phase i study results from an esophageal squamous cell carcinoma escc cohort treated with m7824 msb0011359c a bifunctional fusion protein targeting transforming growth factor β tgf β and pd l1

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Contains reports on twelve research projects.National Science Foundatio

I-CARE, a European Prospective Cohort Study Assessing Safety and Effectiveness of Biologics in Inflammatory Bowel Disease

Background and aims: There is a need to evaluate the benefit-risk ratio of current therapies in inflammatory bowel disease (IBD) patients to provide the best quality of care. The primary objective of I-CARE (IBD Cancer and serious infections in Europe) was to assess prospectively safety concerns in IBD, with specific focus on the risk of cancer/lymphoma and serious infections in patients treated with anti-tumor necrosis factor and other biologic monotherapy as well as in combination with immunomodulators.. Methods: I-CARE was designed as a European prospective longitudinal observational multicenter cohort study to include patients with a diagnosis of Crohn's disease, ulcerative colitis, or IBD unclassified established at least 3 months prior to enrollment. Results: A total of 10,206 patients were enrolled between March 2016 and April 2019, including 6169 (60.4%) patients with Crohn's disease, 3853 (37.8%) with ulcerative colitis, and 184 (1.8%) with a diagnosis of IBD unclassified. Thirty-two percent of patients were receiving azathioprine/thiopurines, 4.6% 6-mercaptopurine, and 3.2% methotrexate at study entry. At inclusion, 47.3% of patients were treated with an anti-tumor necrosis factor agent, 8.8% with vedolizumab, and 3.4% with ustekinumab. Roughly one-quarter of patients (26.8%) underwent prior IBD-related surgery. Sixty-six percent of patients had been previously treated with systemic steroids. Three percent of patients had a medical history of cancer prior to inclusion and 1.1% had a history of colonic, esophageal, or uterine cervix high-grade dysplasia.. Conclusions: I-CARE is an ongoing investigator-initiated observational European prospective cohort study that will provide unique information on the long-term benefits and risks of biological therapies in IBD patients

A Preoperative Clinical Risk Score Including C-Reactive Protein Predicts Histological Tumor Characteristics and Patient Survival after Surgery for Sporadic Non-Functional Pancreatic Neuroendocrine Neoplasms:An International Multicenter Cohort Study

Background: Oncological survival after resection of pancreatic neuroendocrine neoplasms (panNEN) is highly variable depending on various factors. Risk stratification with preoperatively available parameters could guide decision-making in multidisciplinary treatment concepts. C-reactive Protein (CRP) is linked to inferior survival in several malignancies. This study assesses CRP within a novel risk score predicting histology and outcome after surgery for sporadic non-functional panNENs. Methods: A retrospective multicenter study with national exploration and international validation. CRP and other factors associated with overall survival (OS) were evaluated by multivariable cox-regression to create a clinical risk score (CRS). Predictive values regarding OS, disease-specific survival (DSS), and recurrence-free survival (RFS) were assessed by time-dependent receiver-operating characteristics. Results: Overall, 364 patients were included. Median CRP was significantly higher in patients >60 years, G3, and large tumors. In multivariable analysis, CRP was the strongest preoperative factor for OS in both cohorts. In the combined cohort, CRP (cut-off >= 0.2 mg/dL; hazard-ratio (HR):3.87), metastases (HR:2.80), and primary tumor size >= 3.0 cm (HR:1.83) showed a significant association with OS. A CRS incorporating these variables was associated with postoperative histological grading, T category, nodal positivity, and 90-day morbidity/mortality. Time-dependent area-under-the-curve at 60 months for OS, DSS, and RFS was 69%, 77%, and 67%, respectively (all p <0.001), and the inclusion of grading further improved the predictive potential (75%, 84%, and 78%, respectively). Conclusions: CRP is a significant marker of unfavorable oncological characteristics in panNENs. The proposed internationally validated CRS predicts histological features and patient survival

Inter- and intraobserver reliability of the MTM-classification for proximal humeral fractures: A prospective study

