specific highly polymorphic SSR Markers from Pomegranate (Punica granatum L.) cv. Tunisia Genome
The simple sequence repeat (SSR) survey of ‘Tunisia’ genome (296.85 Mb) identified a total of 365,279 perfect SSRs spanning eight chromosomes, with a mean marker density of 1,230.6 SSRs/Mb. We found a positive trend in chromosome length and the SSR abundance as marker density enhanced with a shorter chromosome length. The highest number of SSRs (60,708) was mined from chromosome 1 (55.56 Mb), whereas the highest marker density (1,294.62 SSRs/Mb) was recorded for the shortest chromosome 8 (27.99 Mb). Furthermore, we categorized all SSR motifs into three major classes based on their tract lengths. Across the eight chromosomes, the class III had maximum number of SSR motifs (301,684, 82.59%), followed by the class II (31,056, 8.50%) and the class I (5,003, 1.37%). Examination of the distribution of SSR motif types within a chromosome suggested the abundance of hexanucleotide repeats in each chromosome followed by dinucleotides, and these results are consistent with ‘Tunisia’ genome features as a whole. Concerning major repeat types, AT/AG was the most frequent (14.16%), followed by AAAAAT/AAAAAG (7.89%), A/C (7.54%), AAT/AAG (5.23%), AAAT/AAAG (4.37%), and AAAAT/AAAAG (1.2%) types. We designed and validated a total of 3,839 class I SSRs in the ‘Tunisia’ genome through electronic polymerase chain reaction (ePCR) and found 1,165 (30.34%) SSRs producing a single amplicon. Then, we selected 906 highly variable SSRs (> 40 nt) from the ePCR-verified class I SSRs and in silico validated across multiple draft genomes of pomegranate, which provided us a subset of 265 highly polymorphic SSRs. Of these, 235 primers were validated on six pomegranate genotypes through wet-lab experiment. We found 221 (94%) polymorphic SSRs on six genotypes, and 187 of these SSRs had ≥ 0.5 PIC values. The utility of the developed SSRs was demonstrated by analyzing genetic diversity of 30 pomegranate genotypes using 16 HvSSRs spanning eight pomegranate chromosomes. In summary, we developed a comprehensive set of highly polymorphic genome-wide SSRs. These chromosome-specific SSRs will serve as a powerful genomic tool to leverage future genetic studies, germplasm management, and genomics-assisted breeding in pomegranate
Magnetic moments of the low-lying , resonances within the framework of the chiral quark model
The magnetic moments of the low-lying spin-parity ,
resonances, like, for example, ,
, as well as their transition magnetic moments, are
calculated using the chiral quark model. The results found are compared with
those obtained from the nonrelativistic quark model and those of unitary chiral
theories, where some of these states are generated through the dynamics of two
hadron coupled channels and their unitarization
Analytical time-like geodesics
Time-like orbits in Schwarzschild space-time are presented and classified in
a very transparent and straightforward way into four types. The analytical
solutions to orbit, time, and proper time equations are given for all orbit
types in the form r=r(\lambda), t=t(\chi), and \tau=\tau(\chi), where \lambda\
is the true anomaly and \chi\ is a parameter along the orbit. A very simple
relation between \lambda\ and \chi\ is also shown. These solutions are very
useful for modeling temporal evolution of transient phenomena near black holes
since they are expressed with Jacobi elliptic functions and elliptic integrals,
which can be calculated very efficiently and accurately.Comment: 15 pages, 10 figures, accepted by General Relativity and Gravitatio
Rare variants in optic disc area gene CARD10 enriched in primary open-angle glaucoma
Background: Genome-wide association studies (GWAS) have identified association of common alleles with primary open-angle glaucoma (POAG) and its quantitative endophenotypes near numerous genes. This study aims to determine whether rare pathogenic variants in these disease-associated genes contribute to POAG. Methods: Participants fulfilled strict inclusion criteria of advanced POAG at a young age of diagnosis. Myocilin mutation carriers were excluded using direct sequencing. Whole exome sequencing was performed on 187 glaucoma cases and 103 local screened nonglaucoma controls then joint-called with exomes of 993 previously sequenced Australian controls. GWAS-associated genes were assessed for enrichment of rare predicted pathogenic variants in POAG. Significantly enriched genes were compared against Exome Aggregation Consortium (ExAC) public control. Results: Eighty-six GWAS disease or trait-associated glaucoma genes were captured and sequenced. CARD10 