IN-SYNC. V. Stellar Kinematics and Dynamics in the Orion A Molecular Cloud

Interstellar matter and star formatio

Young and Intermediate-age Distance Indicators

Distance measurements beyond geometrical and semi-geometrical methods, rely mainly on standard candles. As the name suggests, these objects have known luminosities by virtue of their intrinsic proprieties and play a major role in our understanding of modern cosmology. The main caveats associated with standard candles are their absolute calibration, contamination of the sample from other sources and systematic uncertainties. The absolute calibration mainly depends on their chemical composition and age. To understand the impact of these effects on the distance scale, it is essential to develop methods based on different sample of standard candles. Here we review the fundamental properties of young and intermediate-age distance indicators such as Cepheids, Mira variables and Red Clump stars and the recent developments in their application as distance indicators.Comment: Review article, 63 pages (28 figures), Accepted for publication in Space Science Reviews (Chapter 3 of a special collection resulting from the May 2016 ISSI-BJ workshop on Astronomical Distance Determination in the Space Age

SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination

BACKGROUND: Most studies of immunity to SARS-CoV-2 focus on circulating antibody, giving limited insights into mucosal defences that prevent viral replication and onward transmission. We studied nasal and plasma antibody responses one year after hospitalisation for COVID-19, including a period when SARS-CoV-2 vaccination was introduced. METHODS: In this follow up study, plasma and nasosorption samples were prospectively collected from 446 adults hospitalised for COVID-19 between February 2020 and March 2021 via the ISARIC4C and PHOSP-COVID consortia. IgA and IgG responses to NP and S of ancestral SARS-CoV-2, Delta and Omicron (BA.1) variants were measured by electrochemiluminescence and compared with plasma neutralisation data. FINDINGS: Strong and consistent nasal anti-NP and anti-S IgA responses were demonstrated, which remained elevated for nine months (p < 0.0001). Nasal and plasma anti-S IgG remained elevated for at least 12 months (p < 0.0001) with plasma neutralising titres that were raised against all variants compared to controls (p < 0.0001). Of 323 with complete data, 307 were vaccinated between 6 and 12 months; coinciding with rises in nasal and plasma IgA and IgG anti-S titres for all SARS-CoV-2 variants, although the change in nasal IgA was minimal (1.46-fold change after 10 months, p = 0.011) and the median remained below the positive threshold determined by pre-pandemic controls. Samples 12 months after admission showed no association between nasal IgA and plasma IgG anti-S responses (R = 0.05, p = 0.18), indicating that nasal IgA responses are distinct from those in plasma and minimally boosted by vaccination. INTERPRETATION: The decline in nasal IgA responses 9 months after infection and minimal impact of subsequent vaccination may explain the lack of long-lasting nasal defence against reinfection and the limited effects of vaccination on transmission. These findings highlight the need to develop vaccines that enhance nasal immunity. FUNDING: This study has been supported by ISARIC4C and PHOSP-COVID consortia. ISARIC4C is supported by grants from the National Institute for Health and Care Research and the Medical Research Council. Liverpool Experimental Cancer Medicine Centre provided infrastructure support for this research. The PHOSP-COVD study is jointly funded by UK Research and Innovation and National Institute of Health and Care Research. The funders were not involved in the study design, interpretation of data or the writing of this manuscript

Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

One in ten severe acute respiratory syndrome coronavirus 2 infections result in prolonged symptoms termed long coronavirus disease (COVID), yet disease phenotypes and mechanisms are poorly understood1. Here we profiled 368 plasma proteins in 657 participants ≥3 months following hospitalization. Of these, 426 had at least one long COVID symptom and 233 had fully recovered. Elevated markers of myeloid inflammation and complement activation were associated with long COVID. IL-1R2, MATN2 and COLEC12 were associated with cardiorespiratory symptoms, fatigue and anxiety/depression; MATN2, CSF3 and C1QA were elevated in gastrointestinal symptoms and C1QA was elevated in cognitive impairment. Additional markers of alterations in nerve tissue repair (SPON-1 and NFASC) were elevated in those with cognitive impairment and SCG3, suggestive of brain–gut axis disturbance, was elevated in gastrointestinal symptoms. Severe acute respiratory syndrome coronavirus 2-specific immunoglobulin G (IgG) was persistently elevated in some individuals with long COVID, but virus was not detected in sputum. Analysis of inflammatory markers in nasal fluids showed no association with symptoms. Our study aimed to understand inflammatory processes that underlie long COVID and was not designed for biomarker discovery. Our findings suggest that specific inflammatory pathways related to tissue damage are implicated in subtypes of long COVID, which might be targeted in future therapeutic trials

Connecting X-Ray and Infrared Variability Among Young Stellar Objects: Ruling Out Potential Sources of Disk Fluctuations

Variability in the infrared emission from disks around pre-main-sequence stars over the course of days to weeks appears to be common, but the physical cause of the changes in disk structure are not constrained. Here we present coordinated monitoring of one young cluster with the Spitzer and Chandra space telescopes aimed at studying the physical source of the variability. In fall 2011 we obtained 10 epochs of Chandra ACIS photometry over a period of 30 days with a roughly 3 day cadence contemporaneous with 20 epochs of Spitzer [3.6], [4.5] photometry over 40 days with a roughly 2 day cadence of the IC 348 cluster. This cadence allows us to search for week- to month-long responses of the infrared emission to changes in the high-energy flux. We find no strong evidence for a direct link between the X-ray and infrared variability on these timescales among 39 cluster members with circumstellar disks. There is no significant correlation between the shape of the infrared and X-ray light curves or between the sizes of the X-ray and infrared variability. Among the stars with an X-ray flare, none showed evidence of a correlated change in the infrared photometry on timescales of days to weeks following the flare. This lack of connection implies that X-ray heating of the planet-forming region of the disk is not significant, although we cannot rule out rapid or instantaneous changes in infrared emission

Resolving Structure in the Debris Disk around HD 206893 with ALMA

Debris disks are tenuous, dusty belts surrounding main-sequence stars generated by collisions between planetesimals. HD 206893 is one of only two stars known to host a directly imaged brown dwarf orbiting interior to its debris ring, in this case at a projected separation of 10.4 au. Here we resolve structure in the debris disk around HD 206893 at an angular resolution of 0.″6 (24 au) and wavelength of 1.3 mm with the Atacama Large Millimeter/submillimeter Array (ALMA). We observe a broad disk extending from a radius of <51 au to 194-2+13 au. We model the disk with a continuous, gapped, and double power-law model of the surface density profile and find strong evidence for a local minimum in the surface density distribution near a radius of 70 au, consistent with a gap in the disk with an inner radius of 63-16+8 au and width 31-7+11 au. Gapped structure has been observed in four other debris disks - essentially every other radially resolved debris disk observed with sufficient angular resolution and sensitivity with ALMA - and could be suggestive of the presence of an additional planetary-mass companion. © 2021. The American Astronomical Society. All rights reserved.Immediate accessThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]