<p>Abstract</p> <p>Background</p> <p>A precise modular topographic-morphological (MTM) classification for proximal humeral fractures may address current classification problems. The classification was developed to evaluate whether a very detailed classification exceeding the analysis of fractured parts may be a valuable tool.</p> <p>Methods</p> <p>Three observers classified plain radiographs of 22 fractures using both a simple version (fracture displacement, number of parts) and an extensive version (individual topographic fracture type and morphology) of the MTM classification. Kappa-statistics were used to determine reliability.</p> <p>Results</p> <p>An acceptable reliability was found for the simple version classifying fracture displacement and fractured main parts. Fair interobserver agreement was found for the extensive version with individual topographic fracture type and morphology.</p> <p>Conclusion</p> <p>Although the MTM-classification covers a wide spectrum of fracture types, our results indicate that the precise topographic and morphological description is not delivering reproducible results. Therefore, simplicity in fracture classification may be more useful than extensive approaches, which are not adequately reliable to address current classification problems.</p

Does fixed-angle plate osteosynthesis solve the problems of a fractured proximal humerus?: A prospective series of 87 patients

Background and purpose There is considerable controversy about the treatment of complex, displaced proximal humeral fractures. Various types of head-preserving osteosynthesis have been suggested. This prospective case series was designed to evaluate the perioperative and early postoperative complications associated with fixed-angle implants and to record outcome after bone healing

Gamma frequency entrainment attenuates amyloid load and modifies microglia

Changes in gamma oscillations (20-50 Hz) have been observed in several neurological disorders. However, the relationship between gamma oscillations and cellular pathologies is unclear. Here we show reduced, behaviourally driven gamma oscillations before the onset of plaque formation or cognitive decline in a mouse model of Alzheimer's disease. Optogenetically driving fast-spiking parvalbumin-positive (FS-PV)-interneurons at gamma (40 Hz), but not other frequencies, reduces levels of amyloid-β (Aβ)[subscript 1-40] and Aβ [subscript 1-42] isoforms. Gene expression profiling revealed induction of genes associated with morphological transformation of microglia, and histological analysis confirmed increased microglia co-localization with Aβ. Subsequently, we designed a non-invasive 40 Hz light-flickering regime that reduced Aβ[subscript 1-40] and Aβ[subscript 1-42] levels in the visual cortex of pre-depositing mice and mitigated plaque load in aged, depositing mice. Our findings uncover a previously unappreciated function of gamma rhythms in recruiting both neuronal and glial responses to attenuate Alzheimer's-disease-associated pathology.National Institutes of Health (U.S.) (Grant 1R01EY023173)National Institutes of Health (U.S.) (Grant 1DP1NS087724)National Institutes of Health (U.S.) (Grant RF1AG047661)National Institutes of Health (U.S.) (Grant ROIGM104948

Another beauty of analytical chemistry: chemical analysis of inorganic pigments of art and archaeological objects