showed enrichment after Bonferroni correction for rare variants in glaucoma cases (OR = 13.2, P = 6.94 × 10−5) with mutations identified in 4.28% of our POAG cohort compared to 0.27% in controls. CARD10 was significantly associated with optic disc parameters in previous GWAS. The whole GWAS gene set showed no enrichment in POAG overall (OR = 1.12, P = 0.51). Conclusion: We report here an enrichment of rare predicted pathogenic coding variants within a GWAS-associated locus in POAG (CARD10). These findings indicate that both common and rare pathogenic coding variants in CARD10 may contribute to POAG pathogenesis.Tiger Zhou, Emmanuelle Souzeau, Shiwani Sharma, Owen M. Siggs, Ivan Goldberg, Paul R. Healey, Stuart Graham, Alex W. Hewitt, David A. Mackey, Robert J. Casson, John Landers, Richard Mills, Jonathan Ellis, Paul Leo, Matthew A. Brown, Stuart MacGregor, Kathryn P. Burdon and Jamie E. Crai
Magnetic moments of the low-lying {1/2}^- octet baryon resonances
The magnetic moments of the negative parity octet resonances with spin {1/2}:
(1535), (1650), (1620), and (1690) have been
calculated within the framework of the chiral constituent quark model. In this
approach, the presence of the polarized pairs (or the meson cloud,
in other words) is considered by using the Lagrangian for Goldstone boson
emission from the constituent quarks. Further, the explicit contributions
coming from the spin and orbital angular momentum, including the effects of the
configurations mixing between the states with different spins, are obtained.
The motivation for these calculations comes from the recent interest in
experimental measurement of the magnetic moment of the
resonance and of similar calculations being done within lattice quantum
chromodynamics approaches. Our results can be compared with those expected to
come from these sources.Comment: 17 pages, 2 table
Accessing health services in India: Experiences of seasonal migrants returning to Nepal.
Background: Migration to India is a common livelihood strategy for poor people in remote Western Nepal. To date, little research has explored the degree and nature of healthcare access among Nepali migrant workers in India. This study explores the experiences of returnee Nepali migrants with regard to accessing healthcare and the perspectives of stakeholders in the government, support organizations, and health providers working with migrant workers in India. Methods: Six focus group discussions (FGDs) and 12 in-depth interviews with returnee migrants were conducted by trained moderators in six districts in Western Nepal in late 2017. A further 12 stakeholders working in the health and education sector were also interviewed. With the consent of the participants, FGDs and interviews were audio-recorded. They were then transcribed and translated into English and the data were analysed thematically. Results: The interviewed returnee migrants worked in 15 of India’s 29 states, most as daily-wage labourers. Most were from among the lowest castes so called-Dalits. Most migrants had had difficulty accessing healthcare services in India. The major barriers to access were the lack of insurance, low wages, not having an Indian identification card tied to individual biometrics so called: Aadhaar card. Other barriers were unsupportive employers, discrimination at healthcare facilities and limited information about the locations of healthcare services. Conclusions: Nepali migrants experience difficulties in accessing healthcare in India. Partnerships between the Nepali and Indian governments, migrant support organizations and relevant stakeholders such as healthcare providers, government agencies and employers should be strengthened so that this vulnerable population can access the healthcare they are entitled to
Does technology and Innovation Management improve Market Position? Empirical Evidence from Innovating Firms in South Africa
There is a growing recognition of the central role of technology and knowledge management for market success of organizations. Little is empirically know, however, about this relationship. Drawing on the South African Innovation Survey, a unique dataset on innovative behavior of South African firms in manufacturing and services, this paper investigates the question to what extent and in which ways do technology and innovation management activities affect firms’ market position. Findings show that conducting technology strategy activities pays out. Moreover, especially a combination of internal and external technology audits seems to be beneficial for organizational performance
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