42 research outputs found

    The Physics of the B Factories

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    Passive Q-switching and mode-locking for the generation of nanosecond to femtosecond pulses

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    Effect of a stepped-care intervention approach on weight loss in adults: A randomized clinical trial

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    10.1001/jama.2012.6866JAMA - Journal of the American Medical Association307242617-2626JAMA

    Predictive value of known and novel alleles ofCYP2B6 for efavirenz plasma concentrations in HIV-infected individuals

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    © 2008 American Society for Clinical Pharmacology and TherapeuticsTo assess the association of CYP2B6 allelic diversity with efavirenz (EFV) pharmacokinetics, we performed extensive genotyping of 15 relevant single nucleotide polymorphism in 169 study participants, and full resequencing of CYP2B6 in individuals with abnormal EFV plasma levels. Seventy-seven (45.5%) individuals carried a known (CYP2B66,11,15, or 18) or new loss/diminished-function alleles. Resequencing defined two new loss-of-function alleles: allele 27 (marked by 593T>C [M198T]), that results in 85% decrease in enzyme activity and allele 28 (marked by 1132C>T), that results in protein truncation at arginine 378. Median AUC levels were 188.5 g h/ml for individuals homozygous for a loss/diminished-function allele, 58.6 g h/ml for carriers, and 43.7 g h/ml for noncarriers (P<0.0001). Individuals with a poor metabolizer genotype had a likelihood ratio of 35 (95% CI, 11–110) of presenting very high EFV plasma levels. CYP2B6 poor metabolizer genotypes explain to a large extent EFV pharmacokinetics and identify individuals at risk of extremely elevated EFV plasma levels
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