[EN] This lecture text shows what fascinating tasks analytical chemists face in Art Conservation and Archaeology, and it is hoped that students reading it will realize that passions for science, arts or history are by no means mutually exclusive. This study describes the main analytical techniques used since the eighteenth century, and in particular, the instrumental techniques developed throughout the last century for analyzing pigments and inorganic materials, in general, which are found in cultural artefacts, such as artworks and archaeological remains. The lecture starts with a historical review on the use of analytical methods for the analysis of pigments from archaeological and art objects. Three different periods can be distinguished in the history of the application of the Analytical Chemistry in Archaeometrical and Art Conservation studies: (a) the "Formation'' period (eighteenth century1930), (b) the "Maturing'' period (1930-1970), and (c) the "Expansion'' period (1970-nowadays). A classification of analytical methods specifically established in the fields of Archaeometry and Conservation Science is also provided. After this, some sections are devoted to the description of a number of analytical techniques, which are most commonly used in routine analysis of pigments from cultural heritage. Each instrumental section gives the fundamentals of the instrumental technique, together with relevant analytical data and examples of applications.Financial support is gratefully acknowledged from Spanish ‘‘I+D+I MINECO’’ projects CTQ2011-28079-CO3-01 and CTQ2014-53736-C3-1-P supported by ERDEF funds.Domenech Carbo, MT.; Osete Cortina, L. (2016). Another beauty of analytical chemistry: chemical analysis of inorganic pigments of art and archaeological objects. ChemTexts. 2:1-50. https://doi.org/10.1007/s40828-016-0033-5S1502Wilks H (ed) (1987) Science for conservators: a conservation science teaching series. The Conservation Unit Museums and Galleries Commission, LondonSan Andrés Moya M, Viña Ferrer S (2004) Fundamentos de química y física para la conservación y restauración. Síntesis, MadridDoménech-Carbó MT (2013) Principios físico-químicos de los materiales integrantes de los bienes culturales, Universitat Politècnica de ValènciaMills JS, White R (1987) The organic chemistry of museum objects. Butterworths, London, pp 141–159Matteini M, Moles A (1991) La Quimica nel Restauro. I materiali dell’arte pittorica. Nardini, FirenzeGomez MA (1998) La Restauración. Examen científico aplicado a la conservación de obras de arte. Cátedra, MadridTaft WS Jr, Mayer JW (2000) The science of paintings. Springer, New YorkAllen RO (ed) (1989) Archaeological chemistry IV; Advances in chemistry. American Chemical Society, Washington, DCAitken MJ (1990) Science-based dating in archaeology. Longman Archaeology Series, New YorkCiliberto E, Spoto G (eds) (2000) Modern analytical methods in art and archaeology. Wiley, New YorkMatteini M, Moles A (1986) Sciencia e Restauro. Metodi di Indagine, 2nd edn. Nardini, FirenzeOdegaard N, Carroll S, Zimmt W (2000) Material characterization tests for objects of art and archaeology. Archetype Publications, LondonDerrick MR, Stulik DC, Landry MJ (1999) Infrared spectroscopy in conservation science. Getty Conservation Institute, Los AngelesDoménech-Carbó A, Doménech-Carbó MT, Costa V (2009) Electrochemical methods in archaeometry, conservation and restoration. In: Scholz F (ed) Series: Monographs in electrochemistry. Springer, BerlinEdwards HGM, Chalmers JM (eds) (2005) Raman spectroscopy in archaeology and art history. The Royal Society of Chemistry, CambridgeLahanier C (1991) Scientific methods applied to the study of art objects. Mikrochim Acta II:245–254Bitossi G, Giorgi R, Salvadori BM, Dei L (2005) Spectroscopic techniques in cultural heritage conservation: a survey. Appl Spectrosc Rev 40:187–228Odlyha M (2000) Special feature: preservation of cultural heritage. The application of thermal analysis and other advanced analytical techniques to cultural objects. Thermochim Acta 365Feature Special (2003) Archaeometry. Meas Sci Technol 14:1487–1630Aitken MJ (1961) Physics and archaeology. Interscience, New YorkOlin JS (ed) (1982) Future directions in archaeometry. A round table. Smithsonian Institution Press, Washington, DCTownsend JH (2006) What is conservation science? Macromol Symp 238:1–10Nadolny J (2003) The first century of published scientific analyses of the materials of historical