Involvement of glomerular renin−angiotensin system (RAS) activation in the development and progression of glomerular injury

Recently, there has been a paradigm shift away from an emphasis on the role of the endocrine (circulating) renin−angiotensin system (RAS) in the regulation of the sodium and extracellular fluid balance, blood pressure, and the pathophysiology of hypertensive organ damage toward a focus on the role of tissue RAS found in many organs, including kidney. A tissue RAS implies that RAS components necessary for the production of angiotensin II (Ang II) reside within the tissue and its production is regulated within the tissue, independent of the circulating RAS. Locally produced Ang II plays a role in many physiological and pathophysiological processes such as hypertension, inflammation, oxidative stress, and tissue fibrosis. Both glomerular and tubular compartments of the kidney have the characteristics of a tissue RAS. The purpose of this article is to review the recent advances in tissue RAS research with a particular focus on the role of the glomerular RAS in the progression of renal disease

The production deployment of IPv6 on WLCG

The world is rapidly running out of IPv4 addresses; the number of IPv6 end systems connected to the internet is increasing; WLCG and the LHC experiments may soon have access to worker nodes and/or virtual machines (VMs) possessing only an IPv6 routable address. The HEPiX IPv6 Working Group has been investigating, testing and planning for dual-stack services on WLCG for several years. Following feedback from our working group, many of the storage technologies in use on WLCG have recently been made IPv6-capable. This paper presents the IPv6 requirements, tests and plans of the LHC experiments together with the tests performed on the group\u27s IPv6 test-bed. This is primarily aimed at IPv6-only worker nodes or VMs accessing several different implementations of a global dual-stack federated storage service. Finally the plans for deployment of production dual-stack WLCG services are presented

Elevation of the antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline: a blood pressure-independent beneficial effect of angiotensin I-converting enzyme inhibitors

Blockade of the renin-angiotensin system (RAS) is well recognized as an essential therapy in hypertensive, heart, and kidney diseases. There are several classes of drugs that block the RAS; these drugs are known to exhibit antifibrotic action. An analysis of the molecular mechanisms of action for these drugs can reveal potential differences in their antifibrotic roles. In this review, we discuss the antifibrotic action of RAS blockade with an emphasis on the potential importance of angiotensin I-converting enzyme (ACE) inhibition associated with the antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP)

Studying young recipients of alcohol marketing : Two research paradigms and their possible consolidation

Peer reviewe

Problematizations in alcohol policy: WHO's "alcohol problems"

This article examines how the issue of alcohol use has been problematized using past and current World Health Organization reports and associated publications as illustrations. The 2010 Global Strategy to Reduce the Harmful Use of Alcohol serves as a salient example. Applying an approach to policy analysis called ‘‘What’s the Problem Represented to be?’’ this article highlights grounding presuppositions in selected alcohol policies and policy proposals. Particular attention is directed to the genesis and continually evolving and changing key concept ‘‘alcohol problems’’ (or ‘‘alcohol-related problems’’ and other variations). The objective is to raise questions about the implications of public health frameworks of meaning around alcohol policy for how governing takes place and for governed subjects. On the basis of this analysis, this article signals the importance of interrogating the meaning and role of taken-for-granted categories of analysis.Carol Bacch

Chromosome constitution of species in the plant genus Chaenomeles

The chromosome number was studied in plants, derived from seeds collected in the wild, of all four species (C. cathayensis, C. japonica, C. speciosa and C. thibetica) presently recognised in the genus Chaenomeles Lindl. (Maloideae, Rosaceae). For the first time the chromosome number of C. thibetica was also determined. Chaenomeles thibetica was diploid and had a chromosome number of 2n = 34. The results of chromosome counting in the three other species were in agreement with the literature. Thus, all species within the genus Chaenomeles were confirmed to be diploid and to have the same chromosome number, 2n = 34