painting and polychromy, circa 1780–1880. Rev Conserv 4:39–51Montero Ruiz I, Garcia Heras M, López-Romero E (2007) Arqueometría: cambios y tendencias actuales. Trabajos de Prehistoria 64:23–40Fernandes Vieira G, Sias Coelho LJ (2011) Arqueometría: Mirada histórica de una ciencia en desarrollo. Revista CPC 13:107–133Rees-Jones SG (1990) Early experiments in pigment analysis. Stud Conserv 35:93–101Allen RO (1989) The role of the chemists in archaeological studies. In: Allen RO (ed) Archaeological chemistry IV. Advances in chemistry. American Chemical Society, Washington DC, pp 1–17Plesters J (1956) Cross-sections and chemical analysis of paint samples. Stud Conserv 2:110–157 and references thereinGilberg M (1987) Friedrich Rathgen: the father of modern archaeological conservation. J Am Inst Conserv 26:105–120Olin JS, Salmon ME, Olin CH (1969) Investigations of historical objects utilizing spectroscopy and other optical methods. Appl Optics 8:29–39Feller RL (1954) Dammar and mastic infrared analysis. Science 120:1069–1070Hall ET (1963) Methods of analysis (physical and microchemical) applied to paintings and antiquities. In: Thomson G (ed) Recent advances in conservation. Butterworths, London, pp 29–32Feigl F, Anger V (1972) Spot tests in inorganic analysis, 6th English edition, translated by Oesper RE. Elsevier, AmsterdamLocke DC, Riley OH (1970) Chemical analysis of paint samples using the Weisz ring oven technique. Stud Conserv 15:94–101Mairinger F, Schreiner M (1986) Analysis of supports, grounds and pigments. In: van Schoute R, Verougstracte-Marcq H (eds) PACT 13, Xth Anniversary Meeting of PACT Group. Louvain-la Neuve, pp 171–183 (and references therein)Vandenabeele P, Edwards HGM (2005) Overview: Raman spectrometry of artefacts. In: Edwards HGM, Chalmers JM (eds) Raman spectroscopy in archaeology and art history. The Royal Society of Chemistry, Cambridge, pp 169–178Tykot RH (2004) Scientific methods and applications to archaeological provenance studies. In: Proceedings of the International School of Physics “Enrico Fermi”. IOS Press, Amsterdam, pp 407–432Doménech-Carbó A, Doménech-Carbó MT, Valle-Algarra FM, Domine ME, Osete-Cortina L (2013) On the dehydroindigo contribution to Maya Blue. J Mat Sci 48:7171–7183Lovric M, Scholz F (1997) A model for the propagation of a redox reaction through microcrystals. J Solid State Electrochem 1:108–113Fitzgerald AG, Storey BE, Fabian D (1993) Quantitative microbeam analysis. Scottish Universities Sumer School in Physics and Institute of Physics Publishing, BristolDoménech-Carbó A (2015) Dating: an analytical task. ChemTexts 1:5Mairinger F, Schreiner M (1982) New methods of chemical analysis-a tool for the conservator. Science and Technology in the service of conservation, IIC, London, pp 5–13Malissa H, Benedetti-Pichler AA (1958) Anorganische qualitative Mikroanalyse. Springer, New YorkTertian R, Claisse F (1982) Principles of quantitative X-ray fluorescence analysis. Heyden, LondonMantler M, Schreiner M (2000) X-ray fluorescence spectrometry in art and archaeology. X-Ray Spectrom 29:3–17Scholz F (2015) Voltammetric techniques of analysis: the essentials. ChemTexts 1:17Inzelt G (2014) Crossing the bridge between thermodynamics and electrochemistry. From the potential of the cell reaction to the electrode potential. ChemTexts 1:2Milchev A (2016) Nucleation phenomena in electrochemical systems: thermodynamic concepts. ChemTexts 2:2Milchev A (2016) Nucleation phenomena in electrochemical systems: kinetic models. ChemTexts 2:4Seeber R, Zanardi C, Inzelt G (2015) Links between electrochemical thermodynamics and kinetics. ChemTexts 1:18Feist M (2015) Thermal analysis: basics, applications, and benefit. ChemTexts 1:8Stoiber RE, Morse SA (1994) Crystal identification with the polarizing microscope. Springer, BerlinGoldstein JI, Newbury DE, Echlin P, Joy DC, Lyman CE, Echlin P, Lifshin E, Sawyer L, Michael JR (2003) Scanning electron microscopy and X-ray microanalysis. Plenum Press, New YorkDoménech-Carbó A, Doménech-Carbó MT, Más-Barberá X (2007) Identification of lead pigments in nanosamples from ancient paintings and polychromed sculptures using voltammetry of nanoparticles/atomic force microscopy. Talanta 71:1569–1579Reedy TJ, Reedy ChL (1988) Statistical analysis in art conservation research. The Getty Conservation Institute, Los AngelesEastaugh N, Walsh V, Chaplin T, Siddall R (2004) Pigment compendium, optical microscopy of historical pigments. Elsevier, OxfordFeller RL, Bayard M (1986) Terminology and procedures used in the systematic examination of pigment particles with polarizing microscope. In: Feller RL (ed) Artists’ pigment. A handbook of their history and characteristics, vol 1. National Gallery of Art, Washington, pp 285–298Feller RL (ed) (1986) Artists’ pigment. A handbook of their history and characteristics, vol 1. National Gallery of Art, WashingtonRoy A (ed) (1993) Artists’ pigments. A handbook of their history and characteristics, vol 2. National Gallery of Art, WashingtonFitzHugh EW (ed) (1997) Artists’ pigments. A handbook of their history and characteristics, vol 3. National Gallery of Art, WashingtonBerrie BH (ed) (2007) Artists’ pigment. A handbook of their history and characteristics, vol 4. National Gallery of Art, WashingtonHaynes WN (ed) (2015) CRC handbook for physics and chemistry, 96th edn. Taylor and Francis Group, UKFiedler I, Bayard MA (1986) Cadmium yellows, oranges and reds. In: Feller RL (ed) Artists’ pigment. A handbook of their history and characteristics, vol 1. National Gallery of Art, Washington, pp 65–108Domenech-Carbó MT, de Agredos Vazquez, Pascual ML, Osete-Cortina L, Domenech A, Guasch-Ferré N, Manzanilla LR, Vidal C (2012) Characterization of Pre-hispanic cosmetics found in a burial of the ancient city of Teotihuacan (Mexico). J Archaeol Sci 39:1043–1062Mühlethaler B, Thissen J (1993) Smalt. In: Roy A (ed) Artists’ pigments. A handbook of their history and characteristics, vol 2. National Gallery of Art, Washington, pp 113–130Musumarra G, Fichera M (1998) Chemometrics and cultural heritage. Chemometr Intell Lab Syst 44:363–372Hochleitner B, Schreiner M, Drakopoulos M, Snigireva I, Snigirev A (2005) Analysis of paint layers by light microscopy, scanning electron microscopy and synchrotron induced X-ray micro-diffraction. In: Van Grieken R, Janssens K (eds) Cultural heritage conservation and environment impact assessment by non-destructive testing and micro-analysis. AA Balkema Publishers, London, pp 171–182Švarcová S, Kočí E, Bezdička P, Hradil D, Hradilová J (2010) Evaluation of laboratory powder X-ray micro-diffraction for applications in the fields of cultural heritage and forensic science. Anal Bioanal Chem 398:1061–1076Van de Voorde L, Vekemans B, Verhaeven E, Tack P, DeWolf R, Garrevoet J, Vandenabeele P, Vincze L (2015) Analytical characterization of a new mobile X-ray fluorescence and X-ray diffraction instrument combined with a pigment identification case study. Spectrochim Acta B 110:14–19Hochleitner B, Desnica V, Mantler M, Schreiner M (2003) Historical pigments: a collection analyzed with X-ray diffraction analysis and X-ray fluorescence analysis in order to create a database. Spectrochim Acta B 58:641–649Middleton PS, Ospitali F, Di Lonardo F (2005) Case study: painters and decorators: Raman spectroscopic studies of five Romano-British villas and the Domus Coiedii at Suasa, Italy. In: Edwards HGM, Chalmers JM (eds) Raman spectroscopy in archaeology and art history. The Royal Society of Chemistry, Cambridge, pp 97–120Helwig K (1993) Iron oxide pigments: natural and synthetic. In: Roy A (ed) Artists’ pigments. A handbook of their history and characteristics, vol 2. National Gallery of Art, Washington, pp 39–95Silva CE, Silva LP, Edwards HGM, de Oliveira LFC (2006) Diffuse reflection FTIR spectral database of dyes and pigments. Anal Bioanal Chem 386:2183–2191Hummel DO (ed) (1985) Atlas of polymer and plastic analysis, vol 1, Polymers, structures and spectra. Hanser VCH, Münichhttp://www.irug.org (consulted: 1 Feb 2016)http://www.ehu.es/udps/database/database.html (consulted: 1 Feb 2016)Burgio L, Clark RJH (2001) Library of FT-Raman spectra of pigments, minerals, pigment media and varnishes, and supplement to existing library of Raman spectra of pigments with visible excitation. Spectrochim Acta A 57:1491–1521http://www.chem.ucl.ac.uk/resources/raman/speclib.html (consulted: 1 Feb 2016)Madariaga JM, Bersani D (2012) Special feature: Raman spectroscopy in art and archaeology. J Raman Spectrosc 43(11):1523–1844http://minerals.gps.caltech.edu/ (consulted: 1 Feb 2016)http://www.rruff.info (consulted: 1 Feb 2016)Frost RL, Martens WN, Rintoul L, Mahmutagic E, Kloprogge JT (2002) J Raman Spectrosc 33:252–259Smith D (2005) Overwiew: jewellery and precious stones. In: Edwards HGM, Chalmers JM (eds) Raman spectroscopy in archaeology and art history. The Royal Society of Chemistry, Cambridge, pp 335–378Weiner S, Bar-Yosef O (1990) States of preservation of bones from prehistoric sites in the Near East: a survey. J Archaeol Sci 17:187–196Chu V, Regev L, Weiner S, Boaretto E (2008) Differentiating between anthropogenic calcite in plaster, ash and natural calcite using infrared spectroscopy: implications in archaeology. J Archaeol Sci 35:905–911Beniash E, Aizenberg J, Addadi L, Weiner S (1997) Amorphous calcium carbonate transforms into calcite during sea-urchin larval spicule growth. Proc R Soc Lond Ser B 264:461–465Regev L, Poduska KM, Addadi L, Weiner S, Boaretto E (2010) Distinguishing between calcites formed by different mechanisms using infrared spectrometry: archaeological applications. J Archaeol Sci 37:3022–3029Farmer C (ed) (1974) The infrared spectra of mineral, Monograph 4. Mineralogical Society, LondonMadejová J, Kečkéš J, Pálková H, Komadel P (2002) Identification of components in smectite/kaolinite mixtures. Clay Miner 37:377–388Šucha V, Środoń J, Clauer N, Elsass F, Eberl DD, Kraus I, Madejová J (2001) Weathering of smectite and illite–smectite under temperate climatic conditions. Clay Miner 36:403–419Doménech-Carbó A, Doménech-Carbó MT, López-López F, Valle-Algarra FM, Osete-Cortina L, Arcos-Von Haartman E (2013) Electrochemical characterization of egyptian blue pigment in wall paintings using the voltammetry of microparticles methodology. Electroanalysis 25:2621–2630Doménech-Carbó MT, Edwards HGM, Doménech-Carbó A, del Hoyo-Meléndez JM, de la Cruz-Cañizares J (2012) An authentication case study: Antonio Palomino vs. Vicente Guillo paintings in the vaulted ceiling of the Sant Joan del Mercat church (Valencia, Spain). J Raman Spectrosc 43:1250–1259Lovric M, Scholz F (1999) A model for the coupled transport of ions and electrons in redox conductive microcrystals. J Solid State Electrochem 3:172–175Oldham KB (1998) Voltammetry at a three phase junction. J Solid State Electrochem 2:367–377Doménech A, Doménech-Carbó MT, Gimeno-Adelantado JV, Bosch-Reig F, Saurí-Peris MC, Sánchez-Ramos S (2001) Electrochemical identification of iron oxide pigments (earths) from pictorial microsamples attached to graphite/polyester composite electrodes. Analyst 126:1764–1772Doménech A, Doménech-Carbó MT, Moya-Moreno MCM, Gimeno-Adelantado JV, Bosch-Reig F (2000) Identification of inorganic pigments from paintings and polychromed sculptures immobilized into polymer film electrodes by stripping differential pulse voltammetry. Anal Chim Acta 407:275–289Doménech-Carbó A, Doménech-Carbó MT, Valle-Algarra FM, Gimeno-Adelantado JV, Osete-Cortina L, Bosch-Reig F (2016) On-line database of voltammetric data of immobilized particles for identifying pigments and minerals in archaeometry, conservation and restoration (ELCHER database). Anal Chim Acta 927:1–12http://www.elcher.info (consulted: 1 July 2016)Scholz F, Doménech-Carbó A (2010) Special feature: electrochemistry for conservation science. J Solid State Electrochem 14Domenech-Carbó A, Domenech-Carbó MT, Edwards HGM (2007) Identification of earth pigment by hierarchical cluster applied to solid state voltammetry. Application to a severely damaged frescoes. Electroanalysis 19:1890–1900Domenech-Carbó A, Domenech-Carbó MT, Vázquez de Agredos-Pascual ML (2006) Dehydroindigo: a new piece into the Maya Blue puzzle from the voltammetry of microparticles approach. J Phys Chem B 110:6027–6039Doménech-Carbó A, Doménech-Carbó MT, Vázquez de Agredos-Pascual ML (2007) Chemometric study of Maya Blue from the voltammetry of microparticles approach. Anal Chem 79:2812–2821Doménech-Carbó A, Doménech-Carbó MT, Vázquez de Agredos-Pascual ML (2011) From Maya Blue to ‘Maya Yellow’: a connection between ancient nanostructured materials from the voltammetry of microparticles. Angew Chem Int Edit 50:5741–5744Doménech-Carbó A, Doménech-Carbó MT, Vidal-Lorenzo C, Vázquez de Agredos-Pascual ML (2012) Insights into the Maya Blue Technology: greenish pellets from the ancient city of La Blanca. Angew Chem Int Ed 51:700–703Doménech-Carbó A, Doménech-Carbó MT, Osete-Cortina L, Montoya N (2012) Application of solid-state electrochemistry techniques to polyfunctional organic-inorganic hybrid materials: the Maya Blue problem. Micropor Mesopor Mater 166:123–130Doménech-Carbó MT, Osete-Cortina L, Doménech-Carbó A, Vázquez de Agredos-Pascual ML, Vidal-Lorenzo C (2014) Identification of indigoid compounds present in archaeological Maya blue by pyrolysis-silylation-gas chromatography–mass spectrometry. J Anal Appl Pyrol 105:355–36